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成果及论文

2024年

47. Y.Y. Guo,  Rui Wang*High-Resolution Detection of Isoprenylated Adenosine Nucleotides in RNA: A Protocol Employing IMCRT Sequencing Technology.

46. Y.Y. Guo et al. Uncovering the Structural Dynamics of N6-Isopentenyl Adenosine-Modified RNA via Iodine-Induced Hyperchromicity. Submitted.

45. X.Q. Chen, Y.Y. Guo, Rui Wang*. Illuminating 2’-5’-Adenosine Linked Nucleic Acids via Acylation of Secondary Hydroxy Functionality. Bioorg. & Med. Chem. Lett.2024, 129847.

      

44. 周志鹏, 王锐, 陈莎莎, 李益楠, 郭宇扬。一种检测RNA上异戊烯基腺苷修饰的方法中国专利,申请号: 202410199956.2.

43. Chemically inducible 6mA detection in genome at single-base resolution. In Preparation.

42. Compounds and Methods for Labeling Lipidated Nucleotides. US patent. PCT No.: 18661155.

41. Y.Y. Guo, X.Q. Chen, Y.F. Gan, Y.Y. Li, R. Wang*Targeted i6A-RNA Degradation through Sequential Fluorination-Azidation and Click Reaction with Imidazole-based Probes. Bioorg. & Med. Chem. Lett., 2024. 129815 (Prof. Chuan He for winning the Tetrahedron Prize for Creativity in Bioorganic and Medicinal Chemistry, Special Issue).

      

40Yuanyuan Li, Hongling Zhou, Shasha Chen, Yinan Li, Yuyang Guo, Xiaoqian Chen, Sheng Wang, Li Wang, Youfang Gan, Shusheng Zhang, Ya Ying Zheng, Jia Sheng,Zhipeng Zhou,* Rui Wang*.  Bioorthogonal Labeling and Profiling of N6-isopentenyladenosine (i6A) Modified RNA. Nucleic Acids Res., 2024, 52(6), 2808-2820. [IF=17]

   

   


39. 王锐,王升, 李源源,周红玲, “一种单碱基分辨率检测 RNA 中 N6-异戊烯基腺嘌呤修饰的方法”,中国专利,申请号:202210453089.1,授权公告号:2024012300180450申请日:2022-04-24,授权日:2024-01-23

38. Xiaoqian Chen, Yuyang Guo. Youfang Gan, Rui Wang* The Sequencing, Physiological Regulation and Representative Disease Research Progress of RNA m6A Modification. Pharmaceutical Fronts. 2024, 06(01), e29-e46DOI: 10.1055/s-0044-1780506 (Invited & Cover).

     


2023年

37. Xiaoqian Chen, Rui WangChemical Pulldown of Prenylated-Adenosine-Incorporated RNA via Sequential Fluorination-Azidation and a Click Reaction Targeting Prenyl Functionality. Tetrahedron Lett., 2023154856.

36. Xiaoqian Chen, Rui Wang* Regulation of Prenylated Rat Sarcoma Proteins via Sequential Azidation-Selenylation and a Click Reaction. Tetrahedron Lett., 2023, 154883.

35. Youfang Gan, Xiaoqian Chen, Yuanyuan Li, Yuyang Guo, Rui Wang* Sequential Azidation-Azolation of Prenylated Derivatives and a Click Reaction Enable Selective Labeling and Degradation of RAS Protein. J. Org. Chem., 2023, 88(15), 10836-10843 [4.198/Q1].

      


34. H.L. Zhou,  Y.Y. Li,  J.W. Zhang,  L.Wang, Y.Y. Zheng, T. Begley, J. Sheng,* and R. Wang.* Nature-Inspired Chemical Probes for in-cell Labeling of Lipidized RNA and Identification of New Regulatory Enzymes. Submitted (bioRxiv, https://doi.org/10.1101/2022.05.17.492276).

33. H.L. Zhou, Y.F. Gan, Y. Y. Li,  X.Q. Chen, Y.Y. Guo, R. Wang.* Degradation of RAS Proteins Targeting the Posttranslational Prenyl Modifications via Cascade Azidation/Fluorination and Click Reaction. J. Med. Chem., 2023, 66(11), 7243-7252. [8.039/Q1].

   


32. Y. Y. Li, H.L.Zhou, Y.F. Gan, R. Wang.* Development of Nitroso-based Probes for Labeling and Regulation of RAS protein in Cancer Cells via Sequential Ene-ligation and Oxime Condensation.  J. Org. Chem., 2023, 88(3), 1762-1771. DOI: 10.1021/acs.joc.2c02922. [4.198/Q1].

      

31. Y.F. Gan, Y. Y. Li,  X.Q. Chen, Y.Y. Guo, R. Wang.* Recent Advances in The Quinone Methide Chemistry for Protein-Proximity Capturing. Synthesis-Stuttgart, 2023, 55, 1172-1186DOI: 10.1055/s-0042-1751402 (Invited, Special Issue). [3.019/Q2].

