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成果及论文


第一和通讯作者论文:

1. Wang S#, Li W#, Hui H, Tiwari SK, Zhang Q, Croker BA, Rawlings S, Smith D, Carlin AF, Rana TM* (2020) Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol. The EMBO J 39: e106057. (#co-first authors)

2. Wang L#, Wang S#, Wu L, Li W, Bray W, Clark AE, Gonzalez GM, Wang Y, Carlin AF, Rana TM* (2023) PCIF1-mediated deposition of 5'-cap N6, 2'-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection. Proceedings of the National Academy of Sciences 120 (5), e2210361120. (#co-first authors)

3. Wang S#, Zhang Q#, Tiwari SK#, Lichinchi G, Yau EH, Hui H, Li W, Furnari F, Rana TM* (2020) Integrin alphavbeta5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy. Cell Reports 30: 969-983 e4. ( #co-first authors) (Highlighted by a Preview from Cell Stem Cell)

4. Zhang Q#Wang S#, Li W, Yau E, Hui H, Singh P, Achuthan V, Karris M, Engelman A, Rana TM* (2022). Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration. Nucleic Acids Research 50 (12), 6687-6701  (#co-first authors)

5. Zhang LJ#, Wang S#, Xia L, Lv C, Tang HW, Liang Z, Xiao G*, Pang DW* (2020) Lipid-Specific Labeling of Enveloped Viruses with Quantum Dots for Single-Virus Tracking. mBio 11(3). ( #co-first authors)

6. Wang S#, Zhang Q#, Hui H, Agrawal K, Karris MAY, Rana TM* (2020) An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics. Emerging microbes & infections 9(1), 2333-2347.( #co-first authors)

7. Wang S#, Liu Y, Guo J, Wang P, Zhang L, Xiao G, Wang W* (2017) Screening of FDA-approved drugs for inhibitors of Japanese encephalitis virus infection. Journal of Virology 91(21):e01055-17. (Faculty 1000 Recommendation)

8. Wang S#, Liu H, Zu X, Liu Y, Chen L, Zhu X, Zhang L, Zhou Z, Xiao G*, Wang W* (2016) The ubiquitin-proteasome system is essential for the productive entry of Japanese encephalitis virus. Virology 498:116-127.

9. Yu S#, Hu H, Ai Q, Bai R, Ma K, Zhou M, Wang S* (2023) SARS-CoV-2 Spike-Mediated Entry and Its Regulation by Host Innate Immunity. Viruses 15(3), 6.


部分代表作成果:

呼吸道特异表达病毒受体ACE2和蛋白酶TMPRSS2的分子机制

Wang L*& Wang S* et al. PNAS, 2023


CH25H的广谱抗冠状病毒活性鉴定及其独特作用机制的研究

Wang S* & Li W * et al. EMBO J, 2020


寨卡病毒神经嗜性潜在受体的发现与应用

Wang S*, Zhang Q* & Tawari S* et al. Cell Reports, 2020

Vazquez et al. Cell Stem Cell, 2020


系统筛选HIV-1的宿主限制因子及功能验证

Zhang Q* & Wang S* et al. Nucleic Acids Research, 2022