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成果及论文

78. Qin YH, Wang QF, Qian M, Huang RQ*. Single-Atom and Clustered Iron-Embedded Graphitic Nitrogen-Doped Carbon Nanospheres for Cancer Imaging and Ferroptosis. Mater. Today. 2024, doi.org/10.1016/j.mattod.2024.05.005.

77. Nie HF, Huang R, Jiang GW, Li WS, Yang L, Zhang M, Qian M, Guo W, Ye T, Huang RQ*. Modulating Active Targeting Nanoparticle Design According to Tumor Progressions. Acta. Pharm. Sin B. 2024, accepted.

76. Guo W, Ji M, Li YJ, Qian M, Qin YH, Li WS, Nie HF, Lv WX, Jiang GW, Huang R, Lin CT, Li HY, Huang RQ*. Iron ions-sequestrable and antioxidative carbon dot-based nano-formulation with nitric oxide release Parkinson's disease treatment. Biomaterials. 2024, 309:122622. 

75. Qian M, Jiang GW, Guo W, Huang RQ*. A Biodegradable Nanosuspension Locally Used for Inhibiting Postoperative Recurrence and Brain Metastasis of Breast Cancer. Nano Letters. 2024, 24(10):3165-3175.

74. Lin CT, Akhtar M, Li YJ, Ji M*, Huang RQ*. Recent Developments in CaCO3 Nano-Drug Delivery Systems: Advancing Biomedicine in Tumor Diagnosis and Treatment. Pharmaceutics. 2024, 16(2):275.

73. Zhu XR, Shi ZF, Mao Y, Lächelt U, Huang RQ*. Cell membrane perforation: patterns, mechanisms and functions. Small. 2024, e2310605.

72. Zhang FR, Benli-Hoppe T, Guo W, Seidl J, Wang Y, Huang RQ*, Wagner E*. Receptor-Targeted Carbon Nanodot Delivery through Polymer Caging and Click Chemistry-Supported LRP1 Ligand Attachment. Polymers. 2023, 15:4039-4055.

71. Qin YH, Zhu XR, Huang RQ*. Covalent organic frameworks: linkage types, synthetic methods and bio-related applications. Biomater. Sci. 2023, 11(21), 6942-6976.

70. Ling YJ#, Nie DK#, Huang Y#, Deng MY, Liu QQ, Shi JL, Ouyang SG, Yang Y, Deng S, Lu ZC, Yang JL, Wang Y*, Huang RQ*, Shi W*. Antioxidant Cascade Nanoenzyme Antagonize Inflammatory Pain by Modulating MAPK/p-65 Signaling Pathway. Adv. Sci., 2023, e2206934.

69. Qin YH#, Zhang XY#, Lächelt U, Huang RQ*. Unveiling the Multiple Tumor-targeted Impairments of Covalent-organic Framework-switched Photothermal Shielding Nanoparticles. Adv. Funct. Mater. 2023, 33:2211075. 

68. Wang Y#, Qian M#, Xie YB#, Zhang XY, Qin YH, Huang RQ*. Biodegradable Nanoparticles-mediated Targeted Drug Delivery Achieves Trans-spatial Immunotherapy. Fundamental Research, 2022, DOI: 10.1016/j.fmre.2022.11.003.

67. Deng MY#, Zhang M#, Huang R, Li HY, Lv WX, Lin XJ, Huang RQ*, Wang Y*. Diabetes immunity-modulated multifunctional hydrogel with cascade enzyme catalytic activity for bacterial wound treatment. Biomaterials. 2022, 289:121790. 

66. Wang Y#, Huo TT#, Du YL, Qian M, Lin CT, Nie HF, Li WS, Hao TT, Zhang XY, Lin N, Huang RQ*. Sensitive CTC analysis and dual-mode MRI/FL diagnosis based on a magnetic core-shell aptasensor. Biosens Bioelectron. 2022, 215:114530. 

65. Wang SS, Wu W, Liu Y, Wang CH, Xu Q, Lv QZ, Huang RQ*, Li XY*. Targeted peptide modified oxidized mesoporous carbon nanospheres for chemo-thermo combined therapy of ovarian cancer in vitro. Drug Delivery. 2022, 29(1):1947-1952. 

64Huo TT, Zhang XY, Qian M, Nie HF, Liang D, Lin CT, Yang YF, Guo W, Lächelt U, Huang RQ*. A Space-Time Conversion Vehicle for Programmed Multi-drugs Delivery into Pancreatic Tumor to Overcome Matrix and Reflux Barriers. Advanced Science. 2022, 2200608.

