（†共同第一作者，*通讯作者）
（文章列表）
2024
Application of Directed Evolution and Machine Learning to Enhance the Diastereoselectivity of Ketoreductase for Dihydrotetrabenazine Synthesis
Chenming Huang, Li Zhang, Tong Tang, Haijiao Wang, Yingqian Jiang, Hanwen Ren, Yitian Zhang, Jiali Fang, Wenhe Zhang, Xian Jia, Song You*, Bin Qin*
JACS Au 2024, 4 (7), 2547–2556. 10.1021/jacsau.4c00284
Asymmetric Synthesis of β-Hydroxyphosphonates via a Chemoenzymatic Cascade
Jiali Fang†, Hanwen Ren†, Shaowu Xu, Chenming Huang, Yingqian Jiang, Wenhe Zhang, Song You*, Bin Qin*
Organic Letters 2024, 26 (26), 5458–5462. 10.1021/acs.orglett.4c01716
Cobalt-Catalyzed Carbon–Heteroatom Transfer Enables Regioselective Tricomponent 1,4-Carboamination
Kaitong Zhuang, Graham C. Haug, Yangyang Wang, Shuyu Yin, Huiying Sun, Siwen Huang, Ramon Trevino, Kunzhi Shen, Yao Sun, Chao Huang, Bin Qin, Yongxiang Liu, Maosheng Cheng, Oleg V. Larionov*, Shengfei Jin*
Journal of the American Chemical Society 2024, 146 (12), 8508–8519. 10.1021/jacs.3c14828
An oral bacterial pyroptosis amplifier against malignant colon cancer
Xinyu Lou, Jinqiang Wang, Xiru Jin, Xu Wang, Bin Qin, Dongchun Liu, Xianbao Shi, Defang Ouyang, Zhonggui He, Jin Sun*, Hongjun Li*, Mengchi Sun*
Nano Today 2024, 54, 102091. 10.1016/j.nantod.2023.102091
Micro-to-nano Oncolytic Microbial System Shifts from Tumor Killing to Tumor Draining Lymph Nodes Remolding for Enhanced Immunotherapy
Zhichao Chen, Yuhan Liu, Yuxuan Yu, Shihua Yang, Jing Feng, Yinmei Zhu, Wanxu Huang, Bin Qin, Xinyao Guan, Zhonggui He, Mengchi Sun*, Jin Sun*
Advanced Materials 2024, 36 (7), 2306488. 10.1002/adma.202306488
Structure-based reshaping of a new ketoreductase from Sphingobacterium siyangense SY1 toward α-haloacetophenones
Changli Che, Wenhe Zhang, Xin Xu, Zhiran Zheng, Hongli Wei, Bin Qin, Xian Jia*, Weidong Liu*, Song You*
International Journal of Biological Macromolecules 2024, 277, 134157. 10.1016/j.ijbiomac.2024.134157
2023
The Biocatalysis in Cancer Therapy
Junling Liu, Hanwen Ren, Tong Tang, Jiaqi Wang, Jiali Fang, Chenming Huang, Zhendong Zheng,* Bin Qin*
ACS Catalysis 2023, 13 (12), 7730−7755. 10.1021/acscatal.3c01363
A Three-Step Chemoenzymatic Cascade Synthesis of Miconazole Analogues Based on the Asymmetric Synthesis of β-Heteroaryl Amino Alcohols via Ketoreductases
Jiali Fang, Yiping Xu, Hanwen Ren, Chenming Huang, Wenhe Zhang, Xian Jia, Song You,* Bin Qin*
Advanced Synthesis & Catalysis 2023, 365 (23), 4181-4189. 10.1002/adsc.202300740 (Inside Cover)
Discovery and Engineering of an Ene-reductase for Kinetic Resolution and Cascade Reduction of Hajos–Parrish/Wieland–Miescher Ketones
Dongyan Li†, He Dong†, Xianwen Chen, Yangyang Li, Yiping Xu, Jing Wang, Jiali Fang, Chenming Huang, Wenhe Zhang, Xian Jia, Song You,* Bin Qin*
Advanced Synthesis & Catalysis 2023, 365 (17), 2912-2921. 10.1002/adsc.202300326 (Inside Cover)
