科研项目情况：

1. 科学级高灵敏度成像系统高信噪比及自动曝光算法设计，公司委托项目，2022. 04-2023. 12，主持

2. “抗菌-促骨结合”双功能种植体压电声控涂层的构建和机制研究，福建省科技创新联合资金项目，2022-2025，合作主持

3.  生物硬组织激光消融水介导增强效应作用机理的研究，国家自然科学基金面上项目（61575042），2016.01-2019.12，主持

4. 伴水喷雾介导增强生物硬组织激光消融效应的研究，福建省自然科学基金，2017. 04-2020. 04，主持

5. 鼻咽癌转移机制与LMP1蛋白关联性的可视化光学表达，国家自然科学基金面上项目（61475036），2015.01-2018.12，合作主持

6.  脉冲激光生物硬组织水介导消融效应的机制研究. 教育厅重点项目，2011.05-2014.05，主持

7. 多光子显微成像结合拉曼光谱技术用于结直肠癌诊断和评估. 国家自然科学基金青年项目（61575042），2014.01-2016.12，第二成员

期刊论文  ( Selected)：

1. Yanli Huang, Xufeng Wan, Qiang Su, Chunlin Zhao, Jian Cao, Yan Yue, Shuoyuan Li, Xiaoting Chen, Jie Yin, Yi Deng, Tianmin Wu*, Xianzeng Zhang*, Zongke Zhou*, and Duan Wang*, Nature Communications, 15 (1), 1643 (2024).

2. Yanli Huang, Boyan Lv, Chunlin Zhao, Jie Yin, Yabin Wang, Yang Wang, Xinmiao Fu, Tianmin Wu, Jiagang Wu, Xianzeng Zhang*. High‐Efficiency Reactive Oxygen Species Generation by Multiphase and TiO₆ Distortion‐Mediated Superior Piezocatalysis in Perovskite Ferroelectrics[J]. Advanced Functional Materials, 2023: 2210726

3. Yanjin Lu, Yuan Zhou, Xiongwei Liang, Xianzeng Zhang*. Chengke Zhang*., Min Zhu, Kanglai Tang*. Jinxin Lin. Early bone ingrowth of Cu-bearing CoCr scaffolds produced by selective laser melting: An in vitro and in vivo study, Materials & Design, 2023，228, 111822

4.  Yanli Huang, Chunlin Zhao, Bo Wu, Xianzeng Zhang*. Grain size effects and structure origin in high-performance BaTiO₃-based piezoceramics with large grains, Journal of the European Ceramic Society, 2022, 42(6): 2764-2771

5.  薛建伟，吴灵锦，石晓卫，黄靖，梁航，张先增*. 9.3 μm脉冲CO₂激光辐照牙硬组织的消融特性研究[J].中国激光, 2022, 第49卷(15): 55-60

6. Ying Wang, Zhihao Chen, Weijuan Chen, Xianzeng Zhang*. Refractive index and temperature sensor based on fiber ring laser with tapered seven core fiber structure in 2 μm band, Optical Fiber Technology, 2021, 61: 0-102388

7.  吕茗萱，石晓卫，薛建伟，吴灵锦，张先增*.激光诱导液体微射流效应及其在医学领域的应用[J].激光与光电子学进展,2021,第58卷(11): 51-58

8.  石晓卫，苑慧，吕茗萱，蔡佳惠，张先增*.虚拟现实技术在医学领域的研究现状与进展[J].激光与光电子学进展, 2020, 第57卷(1): 66-75

9.  Xianzeng Zhang, Nenrong Liu, Mak PU, Pun SH, Vai MI, Masihzadeh O, Kahook MY, Lei TC, Ammar DA. Three-Dimensional Segmentation and Quantitative Measurement of the Aqueous Outflow System of Intact Mouse Eyes Based on Spectral Two-Photon Microscopy Techniques. Invest Ophthalmol Vis Sci. 2016, 57(7):3159-67.

