面向转化医学的细胞表面化学生物学
细胞表面化学生物学即采用化学手段在细胞表面引入外源性化学小分子或者材料大分子以调节细胞功能和识别生物材料，它有望嫁接生命和非生命体系，从分子层次调控细胞-材料表界面发展疾病的精准诊疗策略，是化学、生物学和医学交叉融合的新兴研究方向。
1. 可视细胞表面过程
化学修饰细胞表面以识别和干预肿瘤细胞，提出癌症诊疗新思路（Angew. Chem. Int. Ed., 2021, 60(12), 6509-6517；Anal. Chem., 2018, 90(11), 6556–6562）。
2. 可控细胞表面功能
化学修饰细胞表面以赋予细胞新功能，构建细胞治疗新载体（Adv. Sci., 2021, 8(3), 2003348；ACS Nano, 2019, 13(2), 1910–1922）。
3. 可创造新型细胞
化学修饰细胞表面以掩蔽血型抗原，构建新型通用红细胞（Sci. Adv., 2020, 6(12): eaaw9679；Chem. Sci., 2014, 5(9), 3463-3468）。
相关实验技术
化学合成；微流控；电子显微镜；细胞培养；动物模型（小鼠或灵长类）
转化医学潜力
癌症早期诊断工具和个性化治疗手段；细胞工程与细胞治疗。
代表性论著
1) Ning Tang, Hanhui Li, Lihong Zhang, Xueyun Zhang, Yanni Chen, Hao Shou, Shuaishuai Feng, Xinhua Chen, Yan Luo, Ruikang Tang*, and Ben Wang*. A macromolecular drug for cancer therapy via extracellular calcification. Angew. Chem. Int. Ed., 2021, 60(12), 6509-6517. (Cover Picture)
2) Jicheng Wu#, Yanni Chen#, Jinxia Xin, Jiale Qin, Weizeng Zheng, Shuaishuai Feng, Chongran Sun, Mei Tian, Zhimin Lu, Ben Wang*. Bioinspired tumor calcification enables early detection and elimination of lung cancer. Adv. Funct. Mater., 2021.
3) Ling Zhang, Guowu Liu, Kaiqi Lv, Jinxia Xin, Yingchao Wang, Jing Zhao, Wangxing Hu, Changchen Xiao, Keyang Zhu, Lianlian Zhu, Jinliang Nan, Ye Feng, Huaying Zhu, Wei Chen, Wei Zhu, Jianyi Zhang, Jian’an Wang, Ben Wang*, and Xinyang Hu*. Surface-anchored nanogel coating endows stem cells with stress resistance and reparative potency via turning down the cytokine-receptor binding pathways. Adv. Sci., 2021, 8(3), 2003348.
4) Yueqi Zhao, Mingjie Fan, Yanni Chen, Zhaoming Liu, Changyu Shao, Biao Jin, Xiaoyu Wang, Lanlan Hui, Shuaifei Wang, Zhaoping Liao, Daishun Ling, Ruikang Tang*, Ben Wang*. Surface-anchored framework for generating RhD-epitope stealth red blood cells. Sci. Adv., 2020, 6(12): eaaw9679.
5) Chuanjiang He, Tingting Ye, Wenqi Teng, Zhi Fang, Wei-Shuyi Ruan, Guowu Liu, Hui Chen, Jizeng Sun, Lanlan Hui, Feng Sheng, Dingyi Pan, Chunming Yang, Yi Zheng, Meng-Bo Luo, Ke Yao, and Ben Wang*. Bioinspired shear flow-driven layer-by-layer in situ self-assembly. ACS Nano, 2019, 13(2), 1910–1922.
6) Qingchang Tian, Chuanjiang He, Guowu Liu, Yueqi Zhao, Lanlan Hui, Ying Mu, Ruikang Tang, Yan Luo, Shu Zheng, and Ben Wang*. Nanoparticle counting by microscopic digital detection: Selective quantitative analysis of exosomes via surface-anchored nucleic acid amplification. Anal. Chem., 2018, 90(11), 6556–6562.
7) Ben Wang#, Guangchuan Wang#, Binjie Zhao, Jiajun Chen, Xueyun Zhang, and Ruikang Tang*. Antigenically shielded universal red blood cells by polydopamine-based cell surface engineering. Chem. Sci., 2014, 5(9), 3463-3468.
8) Ben Wang, Peng Liu, Wenge Jiang, Haihua Pan, Xurong Xu and Ruikang Tang*. Yeast cells with an artificial mineral shell: Protection and modification of living cells by biomimetic mineralization. Angew. Chem. Int. Ed., 2008, 47 (19), 3560-3564.