Stereoselective synthesis of allopregnanolone catalyzed by ketoreductase
Yue Hou, Jiaxiang Lv, Yuzhen Guo, Jiali Fang, Chenming Huang, Wenhe Zhang, Xian Jia, Song You,* Bin Qin*
Molecular Catalysis 2023, 548, 113433. 10.1016/j.mcat.2023.113433
Development of an enzymatic process for the synthesis of (1S)-2-chloro-1-(3, 4-difluorophenyl) ethanol, the key intermediate of ticagrelor
Changli Che, Wenhe Zhang, Yuxi Men, Hengyu Li, Bin Qin*, Xian Jia*, Song You*
Molecular Catalysis 2023, 537, 112963. 10.1016/j.mcat.2023.112963
A Novel NADH-dependent Leucine Dehydrogenase for Multi-step Cascade Synthesis of L-phosphinothricin
Lu Zhao, Wenhe Zhang, Qi Wang, Huibin Wang, Xiao Gao, Bin Qin, Xian Jia*, Song You*
Enzyme and Microbial Technology 2023, 166, 110225. 10.1016/j.enzmictec.2023.110225
Bacteria-driven bio-therapy: From fundamental studies to clinical trials
Yuxuan Yu, Sicen Lin, Zhichao Chen, Bin Qin, Zhonggui He, Maosheng Cheng, Mengchi Sun*, Jin Sun*
Nano Today 2023, 48, 101731. 10.1016/j.nantod.2022.101731
2022
Ketoreductases catalyzed (dynamic) kinetic resolution for biomanufacturing of chiral chemicals
Chenming Huang†, Junling Liu†, Jiali Fang, Xian Jia, Zhendong Zheng*, Song You*, Bin Qin*
Frontiers in Bioengineering and Biotechnology 2022, 10, 929784. 10.3389/fbioe.2022.929784
Enzymes and Chemo-Enzymes Catalyzed Stereodivergent Synthesis
Jiaxiang Lv, Yaqi Ding, Chenming Huang, Lingling Guo, Jiali Fang, Xian Jia, Wenhe Zhang,* Song You*, Bin Qin*
Pharmaceutical Fronts 2022, 04, e121-e135. 10.1055/s-0042-1755556
Rationally Engineering the Cofactor Specificity of LfSDR1 for Biocatalytic Synthesis of the Key Intermediate of Telotristat Ethyl
Hengyu Li, Wenhe Zhang, Changli Che, Huibin Wang, Yutian Jia, Xiao Gao, Xian Jia*, Qin Bin*, Song You*
ChemCatChem 2022, 14 (11), e202201035. 10.1002/cctc.202201035
Efficient Synthesis of Apremilast Precursor and Chiral β-Hydroxy Sulfones via Ketoreductase-Catalyzed Asymmetric Reduction
Jiyang Guo, Xiao Gao, Dong Qian, Huibin Wang, Xian Jia, Wenhe Zhang*, Bin Qin*, Song You*
Organic & Biomolecular Chemistry 2022, 20, 2081-2085. 10.1039/D1OB02485J
Amorphous zirconium metal-organic frameworks assembled from mixed porphyrins as solvent-free catalysts for Knoevenagel condensation
Weiguo Zuo, Shunbin Yang, Yajie Xing, Xiwen Xiao, Duona Fan, Hengyu Li, Guanqun Wang, Bin Qin, Song You*, Xian Jia*
Dalton Transactions 2022, 51, 6631-6637. 10.1039/D2DT00142J
2021
Engineering of Saccharomyces pastorianus Old Yellow Enzyme 1 for the Synthesis of Pharmacologically Active (S)-Profen Derivatives
Guigao Liu, Shang Li, Qinghua Shi, Hengyu Li, Jiyang Guo, Jingping Ouyang, Xian Jia, Lihan Zhang*, Song You*, Bin Qin*
Molecular Catalysis 2021, 507, 111568. 10.1016/j.mcat.2021.111568
