2024
70. Jiahui Jiang, Yunhe Liu, Jiangjiang Qin, Jianfeng Chen, Jingjing Wu, Melissa P. Pizzi, Rossana Lazcano, Kohei Yamashita, Zhiyuan Xu, Guangsheng Pei, Kyung Serk Cho, Yanshuo Chu, Ansam Sinjab, Fuduan Peng, Xinmiao Yan, Guangchun Han, Ruiping Wang, Enyu Dai, Yibo Dai, Bogdan A. Czerniak, Andrew Futreal, Anirban Maitra, Alexander Lazar, Humam Kadara, Amir A. Jazaeri, Xiangdong Cheng, Jaffer Ajani, Jianjun Gao, Jian Hu*, Linghua Wang*. METI: Deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics. Nature Communications 2024; 15: 7312. https://doi.org/10.1038/s41467-024-51708-9
69. Xiangdong Cheng#, Enyu Dai#, Jibo Wu#, Natasha M Flores, Yanshuo Chu, Ruiping Wang, Minghao Dang, Zhiyuan Xu, Guangchun Han, Yunhe Liu, Deyali Chatterjee, Can Hu, Jieer Ying, Yian Du, Litao Yang, Xiaoqing Guan, Shaowei Mo, Xuanye Cao, Guangsheng Pei, Jiahui Jiang, Xiaoyin Lu, Ana Morales Benitez, Rebecca E Waters, Melissa Pool Pizzi, Namita Shanbhag, Yibo Fan, Fuduan Peng, Samir M Hanash, George Calin, Andrew Futreal, Shumei Song, Cassian Yee, Pawel K Mazur*, Jiang-Jiang Qin*, Jaffer A Ajani*, Linghua Wang*. Atlas of metastatic gastric cancer links ferroptosis to disease progression and immunotherapy response. Gastroenterology. 2024 Aug 1:S0016-5085(24)05297-1. doi: 10.1053/j.gastro.2024.07.038. Online ahead of print.
68. Yulong Li, Jinyun Dong*, Jiang-Jiang Qin*. Small molecule inhibitors targeting heat shock protein 90: An updated review. Eur J Med Chem 2024; 275:116562. doi: 10.1016/j.ejmech.2024.116562.
67. Zhijie Xu#, Haiyan Zhou#, Tongfei Li#, Qiaoli Yi, Abhimanyu Thakur, Kui Zhang, Xuelei Ma*, Jiang-Jiang Qin*, Yuanliang Yan*. Application of biomimetic nanovaccines in cancer immunotherapy: A useful strategy to help combat immunotherapy resistance. Drug Resist Updat 2024, 75: 101098. doi: 10.1016/j.drup.2024.101098.
66. Furong Ma#, Yulong Li#, Maohua Cai, Wenyan Yang, Zumei Wu, Jinyun Dong*, Jiang-Jiang Qin*. ML162 derivatives incorporating a naphthoquinone unit as ferroptosis/apoptosis inducers: Design, synthesis, anti-cancer activity, and drug-resistance reversal evaluation. European Journal of Medicinal Chemistry Available online 6 April 2024, 116387. https://doi.org/10.1016/j.ejmech.2024.116387
65. Xiaoqing Guan#, Yichao Wang#, Wenkai Yu, Yong Wei, Yang Lu, Enyu Dai, Xiaowu Dong, Bing Zhao, Can Hu, Li Yuan, Xin Luan, Kai Miao, Bonan Chen, Xiang-Dong Cheng*, Weidong Zhangg*, Jiang-Jiang Qin*. Blocking Ubiquitin-Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl-CoA Desaturase. Advanced Science 2024; 11(18):e2307899. DOI: 10.1002/advs.202307899
64. Fei Cao, Yulong Li, Furong Ma, Zumei Wu, Zheshen Li, Zhe-Sheng Chen, Xiangdong Cheng*, Jiang-Jiang Qin*, Jinyun Dong*. Synthesis and evaluation of WK-X-34 derivatives as P-glycoprotein (P-gp/ABCB1) inhibitors for reversing multidrug resistance. RSC Med. Chem. 2024;15: 506-518. https://doi.org/10.1039/D3MD00612C
63. Xiaomei Huang#, Yichao Wang#, Guangyu Li, Zongze Shao, Jinmei Xia*, Jiang-Jiang Qin*, Weiyi Wang*. Secondary Metabolites from the Deep-sea Derived Fungus Aspergillus terreus MCCC M28183. Frontiers in Microbiology 2024; 15: 1361550. doi: 10.3389/fmicb.2024.1361550
62. Xinchen Lu#, Jinmei Jin#, Ye Wu#, Xiaoxia Liu, Xiaohui Liang, Jiayi Lin, Qingyan Sun, Jiangjiang Qin*, Weidong Zhang*, Xin Luan*. Progress in RAS-targeted therapeutic strategies: From small molecule inhibitors to proteolysis targeting chimeras. Med Res Rev 2024; 44(2):812-832. doi: 10.1002/med.21993.