63. Liang D#, Zhang XY#, Wang Y*, Huo TT, Qian M, Xie YB, Li WS, Yu YQ*, Shi W, Liu QQ, Zhu JL, Luo C, Cao ZJ, Huang RQ*. Magnetic Covalent Organic Framework Nanospheres-based miRNA Biosensor for Sensitive Glioma Detection. Bioactive Materials. 2022, 14:145-151. 

62. Wang Y#, Qian M#, Du YL, Zhou JL, Huo TT, Guo W, Akhtar M, Huang RQ*. Tumor-selective Biodegradation-Regulated Photothermal H2S Donor for Redox Dyshomeostasis- and Glycolysis Disorder-enhanced Theranostics. Small. 2022, 18(8):2106168. 

61. Huo TT, Li WS, Liang D, Huang RQ*. Tumor-Targeted Fluorescence Imaging and Mechanisms of Tumor Cell-Derived Carbon Nanodots. Pharmaceutics. 2022, 14(1):193. 

60. Huo TT, Chen LL, Nie HF, Li WS, Lin CT, Akhtar M, Huang RQ*. Mitochondrial Dysfunction and Antioxidation Dyshomeostasis-Enhanced Tumor Starvation Synergistic Chemotherapy Achieved using a Metal-Organic Framework-Based Nano-Enzyme Reactor. ACS Appl Mater Interfaces. 2022, 14(3):3675-3684. 

59. Wang Y#, Huo TT#, Jiang HL, Xie YB, Zhang XY, Nie HF, Yang YF, Qian M, Li WS, Hao TT, Guo W, Qin YH, Huang RQ*. Sugar-originated Carbon Nanodots Selectively Damage the Tumor and Enhance the Sensitivity of Chemotherapy. Nano Today, 2021, 38:101200.

58. Huo TT, Yang YF, Qian M, Jiang HL, Du YL, Zhang XY, Xie YB, Huang RQ*. Versatile Hollow COF Nanospheres via Manipulating Transferrin Corona for Precise Glioma-Targeted Drug Delivery. Biomaterials. 2020, 260:120305.

57. Jiang HL, Du YL, Chen LL, Qian M, Yang YF, Huo TT, Yan XY, Ye T, Han B*, Wang Y*, Huang RQ*. Multimodal theranostics augmented by transmembrane polymer-sealed nano-enzymatic porous MoS2 nanoflowers. Int J Pharm, 2020, 586:119606.

56. Chen L#, Xu J#, Wang Y* and Huang RQ*. Ultra-small MoS2 Nanodots-Incorporated Mesoporous Silica Nanospheres for pH-Sensitive Drug Delivery and CT Imaging. Journal of Materials Science & Technology, 2021, 63:91-96.

55Chen L#, Qian M#, Jiang HL, Zhou YW, Du YL, Yang YF, Huo TT, Huang RQ*, Wang Y*. Multifunctional mesoporous black phosphorus-based nanosheet for enhanced tumor-targeted combined therapy with biodegradation-mediated metastasis inhibition. Biomaterials. 2020, 236:119770.

54Qian M, Du YL,Jiang HL, Huo TT,Yang YF, Guo W, Wang Y* and Huang RQ*. Biodegradable Mesoporous Silica Achieved via Carbon Nanodots-Incorporated Framework Swelling for Debris-mediated Photothermal Synergistic Immunotherapy. Nano Lett. 2019,19(12):8409-8418.

53. Li CY, Du YL, Qian M, Jiang HL, Wang JX, Murthy N, Wang Y*, Huang RQ*. Side effects-avoided theranostics achieved by biodegradable magnetic silica-sealed mesoporous polymer-drug with ultralow leakage. Biomaterials. 2018, 186:1-7.

52. Qian WB, Qian M, Wang Y, Huang JF, Chen J, Ni LC, Huang QF, Liu QQ, Gong PP, Hou SQ, Zhu H, Jia ZZ, Shen DD, Zhu CL, Jiang R, Sun JL, Yao JZ, Tang ZY , Ji X, Shi JL*, Huang RQ*, Shi W*. Combination Glioma Therapy Mediated by a Dual-Targeted Delivery System Constructed Using OMCN-PEG-Pep22/DOX. Small. 2018, DOI:10.1002/smll.201801905.

