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成果及论文

2023

  1. Wu Y, Wang R, Shen P, Zhou W, Chen C, Yang K, Yang J, Song Y, Han X, Guan X. Boosting immunogenic cell death via hollow MnO2-based multiple stimuli-responsive drug delivery systems for improved cancer immunotherapy. Cancer Nanotechnology 2023, 14(1): 20. https://doi.org/10.1186/s12645-023-00173-y

  2. Wang Y, Gao Y, Pan Y, Zhou D, Liu Y, Yin Y, Yang J, Wang Y, Song Y. Emerging trends in organ-on-a-chip systems for drug screening. Acta Pharmaceutica Sinica B 2023. https://doi.org/10.1016/j.apsb.2023.02.006

  3. Pan Y, Luan X, Gao Y, Zeng F, Wang X, Zhou D, Li W, Wang Y, He B, Song Y. In-Tumor Biosynthetic Construction of Upconversion Nanomachines for Precise Near-Infrared Phototherapy. ACS Nano 2023, 17(5): 4515-4525. https://doi.org/10.1021/acsnano.2c10453

  4. Long W, Yang J, Zhao Q, Pan Y, Luan X, He B, Han X, Wang Y, Song Y. Metal–Organic Framework-DNA Bio-Barcodes Amplified CRISPR/Cas12a Assay for Ultrasensitive Detection of Protein Biomarkers. Analytical Chemistry 2023, 95(2): 1618-1626. https://doi.org/10.1021/acs.analchem.2c04737

  5. Gao Y, Zhou D, Xu Q, Li J, Luo W, Yang J, Pan Y, Huang T, Wang Y, He B, Song Y, Wang Y. Metal–Organic Framework-Mediated Bioorthogonal Reaction to Immobilize Bacteria for Ultrasensitive Fluorescence Counting Immunoassays. ACS Applied Materials & Interfaces 2023, 15(4): 5010-5018. https://doi.org/10.1021/acsami.2c21350

  6. Gao Y, Wang Y, Wang Y, Magaud P, Liu Y, Zeng F, Yang J, Baldas L, Song Y. Nanocatalysis meets microfluidics: A powerful platform for sensitive bioanalysis. TrAC, Trends Anal Chem 2023, 158: 116887. https://doi.org/10.1016/j.trac.2022.116887

  7. Gao Y, Wang Y, Liu X, Zhu Z, Li Z, Zhang Z, Yin Y, Cho WCS, Song Y, Wang Y. One-step self-assembly of multilayer graphene oxide via streamlined click reactions for sensitive colorimetric assays. Analytica Chimica Acta 2023, 1241: 340806. https://doi.org/10.1016/j.aca.2023.340806

  8. Gao Y, Wang Y, He B, Pan Y, Zhou D, Xiong M, Song Y. An Enzyme-Loaded Metal–Organic Framework-Assisted Microfluidic Platform Enables Single-Cell Metabolite Analysis. Angew Chem Int Ed 2023: e202302000. https://doi.org/10.1002/anie.202302000

2022

  1. Zhou D, Yin Y, Zhu Z, Gao Y, Yang J, Pan Y, Song Y. Orally Administered Platinum Nanomarkers for Urinary Monitoring of Inflammatory Bowel Disease. ACS Nano 2022, 16(11): 18503-18514. https://doi.org/10.1021/acsnano.2c06705

  2. Zhao Q, Pan B, Long W, Pan Y, Zhou D, Luan X, He B, Wang Y, Song Y. Metal Organic Framework-Based Bio-Barcode CRISPR/Cas12a Assay for Ultrasensitive Detection of MicroRNAs. Nano Letters 2022, 22(23): 9714-9722. https://doi.org/10.1021/acs.nanolett.2c04022

  3. Xu Q, Pan Y, Liu X, Gao Y, Luan X, Zeng F, Zhou D, Long W, Wang Y, Song Y. Hypoxia-Responsive Platinum Supernanoparticles for Urinary Microfluidic Monitoring of Tumors. Angew Chem Int Ed 2022, 61(14): e202114239. https://doi.org/10.1002/anie.202114239

  4. Wang Y, Gao Y, Yin Y, Pan Y, Wang Y, Song Y. Nanomaterial-assisted microfluidics for multiplex assays. Microchim Acta 2022, 189(4): 139. https://doi.org/10.1007/s00604-022-05226-4

