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成果及论文




    • 35. Zhiyuan ChenGuozhi Xiao* 

      Total Synthesis of Nona-decasaccharide Motif from Ganoderma sinense Polysaccharide Enabled by Modular and One-Pot 

      Stereoselective Glycosylation Strategy 


    • J. Am. Chem. Soc. 2024,146, 17446

    • Highlited by 化学深耕堂,中国科技网,CBG咨询和X-MOL平台等




    34. Kunxiu Shou+, Yunqin Zhang+, Yujie Ji+, Bin Liu, Qingli Zhou, Qiang Tan, Fuying Li, Xiufang Wang, Gang Lu*, Guozhi Xiao* 

    Highly stereoselective α-glycosylation with GalN3 donors enabled collective synthesis of mucin-related tumor 
    associated carbohydrates antigens

    Chem. Sci.  2024156552
    + these authors contributed equally

  •  

    33. Kunxiu Shou, Shanshan Liu, Yunqin Zhang, Guozhi Xiao* 
  •  

Stereoselective α-Glycosylation with GlcN3 Donors Enabled Collective Syntheses of Acinetobacter baumannii Capsular Polysaccharides K43K47 and K88 Repeating Units


Chin. J. Chem.  2024421593


Dedicated to the Special Issue of Emerging Investigators in 2024



  • 32. Ferran Nieto-Fabregat, 
  • Qian Zhu
  • Corinne Vivès
  • Yunqin Zhang
  • Angela Marseglia
  • Fabrizio Chiodo
  • Michel Thépaut
  • Diksha Rai
  • Suvarn S. Kulkarni
  • Flaviana Di Lorenzo
  • Antonio Molinaro
  • Roberta Marchetti
  • Franck Fieschi
  • Guozhi Xiao
  • Biao Yu*
  • Alba Silipo*
  •  

Atomic-Level Dissection of DC-SIGN Recognition of Bacteroides vulgatus LPS Epitopes


JACS Au  20244697


31. Kaifeng Li, Bin Liu, Xiufang Wang,* Guozhi Xiao* 

Highly Stereoselective Synthesis of Branched Fructooligosaccharides ABW90-1 and ABW50-from 
Achyranthes bidentata with Potent Antiosteoporosis Activities

Org. Lett 2024261468


30. Yuxin Ma,+ Yuqin Zhang,+ Zixi Chen, Qingyun Xian, Rui Su, Qiong Jiang, Xiufang Wang, Guozhi Xiao* 

One-Pot Assembly of Mannose-Capped Lipoarabinomannan Motifs up to 101-Mer from the Mycobacterium 

tuberculosis Cell Wall  

J. Am. Chem. Soc. 20241464112 (Cover picture)

+ These authors contributed equally

Highlighted by X-MOL,化学深耕堂,and so on


29. Xiufang Wang, Guozhi Xiao* 

Recent Advances in Chemical Synthesis of Structural Domains of Lipopolysaccharides from the commensal gut-
associated microbiota  

ChemBioChem  2023, 24e202300552 (DOI: 10.1002/cbic.202300552)


28. Zhiyuan Chen, Guozhi Xiao* 

One-pot Assembly of the highly branched Tetradecasaccharide from Ganoderma lucidum Glycan GLSWA-1 with immune 

enhancing activities

Org. Lett 202325, 7395 (DOI: 10.1021/acs.orglett.3c02898)


27. XingChun Sun, Zhiyuan Chen, Rui Yang, Mei Wang, Xiufang Wang, Qi Zhang,* Guozhi Xiao* 

Modular and Stereoselective One-pot Total Synthesis of Icosasaccharide motif from Cordyceps sinensis EPS-1A Glycan

Org. Lett 202325, 7364 (DOI: 10.1021/acs.orglett.3c02842)



26. Xiufang Wang, Guozhi Xiao* 

Recent chemical synthesis of plant polysaccharides

Curr. Opin. Chem. Biol.  202377, 102387.


