王彦君同学的工作发表在《Nano Letters》上，祝贺。彦君为课题组和交大九院联合培养硕士生。

感谢主编和审稿人的认可！

题目：Bio-mimetic lung-targeting nanoparticles with antioxidative and Nrf2 activating properties to treat ischemia reperfusion induced acute lung injury

链接：https://pubs.acs.org/doi/full/10.1021/acs.nanolett.3c03671

该工作通过制备肺靶向的仿生药物递送系统用于降低肺部ROS并激活Nrf通路，用于治疗缺血再灌注造成的急性肺损伤。

摘要：

Ischemia/reperfusion (IR)-induced acute lung injury (ALI) has a high mortality rate. Reactive oxygen species (ROS) play a crucial role in causing cellular damage and death in IR-induced ALI. In this work, we developed a biomimetic lung-targeting nanoparticle (PC@MB) as an antioxidative lung protector for treating IR-induced ALI. PC@MBs showed excellent ROS scavenging and Nrf2 activation properties, along with a lung-targeting function through autologous cell membrane coating. The PC@MBs exhibited an impressive antioxidative and pulmonary protective role via redox homeostasis recovery through Nrf2 and heme oxygenase-1 activation. PC@MBs could maintain cell viability by effectively scavenging the intracellular ROS and restoring the redox equilibrium in the lesion. In the IR mouse model, the PC@MBs preferentially accumulated in the lung and distinctly repaired the pneumonic damage. Our strategy has the potential to offer a promising therapeutic paradigm for treating IR-induced ALI through the incorporation of different therapeutic mechanisms.