  5. Wang Y, Gao Y, Song Y. Microfluidics-Based Urine Biopsy for Cancer Diagnosis: Recent Advances and Future Trends. ChemMedChem 2022, 17(20): e202200422. https://doi.org/10.1002/cmdc.202200422

  6. Pan Y, Luan X, Zeng F, Xu Q, Li Z, Gao Y, Liu X, Li X, Han X, Shen J, Song Y. Hollow covalent organic framework-sheltering CRISPR/Cas12a as an in-vivo nanosensor for ATP imaging. Biosensors and Bioelectronics 2022, 209: 114239. https://doi.org/10.1016/j.bios.2022.114239

  7. Luan X, Pan Y, Zhou Y, Zhou D, Zhao W, Zeng F, Zhu Z, Lu Q, Lu Q, Gao Y, He G, Lu M, Song Y. Targeted Self-assembly of Renal Clearable Cu2-xSe to Induce Lysosome Swelling for Multimodal Imaging Guided Photothermal/Chemodynamic Synergistic Therapy. Advanced Functional Materials 2022, 32(51): 2208354. https://doi.org/10.1002/adfm.202208354

  8. Lu Q, Chen R, Du S, Chen C, Pan Y, Luan X, Yang J, Zeng F, He B, Han X, Song Y. Activation of the cGAS-STING pathway combined with CRISPR-Cas9 gene editing triggering long-term immunotherapy. Biomaterials 2022, 291: 121871. https://doi.org/https://doi.org/10.1016/j.biomaterials.2022.121871

  9. Li Z, Pan Y, Du S, Li Y, Chen C, Song H, Wu Y, Luan X, Xu Q, Guan X, Song Y, Han X. Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy. Acta Pharmaceutica Sinica B 2022, 12(11): 4224-4234. https://doi.org/https://doi.org/10.1016/j.apsb.2022.06.016

  10. Li Y, Pan Y, Chen C, Li Z, Du S, Luan X, Gao Y, Han X, Song Y. Multistage-Responsive Gene Editing to Sensitize Ion-Interference Enhanced Carbon Monoxide Gas Therapy. Small 2022, 18(40): 2204244. https://doi.org/10.1002/smll.202204244

  11. Han Y, Liu X, Zhao Q, Gao Y, Zhou D, Long W, Wang Y, Song Y. Aptazyme-induced cascade amplification integrated with a volumetric bar-chart chip for highly sensitive detection of aflatoxin B1 and adenosine triphosphate. Analyst 2022, 147(11): 2500-2507. https://doi.org/10.1039/d2an00650b

  12. Du S, Chen C, Qu S, Song H, Yang J, Li Y, Liu K, Lu Q, Luo W, Wang R, Guan X, Song Y, Han X. DNAzyme-Assisted Nano-Herb Delivery System for Multiple Tumor Immune Activation. Small 2022, 18(45): 2203942. https://doi.org/https://doi.org/10.1002/smll.202203942

2021

  1. Zhao Q, Pan Y, Luan X, Gao Y, Zhao X, Liu Y, Wang Y, Song Y. Nano-immunosorbent assay based on Cas12a/crRNA for ultra-sensitive protein detection. Biosensors and Bioelectronics 2021, 190: 113450. https://doi.org/10.1016/j.bios.2021.113450

  2. Zeng F, Pan Y, Luan X, Gao Y, Yang J, Wang Y, Song Y. Copper metal-organic framework incorporated mesoporous silica as a bioorthogonal biosensor for detection of glutathione. Sensors and Actuators B: Chemical 2021, 345: 130382. https://doi.org/10.1016/j.snb.2021.130382

  3. Yin Y, Yang J, Pan Y, Guo Z, Gao Y, Huang L, Zhou D, Ge Y, Guo F, Zhu W, Song Y, Li Y. Chylomicrons-Simulating Sustained Drug Release in Mesenteric Lymphatics for the Treatment of Crohn’s-Like Colitis. Journal of Crohn's and Colitis 2021, 15(4): 631-646. https://doi.org/10.1093/ecco-jcc/jjaa200

  4. Yin Y, Yang J, Pan Y, Gao Y, Huang L, Luan X, Lin Z, Zhu W, Li Y, Song Y. Mesopore to Macropore Transformation of Metal–Organic Framework for Drug Delivery in Inflammatory Bowel Disease. Advanced Healthcare Materials 2021, 10(3): 2000973. https://doi.org/10.1002/adhm.202000973