25. Penghua Li, Hanyingzi Fan, Qiang Tan, Guozhi Xiao* 

Highly Stereoselective Assembly of 1,2-cis-Arap Linkages

Org. Lett 202325, 2788 (DOI: 10.1021/acs.orglett.3c00670)


24. Yunqin Zhang, Leilei Wang, Qingli Zhou, Zuoshan Li, Dan Li, Caixia Yin, Xiufang Wang, Guozhi Xiao* 

Modular synthesis of a tridesaccharide motif from Bacteroides vulgatus lipopolysaccharides against inflammatory bowel diseases through an orthogonal one-pot glycosylation strategy

Angew. Chem. Int. Ed 2023, 62e202301351 (cover piture)

Highlighted by chief editor Stephen G. Davey in Nat. Rev. Chem. 2023 (DOI: 10.1038/s41570-023-00500-2)

Dedicated to Professor Flaviana Di Lorenzo and Professor Antonio Molinaro


23. Jie Wan,+ Leilei Wang,+ Guozhi Xiao* 

Total synthesis of Phellinus ribis glycans with immunostimulating activities via orthogonal one-pot glycosylation strategy

Synlett202334, 288-292. DOI: 10.1055/a-1969-3992

+ these authors contributed equally



22. Yuxin Ma, Qiong Jiang, Xiufang Wang, Guozhi Xiao* 

Total synthesis of Cordyceps militaris glycans via stereoselective orthogonal one-pot glycosylation and a-glycosylation strategies

Org. Lett202224, 7950-7954.



21. Rui Yang, Xingchun Sun, Yunqin Zhang, Guozhi Xiao* 

The total synthesis of rhynchosporosides via orthogonal one-pot glycosylation and stereoselective a-glycosylation strategies

Org. Biomol. Chem. 202220, 6755-6758


20. Yunqin Zhang, Yanlei Hu, Shanshan Liu, Haiqing He, Roujing Sun, Gang Lu,* Guozhi Xiao* 

Total synthesis of Lentinus giganteus glycans with antitumor activities via stereoselective a-glycosylation and orthogonal one-pot glycosylation strategies

Chem. Sci. 2022, 13, 7755-7764 

Selected as 2022 Chemical Science Hot Article Collection
Selected as inside front cover

Highlighted in RSC China 官方微信平台



19. Yunqin Zhang, Guozhi Xiao* 

Chemical synthesis of TMG-chitotriomycin 

J. Carbohydr. Chem. 202140, 327-338


18. Rui Yang, Haiqing He, Zixi Chen, Yingying Huang, Guozhi Xiao* 

A one-pot synthesis of glycans and nucleosides based on ortho-(1-phenylvinyl)benzyl glycosides 

Org. Lett202123, 8257-8261.  


17. Guozhi Xiao*, Haiqing He 

Chemical synthesis of the nucleoside antibiotic capuramycin 

Eur. J. Org. Chem20212021, 3681-3689. 

Dedicated to Professors Biao Yu, Peter H. Seeberger and Weiping Tang 

Selected as very important paper (VIP)


16. Yunqin Zhang, Haiqing He, Zixi Chen, Yingying Huang, Guisheng Xiang, Penghua Li, Xingkuan Yang, Gang Lu,* Guozhi Xiao* 

Merging reagent modulation and remote anchimeric assistance for glycosylation: highly stereoselective synthesis of a-glycans up to a 30-mer 

Angew. Chem. Int. Ed2021, 60, 12597-12606.

Dedicated to Professor Xiao-Jiang Hao and Professor Han-Dong Sun for their great contributions to phytochemistry 

Highlighted in WileyChem 官方微信平台


15. Haiqing He+, Lili Xu+, Roujing Sun, Yunqin Zhang, Yingying Huang, Zixi Chen, Penghua Li, Rui Yang, Guozhi Xiao* 

(+ these authors contributed equally)

An orthogonal and reactivity-based one-pot glycosylation strategy for both glycans and nucleosides synthesis: access to TMG-chitotriomycin, lipochitooligosaccharides and capuramycin 

Chem. Sci.  202112, 5143-5151. 


14. Penghua Li+, Haiqing He+, Lili Xu, Yingying Huang, Zixi Chen, Yunqin Zhang, Rui Yang, Guozhi Xiao* 

(+ these authors contributed equally)

Ortho-(1-phenylvinyl)benzyl glycosides: Ether-type glycosyl donors for the efficient synthesis of both O-glycosides and nucleosides 

Green. Synth. Catal20201,160-166. 

Dedicated to the memory of Professor Jun Zhou and Professor Henry N. C. Wong on the occasion of his 70th birthday


13. Yunqin Zhang+, Zixi Chen+, Yingying Huang+, Shaojun He, Xingkuan Yang, Zhibing Wu, Xiufang Wang,* Guozhi Xiao* 

(+ these authors contributed equally)

Modular Synthesis of Nona-decasaccharide Motif from Psidium guajava Polysaccharides: Orthogonal One-Pot Glycosylation Strategy 

Angew. Chem. Int. Ed. 2020, 59,7576-7584 

Dedicated to Professor Biao Yu on the occasion of his 53th birthday


12. Penghua Li+, Haiqing He+, Yunqin Zhang+, Rui Yang, Lili Xu, Zixi Chen, Yingying Huang, Limei Bao, Guozhi Xiao* 

(+ these authors contributed equally)

Glycosyl ortho-(1-phenylvinyl)benzoates versatile glycosyl donors for highly efficient synthesis of both O-glycosides and nucleosides

Nat. Commun. 2020, 11, 405.