61. Xi Chen, Zhijie Xu, Tongfei Li, Abhimanyu Thakur, Yu Wen, Kui Zhang, Yuanhong Liu, Qiuju Liang, Wangrui Liu*, Jiang-Jiang Qin*, Yuanliang Yan*. Nanomaterial-encapsulated STING agonists for immune modulation in cancer therapy. Biomark Res 2024; 12(1):2. doi: 10.1186/s40364-023-00551-z.
60. Che Zhang#, Guangzhao Pan#, Jiang-Jiang Qin*. Role of F-box proteins in human upper gastrointestinal tumors. Biochim Biophys Acta Rev Cancer 2024; 1879(1):189035. doi: 10.1016/j.bbcan.2023.189035.
59. Huize Shen#, Rui Zhu#, Yanyang Liu, Yangjian Hong, Jiaming Ge, Jie Xuan, Wenyuan Niu, Xuefei Yu*, Jiang-Jiang Qin*, Qinglin Li*. Radioiodine-refractory differentiated thyroid cancer: Molecular mechanisms and therapeutic strategies for radioiodine resistance. Drug Resist Updat 2024; 72:101013. doi: 10.1016/j.drup.2023.101013.
58. Jiahan Le, Guangzhao Pan, Che Zhang, Yitao Chen*, Amit K Tiwari*, Jiang-Jiang Qin*. Targeting ferroptosis in gastric cancer: Strategies and opportunities. Immunol Rev 2024; 321(1):228-245. doi: 10.1111/imr.13280.
57. Wenyan Yang#, Shiqun Wang#, Shengqiang Tong, Wei-Dong Zhang*, Jiang-Jiang Qin*. Expanding the ubiquitin code in pancreatic cancer. Biochim Biophys Acta Mol Basis Dis. 2024; 1870(1):166884. doi: 10.1016/j.bbadis.2023.166884.
2023
56. Chun-Xiao Zhu, Jiang-Jiang Qin*. Single-cell RNA Sequencing and Spatial Transcriptomic Technologies and Applications in Exploring Gastric Cancer: A Review. Oncology Advances 2023; 1(1):6-16. doi: 10.14218/OnA.2023.00039
55. Fei Cao, Chu Chu, Jiang-Jiang Qin*, Xiaoqing Guan*. Research progress on antitumor mechanisms and molecular targets of Inula sesquiterpene lactones. Chin Med. 2023; 18(1):164. doi: 10.1186/s13020-023-00870-1.
54. Jiaqing Zhang#, Can Hu#, Ruolan Zhang#, Jingli Xu, Yanqiang Zhang, Li Yuan, Shengjie Zhang, Siwei Pan, Mengxuan Cao, Jiangjiang Qin*, Xiangdong Cheng*, Zhiyuan Xu*. The role of macrophages in gastric cancer. Front Immunol 2023;14:1282176. doi: 10.3389/fimmu.2023.1282176.
53. Zhiyuan Xu#, Yida Huang#, Can Hu#, Lingbin Du, Yi-An Du, Yanqiang Zhang, Jiangjiang Qin, Wanshan Liu, Ruimin Wang, Shouzhi Yang, Jiao Wu, Jing Cao, Juxiang Zhang, Gui-Ping Chen, Hang Lv, Ping Zhao, Weiyang He, Xiaoliang Wang, Min Xu, Pingfang Wang, Chuanshen Hong, Li-Tao Yang, Jingli Xu, Jiahui Chen, Qing Wei, Ruolan Zhang, Li Yuan*, Kun Qian*, Xiangdong Cheng*. Efficient plasma metabolic fingerprinting as a novel tool for diagnosis and prognosis of gastric cancer: a large-scale, multicentre study. Gut 2023; 72(11):2051-2067. doi: 10.1136/gutjnl-2023-330045.
52. Ruiping Wang#, Shumei Song#, Jiangjiang Qin#, Katsuhiro Yoshimura, Fuduan Peng, Yanshuo Chu, Yuan Li, Yibo Fan, Jiankang Jin, Minghao Dang, Enyu Dai, Guangsheng Pei, Guangchun Han, Dapeng Hao, Yating Li, Deyali Chatterjee, Kazuto Harada, Melissa Pool Pizzi, Ailing W Scott, Ghia Tatlonghari, Xinmiao Yan, Zhiyuan Xu, Can Hu, Shaowei Mo, Namita Shanbhag, Yang Lu, Matheus Sewastjanow-Silva, Ahmed Adel Fouad Abdelhakeem, Guang Peng, Samir M Hanash, George A Calin, Cassian Yee, Pawel Mazur, Autumn N Marsden, Andrew Futreal, Zhenning Wang, Xiangdong Cheng, Jaffer A Ajani*, Linghua Wang*. Evolution of immune and stromal cell states and ecotypes during gastric adenocarcinoma progression. Cancer Cell. 2023; 41(8):1407-1426.e9. doi: 10.1016/j.ccell.2023.06.005.