  5. Yang J, Pan B, Zeng F, He B, Gao Y, Liu X, Song Y. Magnetic Colloid Antibodies Accelerate Small Extracellular Vesicles Isolation for Point-of-Care Diagnostics. Nano Letters 2021, 21(5): 2001-2009. https://doi.org/10.1021/acs.nanolett.0c04476

  6. Luan X, Pan Y, Gao Y, Song Y. Recent near-infrared light-activated nanomedicine toward precision cancer therapy. Journal of Materials Chemistry B 2021, 9(35): 7076-7099. https://doi.org/10.1039/d1tb00671a

  7. Liu X, Wang Y, Gao Y, Song Y. Gas-propelled biosensors for quantitative analysis. Analyst 2021, 146(4): 1115-1126. https://doi.org/10.1039/d0an02154g

  8. Li X, Pan Y, Chen C, Gao Y, Liu X, Yang K, Luan X, Zhou D, Zeng F, Han X, Song Y. Hypoxia‐Responsive Gene Editing to Reduce Tumor Thermal Tolerance for Mild‐Photothermal Therapy. Angew Chem Int Ed 2021, 60(39): 21200-21204. https://doi.org/10.1002/anie.202107036

  9. Chen C, Ma Y, Du S, Wu Y, Shen P, Yan T, Li X, Song Y, Zha Z, Han X. Controlled CRISPR-Cas9 Ribonucleoprotein Delivery for Sensitized Photothermal Therapy. Small 2021, 17(33): 2101155. https://doi.org/10.1002/smll.202101155

2020

  1. Yang J, Wang C, Liu X, Yin Y, Ma YH, Gao Y, Wang Y, Lu Z, Song Y. Gallium–Carbenicillin Framework Coated Defect‐Rich Hollow TiO2 as a Photocatalyzed Oxidative Stress Amplifier against Complex Infections. Advanced Functional Materials 2020, 30(43): 2004861. https://doi.org/10.1002/adfm.202004861

  2. Sun L, Zhao Q, Liu X, Pan Y, Gao Y, Yang J, Wang Y, Song Y. Enzyme-mimicking accelerated signal enhancement for visually multiplexed quantitation of telomerase activity. Chemical Communications 2020, 56(51): 6969-6972. https://doi.org/10.1039/d0cc01951h

  3. Luan X, Pan Y, Zhou D, He B, Liu X, Gao Y, Yang J, Song Y. Cerium metal organic framework mediated molecular threading for point-of-care colorimetric assays. Biosensors and Bioelectronics 2020, 165: 112406. https://doi.org/10.1016/j.bios.2020.112406

  4. Liu X, Pan Y, Yang J, Gao Y, Huang T, Luan X, Wang Y, Song Y. Gold nanoparticles doped metal-organic frameworks as near-infrared light-enhanced cascade nanozyme against hypoxic tumors. Nano Research 2020, 13(3): 653-660. https://doi.org/10.1007/s12274-020-2668-1

2019

  1. Yang J, Liu X, Pan Y, Yang J, He B, Fu Y, Song Y. A self-powered microfluidic chip integrated with fluorescent microscopic counting for biomarkers assay. Sensors and Actuators B: Chemical 2019, 291: 192-199. https://doi.org/10.1016/j.snb.2019.04.071

  2. Yang J, Liu X, Fu Y, Song Y. Recent advances of microneedles for biomedical applications: drug delivery and beyond. Acta Pharmaceutica Sinica B 2019, 9(3): 469-483. https://doi.org/10.1016/j.apsb.2019.03.007

  3. Pan Y, Yang J, Luan X, Liu X, Li X, Yang J, Huang T, Sun L, Wang Y, Lin Y, Song Y. Near-infrared upconversion–activated CRISPR-Cas9 system: A remote-controlled gene editing platform. Science Advances 2019, 5(4): eaav7199. https://doi.org/10.1126/sciadv.aav7199

  4. Huang T, Yang J, Zhou W, Liu X, Pan Y, Song Y. Rapid identification of urinary tract infections based on ultrasensitive bacteria detection using volumetric bar-chart chip. Sensors and Actuators B: Chemical 2019, 298: 126885. https://doi.org/10.1016/j.snb.2019.126885

