Ø  发表文章列表

2024

44. Luo Z, Lin Y, Meng Y, Li M, Ren H, Shi H, Cheng Q*, Wei T*. Spleen-Targeted mRNA Vaccine Doped with Manganese Adjuvant for Robust Anticancer Immunity In Vivo. ACS Nano. 2024, doi: 10.1021/acsnano.4c09902.

43. Fei Y¹, Yu X¹, Liu P, Ren H, Wei T*, Cheng Q*. Simplified Lipid Nanoparticles for Tissue‐ And Cell‐Targeted mRNA Delivery Facilitate Precision Tumor Therapy in a Lung Metastasis Mouse Model. Advanced Materials. 2024,  https://doi: 10.1002/adma.202409812.

2023

42.  Lin Y, Cheng Q*, Wei T*. Surface Engineering of Lipid Nanoparticles: Targeted Nucleic Acid Delivery and Beyond. Biophys Rep. 2023, 9(5):255-278. (Invited Review)

41.  Cheng Q¹, Farbiak L¹, Vaidya A, Guerrero E, Lee EE, Rose EK, Wang X, Robinson J, Lee SM, Wei T, Miller WE, Benedicto EA, Lian X, Wang RC, Siegwart DJ*. In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma. Proc Natl Acad Sci U S A. 2023, 120(52):e2313009120. (IF=11.1)

40.  Wei T¹, Sun Y¹, Cheng Q¹, Chatterjee S, Traylor Z, Johnson LT, Coquelin ML, Wang J, Torres MJ, Lian X, Wang X, Xiao Y, Hodges CA, Siegwart DJ. Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models. Nat Commun. 2023, 14(1):7322. 

39. Zong Y, Wei T, Cheng Q*. Recent advances in strategies for developing tissue-selective mRNA-LNP technology (in Chinese). Chin Sci Bul. 2023, doi:10.1360/TB-2023-0613. 

38. Zong Y, Lin Y, Wei T*, Cheng Q*. Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy. Adv Mater. 2023, https://doi.org/10.1002/adma.202303261.

37. Wu Z¹, Lu M¹, Liu D¹, Shi Y¹, Ren J¹, Wang S¹, Jing Y, Zhang S, Zhao Q, Li H, Yu Z, Liu Z, Bi S, Wei T, Yang YG, Xiao J, Belmonte JCI, Qu J*, Zhang W*, Ci W*, Liu GH*. m⁶A epitranscriptomic regulation of tissue homeostasis during primate aging. Nat Aging. 2023, https://doi.org/10.1038/s43587-023-00393-2.

2022

36. Wang X, Liu S, Sun Y, Yu X, Lee SM, Cheng Q, Wei T, Gong J, Robinson J, Zhang D, Lian X, Basak P, Siegwart DJ*. Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery. Nat Protoc. 2022,  doi: 10.1038/s41596-022-00755-x. (IF=17.021)

35. Wei T*, Tao W*, Cheng Q*. Lipid nanoparticles for mRNA therapy: recent advances in targeted delivery. Life Medicine, 2022,  https://doi.org/10.1093/lifemedi/lnac004. （荣获Life Medicine 2022年最受欢迎论文）

34. Zhang D, Wang G, Yu X, Wei T, Farbiak L, Johnson LT, Taylor AM, Xu J, Hong Y, Zhu H, Siegwart DJ*. Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy. Nat Nanotechnol. 2022, doi: 10.1038/s41565-022-01122-3. (IF=39.213)

2021

33. Yu X, Liu S, Cheng Q, Lee SM, Wei T, Zhang D, Farbiak L, Johnson LT, Wang X, Siegwart DJ. Hydrophobic Optimization of Functional Poly (TPAE-co-suberoyl chloride) for Extrahepatic mRNA Delivery following Intravenous Administration. Pharmaceutics. 2021, 13(11):1914. (IF=5.875)

32. Liu J, Chen C, Wei T, Gayet O, Loncle C, Borge L, Dusetti N, Ma X, Marson D, Laurini E, Pricl S, Gu Z, Iovanna J, Peng L, Liang X-J. Dendrimeric nanosystem consistently circumvents heterogeneous drug response and resistance in pancreatic cancer. Exploration. 2021, https://doi.org/10.1002/EXP.20210003.

