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成果及论文

代表性论文

1. Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer, Molecular cancer, 2021, 20(1): 126 (中科院TOP1区, IF=27.401)

2. Epidemiological analysis of 1234 cases of laryngeal cancer in Shanxi province, China, Cancer control, 2021, 28:10732748211041236.(中科院3区, IF=3.302) 

3. Regulatory role and mechanism of m6A RNA modification in human metabolic diseases, Molecular Therapy- Oncolytics, 2021 , doi.org/10.1016/j.omto.2021.05.003 (中科院2区, IF=7.2)

4. Alterations of bacterial communities of vocal cord mucous membrane increases the risk for glottic laryngeal squamous cell carcinoma, Journal of cancer, 2021, 12(13): 4049-4063 (中科院3区, IF=4.207) 

5. miR-1207-5p suppresses laryngeal squamous cell carcinoma progression by downregulating SKA3 and inhibiting epithelial-mesenchymal transition, Molecular Therapy-Oncolytics, 2021, 19(22):152-165. (中科院2区, IF=7.2)

6. Petroleum extract of Farfarae Flos alleviates nasal symptoms by regulating the Th1-Th2 cytokine balance in a mouse model of Allergic Rhinitis, International journal of medical sciences, 2021, 18(2): 555-563 (中科院3区, IF=3.738)

7. Tumor microenvironment and immune-related therapies of Head and neck squamous cell carcinoma, Molecular therapy-oncolytics, 2021, 20:342-351 (中科院2区, IF=7.2)

8. circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway, Molecular Cancer, 2020, 19(1):166 (中科院TOP1区, IF=27.401)

9. Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1-AKT axis-mediated glycolysis, Cell Death & Disease, 2020, 11(10): 919 (中科院2区, IF=8.469)

10. Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/ PBX3 axis, Molecular Cancer, 2020, 19(1): 99 (中科院TOP1区, IF=27.401)

11. Serum Exosomal miR-941 as a promising Oncogenic Biomarker for Laryngeal Squamous Cell Carcinoma, Journal of Cancer, 2020, 11(18): 5329-5344 (中科院3区, IF=4.207)

12. c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis, Nature communications, 2020, 11(1): 4980 (中科院TOP1区, IF=14.919) 

13. Ipr1 Regulation by Cyclic GMP-AMP Synthase/Interferon Regulatory Factor 3 and Modulation of Irgm1 Expression via p53, Molecular and Cellular Biology, 2020, 40(8):e00471-19 (中科院2区,IF=4.272)

14. Promoter Methylation-Regulated miR-145-5p Inhibits Laryngeal Squamous Cell Carcinoma Progression by Targeting FSCN1, Molecular Therapy, 2019, 27(2): 365-379 (中科院TOP1区, IF=11.454, ESI高被引)

15. Identification of miR-145-5p-centered competing endogenous RNA network in laryngeal squamous cell carcinoma, Proteomics, 2019, 6(21-22): e1900020 (中科院2区, IF=3.984)

16. Astragali radix total flavonoid synergizes cisplatin to inhibit proliferation and enhances the chemosensitivity of laryngeal squamous cell carcinoma, Rsc Advances, 2019, 9(42): 24471-24482 (中科院3区, IF=3.361)

17. Mass Spectrometric Analysis Identifies AIMP1 and LTA4H as FSCN1 Binding Proteins in Laryngeal Squamous Cell Carcinoma, Proteomics, 2019, 19(21-22): e1900059 (中科院2区, IF=3.984)

18. LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription, Nature Communications, 2019, 10(1): 5334(大类TOP1区, IF=14.919)

19. AlloDriver: a method for the identification and analysis of cancer driver targets, Nucleic Acids Research, 2019, 47(W1): W315-W321 (大类TOP1区, IF=16.971)

20. Whole-Transcriptome Analysis of CD133+CD44+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells, Cellular physiology and biochemistry, 2018, 47(4): 1696-1710 (中科院2区, IF=5.5)

21. MicroRNA-27b Modulates Inflammatory Response and Apoptosis during Mycobacterium tuberculosis Infection, Journal of Immunology, 2018, 200(10):3506-3518 (中科院2区,IF= 5.422) 

22. Identification and characterization of CD133+CD44+ cancer stem cells from human laryngeal squamous cell carcinoma cell lines, Journal of Cancer, 2017, 8(3): 497-506 (大类3区, IF=4.207)

