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成果及论文

获奖情况: 
2021年北美华人色谱学会,优秀学生奖
2017年-2020年香港政府博士生奖学金
2020年中国分析测试协会科学技术奖CAIA奖,特等奖,第7主要完成人
 

论文代表作:

(1) Shao Xiaojian, Xing Fangrong, Zhang Yiwei, Lok Chun-Nam, Che Chi-Ming*. Integrative chemoproteomics reveals anticancer mechanisms of silver(i) targeting the proteasome regulatory complex. Chemical Science 2024.
(2) Shao Xiaojian, Zhang Hailei, Zhu Zhou, Ji Fenfen, He Zhao, Yang Zhu*, Xia Yiji*, Cai Zongwei*. DpCoA tagSeq: barcoding dpCoA-capped RNA for direct nanopore sequencing via maleimide-thiol reaction. Analytical Chemistry 2023, 95, 11124-11131.
(3) Shao Xiaojian, Zhang Hailei, Zhu Zhou, Ji Fenfen, He Zhao, Yang Zhu*, Xia Yiji*, Cai Zongwei*. Response to the comment on "DpCoA tagSeq: barcoding dpCoA-capped RNA for direct nanopore sequencing via maleimide-thiol reaction". Analytical Chemistry 2023, 96, 610-613.
(4) Zhang Hailei, Zhong Huan, Wang Xufeng, Zhang Shoudong, Shao Xiaojian, Hu Hao, Yu Zhiling, Cai Zongwei, Chen Xuemei*, Xia Yiji*. Use of NAD tagSeq II to identify growth phase-dependent alterations in E. coli RNA NAD+ capping. Proceedings of the National Academy of Sciences 2021, 118.
(5) Shao Xiaojian, Zhang Hailei, Yang Zhu, Zhu Lin, Cai Zongwei*. Quantitative profiling of protein-derived electrophilic cofactors in bacterial cells with a hydrazine-derived probe. Analytical Chemistry 2020, 92, 4484-4490.
(6) Shao Xiaojian, Zhang Hailei, Yang Zhu, Zhong Huan, Xia Yiji*, Cai Zongwei*. NAD tagSeq for transcriptome-wide identification and characterization of NAD+-capped RNAs. Nature Protocols 2020, 15, 2813-2836.
(7) Zhang Hailei, Zhong Huan, Zhang Shoudong, Shao Xiaojian, Ni Min, Cai Zongwei, Chen Xuemei*, Xia Yiji*. NAD tagSeq reveals that NAD+-capped RNAs are mostly produced from a large number of protein-coding genes in  Arabidopsis. Proceedings of the National Academy of Sciences 2019, 116, 12072-12077.
(8) Zhang Hongna, Shao Xiaojian, Zhao Hongzhi, Li Xiaona, Wei Juntong, Yang Chunxue, Cai Zongwei*. Integration of metabolomics and lipidomics reveals metabolic mechanisms of triclosan-induced toxicity in human hepatocytes. Environmental Science & Technology 2019, 53, 5406-5415.
(9) Li Dapeng, Zhang Jinghui, Xie Guangshan, Ji Fenfen, Shao Xiaojian, Zhu Lin, Cai Zongwei*. A dual-zwitterion functionalized ultra-hydrophilic metal–organic framework with ingenious synergy for enhanced enrichment of glycopeptides. Chemical Communications 2019, 55, 13967-13970.
(10) Ji Fenfen, Sreenivasmurthy Sravan Gopalkrishnashetty, Wei Juntong, Shao Xiaojian, Luan Hemi, Zhu Lin, Song Juxian, Liu Liangfeng, Li Min, Cai Zongwei*. Study of BDE-47 induced Parkinson's disease-like metabolic changes in C57BL/6 mice by integrated metabolomic, lipidomic and proteomic analysis. Journal of Hazardous materials 2019, 378, 120738.
(11) Shao Xiaojian, Ji Fenfen, Wang Yawei, Zhu Lin, Zhang Zhen, Du Xiubo, Chung Arthur Chi Kong, Hong Yanjun, Zhao Qian, Cai Zongwei*. Integrative chemical proteomics-metabolomics approach reveals Acaca/Acacb as direct molecular targets of PFOA. Analytical Chemistry 2018, 90, 11092-11098.
(12) Shao Xiaojian, Gao Dan*, Chen Yongli, Jin Feng, Hu Guangnan, Jiang Yuyang, Liu Hongxia*. Development of a blood-brain barrier model in a membrane-based microchip for characterization of drug permeability and cytotoxicity for drug screening. Analytica Chimica Acta 2016, 934, 186-193.
(13) Shao Xiaojian, Gao Dan*, Wang Yini, Jin Feng, Wu Qin, Liu Hongxia*. Application of metabolomics to investigate the antitumor mechanism of flavopiridol in MCF-7 breast cancer cells. Journal of Chromatography B 2016, 1025, 40-47.