       


30. J.Z. Zhao, H.M. Hu, J.W. Zhang, H.L.Zhou, S. Wang, R. Wang.* Cell Bio. Tox., 2023, 39, 2421-2429. [6.819/Q1]. 

      

2022年


29. Y. Y. Li, H.L.Zhou, Y.F. Gan, R. Wang.* Tetrahedron Lett., 2022, 153980.

28. Y.-F Gan, Y.-Y. Li, H.-L. Zhou, R.Wang.* Deciphering Regulatory Protein of Prenylated Protein via FRET Technique using Nitroso-based Ene-Ligation and Sequential Azidation and Click Reaction. Org. Lett., 2022, 24(36), 6625-6630. [6.072/Q1]

        

27.王锐,张菁雯,王升,赵纪中,胡洪梅,“一种异戊烯类修饰的生物分子的分子探针及其应用”,中国专利,申请号:202010734230.6,授权公告号:CN 111909993 B,申请日:2020年,授权日:2022年02月23日.

26. H.L. Zhou, Y.Y. Li, S. Wang, L. Wang and R. Wang.*  Tetrahedron Lett., 2022, 92153678.

25. H.L. Zhou, Y.Y. Li, Y.F. Gan, R. Wang.*   Topics in Curr. Chem.,  2022, 380 16 [8.600/Q1].

24. S. Wang,Y.Y. Li, H.L., Zhou, L. Wang, R. Wang.* J. Org. Chem., 202287(13), 8648-8655. [4.198/Q1].

          

23. S. Wang, Y.-Y. Li, Y.F. Gan, H.L., Zhou, R. Wang.* Tetrahedron Lett., 2022, 153873.

22. S. Wang, Y.-Y. Li, Y.F. Gan, R. Wang.* Tetrahedron Lett., 2022, 153793 (selected as Cover paper).

           


          

21. J.Z. Zhao, H.M. Hu, J.W. Zhang, Y.Y. Li, L. Wang, H.L. Zhou and R. Wang. *  New. J. Chem., 2022, 46, 2472-7. [3.925/Q2]

          


2021年

20. P. Yu, H.L. Zhou, Y.Y. Li, Z.F. Du, R. Wang. *  Nucl. Nucl. & Nucl. Acids, 2021, 40 (7), 754-766.

          

19. J.W. Zhang, Y.Y. Li, S. Wang, R. Wang. * Tetrahedron Lett., 2021, 74, 153162.

18. J.Z. Zhao, H.M. Hu, S. Wang, L. Wang and R.Wang.* Genes 2021, 12, 1488. (Invited, Special Issue of "RNA Chemical Biology") [4.141/Q2]

          

17. J.W. Zhang,  J.Z. Zhao, L. Wang, H.M. Hu, S. Wang,  P. Yu, R.Wang.* Tetrahedron 202181, 131917. 


2020年

16. S. Wang, J.Z. Zhao, L. Wang, J.W. Zhang, H.M. Hu, P. Yu, and R. Wang.* Asian J. Org. Chem., 2020, 210. [3.116/Q2]

15. L. Wang, J.W. Zhang, J.Z. Zhao, P. Yu, S. Wang, H.M. Hu & R. Wang.* Cat. Rev., 2020, 1-42. [IF=20]


2019

14. R. Wang, S. V. Ranganathan, P. Haruehanroengra, S. Mao, M. Scalabrin, D. Fabris, A. Chen, H. Liu, A.E.A. Hassan, J. Gan,  J. Sheng. J Biomol. Struct. Dyn. 2019, 37(3), 551-561. [IF=4.4]


2018年 

13. H. Liu, R. Wanget al., Nucleic Acids Res., 2018, 46 (21), 11627-11638. [IF=17]


2017年

12. V. Valsangkar, A.R. Chandrasekaran, R. Wang, P. Haruehanroengra, O. Levchenko, K. Halvorsen and J. Sheng. J. Mater. Chem. B, 20175, 2074-2077.

11. R. Wang, P. Haruehanroengra, J. Sheng. Synthesis of Geranyl-2-Thiouridine-Modified RNA. Curr. Protoc. Nucleic Acid Chem. 2017, 68, 4.72.1-4.72.13. 

Prior to HUST
代表性论文:
10. H. H. Liu, X. Yu, Y. Q. Chen, J. Zhang, B. X. Wu, L. Zheng, P. Haruehanroengra, R. Wang et al., Nature Commun., 2017, 8, 2006. [IF=17]
9. R. Wang et al., Nucleic Acid Res., 2016, 44(13), 6036-6045. [IF=17]
8. R. Wang et al., Nucleic Acid Res., 2016, 44(10), 4968-4977. [IF=17]
7. F. Shen,Z. P. Luo., H. Liu, R. Wang et al., Nucleic Acid Res., 2017, 45(6), 3537-3546. [IF=17]
6. R. Wang et al., Chem. Comm., 2015, 51, 16369-16372.
5. R. Wang et al., Chem. Comm., 2015, 51, 16389-16392.
4. M. Basanta-Sanches,# R. Wang# et al., ChemBioChem., 2017, 18(1), 72-76.
3. E. Agustin, O. Papa-Ni, i. Khan, M. Miller, R. Wang et al., Chem. Comm., 2016, 52, 1405-1408.
2. P. Haruehanroengra, S. Vangaveti, S. R. Ranganathan, R. Wang et al., ACS Chem. Bio., 2017, 12(6), 1504-1513.
1. R. Wang*, J. R. Falck. Cat. Rev., 2014, 56, 288-331. [IF=20]