Development of an enzymatic process for the synthesis of the key intermediate of telotristat ethyl
Hengyu Li, Wenhe Zhang, Xianyan Jiang, Huibin Wang, Qi Wang, Jiajun Wang, Xian Jia, Bin Qin*, Song You*
Advanced Synthesis & Catalysis 2021, 363 (2), 540-548. 10.1002/adsc.202001110
Identification of Four Ene Reductases and Their Preliminary Exploration in the Asymmetric Synthesis of (R)-Dihydrocarvone and (R)-Profen Derivatives
Qinghua Shi, Yutian Jia, Huibin Wang, Shang Li, Hengyu Li, Jiyang Guo, Tong Dou, Bin Qin*, Song You*
Enzyme and Microbial Technology 2021, 150, 109880. 10.1016/j.enzmictec.2021.109880
Both-In-One Hybrid Bacteria Suppress the Tumor Metastasis and Relapse via Tandem-Amplifying Reactive Oxygen Species-Immunity Responses
Mengchi Sun, Hao Ye, Qinghua Shi, Jun Xie, Xiang Yu, Hao Ling, Song You, Zhonggui He, Bin Qin*, Jin Sun*
Advanced Healthcare Materials 2021, 2100950. 10.1002/adhm.202100950
2020
Old yellow enzymes: structures and structure-guided engineering for stereocomplementary bioreduction
Qinghua Shi, Huibin Wang, Junling Liu, Shang Li, Jiyang Guo, Hengyu Li, Xian Jia, Hua Huo, Zhendong Zheng, Song You*, Bin Qin*
Applied Microbiology and Biotechnology 2020, 104 (19), 8155-8170. 10.1007/s00253-020-10845-z
Engineering of Saccharomyces pastorianus Old Yellow Enzyme 1 for the Synthesis of Pharmacologically Active (S)-Profen Derivatives
Guigao Liu, Shang Li, Qinghua Shi, Hengyu Li, Jiyang Guo, Jingping Ouyang, Xian Jia, Lihan Zhang, Song You*, Bin Qin*
ChemRxiv 2020. 10.26434/chemrxiv.12894056.v1
2019
Key sites insight on the stereoselectivity of four mined aldo-keto reductases toward α-keto esters and halogen-substituted acetophenones
Wenhe Zhang, Tianhui Zhu, Hengyu Li, Fengyu Qin, Feiting Zhang, Rui Zhang, Xian Jia, Bin Qin*, Song You*
Applied Microbiology and Biotechnology 2019, 103 (15), 6119-6128. 10.1007/s00253-019-09932-7
2018
Discovery of a switch between Prelog and Anti-Prelog reduction toward halogen-substituted acetophenones in short-chain dehydrogenase/reductases
Fengyu Qin†, Bin Qin*,†, Wenhe Zhang, Yalin Liu, Xin Su, Tianhui Zhu, Jingping Ouyang, Jiyang Guo, Yuxin Li, Feiting Zhang, Jun Tang, Xian Jia*, Song You*
ACS Catalysis 2018, 8 (7), 6012-6020. 10.1021/acscatal.8b00807
Stereodivergent synthesis of carveol and dihydrocarveol through ketoreductases/ene‐reductases catalysed asymmetric reduction
Jiyang Guo†, Rui Zhang†, Jingping Ouyang, Feiting Zhang, Fengyu Qin, Guigao Liu, Wenhe Zhang, Hengyu Li, Xiaohong Ji, Xian Jia, Bin Qin*, Song You*
ChemCatChem 2018, 10 (23), 5496-5504. 10.1002/cctc.201801391
Selective oxidations of cyperenoic acid by slightly reshaping the binding pocket of cytochrome P450 BM3
Yuxin Li†, Bin Qin†, Xiaoqin Li, Jun Tang, Yu Chen, Lina Zhou*, Song You*
ChemCatChem 2018, 10 (3), 559-565. 10.1002/cctc.201701088
2017
Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides.
