1.      Wenjie Guo^#, Wen Liu^#, Zhen Chen, Yanhong Gu, Shuang Peng, Lihong Shen, Yan Shen, Xingqi Wang, Gen-Sheng Feng, Yang Sun*, Qiang Xu*. Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. Nat Commun 2017; 8: 2168.

原文链接：https://www.nature.com/articles/s41467-017-02351-0

2.  Mingxia Zhao^#, Wenjie Guo^#, Yuanyuan Wu^#, Chenxi Yang, Liang Zhong, Guoliang Deng, Yuyu Zhu, Wen Liu, Lingdong Kong, Yanhong Gu, Xiangbao Meng*, Qiang Xu*, Yang Sun*. SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade. Acta Pharm Sin B 2019; 9(2): 304-315. Cover story. 高被引

原文链接：https://www.sciencedirect.com/science/article/pii/S2211383518306245?via%3Dihub

3. Zhen-Dong Song^#, Mei-Jing Wang^#, Yang Ge, Xue-Ping Chen, Zi-Yang Xu, Yang Sun*, Xiao-Feng Xiong*. Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies. Acta Pharm Sin B 2021;11(1):13-29. 高被引

原文链接：https://www.sciencedirect.com/science/article/pii/S2211383520306523?via%3Dihub

4. Yuyu Zhu^#, Ning Wan^#, Xinni Shan, Guoliang Deng,Qiang Xu, Hui Ye^*, Yang Sun*. Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice. Acta Pharm Sin B 2021; 11(5): 1200-1212. Cover story.

原文链接：https://www.sciencedirect.com/science/article/pii/S2211383520308418?via%3Dihub

5. Wen Liu^#, Meijing Wang^#, Lihong Shen^#, Yuyu Zhu, Hongyue Ma, Bo Liu, Liang Ouyang, Wenjie Guo^*, Qiang Xu^*, Yang Sun*. SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice. Signal Transduc Target Thera 2021; 6(1): 34.

原文链接：https://www.nature.com/articles/s41392-021-00474-x

6. Fenli Shao^#, Qianqian Liu^#, Yuyu Zhu^#, Zhidan Fan^#,Shijia Liu, Wenjun Chen, Xiaohui Li, Wenjie Guo, Gen-Sheng Feng, Haiguo Yu*, Qiang Xu*, Yang Sun*. Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis. Nat Commun 2021; 12: 6540.

原文链接：https://www.nature.com/articles/s41467-021-26750-6

7. Binglin Wang^#, Yi Wang^#, Xiaofan Sun, Guoliang Deng, Wei Huang, Xingxin Wu, Yanhong Gu, Zhigang Tian, Zhimin Fan, Qiang Xu*, Hongqi Chen*,Yang Sun*. CXCR6 is required for antitumor efficacy of intratumoral CD8⁺ T cell. J Immunothera Cancer 2021; 9(8):e003100.

原文链接：https://jitc.bmj.com/content/9/8/e003100

8. Jian Gao^#, Zhigui Wu^#, Mingxia Zhao^#, Rui Zhang, Manru Li, Dongdong Sun, Haibo Cheng, Xianjia Qi, Yuxian Shen, Qiang Xu*, Hongqi Chen*, Dijun Chen*, Yang Sun*. Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics. Acta Pharm Sin B 2022; 12(1): 149-166.

原文链接：https://www.sciencedirect.com/science/article/pii/S2211383521002963?via%3Dihub

9. Qianqian Liu^#, Linhui Zhai^#, Mingrui Han^#, Dongquan Shi^#, Ziying Sun, Meijing Wang, Chenyang Zhang, Dijun Chen, Qing Jiang, Qiang Xu*, Minjia Tan*, Yang Sun*. SH2 Domain-Containing Phosphatase 2 Inhibition Attenuates Osteoarthritis by Maintaining Homeostasis of Cartilage Metabolism via the Docking Protein 1/Uridine Phosphorylase 1/Uridine Cascade. Arthritis Rheumatol 2022; 74(3): 462-474.

原文链接：https://onlinelibrary.wiley.com/doi/10.1002/art.41988

10. Yuyu Zhu^#, Zhigui Wu^#, Wei Yan^#, Fenli Shao^#, Bowen Ke, Xian Jiang, Xianjia Qi, Wenjie Guo, Yuping Lai, Dijun Chen, Qiang Xu, Yang Sun*. Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis. EMBO Mol Med 2022; 14(3): e14455. Cover story.

原文链接：https://www.embopress.org/doi/full/10.15252/emmm.202114455

11. Qianqian Liu#, Mingrui Han#, Zhigui Wu#, Wenqiang Fu#, Jun Ji, Qingqing Liang, Minjia Tan, Linhui Zhai, Jian Gao, Dongquan Shi, Qing Jiang, Ziying Sun, Yuping Lai, Qiang Xu*, Yang Sun*. DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding. Nature Aging 2024; 4: 664-680. 

      原文链接：https://www.nature.com/articles/s43587-024-00624-0

南京大学分子药理实验室孙洋课题组招新！

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