31. Farbiak L, Cheng Q, Wei T, Álvarez-Benedicto E, Johnson LT, Lee S, Siegwart DJ. All-In-One Dendrimer-Based Lipid Nanoparticles Enable Precise HDR-Mediated Gene Editing In Vivo. Adv Mater. 2021, 33(30):e2006619. (IF=30.849)

30. Liu S, Cheng Q, Wei T, Yu X, Johnson LT, Farbiak L, Siegwart DJ. Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing. Nat Mater. 2021, 20(5):701. (IF=43.841, ESI 高被引论文)

2020

29. Wei T¹, Cheng Q¹, Min YL, Olson EN, Siegwart DJ*. Systemic nanoparticle delivery of CRISPR/Cas9 ribonucleoproteins for effective tissue-specific genome editing. Nat Commun. 2020, 11(1):3232. ( IF=14.919, ESI 高被引论文)

28. Cheng Q¹, Wei T¹, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ*. Selective ORgan Targeting (SORT) nanoparticles for tissue specific mRNA delivery and CRISPR/Cas gene editing. Nat Nanotechnol. 2020, 15(4):313. (IF=39.213, ESI 高被引论文)

27. Wei T, Cheng Q, Farbiak L, Anderson DG*, Langer R*, Siegwart DJ*. Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for in Vivo CRISPR/Cas-Based Genome Editing. ACS Nano. 2020, 14(8):9243. (IF=15.881)

26. Xiong H, Liu S, Wei T, Cheng Q, Siegwart DJ. Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo. J Control Release. 2020, 325:198. (IF=9.776)

25. Yu X, Liu S, Cheng Q, Wei T, Lee S, Zhang D, Siegwart DJ. Lipid-Modified Aminoglycosides for mRNA Delivery to the Liver. Adv Healthc Mater. 2020:e1901487. (IF=9.933)

2011-2019

24. Zhao C, Liu A, Santamaria CM, Shomorony A, Ji T, Wei T, Gordon A, Elofsson H, Mehta M, Yang R, Kohane DS. Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity. Nat Commun. 2019, 10(1):2566. (IF=14.919)

23. Cheng Q, Wei T, Jia Y, Farbiak L, Zhou K, Zhang S, Wei Y, Zhu H, Siegwart DJ. Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I. Adv Mater. 2018, 30(52):e1805308. (IF=30.849)

22. Liu Q, Santamaria CM, Wei T, Zhao C, Ji T, Yang T, Shomorony A, Wang BY, Kohane DS. Hollow Silica Nanoparticles Penetrate the Peripheral Nerve and Enhance the Nerve Blockade from Tetrodotoxin. Nano Lett. 2018, 18(1):32. (IF=11.189)

21. Prieto M, Rwei AY, Alejo T, Wei T, Lopez-Franco MT, Mendoza G, Sebastian V, Kohane DS, Arruebo M. Light-Emitting Photon-Upconversion Nanoparticles in the Generation of Transdermal Reactive-Oxygen Species. ACS Appl Mater Interfaces. 2017, 9(48):41737. (IF=9.229)

20. Yang R, Wei T, Goldberg H, Wang W, Cullion K, Kohane DS. Getting Drugs Across Biological Barriers. Adv Mater. 2017, 29(37), doi: 10.1002/adma.201606596. (IF=30.849)

19. Zhou J, Song X, Han S, Wei T, Wang X, Cao H, Liang X-J, Liang Z, Cheng Q, Deng L, Dong A. Balancing Biocompatibility, Internalization and Pharmacokinetics of Polycations/siRNA by Structuring the Weak Negative Charged Ternary Complexes with Hyaluronic Acid. J Biomed Nanotechnol. 2017, 13(11):1533. (IF=4.099)