Lihan Zhang†, Takuya Hashimoto†, Bin Qin, Junko Hashimoto, Ikuko Kozone, Teppei Kawahara, Masahiro Okada, Takayoshi Awakawa, Takuya Ito, Yoshinori Asakawa, Masashi Ueki, Shunji Takahashi, Hiroyuki Osada, Toshiyuki Wakimoto, Haruo Ikeda*, Kazuo Shin-ya*, Ikuro Abe*
Angewandte Chemie International Edition 2017, 56 (7), 1740-1745. 10.1002/anie.201611371
Enantioselective bioreduction of benzo-fused cyclic ketones with engineered Candida glabrata ketoreductase 1–a promising synthetic route to ladostigil (TV3326)
Jingping Ou-yang, Wenhe Zhang, Fengyu Qin, Weiguo Zuo, Shaoyu Xu, Yan Wang, Bin Qin, Song You*, Xian Jia*
Organic & Biomolecular Chemistry 2017, 15(35), 7374-7379. 10.1039/c7ob01803g
2016
An unusual chimeric diterpene synthase from Emericella variecolor and its functional conversion to a sesterterpene synthase by domain swapping
Bin Qin†, Yudai Matsuda†, Takahiro Mori, Masahiro Okada, Zhiyang Quan, Takaaki Mitsuhashi, Toshiyuki Wakimoto, Ikuro Abe*
Angewandte Chemie International Edition 2016, 55 (5), 1658-1661. 10.1002/anie.201509263
Engineering of Candida glabrata ketoreductase 1 for asymmetric reduction of α-halo ketones
Fengyu Qin†, Bin Qin†, Takahiro Mori, Yan Wang, Lingxin Meng, Xin Zhang, Xian Jia, Ikuro Abe, Song You*
ACS Catalysis 2016, 6 (9), 6135-6140. 10.1021/acscatal.6b01552
Genome-based discovery of an unprecedented cyclization mode in fungal sesterterpenoids biosynthesis
Masahiro Okada†, Yudai Matsuda†, Takaaki Mitsuhashi, Shotaro Hoshino, Takahiro Mori, Kazuya Nakagawa, Zhiyang Quan, Bin Qin, Huiping Zhang, Fumiaki Hayashi, Hiroshi Kawaide, Ikuro Abe*
Journal of the American Chemical Society 2016, 138 (31), 10011-10018. 10.1021/jacs.6b05799
2013-2015
“Mirror-Image” manipulation of curdione stereoisomer scaffolds by chemical and biological approaches: development of a sesquiterpenoid library
Bin Qin, Yuxin Li, Lingxin Meng, Jingping Ouyang, Danni Jin, Lei Wu, Xin Zhang, Xian Jia, Song You*
Journal of Natural Products 2015, 78 (2), 272-278. 10.1021/np500864e
Prelog and anti-Prelog stereoselectivity of two ketoreductases from Candida glabrata
Ping Liang†, Bin Qin†, Mao Mu, Xin Zhang, Xian Jia, Song You*
Biotechnology Letters 2013, 35 (9), 1469-1473. 10.1007/s10529-013-1228-0
Directed evolution of Candida antarctica lipase B for kinetic resolution of profen esters
Bin Qin, Ping Liang, Xian Jia, Xin Zhang, Mao Mu, Xiaoying Wang, Guozhen Ma, Danni Jin, Song You*
Catalysis Communications 2013, 38, 1-5. 10.1016/j.catcom.2013.03.040