23. Unphosphorylated STAT1 represses apoptosis in macrophages during Mycobacterium tuberculosis infection, Journal of Cell Science, 2017,130(10):1740-1751 (中科院2区,IF=5.285)

24. The Transcriptional Foundations of Sp110-mediated Macrophage (RAW264.7)Resistance to Mycobacterium tuberculosis H37Ra, Scientific Reports, 2016, 6: 22041 (中科院3区,IF=4.379)

25. Characterization of promoter of the tuberculosis-resistant gene intracellular pathogen resistance 1, Immunologic Research, 2016, 64(1): 143-154 (中科院3区,IF=2.829)

26. Maintenance of Self-Renewal and Pluripotency in J1 Mouse Embryonic Stem Cells through Regulating Transcription Factor and MicroRNA Expression Induced by PD0325901, Stem Cells International, 2016, 2016: 1792573 (中科院2区,IF=5.443)

27. GSK3 inhibitors CHIR99021 and 6-bromoindirubin-3'-oxime inhibit microRNA maturation in mouse embryonic stem cells, Scientific Reports, 2015(5): 8666 (中科院3区,IF=4.379)

28. Vitamin C induces a pluripotent state in mouse embryonic stem cells by modulating microRNA expression, FEBS Journal, 2015, 282(4):685-699 (中科院2区,IF=5.542)

29. Vitamin C enhances Nanog expression via activation of the JAK/STAT signaling pathway, Stem Cells, 2014, 32(1):166-176 (中科院2区,IF=6.277)

30. Mechanism of SB431542 in inhibiting mouse embryonic stem cell differentiation, Cellular Signalling, 2014, 26(10):2107-2116 (中科院2区,IF=4.315)

31. CHIR99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding RNA expression, Experimental Cell Research, 2013, 319(17): 2684-2699 (中科院2区,IF=3.905)

32. Oct4 and the small molecule inhibitor, SC1, regulates Tet2 expression in mouse embryonic stem cells, Molecular Biology Reports, 2013, 40(4):2897-906 (中科院4区,IF=2.316)

33. SUMOylation Represses Nanog Expression via Modulating Transcription Factors Oct4 and Sox2, PloS One, 2012, 7(6): e39606 (中科院3区,IF=3.24)


知识产权成果:

(1)第一发明人,一种慢病毒单质粒体内生物素化载体及制备方法,2019.11.19,中国,ZL 201610928951.4,发明专利

(2)第一发明人,可调节的琼脂糖凝胶回收切胶器,2019.10.18,中国,ZL 201930041826.6,外观设计专利

(3)第一发明人,一种带UV紫外线灯的离心管架,2016.08.31,中国,ZL 201620339275.2,实用新型专利

(4)第一发明人,一种摇床,2019.11.22,中国,ZL 201920109376.4,实用新型专利

(5)第二发明人,一种细胞平板克隆形成图像采集仪,2016.03.30,中国,ZL 201520998317.9,实用新型专利

(6)第二发明人,一种可调节的琼脂糖凝胶回收切胶器,2019.10.18,中国,ZL 201920124174.7,实用新型专利

(7)第二发明人,摇床,2019.06.21,中国,ZL 201930036349.4,外观设计专利

(8)第三发明人,一种尸头解剖固定架,2019.02.19,中国,ZL 201820029259.2,实用新型专利

(9)第三发明人,尸头解剖固定架,2018.06.19,中国,ZL 201830007713.X,外观设计专利

(10)第一权利人,实验室实验技能在线考试管理系统,2019SR0947048,原始取得,全部权利,2019.09.11,软件著作权

(11)第二权利人,科研业务综合管理系统V5.0,2016SR107789,原始取得,全部权利,2016.05.17,软件著作权

(12)第二权利人,科研综合业务云智慧管理系统,2019SR0262022,原始取得,全部权利,2019.03.19,软件著作权

(13)第三权利人,头颈肿瘤转录组与随访数据管理系统V1.0,2019SR0807557,原始取得,全部权利,2019.08.02,软件著作权


科研奖励:

(1)第三完成人,喉鳞癌转录组差异网络构建与关键生物学功能调控机制研究,山西省科学技术奖,一等奖,2019

(2)第十完成人,牛羊基因定点精确编辑技术,陕西省科学技术奖,一等奖,2016