51. Du YL, Qian M, Li CY, Jiang HL, Yang YF, Huang RQ*. Facile marriage of Gd3+ to polymer-coated carbon nanodots with enhanced biocompatibility for targeted MR/fluorescence imaging of glioma. International journal of pharmaceutics. 2018, 552(1-2):84-90.

50. Qian M, Du YL, Wang SS, Li CY, Jiang HL, Shi W, Chen J, Wang Y*, Wagner E, Huang RQ*. Highly Crystalline Multicolor Carbon Nanodots for Dual-Modal Imaging-Guided Photothermal Therapy of Glioma. ACS Appl Mater Interfaces. 2018, 10(4):4031-40.

49. Wang SS, Li CY, Qian M, Jiang HL, Shi W, Chen J, L?chelt U, Wagner E, Lu WY, Wang Y*, Huang RQ*.Augmented glioma-targeted theranostics using multifunctional polymer-coated carbon nanodots. Biomaterials. 2017, 141:29-39.

48. Li CY, Qian M, Wang SS, Jiang HL, Du YL, Wang JX, Lu WY, Murthy N, Huang RQ*. Aptavalve-gated Mesoporous Carbon Nanospheres image Cellular Mucin and provide On-demand Targeted Drug Delivery. Theranostics. 2017, 7(13):3319-25.

47. Wang S, Reinhard S, Li C, Qian M, Jiang H, Du Y, Lachelt U, Lu W, Wagner E*, Huang R*. Antitumoral Cascade-Targeting Ligand for IL-6 Receptor-Mediated Gene Delivery to Glioma. Mol Ther. 2017, 25(7):1556-66.

46. Wang Y#, Shi W#, Wang SS, Li CY, Qian M, Chen J*, Huang RQ*. Facile Incorporation of dispersed Fluorescent Carbon Nanodots into Mesoporous Silica Nanosphere for pH-triggered Drug Delivery and Imaging. Carbon. 2016, 108:146-153.

45. Wang Y, Wang SS, Li CY, Qian M, Bu J, Wang JX, Huang RQ*. Facile Growth of Well-dispersed and Ultra-small MoS2 Nanodots in Ordered Mesoporous Silica Nanoparticles. Chem Commun. 2016, 52, 10217-10220.

44. Meng Y, Wang SS, Li CY, Qian M, Yan XY, Yao SC, Peng XY, Wang Y*, Huang RQ*. Photothermal combined gene therapy achieved by polyethyleneimine-grafted oxidized mesoporous carbon nanospheres. Biomaterials. 2016, 100:134-42.

43. Wang SS, Meng Y, Li CY, Qian M, Huang RQ*. Receptor-Mediated Drug Delivery Systems Targeting to Glioma. Nanomaterials. 2016, 6(1):3-19. (invited review)

42. Meng Y, Wang SS, Li CY, Qian M, Zheng YF, Yan XY, Huang RQ*. TKD peptide as a ligand targeting drug delivery systems to memHsp70-positive breast cancer. Int J Pharm. 2016, 498(1-2):40-48.

41. Li CY, Meng Y, Wang SS, Qian M, Wang JX, Lu WY, Huang RQ*. Mesoporous Carbon Nanospheres Featured Fluorescent Aptasensor for Multiple Diagnosis of Cancer in Vitro and in Vivo. ACS Nano. 2015, 9(12):12096-12103.

40. Wang Y, Meng Y, Wang SS, Li CY, Shi W, Chen J, Wang JX, Huang RQ*. Direct solvent-derived polymer-coated nitrogen-doped carbon nanodots with high water solubility for targeted fluorescence imaging of glioma. Small. 2015, 11(29):3575-81.

39. Wang KY, Yao H, Meng Y, Wang Y*, Yan XY*, Huang RQ*. Specific aptamer-conjugated mesoporous silica-carbon nanoparticles for HER2-targeted chemo-photothermal combined therapy. Acta Biomater. 2015, 16:196-205.

38. Yao H, Wang KY, Wang Y, Wang SS, Li JF, Lou JN, Ye LY, Yan XY, Lu WY, Huang RQ*. Enhanced blood-brain barrier penetration and glioma therapy mediated by a new peptide modified gene delivery system. Biomaterials. 2015, 37:345-352.

37. Huang YJ*, Kannan P, Zhang L, Rong Y, Dai LW, Huang RQ, Chen T*. Close-packed assemblies of discrete tiny silver nanoparticles on triangular gold nanoplates as a high performance SERS probe. RSC Adv. 2015, 5:94849-94854.

