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成果及论文

已发表的论文(#为共同第一作者,*为通讯作者)

1.  Shang J#, Ye G#, Shi K#, Wan Y#, Luo C, Aihara H, Geng Q, Auerbach A, Li F*. Structural basis of receptor recognition by SARS-CoV-2. Nature. 2020 May;581(7807):221-224.

2. Shang J#, Wan Y#, Luo C#, Ye G, Geng Q, Auerbach A, Li F*. Cell entry mechanisms of SARS-CoV-2. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11727-11734.

3.  Shang J#, Wan Y#, Liu C#, Yount B, Gully K, Yang Y, Auerbach A, Peng G, Baric R, Li F*. Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry. PLoS Pathog. 2020 Mar 9;16(3):e1008392.

4. Shang J#, Zheng Y#, Yang Y#, Liu C, Geng Q, Luo C, Zhang W, Li F*. Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus spike proteins. PLoS Pathog. 2018 Apr 23;14(4):e1007009.

5. Shang J#, Zheng Y#, Yang Y#, Liu C, Geng Q, Tai W, Du L, Zhou Y, Zhang W*, Li F*. Cryo-Electron Microscopy Structure of Porcine Deltacoronavirus Spike Protein in the Prefusion State. J Virol. 2018 Feb 15;92(4):e01556-17.

6. Shang J, Zheng Y, Mo J, Wang W, Luo Z, Li Y, Chen X, Zhang Q, Wu K, Liu W, Wu J*. Sox4 represses host innate immunity to facilitate pathogen infection by hijacking the TLR signaling networks. Virulence. 2021 Dec;12(1):704-722.

7. Shang J, Zheng Y, Guo X, Mo J, Xie X, Xiong Y, Liu Y, Wu K, Wu J*. Hepatitis B virus replication and sex-determining region Y box 4 production are tightly controlled by a novel positive feedback mechanism. Sci Rep. 2015 May 13;5:10066.

8.  Wan Y#, Shang J#, Graham R, Baric RS, Li F*. Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol. 2020 Mar 17;94(7):e00127-20.

9.  Wan Y#, Shang J#, Sun S#, Tai W, Chen J, Geng Q, He L, Chen Y, Wu J, Shi Z, Zhou Y, Du L*, Li F*. Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry. J Virol. 2020 Feb 14;94(5):e02015-19. 

10.  Zheng Y#, Shang J#, Yang Y#, Liu C, Wan Y, Geng Q, Wang M, Baric R, Li F*. Lysosomal Proteases Are a Determinant of Coronavirus Tropism. J Virol. 2018 Nov 27;92(24):e01504-18. 

11.  Zhang N#, Shang J#, Li C, Zhou K, Du L*. An overview of Middle East respiratory syndrome coronavirus vaccines in preclinical studies. Expert Rev Vaccines. 2020 Sep;19(9):817-829.

12.  Wang N, Shang J, Jiang S, Du L*. Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses. Front Microbiol. 2020 Feb 28;11:298.

13.  Liu C, Ma Y, Yang Y, Zheng Y, Shang J, Zhou Y, Jiang S, Du L, Li J, Li F*. Cell Entry of Porcine Epidemic Diarrhea Coronavirus Is Activated by Lysosomal Proteases. J Biol Chem. 2016 Nov 18;291(47):24779-24786.

14.     Zhao G, He L, Sun S, Qiu H, Tai W, Chen J, Li J, Chen Y, Guo Y, Wang Y, Shang J, Ji K, Fan R, Du E, Jiang S, Li F, Du L, Zhou Y*. A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV. J Virol. 2018 Aug 29;92(18):e00837-18. 

15.     Geng Q, Tai W, Baxter VK, Shi J, Wan Y, Zhang X, Montgomery SA, Taft-Benz SA, Anderson EJ, Knight AC, Dinnon KH 3rd, Leist SR, Baric RS, Shang J, Hong SW, Drelich A, Tseng CK, Jenkins M, Heise M, Du L, Li F*. Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection. PLoS Pathog. 2021 Sep 7;17(9):e1009897.

16.     Ye G, Gallant J, Zheng J, Massey C, Shi K, Tai W, Odle A, Vickers M, Shang J, Wan Y, Du L, Aihara H, Perlman S, LeBeau A, Li F*. The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates. Elife. 2021 Aug 2;10:e64815. 

17.     Yang H, Zhou Y, Mo J, Xiang Q, Qin M, Liu W, Shang J, Yang Q, Xu W, Yang G, Tan Q, Wu K, Liu Y, Wu J*. SOX9 represses hepatitis B virus replication through binding to HBV EnhII/Cp and inhibiting the promoter activity. Antiviral Res. 2020 May;177:104761.