51. Jinyun Dong*, Li Yuan, Can Hu, Xiangdong Cheng*, Jiang-Jiang Qin*. Strategies to overcome cancer multidrug resistance (MDR) through targeting P-glycoprotein (ABCB1): An updated review Pharmacol Ther. 2023 Jul 11; 249:108488. doi: 10.1016/j.pharmthera.2023.108488.
50. Maohua Cai#, Furong Ma#, Can Hu, Haobin Li, Fei Cao, Yulong Li, Jinyun Dong*, Jiang-Jiang Qin*. Design and synthesis of proteolysis-targeting chimeras (PROTACs) as degraders of glutathione peroxidase 4. Bioorg Med Chem 2023 Jul 15;90:117352. doi: 10.1016/j.bmc.2023.117352.
49. Yanshuo Chu, Enyu Dai, Yating Li, Guangchun Han, Guangsheng Pei, Davis R Ingram, Krupa Thakkar, Jiang-Jiang Qin, Minghao Dang, Xiuning Le, Can Hu, Qing Deng, Ansam Sinjab, Pravesh Gupta, Ruiping Wang, Dapeng Hao, Fuduan Peng, Xinmiao Yan, Yunhe Liu, Shumei Song, Shaojun Zhang, John V Heymach, Alexandre Reuben, Yasir Y Elamin, Melissa P Pizzi, Yang Lu, Rossana Lazcano, Jian Hu, Mingyao Li, Michael Curran, Andrew Futreal, Anirban Maitra, Amir A Jazaeri, Jaffer A Ajani, Charles Swanton, Xiang-Dong Cheng, Hussein A Abbas, Maura Gillison, Krishna Bhat, Alexander J Lazar, Michael Green, Kevin Litchfield, Humam Kadara, Cassian Yee, Linghua Wang*. Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance. Nature Medicine 2023 Jun;29(6):1550-1562. doi: 10.1038/s41591-023-02371-y.
48. Handong Xu #, Can Hu #, Yi Wang, Yunfu Shi, Li Yuan, Jingli Xu, Yanqiang Zhang, Jiahui Chen, Qin Wei, Jiangjiang Qin*, Zhiyuan Xu*, Xiangdong Cheng*. Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism. Oncogene Jun;42(24):1994-2006. doi: 10.1038/s41388-023-02708-4.
47. Qianqian Xu#, Guangzhao Pan#*, Zhonglan Wang#, Lingling Wang, Yancheng Tang, Jinyun Dong, Jiang-Jiang Qin*.Platycodin D inhibits the proliferation of gastric cancer cells through promoting ubiquitination of c-Myc. Frontiers in Pharmacology 2023; 14:1138658. doi: 10.3389/fphar.2023.1138658
46. Xiaoqing Guan#, Jing Yang#, Weiyi Wang#*, Bing Zhao, Shiyu Hu, Dehua Yu, Li Yuan, Yunfu Shi, Jingli Xu, Jinyun Dong, Jinxin Wang, Xiang-Dong Cheng*, Jiang-Jiang Qin*. Dual inhibition of MYC and SLC39A10 by a novel natural product STAT3 inhibitor derived from Chaetomium globosum suppresses tumor growth and metastasis in gastric cancer. Pharmacological Research 2023; 189:106703 https://doi.org/10.1016/j.phrs.2023.106703
45. Shengli Li#, Li Yuan#, Zhi-Yuan Xu, Jing-Li Xu, Gui-Ping Chen, Xiaoqing Guan, Guang-Zhao Pan, Can Hu, Jinyun Dong, Yi-An Du, Li-Tao Yang, Mao-Wei Ni, Rui-Bin Jiang, Xiu Zhu, Hang Lv, Han-Dong Xu, Sheng-Jie Zhang, Jiang-Jiang Qin*, Xiang-Dong Cheng*. Integrative proteomic characterization of adenocarcinoma of esophagogastric junction. Nature Communications 2023; 14:778. https://doi.org/10.1038/s41467-023-36462-8
44. Li Yuan#, Lin Yang#, Shichuan Zhang#, Zhiyuan Xu#, Jiangjiang Qin#, Yunfu Shi, Pengcheng Yu, Yi Wang, Zhehan Bao, Yuhang Xia, Jiancheng Sun, Weiyang He, Tianhui Chen, Xiaolei Chen, Can Hu, Yunlong Zhang, Changwu Dong, Ping Zhao, Yanan Wang, Nan Jiang, Bin Lv, Yingwei Xue, Baoping Jiao, Hongyu Gao, Kequn Chai, Jun Li, Hao Wang, Xibo Wang, Xiaoqing Guan, Xu Liu, Gang Zhao, Zhichao Zheng, Jie Yan, Haiyue Yu, Luchuan Chen, Zaisheng Ye, Huaqiang You, Yu Bao, Xi Cheng, Peizheng Zhao, Liang Wang, Wenting Zeng, Yanfei Tian, Ming Chen, You You, Guihong Yuan, Hua Ruan, Xiaole Gao, Jingli Xu, Handong Xu, Lingbin Du, Shengjie Zhang, Huanying Fu, Xiangdong Cheng*. Development of a tongue image-based machine learning tool for the diagnosis of gastric cancer: a prospective multicentre clinical cohort study. EClinicalMedicine 2023; 57:101834. https://doi.org/10.1016/j.eclinm.2023.101834
43. Can Hu#, Dan Zu#, Jingli Xu#, Hangdong Xu#, Li Yuan, Jiahui Chen, Qin Wei, Yanqiang Zhang, Jing Han, Tao Lu, Jinyun Dong*, Jiang-Jiang Qin*, Zhiyuan Xu*, Xiangdong Cheng*. Polyphyllin B Suppresses Gastric Tumor Growth By Modulating Iron Metabolism And Inducing Ferroptosis. International Journal of Biological Sciences 2023;19(4):1063-1079. doi:10.7150/ijbs.80324.