36. Wang Y, Wang KY, Zhang R, Liu XG, Yan XY, Wang JX, Wagner E, Huang RQ*. Synthesis of core-shell graphitic carbon@silica nanospheres with dual-ordered mesopores for cancer-targeted photothermochemotherapy. ACS Nano. 2014, 8(8):7870-9.

35. Wang Y#, Huang RQ#, Liang GH, Zhang ZY, Zhang P, Yu SN, Kong JL*. MRI-visualized, dual-targeting and combined tumor therapy using magnetic draphene-based mesoporous silica. Small. 2014, 10(1):109-16. (#Co-first author, cover page).

34. Wang Y, Wang KY, Yan XY, Huang RQ*. A general strategy for dual-triggered combined tumor therapy based on template semi-graphitized mesoporous silica nanoparticles. Adv. Healthc. Mater. 2014, 3(4):485-9.

33. Wang Y, Wang KY, Zhao JF, Liu XG, Bu J, Yan XY, Huang RQ*. Multifunctional mesoporous silica-coated graphene nanosheet used for chemo-photothermal synergistic targeted therapy of glioma. J. Am. Chem. Soc. 2013, 135(12):4799-804.

32. Huang RQ#, Ma HJ#, Guo YB, Liu SH, Kuang YY, Shao K, Li JF, Liu Y, Han L, Huang SX, An S, Ye LY, Lou JN, Jiang C. Angiopep-conjugated nanoparticles for targeted long-term gene therapy of Parkinson’s Disease. Pharm Res. 2013, 30(10):2549-59. (#Co-first author)

31. Wang Y, Shi W, Song WS, Wang L, Liu XG, Chen J*, Huang RQ*. Tumor cell targeted delivery by specific peptide-modified mesoporous silica nanoparticles. J. Mater. Chem. 2012, 22(29):14608-16.

30Liu SH, Guo YB, Huang RQ, Li JF, Huang SX, Kuang YY, Han LJiang CGene and doxorubicin co-delivery system for targeting therapy of glioma. Biomaterials. 2012, 33(19):4907-16.

29. Huang RQ, Han L, Li JF, Liu SH, Shao K, Kuang YY, Hu X, Wang XX, Lei H, Jiang C. Chlorotoxin-modified macromolecular contrast agent for MRI tumor diagnosis. Biomaterials. 2011, 32(22):5177-86.

28. Huang RQ, Ke WL, Han L, Li JF, Liu SH, Jiang C. Targeted delivery of chlorotoxin-modified DNA-loaded nanoparticles to glioma via intravenous administration. Biomaterials. 2011, 32(9):2399-406.

27Han LHuang RQ, Li JF, Liu SH, Huang SX, Jiang C. Plasmid pORF-hTRAIL and doxorubicin co-delivery targeting to tumor using peptide-conjugated polyamidoamine dendrimer. Biomaterials. 2011, 32(4):1242-52.

26. Liu Y, Huang RQ, Jiang C. Non-viral gene delivery and therapeutics targeting to brain. Curr Nanosci 2011, 7(1):50-70.

25Han LLi JF, Huang SX, Huang RQ, Liu SH, Hu XYi PW, Shan DWang XX, Lei HJiang C. Peptide-conjugated polyamidoamine dendrimer as a nanoscale tumor-targeted T1 magnetic resonance imaging contrast agent. Biomaterials. 2011, 32(11):2989-98.

24. Li JF, Zhou L, Ye DY, Huang SX, Shao K, Huang RQ, Han L, Liu Y, Liu SH, Ye LY, Lou JN, Jiang C. Choline-derivate-modified nanoparticles for brain-targeting gene delivery. Adv Mater. 2011, 23(39):4516-20.

23. Huang SX, Li JF, Han L, Liu SH, Ma HJ, Huang RQ, Jiang C. Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma. Biomaterials. 2011, 32(28):6832-8.

22. Huang RQ, Liu SH, Shao K, Han L, Ke WL, Liu Y, Huang SX, Jiang C. Evaluation and mechanism studies of PEGylated dendrigraft poly-L-lysines as novel gene delivery vectors. Nanotechnology. 2010, 21(26):265101.

21Huang RQ, Ke WL, Han LLiu YShao KJiang CPei YY. Lactoferrin-modified nanoparticles could mediate efficient gene delivery to the brain in vivo. Brain Res Bull. 2010, 81(6):600-4.