10.  Xianzeng Zhang, Chen Chuanguo, Chen Faner, Zhan Zhenlin, Xie Shusen, Ye Qing. In vitro investigation on Ho: YAG laser-assisted bone ablation underwater, Lasers in Medical Science, 2016,31(5): 891-898

11.  Zhang Xianzeng, Zhenlin Zhan, Haibin Zhao, et al.. Influence of water-layer thickness on hard tissue ablation with pulse CO₂ laser. Journal of Biomedical Optics, 2012, 17(3):038003

12.  李旭伟，陈传国，张先增*，詹振林，谢树森. 聚焦辐照条件对脉冲CO₂激光诱导液体气穴通道效应的影响. 光学学报, 2015, 35(2): 0217001 

13.  Zhang Xianzeng, Gen Yan, Ye Qin, et al.. Volumetric label-free imaging and 3D reconstruction of mammalian cochlea based on two-photon excitation fluorescence microscopy. Laser physics. 2013, 23(11): 115601

14.  Liu Nenrong, Xianzeng Zhang*, Qiu Yishen, et al.. Nonlinear optical imaging characteristics in rat tail tendon. Laser Physics Letters. 2013. 23(11): 115601

15.  Zhenlin Zhan, Xianzeng Zhang*, Wenqing Guo, et al. Assessment of composition changes in demineralization and remineralization of human dentin using Raman spectroscopy. Photonics & Lasers in Medicine, 2013, 2(1):45-50.

16. Zhenlin Zhan, Xianzeng Zhang*, Wenqing Guo, et al. Determining ablation threshold of dental hard tissues irradiated with Er:YAG and Er,Cr:YSGG laser. Chinese Optics Letters. 2013, 11(5)

17.  张先增，郭健，詹振林，谢树森. 脉冲CO₂激光伴水喷雾的骨组织消融. 光学学报. 2010, 30(7): 2069-2073

18. Zhang Xianzeng, Xie Shusen, Zhan Zhenlin, et al.. Evaluation of Er, Cr:YSGG laser for hard tissue ablation. Frontier of Optoelectronics in China. 2010, 3(2) :163-168

19. 赵海滨，张先增，詹振林，谢树森. 组织表面附着水膜层对脉冲CO₂激光骨硬组织消融的影响. 中国激光, 2011, 38(1): 0104002。

20.  詹振林, 张先增, 郭文庆, 刘海山, 谢树森. 牙硬组织消融光学研究进展. 激光与光电子学进展, 2012, 49(10): 100005。

21.  Zhang Xianzeng, Xie Shusen, Ye Qing, et al.. Influence of scanning velocity on bovine shank bone ablation with pulsed C_O2 laser. Chinese Optics Letters, 2009, 7(2): 138-141

22. 张先增，王晓燕，詹振林,等. 脉冲CO₂和Er:YAG激光颅骨组织消融的比较研究.中国激光, 2009, 36（10）：2577-2581

23. Zhang Xianzeng, Wang Xiaoyan, Zhan Zhenlin, et al.. Fenestration operation in middle ear bone with pulse infrared lasers: an in-vivo study. Chinese Optics Letters, 2009, 7(9):830-833

24. 张先增,谢树森,詹振林,叶青. 脉冲激光生物硬组织消融的研究进展. 激光与光电子学进展, 2009, 46(12): 72-79

  授权发明专利:

1.      张先增，张晓奇. 一种基于视频提取脉搏波的血压检测方法及终端. CN1188092B, 2022-08-19, 32.

2.      张先增，卢智全，吴剑峰，连渊坡，一种非接触式复杂表面锥体体积测量系统及方法，2014.12.10，中国，CN201410446494.6

3.      张先增，詹振林，刘海山，谢树森，一种水膜层厚度的精确控制调节装置，2013.06.05，中国，CN201110137705.4

4.      张先增，詹振林，刘海山，赵海滨，谢树森，容器内液面高度精确调节控制装置，2011.12.14，中国，CN201120170854.6