42. Yancheng Tang, Liming Wang, Jiangjiang Qin, Ying-Ying Lu, Han-Ming Shen*, Hu-Biao Chen*. Targeting Mitophagy to Promote Apoptosis is Therapeutic Strategy for Cancer. Autophagy 2023;19(3):1031-1033. https://doi.org/10.1080/15548627.2022.2112830
2022
41. Xiaofan Wu, Hongjian Yang, Xingfei Yu*, Jiang-Jiang Qin*. Drug-resistant HER2-positive breast cancer: Molecular mechanisms and overcoming strategies. Front Pharmacol 2022; 13:1012552. doi: 10.3389/fphar.2022.1012552
40. Chunxiao Zhu#, Xiaoqing Guan#, Xinuo Zhang#, Xin Luan, Zhengbo Song, Xiang-Dong Cheng*, Weidong Zhang*, Jiang-Jiang Qin*. Targeting KRAS mutant cancers: From druggable therapy to drug resistance. Molecular Cancer 2022;21:159. https://doi.org/10.1186/s12943-022-01629-2
39. Haobin Li#, Maohua Cai#, Fei Cao#, Dehua Yu, JIng Yang, Wenkai Yu, Chu Chu, Xiaoqing Guan, Jiang-Jiang Qin*, Jinyun Dong*. S3I-201 derivative incorporating naphthoquinone unit as effective STAT3 inhibitors: design, synthesis and anti-gastric cancer evaluation. Bioorganic & Medicinal Chemistry 2022, 71:116941 https://doi.org/10.1016/j.bmc.2022.116941
38. Jing Yang#, Lingling Wang#, Xiaoqing Guan*, Jiang-Jiang Qin*. Inhibiting STAT3 signaling pathway by natural products for cancer prevention and therapy: In vitro and in vivo activity and mechanisms of action. Pharmacological Research 2022; 182: 106357. https://doi.org/10.1016/j.phrs.2022.106357
37. Jinyun Dong, Jing Yang, Wenkai Yu, Haobin Li, Maohua Cai, Jing-Li Xu, Han-Dong Xu, Yun-Fu Shi, Xiaoqing Guan*, Xiangdong Cheng*, Jiang-Jiang Qin*. Discovery of benzochalcone derivative as a potential antigastric cancer agent targeting signal transducer and activator of transcription 3 (STAT3). J Enzyme Inhib Med Chem 2022; 37(1):2002-2016. doi: 10.1080/14756366.2022.2100366
36. Haobin Li#, Lingling Wang#, Fei Cao, Dehua Yu, Jing Yang, Xuefei Yu, Jinyun Dong, Jiang-Jiang Qin*, Xiaoqing Guan*. Design, Synthesis, and Biological Characterization of a Potent STAT3 Degrader for the Treatment of Gastric Cancer. Front Pharmacol 2022; 13:944455. https://www.frontiersin.org/articles/10.3389/fphar.2022.944455/full
35. Weihui Zheng, Chun Liu, Jiaoyue Jin, Wei Sun, Jianqiang Zhao, Ming Zhao, Shili Yao, Bing Zhu, Fan Chen, Jinbiao Shang, Kejing Wang, Peng Guo*, Jiangjiang Qin*, Xiangdong Cheng*. Biodegradable iron oxide nanoparticles for intraoperative parathyroid gland imaging in thyroidectomy. PNAS Nexus, 2022; 1(3): pgac087. https://doi.org/10.1093/pnasnexus/pgac087
34. Dongli Lv#, Jinmei Xia#, Xiaoqing Guan#, Qiliang Lai#, Beibei Zhang, Jianhui Lin, Zongze Shao, Sulan Luo, Dongting Zhangsun*, Jiang-Jiang Qin*, Weiyi Wang*. Indole diketopiperazine alkaloids isolated from the marine-derived fungus Aspergillus chevalieri MCCC M23426. Frontiers in Microbiology 2022; 13:950857. DOI: 10.3389/fmicb.2022.950857
33. Jing-Li Xu#, Li Yuan#, Can Hu, Chun-Yan Weng, Han-Dong Xu, Yunfu Shi, Ling Huang, Jie-Er Ying, Zhi-Yuan Xu*, Jiang-Jiang Qin*, Xiangdong Cheng*. Trametes robiniophila Murr sensitizes gastric cancer cells to 5-fluorouracil by modulating tumor microenvironment. Front Pharmacol 2022; 13:911663. DOI: 10.3389/fphar.2022.911663
