科研项目 (2017 年—至今)：
* 承担包括国家自然科学基金、广东省“珠江人才计划—青年拔尖人才”项目、广东省自然科学基金、中药材规范化生产研究基金等各类型项目 14 项。
SCI 论文和专利 (#, 共同第一作者；*，通讯作者)：
Year: 2024
30. Yun Liu#, Wei Xie#, Yurou Zhang, Shuangcheng Liang, Sidi Wang, Ruoting Zhan, Jiangyong Gu*, Caiyan Wang*, Kui Wang* (通讯作者). Structural and functional insights into the mechanism that GH8 endoxylanase specifically produces a wide range of xylooligosaccharides. 2024. (Submission)
29. Qibin Lin#, Xiaoru Wang#, Liang Zhang#, Yingyu Shu, Yurou Zhang, Ruoting Zhan*, Kui Wang* (通讯作者). Investigations in mutation breeding and culturing media by Xanthophyllomyces dendrorhous. Biocatalysis and Agricultural Biotechnology, 2024. DOI: 10.1016/j.bcab.2023.103008. PubDate: 2024.01.01. Online: 2023.10.29 (Accepted, IF=4.0)
Year: 2023
28. Ying Liu# , Ying Zhang#, Minghuan Wang, Lisheng Wang, Wanting Zheng, Qiannuo Zeng, Kui Wang* (通讯作者). Comparison of the basic processes of aerobic, anaerobic and aerobic-anaerobic coupling composting of Chinese medicinal herbal residues. Bioresource Technology, 2023, 379: 128996. DOI: 10.1016/j.biortech.2023.128996. PubDate (Online): 2023.04.01 (中科院一区 Top 期刊, IF=11.4)
27. Wei Xie, Ying Zhang, Lin Zhang, Liangkai Cheng, Zhongqiu Liu, Kui Wang* (通讯作者), Caiyan Wang*. Application prospects and enzyme enginerring of GH10 family xylanase. Biotechnology and Genetic Engineering Reviews, 2023. (Accepted) (中科院三区, IF=3.2)
26. Yurou Zhang#, Yun Liu#, Chunxiu Zeng, Yinyu Shu, Xiaoru Wang, Shuangcheng Liang, Sidi Wang*, Ruoting Zhan*, Kui Wang* (通讯作者). Characterization of two novel highly active glycoside hydrolase family 53 endo-1,4-β-galactanases and their synergism with other carbohydrases in plant polysaccharide decomposition. International Journal of Biological Macromolecules, 2023, 224 (2023): 653–666. DOI: 10.1016/j.ijbiomac.2022.10.154. PubDate: 2023.01.01. Online: 2022.10.22 (中科院一区 Top 期刊, IF=8.2)
Year: 2022
25. Ruiqin Zhang, Dongxia Lin, Liang Zhang, Ruoting Zhan, Sidi Wang*, Kui Wang* (通讯作者). Molecular and biochemical analyses of a novel trifunctional endoxylanase/endoglucanase/feruloyl esterase from the human colonic bacterium Bacteroides intestinalis DSM 17393. Journal of Agricultural and Food Chemistry, 2022, 70: 4044−4056. DOI: 10.1021/acs.jafc.2c01019. PubDate (Online): 2022.03.22 (中科院一区 Top 期刊, Supplemetary Cover Article【内封面论文】, IF=6.1)
24. 王魁，张瑞勤，汪思迪. 一种兼具木聚糖酶、葡聚糖酶和阿魏酸酯酶活性的三功能酶Bi76及其应用. 中国发明专利, 2022. (申请号：2022102434832)
23. Lin Zhang, Wei Xie, Xiaojun Teng, Kui Wang, Wei Xie*, Caiyan Wang*. Improving the extraction of active ingredients from medicinal plants by XynA modification. Journal of Chemistry, 2022, 2022: 2483797. DOI: 10.1155/2022/2483797. PubDate (Online): 2022.02.03 (JCR Q3, IF=3.241)
Year: 2021
22. 王魁，刘云，汪思迪，张亮，张瑞勤，陈茜. 一种特异性产生木寡糖的木聚糖酶 BgXyn8A 及其基因与应用. 中国发明专利, 2021. (申请号：2021106816032)
21. Wei Xie, Qi Yu, Ruiqing Zhang, Yun Liu, Ruoting Cao, Sidi Wang, Ruoting Zhan, Zhongqiu Liu, Kui Wang* (通讯作者), Caiyan Wang*. Insights into the catalytic mechanism of a novel XynA and structure-based engineering for improving bifunctional activities. Biochemistry, 2021, 60(26):2071−2083. DOI: 10.1021/acs.biochem.1c00134. PubDate (Online): 2021.06.22 (JCR Q3, IF=3.321)