2018

  1. Wang Y, Song Y, Zhu G, Zhang D, Liu X. Highly biocompatible BSA-MnO2 nanoparticles as an efficient near-infrared photothermal agent for cancer therapy. Chinese Chemical Letters 2018, 29(11): 1685-1688. https://doi.org/10.1016/j.cclet.2017.12.004

  2. Liu X, Wang Y, Song Y. Visually multiplexed quantitation of heavy metal ions in water using volumetric bar-chart chip. Biosensors and Bioelectronics 2018, 117: 644-650. https://doi.org/10.1016/j.bios.2018.06.046

2016

  1. Wang Y, Zhu G, Qi W, Li Y, Song Y. A versatile quantitation platform based on platinum nanoparticles incorporated volumetric bar-chart chip for highly sensitive assays. Biosensors and Bioelectronics 2016, 85: 777-784. https://doi.org/10.1016/j.bios.2016.05.090

  2. Wang Y, Qi W, Song Y. Antibody-free detection of protein phosphorylation using intrinsic peroxidase-like activity of platinum/carbon dot hybrid nanoparticles. Chemical Communications 2016, 52(51): 7994-7997. https://doi.org/10.1039/c6cc02771g

  3. Song Y, Wang Y, Qi W, Li Y, Xuan J, Wang P, Qin L. Integrative volumetric bar-chart chip for rapid and quantitative point-of-care detection of myocardial infarction biomarkers. Lab on a Chip 2016, 16(15): 2955-2962. https://doi.org/10.1039/C6LC00561F

Before NJU

  1. Li Y, Xuan J, Song Y, Qi W, He B, Wang P, Qin L. Nanoporous Glass Integrated in Volumetric Bar-Chart Chip for Point-of-Care Diagnostics of Non-Small Cell Lung Cancer. ACS Nano 2016, 10(1): 1640-1647. https://doi.org/10.1021/acsnano.5b07357

  2. Wang Y, Li Y, Qi W, Song Y. Luminescent lanthanide graphene for detection of bacterial spores and cysteine. Chemical Communications 2015, 51(55): 11022-11025. https://doi.org/10.1039/c5cc02889b

  3. Li Y, Xuan J, Xia T, Han X, Song Y, Cao Z, Jiang X, Guo Y, Wang P, Qin L. Competitive Volumetric Bar-Chart Chip with Real-Time Internal Control for Point-of-Care Diagnostics. Analytical Chemistry 2015, 87(7): 3771-3777. https://doi.org/10.1021/ac504301y

  4. Li Y, Xuan J, Song Y, Wang P, Qin L. A microfluidic platform with digital readout and ultra-low detection limit for quantitative point-of-care diagnostics. Lab on a Chip 2015, 15(16): 3300-3306. https://doi.org/10.1039/C5LC00529A

  5. Song Y, Xia X, Wu X, Wang P, Qin L. Integration of Platinum Nanoparticles with a Volumetric Bar-Chart Chip for Biomarker Assays. Angew Chem Int Ed 2014, 53(46): 12451-12455. https://doi.org/10.1002/anie.201404349

  6. Song Y, Huang Y-Y, Liu X, Zhang X, Ferrari M, Qin L. Point-of-care technologies for molecular diagnostics using a drop of blood. Trends in Biotechnology 2014, 32(3): 132-139. https://doi.org/10.1016/j.tibtech.2014.01.003

  7. Song Y, Wang Y, Qin L. A Multistage Volumetric Bar Chart Chip for Visualized Quantification of DNA. J Am Chem Soc 2013, 135(45): 16785-16788. https://doi.org/10.1021/ja4085397

  8. Song Y, Zhang Y, Bernard PE, Reuben JM, Ueno NT, Arlinghaus RB, Zu Y, Qin L. Multiplexed volumetric bar-chart chip for point-of-care diagnostics. Nat Commun 2012, 3(1): 1283. https://doi.org/10.1038/ncomms2292

  9. Zhao C, Qu K, Song Y, Ren J, Qu X. A Universal, Label-Free, and Sensitive Optical Enzyme-Sensing System for Nuclease and Methyltransferase Activity Based on Light Scattering of Carbon Nanotubes. Advanced Functional Materials 2011, 21(3): 583-590. https://doi.org/10.1002/adfm.201001745

  10. Song Y, Xu C, Wei W, Ren J, Qu X. Light regulation of peroxidase activity by spiropyran functionalized carbon nanotubes used for label-free colorimetric detection of lysozyme. Chemical Communications 2011, 47(32): 9083. https://doi.org/10.1039/c1cc13279b