32. Li Yuan#, Jing-Li Xu#, Yunfu Shi, Zhiyuan Jin, Zhehan Bao, Pengcheng Yu, Yi Wang, Yuhang Xia, Jiang-Jiang Qin*, Bo Zhang*, Qinghua Yao*. CD3D is an independent prognostic factor and correlates with immune infiltration in gastric cancer. Front Oncol 2022; 11:913670. DOI: 10.3389/fonc.2022.913670
31. Xuefei Yu, Xuhang Zhu, Lizhuo Zhang, Jiang-Jiang Qin*, Chunlai Feng*, Qinglin Li*. In silico screening and validation of PDGFRA inhibitors enhancing radioiodine sensitivity in thyroid cancer. Front Pharmacol 2022; 13:883581. DOI: 10.3389/fphar.2022.883581
30. Xuan Hong#, Xiaoqing Guan#, Qiliang Lai#, Dehua Yu, Zhongwei Chen, Xiaoteng Fu, Beibei Zhang, Changkun Chen, Zongze Shao, Jinmei Xia*, Jiang-Jiang Qin*, Weiyi Wang*. Characterization of a Bioactive Meroterpenoid Isolated from the Marine-Derived Fungus Talaromyces sp. Appl Microbiol Biotechnol 2022; 106:2927-2935. https://doi.org/10.1007/s00253-022-11914-1
29. Fei Cao#, Can Hu#, Zhi-Yuan Xu, Yan-Qiang Zhang, Ling Huang, Jia-Hui Chen, Jiang-Jiang Qin*, Xiang-Dong Cheng*. Current treatments and outlook in adenocarcinoma of the esophagogastric junction: a narrative review. Ann Transl Med 2022; 10(6):377. doi: 10.21037/atm-22-1064
28. Dehua Yu#, Simin Qi#, Xiaoqing Guan#, Wenkai Yu, Xuefei Yu, Maohua Cai, Qinglin Li, Weiyi Wang*, Weidong Zhang*, Jiang-Jiang Qin*. Inhibition of STAT3 Signaling Pathway by Terphenyllin Suppresses Growth and Metastasis of Gastric Cancer. Front Pharmacol 2022; 13:870367. DOI: 10.3389/fphar.2022.870367
27. Simin Qi#, Xiaoqing Guan#, Jia Zhang#, Dehua Yu, Xuefei Yu, Qinglin Li, Wenjuan Yin, Xiang-Dong Cheng*, Weidong Zhang*, Jiang-Jiang Qin*. Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis. Molecular Cancer 2022; 21:70. https://doi.org/10.1186/s12943-022-01538-4
26. Maohua Cai#, Jinyun Dong#,*, Haobin Li, Jiang-Jiang Qin*. Recent developments in targeting bromodomain and extra terminal domain proteins for cancer therapeutics. Curr Med Chem 2022; 29(25):4391-4409 . DOI: 10.2174/0929867329666220211091806
25. Mengyi Shan, Chen Jiang, Jing Chen, Lu-Ping Qin*, Jiang-Jiang Qin*, Gang Cheng*. Predicting hERG Channel Blockers with Directed Message Passing Neural Networks. RSC Advances 2022; 12:3423-3430. DOI: 10.1039/D1RA07956E
2021
23. Jinyun Dong, Xiang-Dong Cheng, Wei-Dong Zhang, Jiang-Jiang Qin*. Recent Update on Development of Small-Molecule STAT3 Inhibitors for Cancer Therapy: From Phosphorylation Inhibition to Protein Degradation. J Med Chem 2021; 64(13): 8884-8915. DOI: 10.1021/acs.jmedchem.1c00629.
22. Libin Song#, Simin Qi#, Wei Hu#, Zhixiao Fang#, Dehua Yu, Teng Liu, Jingni Wu, Yangjun Wu, Aiwei Wu, Lanyun Feng, Jing Xie, Bo Zhang, Wenguang He, Zhouyu Ning, Luming Liu*, Jiang-Jiang Qin*, Shengli Li*. Integrative analysis reveals clinically relevant molecular fingerprints in pancreatic cancer. Mol Ther Nucleic Acids 2021; 26:11-21. Available online 2 July 2021. DOI: 10.1016/j.omtn.2021.06.015.
21. Li Yuan#, Shao-Wei Mo#, Zhi-Yuan Xu#, Hang Lv, Jing-Li Xu, Kai-Bo Guo, Can Hu, Xiao-Feng Wang, Gui-Ping Chen, Jiang-Jiang Qin*, Xiang-Dong Cheng*. p-MEK Expression Predicts Prognosis of Patients with Adenocarcinoma of Esophagogastric Junction (AEG) and Plays a Role in Anti-AEG Efficacy of Huaier. Pharmacol Res 2021; 165: 105411. DOI: 10.1016/j.phrs.2020.105411.