20. MinghuanWang, Ying Liu, Shanqi Wang, Kui Wang, Ying Zhang*. Development of a compound microbial agent beneficial to the composting of Chinese medicinal herbal residues. Bioresource Technology, 2021, 330: 124948. DOI: 10.1016/j.biortech.2021.124948. PubDate (Online): 2021.03.10 (中科院一区 Top 期刊, IF=11.888)
19. Xi Chen#, Xinhai Wang#, Yun Liu, Ruoting Cao, Sidi Wang, Ruoting Zhan, Kui Wang* (通讯作者). Biochemical analyses of a novel thermostable GH5 endo beta-1,4-mannanase with minor beta-1,4-glucosidic cleavage activity from Bacillus sp. KW1 and its synergism with a commercial alpha-galactosidase on galactomannan hydrolysis. International Journal of Biological Macromolecules, 2021, 166: 778−788. DOI: 10.1016/j.ijbiomac.2020.10.235. PubDate: 2021.01.01. Online: 2020.11.02 (中科院一区 Top 期刊, IF=8.025)
Year: 2020
18. Xiongyu Ji, Shumin Lin, Yuanyuan Chen, Jiawei Liu, Xiaoyun Yun, Tiancheng Wang, Jialiang Qin, Chaoquan Luo, Kui Wang, Zhongxiong Zhao, Ruoting Zhan*, Hui Xu*. Identification of alpha-amyrin 28-carboxylase and glycosyltransferase from Ilex asprella and production of ursolic acid 28-O-beta-D-glucopyranoside in engineered yeast. Frontiers in Plant Science, 2020, 11: 612. (JCR Q1, IF=5.753)
Year: 2019
17. Qibin Lin#, Sidi Wang#, Meiling Wang, Ruoting Cao, Ruiqing Zhang, Ruoting Zhan, Kui Wang*(通讯作者). A novel glycoside hydrolase family 42 enzyme with bifunctional beta-galactosidase and alpha-L-arabinopyranosidase activities and its synergistic effects with cognate glycoside hydrolases in plant polysaccharides degradation. International Journal of Biological Macromolecules, 2019, 140: 129−139. DOI: 10.1016/j.ijbiomac.2019.08.037. PubDate (Online): 2019.08.10 (中科院一区 Top 期刊, IF=5.162)
16. Kui Wang#,* (通讯作者), Ruoting Cao#, Meiling Wang, Qibin Lin, Ruoting Zhan, Hui Xu, Sidi Wang*. A novel thermostable GH10 xylanase with activities on a wide variety of cellulosic substrates from a xylanolytic Bacillus strain exhibiting significant synergy with commercial Celluclast 1.5 L in pretreated corn stover hydrolysis. Biotechnology for Biofuels, 2019, 12: 48. DOI: 10.1186/s13068-019-1389-8. PubDate (Online): 2019.03.09 (中科院一区 Top 期刊, IF=4.815)
15. Zhixue Wu#, Hui Xu#, Meiling Wang, Ruoting Zhan, Weiwen Chen, Kui Wang* (通讯作者), Jiangyong Gu*. Molecular docking and molecular dynamics studies on selective synthesis of alpha-amyrin and beta-amyrin by oxidosqualene cyclases from Ilex asprella. International Journal of Molecular Sciences, 2019, 20: 3469. DOI: 10.3390/ijms20143469. PubDate (Online): 2019.07.15 (JCR Q2, IF=4.556)
14. Yuanyuan Chen, Meihong Lai, Xiaoyun Yun, Kui Wang* (通讯作者), Hui Xu*. Discovery and functional analysis of a cytochrome P450 gene involved in C-28 oxidation of the triterpenoids from Ilex pubescens. Journal of China Pharmaceutical University, 2019, 50: 459−467.
