基本情况：

民族：汉  

出生年月：1994年3月

常用邮箱：18738668913@163.com

教育及工作经历：

2020.09-2024.06        南京大学        药学       博士

2017.09—2020.06      南京大学       制药工程       硕士

2013.09—2017.07     信阳师范学院     生物制药      工学学士

发表文章：

[1] Guoliang Deng#, Lisha Zhou#, Binglin Wang#, Xiaofan Sun, Hongqi Chen, Dongdong Sun*, Yang Sun*, Haibo Cheng*. Targeting cathepsin B by cycloastragenol enhances anti-tumor immunity via inhibiting MHC-1 degradation and promoting the presentation of tumor antigen. Journal for ImmunoTherapy of Cancer 2022, in press.

[2] Gu Y, Zhu Y, Deng G, Liu S, Sun Y, Lv W. Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation. Int Immunopharmacol. 2021 Jan 29;93:107375. doi: 10.1016/j.intimp.2021.107375. Epub ahead of print. PMID: 33517224.

[3] Liu W, Yin Y, Wang M, Fan T, Zhu Y, Shen L, Peng S, Gao J, Deng G, Meng X, Kong L, Feng GS, Guo W, Xu Q, Sun Y. Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels. J Biol Chem. 2020 Jul 31;295(31):10842-10856. doi: 10.1074/jbc.RA119.011840. Epub 2020 Jun 16. PMID: 32546483; PMCID: PMC7397102.

[4] Zhao M, Shen L, Ouyang Z, Li M, Deng G, Yang C, Zheng W, Kong L, Wu X, Wu X, Guo W, Yin Y, Xu Q, Sun Y. Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis. J Mol Cell Biol. 2020 May 18;12(4):277-290. doi: 10.1093/jmcb/mjz050. PMID: 31169879; PMCID: PMC7232127.

[5] Deng G, Chen W, Wang P, Zhan T, Zheng W, Gu Z, Wang X, Ji X, Sun Y. Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice. Int Immunopharmacol. 2019 Sep;74:105682. doi: 10.1016/j.intimp.2019.105682. Epub 2019 Jun 13. PMID: 31203155.

[6] Zhao M, Guo W, Wu Y, Yang C, Zhong L, Deng G, Zhu Y, Liu W, Gu Y, Lu Y, Kong L, Meng X, Xu Q, Sun Y. SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade. Acta Pharm Sin B. 2019 Mar;9(2):304-315. doi: 10.1016/j.apsb.2018.08.009. Epub 2018 Sep 5. PMID: 30972278; PMCID: PMC6437555.