20. Saisai Tian#, Lu Fu#, Jinbo Zhang#, Jia Xu, Li Yuan, JiangJiang Qin*, Weidong Zhang*. Identification of a DNA methylation-driven genes-based prognostic model and drug targets in breast cancer: In silico screening of therapeutic compounds and in vitro characterization. Front Immunol 2021; 12:761326. DOI: 10.3389/fimmu.2021.761326.
19. Xiaoqing Guan, Zhi-Yuan Xu, Runzhe Chen, Jiang-Jiang Qin*, Xiang-Dong Cheng*. Identification of an Immune Gene-associated Prognostic Signature and Its Association with a Poor Prognosis in Gastric Cancer Patients. Front Oncol 2021; 10: 629909; DOI: 10.3389/fonc.2020.629909.
18. Si-Min Qi#, Jinyun Dong#, Zhi-Yuan Xu, Xiang-Dong Cheng*, Wei-Dong Zhang*, Jiang-Jiang Qin*. PROTAC: An effective targeted protein degradation strategy for cancer therapy. Front Pharmacol 2021; 12: 692574. DOI: 10.3389/fphar.2021.692574.
17. Beihua Xu, Li Yuan, Ying Hu, Zhiyuan Xu, Jiang-Jiang Qin*, Xiang-Dong Cheng*. Synthesis, Characterization, Cellular Uptake, and In Vitro Anticancer Activity of Fullerenol-Doxorubicin Conjugates. Front Pharmacol 2021; 11: 598155. DOI: 10.3389/fphar.2020.598155.
16. Dehua Yu, Zhiyuan Xu, XiangDong Cheng, Jiang-Jiang Qin*. The role of miRNAs in MDMX-p53 interplay. J Evid Based Med 2021; 14(2):152-160. DOI: 10.1111/jebm.12428.
15. Yancheng Tang, Liming Wang, Tao Yi, Jun Xu, Jigang Wang, Jiang-Jiang Qin, Qilei Chen, Ka-Man Yip, Yihang Pan, Peng Hong, Yingying Lu*, Han-Ming Shen*, Hu-Biao Chen*. Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy. Acta Pharm Sin B 2021; 11(12): 3966-3982. DOI: 10.1016/j.apsb.2021.06.007. 
2020
13. Li Yuan#, Zhi-Yuan Xu#, Shan-Ming Ruan, Shaowei Mo, Jiang-Jiang Qin*, Xiang-Dong Cheng*. Long non-coding RNAs towards precision medicine in gastric cancer: Early diagnosis, treatment, and drug resistance. Mol Cancer 2020; 19:96. DOI: 10.1186/s12943-020-01219-0.
12. Yuan Zhou, Runzhe Chen, Xiaofang Luo, Wei-Dong Zhang*, Jiang-Jiang Qin*. UbcH5c: An emerging target in cancer and immune disorders. Drug Discov Today 2020; 25(11):1988-1997. DOI: 10.1016/j.drudis.2020.09.015
11. Weiyi Wang#,*, Jing Yang#, Yan-Yan Liao, Gang Cheng, Jing Chen, Xiang-Dong Cheng*, Jiang-Jiang Qin*, Zongze Shao*. Cytotoxic nitrogenated azaphilones from the deep-sea derived fungus Chaetomium globosum MP4-S01-7. J Nat Prod 2020; 83(4):1157-1166. DOI: 10.1021/acs.jnatprod.9b01165.
10. Weiyi Wang#,*, Jing Yang#, Yan-Yan Liao, Gang Cheng, Jing Chen, Shaowei Mo, Li Yuan, Xiang-Dong Cheng*, Jiang-Jiang Qin*, Zongze Shao*. Aspeterreurone A, a cytotoxic benzodifuranone from a deep sea derived fungus Aspergillus terreus CC-S06-18. J Nat Prod 2020; 83(6):1998-2003. DOI: 10.1021/acs.jnatprod.0c00189.
9. Si-Min Qi, Gang Cheng, Xiang-Dong Cheng*, Zhiyuan Xu, Beihua Xu, Wei-Dong Zhang*, Jiang-Jiang Qin*. Targeting USP7-mediated deubiquitination of MDM2/MDMX-p53 pathway for cancer therapy: Are we there yet? Front Cell Dev Biol 2020; 8:233. DOI: 10.3389/fcell.2020.00233.
8. Jing-Li Xu, Li Yuan, Yan-Cheng Tang , Zhi-Yuan Xu, Han-Dong Xu, Xiang-Dong Cheng*, Jiang-Jiang Qin*. The Role of Autophagy in Gastric Cancer Chemoresistance: Friend or Foe? Front Cell Dev Biol 2020; 8:621428. DOI: 10.3389/fcell.2020.621428.
7. Jia Zhang#, Weiyi Wang#,*, Yuan Zhou#, Jing Yang#, Jingli Xu, Zhiyuan Xu, Beihua Xu, Li Yan, Xiang-Dong Cheng, Minghua Li*, Jiang-Jiang Qin*. Terphenyllin Suppresses Orthotopic Pancreatic Tumor Growth and Prevents Metastasis in Mice. Front Pharmacol 2020; 11:457. DOI: 10.3389/fphar.2020.00457.
