In this work, glucose oxidase (GOx) and quasi-amorphous Fe are co-incorporated into Zn-MOF nanoparticle (F-GZ) for cascade enzyme catalytic activities, where not only the high blood glucose in the wound is consumed via the GOx catalysis, but also the effective anti-bacteria is achieved via the degradedly released Zn²⁺ at the relatively elevated pH environment during the wound recovery period. By loading this MOF-based nanoparticle uniformly on an injectable and self-healing hydrogel (F-GZ@G) formed from oxidized hyaluronic acid (OHA) and N-carboxyethyl chitosan (CEC), the toxic side effects of the nanoparticle were significantly reduced and wound repair was accelerated. More importantly, this hydrogel is found to modulate the diabetes immunity possibly mediated via the released Zn²⁺, which thus contributes to the recovered pancreatic islet functions with improved glucose tolerance and increased insulin secretion for enhanced diabetic wound treatments. This work initiates a new strategy for simultaneous diabetic wound management and also suggests a potential way for diabetic immunity modulation. This work was mainly accomplished by Ph.D. candidate Meng Zhang and Master candidate Mengyuan Deng.