Highlighted in Nature Communications


11. Yunqin Zhang, Guisheng Xiang, Shaojun He, Yikao Hu, Yanjun Liu, Lili Xu, Guozhi Xiao*

Orthogonal one-pot synthesis of oligosaccharides based on glycosyl ortho-alkynylbenzoates 

Org. Lett. 2019, 21, 2335−2339.

Dedicated to Professor Yongzheng Hui on the occasion of his 80th birthday


10. Guozhi Xiao,* Xiaofei Shao, Dapeng Zhu, Biao Yu*

Chemical synthesis of marine saponins

Nat. Prod. Rep., 2019, 36, 769-787



博士和博士后:

 

9. Youxi Chen+, Guozhi Xiao+, Dapeng Zhu,* Biao Yu*

(+ these authors contributed equally)

Total Synthesis of Starfish Cyclic Steroid Glycosides. Part 2, Model Synthesis via Intramolecular Etherification

Chin. J. Chem. 202341, 897-902.


8. Stephanie A. Blaszczyk+, Guozhi Xiao+, Peng Wen+, Hua Hao, Jessica Wu, Bo Wang,Francisco Carattino, Ziyuan Li, Daniel A. Glazier, Bethany J. McCarty, Peng Liu,* Weiping Tang*

(+ these authors contributed equally)

S-Adamantyl Group Directed Site-Selective Acylation: Applications in Streamlined Assembly of Oligosaccharides

Angew. Chem. Int. Ed. 2019, 58, 9542-9546.

 

7. Andreas Geissner, Anika Reinhardt, Christoph Rademacher, Timo Johannssen, João Monteiro, Bernd Lepenies, Michel Thépaut, Franck Fieschi, Jana Mrázková, Michaela Wimmerova, Frank Schuhmacher, Sebastian Götze, Dan Grünstein, Xiaoqiang Guo, Heung Sik Hahm, Jeyakumar Kandasamy, Daniele Leonori, Christopher E. Martin, Sharavathi G. Parameswarappa, Sandip Pasari, Mark K. Schlegel, Hidenori Tanaka, Guozhi Xiao, You Yang, Claney L. Pereira, Chakkumkal Anish, and Peter H. Seeberger*

Microbe-focused glycan array screening platform

Proc. Natl. Acad. Sci. USA 2019, 116, 1958-1967.

 

6. Hao-Yuan Wang, Stephanie A. Blaszczk, Guozhi Xiao and Weiping Tang*

Chiral reagents in glycosylation and modification of carbohydrates

Chem. Soc. Rev. 2018, 47, 681-701.

 

5. Elizabeth Diago-Navarro, Michael P. Motley, Gonzalo Ruiz-Peréz, Winnie Yu, Julianne Austin, Bruna M. S. Seco, Guozhi Xiao, Aniska Chikhalya, Peter H. Seeberger, Bettina C. Fries*

Novel, Broadly Reactive Anticapsular Antibodies against Carbapenem-Resistant Klebsiella pneumoniae Protect from Infection

mBio 2018, 9, e00091-18

 

4. Guozhi Xiao, Gabriel A. Cintron-Rosado, Daniel A. Glazier,Bao-min Xi, Can Liu, Peng Liu* and Weiping Tang*

Catalytic site-selective acylation of carbohydrates directed by cation-n interaction 

J. Am. Chem. Soc. 2017, 139, 4346-4349..

Highlighted in J. Am. Chem. Soc. 2017, 139, 5625

 

3. Peter H. Seeberger*, Claney L. Pereira*, Naeem Khan+, Guozhi Xiao+, Elizabeth Diago-Navarro, KatrinReppe, Bastian Opitz, Bettina C. Fries and Martin Witzenrath

(+these authors contributed equally)

A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumonia

Angew. Chem. Int. Ed. 2017, 56, 13973-13978

 

2. Tomoya Nobuta+, Guozhi Xiao+, Diego Ghislieri, Kerry Gilmore* and Peter H. Seeberger*

(+these authors contributed equally)

Continuous and convergent access to vicinyl amino alcohols

Chem. Commun., 2015, 51, 15133-15136.

 

1. Guozhi Xiao, Biao Yu*

Total Synthesis of Starfish Saponin Goniopectenoside B.

Chem. Eur. J. 2013,19, 7708-7712.