6. Wen-Kai Yu, Zhi-Yuan Xu, Li Yuan , Shaowei Mo, Beihua Xu, Xiang-Dong Cheng, Jiang-Jiang Qin*. Targeting β-catenin signaling by natural products for cancer prevention and therapy. Front Pharmacol 2020; 11: 984. DOI: 10.3389/fphar.2020.00984.
5. De-Hua Yu, Zhi-Yuan Xu, Shaowei Mo, Li Yuan, Xiang-Dong Cheng*, Jiang-Jiang Qin*. Targeting MDMX for Cancer Therapy: Rationale, Strategies and Challenges. Front Oncol. 2020; 10: 1389. DOI: https://doi.org/10.3389/fonc.2020.01389
4. Yubin Li#, Runzhe Chen#, Jian Yang#, Shaowei Mo, Kelly Quek, Chung H Kok, Xiang-Dong Cheng, Saisai Tian*, Weidong Zhang*, Jiang-Jiang Qin*. Integrated bioinformatics analysis reveals key candidate genes and pathways associated with clinical outcome in hepatocellular carcinoma. Front Genet . 2020; 11: 814. DOI: https://doi.org/10.3389/fgene.2020.00814
2019
3. Jiang-Jiang Qin*, Xiang-Dong Cheng, Jia Zhang, Wei-Dong Zhang*. Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: A systematic review. Cell Commun Signal. 2019; 17(1):121. DOI: https://doi.org/10.1186/s12964-019-0435-2
2. Jiang-Jiang Qin#,*, Yan Li#, Jia Zhang, Wei-Dong Zhang*. STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review. J Exp Clin Cancer Res. 2019; 38(1):195. DOI: https://doi.org/10.1186/s13046-019-1206-z (ESI 1%高被引用论文)
1. Jiang-Jiang Qin*. Is CDK9 a Promising Target for Both Primary And Metastatic Osteosarcoma? EBioMedicine 2019; 40: 27-28. DOI: https://doi.org/10.1016/j.ebiom.2019.01.016
Editorial:
2. Jian-Ye Zhang*, Jiang-Jiang Qin, Dongmei Zhang, Dong-Hua Yang. Editorial: Biology and Pharmacological Effects of Extracellular Vesicles in Cancer. Front Mol Biosci 2022; 9:896561. doi: 10.3389/fmolb.2022.896561
1. Songtao Li*, Zhenyuan Song, Ping Yao, Jiangjiang Qin. Editorial: Alcohol Consumption and Liver Diseases: From Pathology to Phytotherapy. Front Pharmacol 2022; 13:848334. DOI: https://doi.org/10.3389/fphar.2022.848334
Selected Publications Before 2019
32. Wei Wang, Jiang-Jiang Qin, Mehrdad Rajaei, Xin Li, Xiaoyi Yu, Courtney Hunt, Ruiwen Zhang. Targeting MDM2 for novel molecular therapy: Beyond oncology. Med Res Rev. 2020; 40(3):856-880. DOI: https://doi.org/10.1002/med.21637
31. Wei Wang#,*, Jian-Wen Cheng#, Jiang-Jiang Qin#, Bo Hu, Xin Li, Bhavitavya Nijampatnam, Sadanandan E Velu, Jia Fan, Xin-Rong Yang*, Ruiwen Zhang*. MDM2-NFAT1 Dual Inhibitor, MA242: Effective against Hepatocellular Carcinoma, Independent of p53. Cancer Lett. 2019; 459: 156-167.DOI: https://doi.org/10.1016/j.canlet.2019.114429
30. Wei Wang#,*, Bo Hu#, Jiang-Jiang Qin#, Jian-Wen Cheng, Xin Li, Mehrdad Rajaei, Jia Fan, Xin-Rong Yang*, Ruiwen Zhang*. A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance. Genes Dis 2019; 6(4): 419-430. Erratum in: Genes Dis. 2019 Dec 28;7(1):160-161. DOI: 10.3389/fphar.2018.00005
29. Jiang-Jiang Qin#, Wei Wang#,*, Xin Li, Hemantkumar Deokar, John K Buolamwini, Ruiwen Zhang*. Inhibiting β-catenin by β-carboline-type MDM2 inhibitor for pancreatic cancer therapy. Front Pharmacol 2018; 9: 5. DOI: 10.3389/fphar.2018.00005
28. Wei Wang#,*, Jiang-Jiang Qin#, Sukesh Voruganti, Bhavitavya Nijampatnam, Sadanandan E Velu, Ke-He Ruan, Ming Hu, Jianwei Zhou, Ruiwen Zhang*. Discovery and characterization of dual inhibitors of MDM2 and NFAT1 for pancreatic cancer therapy. Cancer Res 2018; 78(19): 5656-5667. DOI: 10.1158/0008-5472.CAN-17-3939
27. Jiang-Jiang Qin, Xin Li, Courtney Hunt, Wei Wang, Hui Wang, Ruiwen Zhang*. Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine. Genes Dis 2018; 5(3): 204-219. DOI: 10.1016/j.gendis.2018.07.002