陈媛媛，赖美红，贠小芸，王魁* (通讯作者)，徐晖*. 毛冬青三萜C-28位氧化修饰相关CYP450基因的发掘和功能鉴定. 中国药科大学学报, 2019, 50: 459−467.
Year: 2017
13. Daniel Wefers, Janaina J. V. Cavalcante, Rachel R. Schendel, Jaigeeth Deveryshetty, Kui Wang, Zdzislaw Wawrzak, Roderick I. Mackie, Nicole M. Koropatkin, Isaac Cann*. Biochemical and structural analyses of two cryptic esterases in Bacteroides intestinalis and their synergistic activities with cognate xylanases. Journal of Molecular Biology, 2017, 429(16): 2509−2527. (JCR Q1, IF=4.894)
12. 王耀辉，谢建华，王魁，李小明，何志梅，徐莉敏，王源丰. 用于生产具有耐温性脂肪酶的基因. 中国发明专利, 2017. (公开号：CN106868026A)
Year: 2016
11. Kui Wang, Gabriel Vasconcelose Pereira, Janaina Cavalcante, Meiling Zhang, Roderick Mackie, Isaac Cann*. Bacteroides intestinalis DSM 17393, a member of the human colonic microbiome, upregulates multiple endoxylanases during growth on xylan. Scientific Reports, 2016, 6: 34360. (JCR Q1, IF=5.228).
Year: 2013
10. Sidi Wang, Kui Wang, Yuhuan Liu*. Isolation and characterization of a novel organic solvent-tolerant and halotolerant esterase from a soil metagenomic library. Journal of Molecular Catalysis B-Enzymatic, 2013, 95: 1−8. (IF=2.745)
Year: 2012
9. Kui Wang, Yi Lu, Weiqu Liang, Sidi Wang, Yang Jiang, Rui Huang, Yuhuan Liu*. Enzymatic synthesis of Galacto-oligosaccharides in an organic-aqueous biphasic System by a novel beta-galactosidase from a metagenomic library. Journal of Agricultural and Food Chemistry, 2012, 60: 3940−3946. (JCR Q1, 中科院一区, IF=3.154).
8. Kui Wang, Sidi Wang, Rui Huang, Yuhuan Liu. Advances of metagenomics in discovering novel biocatalysts. Chinese Journal of Biotechnology, 2012, 28: 420−431.
7. Shang-ke Chen, Kui Wang, Yuhuan Liu*, Xiaopeng Hu*. Crystallization and preliminary X-ray analysis of a novel halotolerant feruloyl esterase identified from a soil metagenomic library. Acta Crystallographica Section F, 2012,68: 767−770. (IF=0.52).
6. 刘玉焕，刘孝龙，王魁，鲁毅.一种具有高效转糖基β-半乳糖苷酶的新基因及应用. 中国发明专利, 2012. (授权公开号：CN 102154239 B)
Year: 2011
5. Liping Zhang#, Kui Wang# (共同第一作者), Zhongxing Mo, Yuhuan Liu*, Xiaopeng Hu*. Crystallization and preliminary X-ray analysis of a cold-active beta-galactosidase from the psychrotrophic and halotolerant Planococcus sp. L4. Acta Crystallographica Section F, 2011, 67: 911−913. (IF=0.56)
4. Xinjiong Fan, Xiaolong Liu, Kui Wang, Sidi Wang, Rui Huang, Yuhuan Liu*. Highly soluble expression and molecular characterization of an organic solvent-stable and thermotolerant lipase originating from the metagenome. Journal of Molecular Catalysis B-Enzymatic, 2011, 72, 319−326. (IF=2.823)
3. 王魁，刘玉焕. 一种新型 β-半乳糖苷酶高效转糖基化作用的研究. 第八届中国酶工程学术研讨会论文，2011.
Year: 2010
2. Kui Wang#, Gang Li#, Shi Qin Yu, Chen Ting Zhang, Yuhuan Liu*. A novel metagenome-derived beta-galactosidase: gene cloning, overexpression, purification and characterization. Applied Microbiology and Biotechnology, 2010, 88: 155−165. (JCR Q2, IF=3.28).
Year: 2008
1. Gang Li#, Kui Wang# (共同第一作者), Yuhuan Liu*. Molecular cloning and characterization of a novel pyrethroid-hydrolyzing esterase originating from the metagenome. Microbial Cell Factories, 2008, 7: 38. (JCR Q2, IF=3.34).