18. Liu J¹, Wei T¹, Zhao J, Huang Y, Deng H, Kumar A, Wang C, Liang Z, Ma X*, Liang X-J*. Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance. Biomaterials. 2016, 91:44. (IF=12.479)

17. Zhao J, Liu J, Wei T, Ma X, Cheng Q, Huo S, Zhang C, Zhang Y, Duan X, Liang XJ. Quercetin-loaded nanomicelles to circumvent human castration-resistant prostate cancer in vitro and in vivo. Nanoscale. 2016, 8(9):5126. (IF=7.79)

16. Xue X, Yang JY, He Y, Wang LR, Liu P, Yu LS, Bi GH, Zhu MM, Liu YY, Xiang RW, Yang XT, Fan XY, Wang XM, Qi J, Zhang HJ, Wei T, Cui W, Ge GL, Xi ZX, Wu CF, Liang XJ. Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice. Nat Nanotechnol. 2016, 11(7):613. (IF=39.213)

15. Liu J, Ma X, Jin S, Xue X, Zhang C, Wei T, Guo W, Liang XJ. Zinc oxide nanoparticles as adjuvant to facilitate doxorubicin intracellular accumulation and visualize pH-responsive release for overcoming drug resistance. Mol. Pharmaceutics, 2016, 13(5):1723. (IF=4.939)

14. Liu J, Ma X, Lei C, Xue X, Wei T, Zhao J, Li S, Liang XJ. A self-assembled DNA nanostructure for targeted and pH-triggered drug delivery to combat doxorubicin resistance. J Mater Chem B. 2016, 4(22): 3854. (IF=6.331)

13. Cheng Q, Du L, M eng L, Han S, Wei T, Wang X, Wu Y, Song X, Zhou J, Zheng S, Huang Y, Liang XJ, Cao H, Dong A, Liang Z. The Promising Nanocarrier for Doxorubicin and siRNA Co-delivery by PDMAEMA-based Amphiphilic Nanomicelles. ACS Appl Mater Interfaces. 2016, 8(7):4347. (IF=9.229)

12. Wei T, Chen C, Liu J, Liu C, Posocco P, Liu X, Cheng Q, Huo S, Liang Z, Fermeglia M, Pricl S, Liang X-J*, Rocchi P, Peng L*. Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance. Proc Natl Acad Sci U S A. 2015, 112(10):2978. (IF=11.205)

11. Han S, Cheng Q, Wu Y, Zhou J, Long X, Wei T, Huang Y, Zheng S, Zhang J, Deng L, Wang X, Liang X-J, Cao H, Liang Z, Dong A. Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery. Biomaterials. 2015, 48:45. (IF=12.479)

10. Huang Y, Wei T, Yu J, Hou Y, Cai K, Liang X-J. Multifunctional metal rattle-type nanocarriers for MRI-guided photothermal cancer therapy. Mol. Pharmaceutics, 2014, 11(10):3386. (IF= 4.939)

9. Wei T¹, Liu J¹, Ma H, Cheng Q, Huang Y, Zhao J, Huo S, Xue X, Liang Z, Liang X-J*. Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo. Nano Lett. 2013, 13(6):2528. (IF=11.189)

8. Zhang W, Cheng Q, Guo S, Lin D, Huang P, Liu J, Wei T, Deng L, Liang Z, Liang XJ, Dong A. Gene transfection efficacy and biocompatibility of polycation/DNA complexes coated with enzyme degradable PEGylated hyaluronic acid. Biomaterials. 2013, 34(27):6495. (IF=12.479)

7. Cheng Q, Huang Y, Zheng H, Wei T,  Zheng S, Huo S, Wang X, Du Q, Zhang X, Zhang H, Liang X-J, Wang C, Tang R, Liang Z. The effect of guanidinylation of PEGylated poly(2-aminoethyl methacrylate) on the systemic delivery of siRNA. Biomaterials. 2013, 34(12):3120. (IF=12.479)