  11. Song Y, Wei W, Qu X. Colorimetric Biosensing Using Smart Materials. Advanced Materials 2011, 23(37): 4215-4236. https://doi.org/10.1002/adma.201101853

  12. Song Y, Feng L, Ren J, Qu X. Stabilization of unstable CGC+ triplex DNA by single-walled carbon nanotubes under physiological conditions. Nucleic Acids Research 2011, 39(15): 6835-6843. https://doi.org/10.1093/nar/gkr322

  13. Song Y, Chen Y, Feng L, Ren J, Qu X. Selective and quantitative cancer cell detection using target-directed functionalized graphene and its synergetic peroxidase-like activity. Chemical Communications 2011, 47(15): 4436. https://doi.org/10.1039/c0cc05533f

  14. Zhao C, Song Y, Qu K, Ren J, Qu X. Luminescent Rare-Earth Complex Covalently Modified Single-Walled Carbon Nanotubes: Design, Synthesis, and DNA Sequence-Dependent Red Luminescence Enhancement. Chemistry of Materials 2010, 22(20): 5718-5724. https://doi.org/10.1021/cm101767c

  15. Zhao C, Qu K, Song Y, Xu C, Ren J, Qu X. A Reusable DNA Single-Walled Carbon-Nanotube-Based Fluorescent Sensor for Highly Sensitive and Selective Detection of Ag+ and Cysteine in Aqueous Solutions. Chemistry - A European Journal 2010, 16(27): 8147-8154. https://doi.org/10.1002/chem.201000306

  16. Wang X, Wang C, Qu K, Song Y, Ren J, Miyoshi D, Sugimoto N, Qu X. Ultrasensitive and Selective Detection of a Prognostic Indicator in Early-Stage Cancer Using Graphene Oxide and Carbon Nanotubes. Advanced Functional Materials 2010, 20(22): 3967-3971. https://doi.org/10.1002/adfm.201001118

  17. Song Y, Wang X, Zhao C, Qu K, Ren J, Qu X. Label-Free Colorimetric Detection of Single Nucleotide Polymorphism by Using Single-Walled Carbon Nanotube Intrinsic Peroxidase-Like Activity. Chemistry - A European Journal 2010, 16(12): 3617-3621. https://doi.org/10.1002/chem.200902643

  18. Song Y, Qu K, Zhao C, Ren J, Qu X. Graphene Oxide: Intrinsic Peroxidase Catalytic Activity and Its Application to Glucose Detection. Advanced Materials 2010, 22(19): 2206-2210. https://doi.org/10.1002/adma.200903783

  19. Song Y, Qu K, Xu C, Ren J, Qu X. Visual and quantitative detection of copper ions using magnetic silica nanoparticles clicked on multiwalled carbon nanotubes. Chemical Communications 2010, 46(35): 6572. https://doi.org/10.1039/c0cc01593h

  20. Zhao C, Song Y, Ren J, Qu X. A DNA nanomachine induced by single-walled carbon nanotubes on gold surface. Biomaterials 2009, 30(9): 1739-1745. https://doi.org/10.1016/j.biomaterials.2008.12.034

  21. Wang X, Song Y, Ren J, Qu X. Knocking-Down Cyclin A2 by siRNA Suppresses Apoptosis and Switches Differentiation Pathways in K562 Cells upon Administration with Doxorubicin. PLoS ONE 2009, 4(8): e6665. https://doi.org/10.1371/journal.pone.0006665

  22. Song Y, Zhao C, Ren J, Qu X. Rapid and ultra-sensitive detection of AMP using a fluorescent and magnetic nano-silica sandwich complex. Chemical Communications 2009(15): 1975. https://doi.org/10.1039/b818415a

  23. Peng Y, Song Y, Feng L, Ren J, Qu X. 7-Amino actinomycin D bound to single-stranded hairpin DNA enhanced by loop sequence-dependent luminescent Eu3+ and Tb3+ binding. Journal of Inorganic Biochemistry 2009, 103(12): 1675-1679. https://doi.org/10.1016/j.jinorgbio.2009.09.010

  24. Zhao C, Peng Y, Song Y, Ren J, Qu X. Self-Assembly of Single-Stranded RNA on Carbon Nanotube: Polyadenylic Acid to Form a Duplex Structure. Small 2008, 4(5): 656-661. https://doi.org/10.1002/smll.200701054