20. Huang RQ, Ke WL, Liu Y, Wu DD, Feng LY, Jiang C, Pei YY. Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic parkinson model. J Neurol Sci. 2010, 290(1-2):123-30.

19. Han L, Huang RQ, Liu SH, Huang SX, Jiang C. Peptide-conjugated PAMAM for targeted doxorubicin delivery to transferrin receptor over-expressed tumors. Mol Pharm. 2010, 7(6):2156-65.

18. Shao K, Huang RQ, Li JF, Han L, Ye LY, Lou JN, Jiang C. Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain. J Control Release 2010, 147(1):118-26.

17. Liu Y, Li JF, Shao K, Huang RQ, Ye LY, Lou JN, Jiang C. A leptin derived 30-amino-acid peptide modified pegylated poly-L-lysine dendrigraft for brain targeted gene delivery. Biomaterials. 2010, 31:5246-57.

16. Huang RQ, Ke WL, Jiang C, Pei YY. Progresses in brain-targeting non-viral gene delivery systems. J Int Pharm Res. 2010, 37(1):36-9.

15. Huang RQ, Ke WL, Han L, Liu Y, Shao K, Ye LY, Lou JN, Jiang C, Pei YY. Brain-targeting mechanisms of lactoferrin-modified DNA-loaded nanoparticles. J Cereb Blood Flow Metab. 2009, 29(12):1914-23.

14. Huang RQ#, Han L#, Li JH, Ren FL, Ke WL, Jiang C, Pei YY. Neuroprotection in a 6-OHDA-lesioned parkinson model using lactoferrin-modified nanoparticles. J Gene Med. 2009, 11(9):754-63.

13. Liu Y, Huang RQ, Han L, Ke WL, Shao K, Ye LY, Lou JN, Jiang C. Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles. Biomaterials. 2009, 30(25):4195-202.

12. Zhu SJ, Huang RQ, Hong MH, Jiang YY, Hu Z, Liu C, Pei YY. Effects of Polyoxyethylene (40) Stearate on the activity of P-glycoprotein and Cytochrome P450. Eur J Pharm Sci. 2009, 37(5):573-80.

11. Ke WL, Shao K, Huang RQ, Han L, Liu Y, Li JF, Kuang YY, Ye LY, Lou JN, Jiang C. Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. Biomaterials. 2009, 30(36):6976-85.

10. Huang RQ, Ke WL, Liu Y, Jiang C, Pei YY. The use of lactoferrin as a ligand for targeting the polyamidoamine-based gene delivery system to the brain. Biomaterials. 2008, 29(2):238-46.

9. Ke WL, Zhao YS, Huang RQ, Jiang C, Pei YY. Enhanced oral bioavailability of doxorubicin in a dendrimer drug delivery system. J Pharm Sci. 2008, 97(6):2208-16.

8. Huang RQ, Qu YH, Ke WL, Zhu JH, Pei YY, Jiang C. Efficient gene delivery targeted to the brain using a transferrin-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. FASEB J. 2007, 21(4):1117-25.

7. Huang RQ, Ke WL, Qu YH, Zhu JH, Pei YY, Jiang C. Characterization of lactoferrin receptor in brain endothelial capillary cells and mouse brain. J Biomed. Sci. 2007, 14(1):121-8.

6. Huang RQ, Pei YY, Jiang C. Enhanced gene transfer into brain capillary endothelial cells using Antp-modified DNA-loaded nanoparticles. J Biomed Sci. 2007, 14(5):595-605.

5. Huang RQ, Yang WL, Jiang C, Pei YY. Gene delivery into brain capillary endothelial cells using Antp-modified DNA-loaded nanoparticles. Chem Pharm Bull (Tokyo). 2006, 54(9):1254-8.

4. Huang RQ, Pei YY. Progresses in the drug delivery systems actively targeting to the tumors. Chin J Pharma. 2005, 36(8):505-9.

3. Huang RQ, Pei YY. Progresses in the non-viral vectors in gene therapy. Fore Med Sci Sect Phar. 2005, 32(2):77-81.

2. Jiang YY, Huang RQ, Zhen LM, Pei YY. Bioavailability evaluationof sustained-release metformin formulation after single and multiple oral dosing in healthy volunteers. Fudan Univ J Med Sci. 2005, 32(2):178-81.

1. Jiang YY, Mao DZ, Huang RQ, Zheng LM, Pei YY. An improving HPLC method for determination of metformin hydrochloride in human plasma. Chin J Clin Phar, 2004, 13(6):338-41.