6. Huo S, Ma H, Huang K, Liu J, Wei T, Jin S, Zhang J, He S and Liang, X-J. Superior penetration and retention behavior of 50nm gold nanoparticles in tumor. Cancer Res, 2013, 73(1):319. (IF=12.701, ESI 高被引论文)

5. Liu J, Ma H, Wei T, Liang X. CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells. Chem. Commun. 2012, 48(40):4869. (IF=6.222)

4. Huang K, Ma H, Liu J, Huo S, Kumar A, Wei T, Zhang X, Jin S, Gan Y, Wang P, He S, Liang X-J. Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo. ACS Nano. 2012, 6(5):4483. (IF=15.881, ESI 高被引论文)

3. Kumar A, Ma H, Zhang X, Huang K, Jin S, Liu J, Wei T, Cao W, Zou G, Liang X-J. Gold nanoparticles functionalized with therapeutic and targeted peptides for cancer treatment. Biomaterials, 2012, 33(4):1180. (IF=12.479)

2. Guo S, Huang Y, Zhang W, Wang W, Wei T, Lin D, Liang Z, Liang X-J, Dong A. Ternary Complexes of Amphiphilic Polycaprolactone-graft-Poly(N,N-dimethylaminoethyl methacrylate), DNA and Polyglutamic-graft-Poly(ethylene glycol) for Gene Delivery. Biomaterials, 2011, 32(18):4283. (IF=12.479)

1. Guo S, Huang Y, Wei T, Zhang W, Wang W, Lin D, Zhang X, Kumar A, Du Q, Xing J, Deng L, Liang Z, Wang PC, Dong A, Liang X-J. Amphiphilic and biodegradable methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethy lamino)-ethyl methacrylate)) as an effective gene carrier. Biomaterials. 2011, 32(3):879. (IF=12.479)

Ø 发明专利

9.      魏妥，罗自金. 一种掺杂金属离子佐剂的脾脏靶向 mRNA 疫苗及其制备方法与应用（中国申请号：2024110561345；申请日期：2024/08/02）

8.      程强，魏妥，林艺，李梦尧. 肽基可离子化脂质合成及其应用（PCT申请号：PCT/CN2024/104390；申请日期：2024/07/09）

7.      程强，魏妥，费圆，于晓璐. 脂质纳米颗粒及其应用（申请号：2023110328168；申请日期：2023/08/16）

6.      Cheng Q, Wei T and Siegwart DJ. Compositions and methods for organ specific delivery of nucleic acids (Application number: PCT/US2019/049552, Publication Date: 2020/03/12)

5.      Cheng Q, Wei T and Siegwart DJ. Compositions and methods for organ specific delivery of nucleic acids (Application number: PCT/US2019/049565, Publication Date: 2020/03/12)

4.      Siegwart DJ, Wei T, Cheng Q and Torres M. Compositions, Methods and Uses for Treating Cystic Fibrosis and Related Disorders. (Application number: PCT/US2022/023333, Publication Date: 2022/10/13)

3.      Siegwart DJ, Liu S, Yu X, Cheng Q and Wei T. Functional ionizable phospholipids (Application number: PCT/US2021/047203, Publication Date: 2022/02/24)

2.      Torres M, Siegwart DJ, Eby J, Bhattacharjee R, Wustman B, Kharitonov V, Cheng Q and Wei T. Compositions and methods for targeted delivery to cells. (Application number: PCT/US2022/021176, Publication Date: 2022/09/29)

1.      Liang X-J, Ma H, Liu J, Wei T. Nucleic acid, drug carrier, pharmaceutical composition and preparation method of drug carrier and pharmaceutical composition (Application number: CN201110421565.3A, Granted Date: 2014/09/24)