Selected Publications (See full publication list on Pubmed or GoogleScholar) （*Corresponding author）

2024

Qi Xiong#, Zhini Zhu#, Tingting Li#, Xiaotian Li, Zixuan Zhou, Yulin Chao, Chuanhui Yang, Suihan Feng, Qianhui Qu*, Dianfan Li* (2024) Molecular architecture of human LYCHOS involved in lysosomal cholesterol signaling. Nature Structural & Molecular Biology

Fang Tong, Shuai Liu, Chen Zhang, Xicheng GU, Wan-Jie Du, Huan Yang, Bin Zhou, Xiaomeng Zhou, Ziyue Chen, Yun-yun Wang, Jianwei Chen, Qianhui Qu, Qingjian Han* (2024) Elevated vesicular Zn²⁺ in TMEM163⁺ primary afferents underlies senile pruritus. PLOS Biology

Peipei Li#, Zhini Zhu#, Yong Wang^#,*, Xuyuan Zhang^#, Chuanhui Yang#, Yalan Zhu^#, Zixuan Zhou, Yulin Chao, Yonghui Long, Yina Gao, Songqing Liu, Liguo Zhang*, Pu Gao*, Qianhui Qu* (2024) Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3. Nature Communications

Yonghui Long#, Zhini Zhu^#, Zixuan Zhou#, Chuanhui Yang^#, Yulin Chao#,  Yuwei Wang, Qiangtong Zhou, Ming-Wei Wang, Qianhui Qu* (2024) Structural insights into human zinc transporter ZnT1 mediated Zn²⁺ efflux. EMBO Reports 

Shujin Liu#, Yulin Chao#, Zixuan Zhou#, Chuanhui Yang, Zhini Zhu, Yuwei Wang, Qianhui Qu* (2024) Recognition of antiepileptic brivaracetam by synaptic vesicle protein 2A. Cell Discovery. 

Yuwei Wang#, Pei Zhang#, Yulin Chao#, Zhini Zhu#, Chuanhui Yang#, Zixuan Zhou#, Yaohui Li, Yonghui Long, Yuehua Liu, Dianfan Li, Sheng Wang*, Qianhui Qu* (2024) Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines. Cell Research. 

Research Highlight: Packaging monoamine neurotransmitters. Cell Research. 2024

Spotlight: VMAT structures reveal exciting targets for drug development. Trends in Pharmacological Sciences. 2024

Jingjing Hong#, Tingting Li#, Yulin Chao#, Yidan Xu, Zhini Zhu, Zixuan Zhou, Weijie Gu, Qianhui Qu*, Dianfan Li* (2024) Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis. Nature Communications.

2023

Yidan Xu#, Tingting Li#, Zixuan Zhou#, Jingjing Hong, Yulin Chao, Zhini Zhu, Ying Zhang, Qianhui Qu*, Dianfan Li* （2023）Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis. Nature Communications.

Xu Zhang#, Zixuan Zhou#, Lin Dai, Yulin Chao, Zheng Liu, Mingdong Huang, Qianhui Qu*, Zhonghui Lin* (2023) Cryo-EM structures of the RuvAB-Holliday junction intermediate complex from Pseudomonas aeruginosa. Frontiers in Plant Science. 

Abdelfattah Faouzi#, Haoqing Wang#, Saheem A Zaidi#, Jeffrey F DiBerto#, Tao Che#, Qianhui Qu#, Michael J Robertson, Manish K Madasu, Amal El Daibani, Balazs R Varga, Tiffany Zhang, Claudia Ruiz, Shan Liu, Jin Xu, Kevin Appourchaux, Samuel T Slocum, Shainnel O Eans, Michael D Cameron, Ream Al-Hasani, Ying Xian Pan, Bryan L Roth, Jay P McLaughlin, Georgios Skiniotis*, Vsevolod Katritch*, Brian K Kobilka*, Susruta Majumdar* (2023) Structure-based design of bitopic ligands for the µ-opioid receptor. Nature.

Qianhui Qu#, Weijiao Huang#, Deniz Aydin#, Joseph M Paggi#, Alpay B Seven#, Haoqing Wang, Soumen Chakraborty, Tao Che, Jeffrey F DiBerto, Michael J Robertson, Asuka Inoue, Carl-Mikael Suomivuori, Bryan L Roth, Susruta Majumdar*, Ron O Dror*, Brian K Kobilka*, Georgios Skiniotis* (2023) Insights into distinct signaling profiles of the µOR activated by diverse agonists. Nature Chemical Biology.

2022

Yidan Xu#, Guowen Jia#, Tingting Li#, Zixuan Zhou#, Yitian Luo, Yulin Chao, Juan Bao, Zhaoming Su*, Qianhui Qu*, Dianfan Li* (2022) Molecular insights into the biogenesis of glycosylphosphatidylinositol anchor proteins. Nature Communications

Susu Wu, Liping Li, Min Li, Shiyu Sun, Yuting Zhao, Xiaowen Xue, Feiyu Chen, Jingli Zhong, Junfan Guo, Qianhui Qu, Xiongjun Wang*, Zhen Liu*, Yunbo Qiao *（2022）Two Compact Cas9 Ortholog-Based Cytosine Base Editors Expand the DNA Targeting Scope and Applications In Vitro and In Vivo.  Frontiers in cell and developmental biology

Haoqing Wang#, Florian Hetzer#, Weijiao Huang#, Qianhui Qu#, Justin Meyerowitz, Jonas Kaindl, Harald Hübner, Georgios Skiniotis*, Brian K. Kobilka*, Peter Gmeiner* （2022）Structure-based Evolution of G protein-biased μ-opioid Receptor Agonists. Angewandte Chemie

 Naotaka Tsutsumi#, Shoji Maeda#, Qianhui Qu#, Martin Vögele#, Kevin M Jude, Carl-Mikael Suomivuori, Ouliana Panova, Deepa Waghray, Hideaki E Kato, Andrew Velasco, Ron O Dror, Georgios Skiniotis, Brian K Kobilka, K Christopher Garcia* （2022） Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins. Science Advances

Lei Han#, Qianhui Qu#, Deniz Aydin#, Ouliana Panova, Michael J. Robertson, Yan Xu, Ron O. Dror, Georgios Skiniotis* & Liang Feng* (2022) Structure and mechanism of the SGLT family of glucose transporters. Nature

             News and Views in Nature: Transporter-protein structures show how salt gets a sweet ride into cells.

2021

Yitian Luo#, Guoyue Wan#, Xiang Zhang#, Xuan Zhou#, Qiuwen Wang, Jialin Fan, Hongmin Cai, Liya Ma, Hailong Wu, Qianhui Qu*, Yao Cong*, Yun Zhao*, Dianfan Li* (2021) Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae. Structure 

Naotaka Tsutsumi#, Qianhui Qu#, Masa Mavri#, MaibrittS. Baggesen, Shoji Maeda, Deepa Waghray, Christian Berg, Brian K. Kobilka, Mette M. Rosenkilde, Georgios Skiniotis, Christopher K Garcia (2021) Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1. Immunity 

2020

Bowen Rong, Qian Zhang, Jinkai Wan, Shenghui Xing, Ruofei Dai, Yuan Li, Jiabin Cai, Jiaying Xie, Yang Song, Jiawei Chen, Lei Zhang, Guoquan Yan, Wen Zhang, Hai Gao, Jing-Dong J Han, Qianhui Qu, Honghui Ma*, Ye Tian*, Fei Lan*  (2020) Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth. Cell Reports

Weijiao Huang#, Matthieu Masureel#, Qianhui Qu#, John Janetzko#, Asuka Inoue, Khanh Nguyen, Hideaki Kato,  Jeffrey Glenn, Michael Robertson, Georgios Skiniotis*, Brian K. Kobilka* (2020) Structure of the Neurotensin Receptor 1 in complex with β-arrestin Nature 579, 303–308

        Preview in Cell: Terminating G-protein Coupling: Structural snapshots of GPCR-β-Arrestin complexes

Prior to Independent:

Shoji Maeda#, Qianhui Qu#, Michael J. Robertson, Georgios Skiniotis*, Brian K. Kobilka* (2019) Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes. Science Vol. 364, Issue 6440, pp. 552-557

Qianhui Qu#, Qian Zhang#, Lu Yang#, Xiaofeng Zhu, Hong Liu (2019) SET binding to Sgo1 inhibits Sgo1-cohesin interactions and promotes chromosome segregation. Journal of Cell Biology DOI: 10.1083/jcb.201810096

Qianhui Qu#, Yohhei Takahashi#, Yidai Yang, Hongli Hu, Yan Zhang, Joseph S Brunzelle, Jean-François Couture, Ali Shilatifard*, Georgios Skiniotis* (2018) Structure and conformational dynamics of COMPASS histone H3K4 methyltransferase. Cell 174(5):1117-1126

Antoine Koehl#, Hongli Hu#, Shoji Maeda#, Yan Zhang, Qianhui Qu, Joseph M. Paggi, Naomi Latorraca, Daniel Hilger, Roger Dawson, Hugues Matile, Sebastien Granier, William I. Weis, Ron O. Dror, Aashish Manglik, Georgios Skiniotis*, Brian K. Kobilka* (2018) Structure of the µ Opioid Receptor-Gi Protein Complex. Nature 558, 547-552.

Yan Zhang#, Bingfa Sun#, Dan Feng, Hongli Hu, Matthew Chu, Qianhui Qu, Jeffrey T. Tarrasch, Shane Li, Tong Sun Kobilka, Brian K. Kobilka*, Georgios Skiniotis* (2017) Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature 546, 248-253

Hong Liu, Qianhui Qu, Ross Warrington, Allyson Rice, Ningyan Cheng, and Hongtao Yu (2015) Mitosis Transcription Installs Sgo1 at Centromeres to Coordinate Chromosome Segregation. Molecular Cell. 59(3):426-36.

Kodai Hara#, Ge Zheng#, Qianhui Qu, Hong Liu, Zhuqing Ouyang, Zhe Chen, Diana R Tomchick & Hongtao Yu (2014) Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion. Nature Structural & Molecular Biology. 21, 864-870