26. Jiang-Jiang Qin, Xin Li, Wei Wang, Xiaolin Zi, Ruiwen Zhang*. Targeting the NFAT1-MDM2-MDMX network inhibits the proliferation and invasion of prostate cancer cells, independent of p53 and androgen. Front Pharmacol 2017; 8: 917.DOI: 10.3389/fphar.2017.00917
25. Jiangjiang Qin, Wei Wang, Ruiwen Zhang*. Novel natural product therapeutics targeting both inflammation and cancer. Chin J Nat Med (中国天然药物) 2017; 15(6): 401-416. DOI: 10.1016/S1875-5364(17)30062-6
24. Jiangjiang Qin, Wei Wang, Ruiwen Zhang*. Experimental therapy of advanced breast cancer: Targeting NFAT1-MDM2-p53 pathway. Prog Mol Biol Transl Sci 2017; 151: 195-216. DOI: 10.1016/bs.pmbts.2017.07.005
23. Jiangjiang Qin, Wei Wang, Sushanta Sarkar, Ruiwen Zhang*. Oral delivery of anti-MDM2 inhibitor SP141-loaded FcRn-targeted nanoparticles to treat breast cancer and metastasis. J Control Release 2016; 237: 101-114. DOI: 10.1016/j.jconrel.2016.07.008
22. Jiang-Jiang Qin, Sushanta Sarkar, Sukesh Voruganti, Rajesh Agarwal, Wei Wang, Ruiwen Zhang*. Identification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapy. J Biomed Res 2016; 30(4): 322-333. DOI: 10.7555/JBR.30.20160018
21. Sukesh Voruganti#, Fangxiu Xu#, Jiang-Jiang Qin#, Yan Guo, Sushanta Sarkar, Ming Gao, Zhijie Zheng, Ming-Hai Wang, Jianwei Zhou, Biyun Qian*, Ruiwen Zhang*, Wei Wang*. RYBP predicts survival of patients with non-small cell lung cancer and regulates tumor cell growth and the response to chemotherapy. Cancer Lett. 2015; 369(2):386-395. DOI: 10.1016/j.canlet.2015.09.003
20. Subhasree Nag#, Jiang-Jiang Qin#, Sukesh Voruganti, Ming-Hai Wang, Horrick Sharma, Shivaputra Patil, John K Buolamwini, Wei Wang*, Ruiwen Zhang*. Development and validation of a rapid HPLC method for quantitation of SP-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice. Biomed Chromatogr 2015; 29: 654-663. DOI: 10.1002/bmc.3327
19. Wei Wang, Jiang-Jiang Qin, Sukesh Voruganti, Kalkunte S Srivenugopal, Subhasree Nag, Shivaputra Patil, Horrick Sharma, Ming-Hai Wang, Hui Wang, John K Buolamwini*, Ruiwen Zhang*. The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat Commun 2014; 5: 5086. DOI: 10.1038/ncomms6086
18. Wei Wang, Jiang-Jiang Qin, Sukesh Voruganti, Ming-Hai Wang, Horrick Sharma, Shivaputra Patil, Jianwei Zhou, Hui Wang, Debabrata Mukhopadhyay, John K Buolamwini*, Ruiwen Zhang*. Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice. Gastroenterology 2014; 147(4): 893-902.e2. DOI: 10.1053/j.gastro.2014.07.001
17. Jiang-Jiang Qin#, Subhasree Nag#, Wei Wang, Jianwei Zhou, Wei-Dong Zhang, Hui Wang, Ruiwen Zhang*. NFAT as cancer target: Mission possible? BBA-Rev Cancer 2014; 1846: 297-311. DOI: 10.1016/j.bbcan.2014.07.009
16. Subhasree Nag#, Jiang-Jiang Qin#, Shivaputra Patil, Hemantkumar Deokar, John K Buolamwini, Wei Wang*, Ruiwen Zhang*. A quantitative LC-MS/MS method for determination of SP-141, a novel pyrido[b]indole anticancer agent, and its application to a mouse PK study. J Chromatogr B 2014; 969: 235-240. DOI: 10.1016/j.jchromb.2014.08.030
15. Jiang-Jiang Qin#, Hui-Zi Jin#, Ying Huang, Shou-De Zhang, Lei Shan, Sukesh Voruganti, Subhasree Nag, Wei Wang, Wei-Dong Zhang*, Ruiwen Zhang*. Selective cytotoxicity, inhibition of cell cycle progression, and induction of apoptosis in human breast cancer cells by sesquiterpenoids from Inula lineariifolia Turcz. Eur J Med Chem 2013; 68: 473-481. DOI: 10.1016/j.ejmech.2013.07.018
14. Ji Ye#, Jiang-Jiang Qin#, Juan Su*, Shan Lin, Ying Huang, Hui-Zi Jin,Wei-Dong Zhang*. Identification and structural characterization of dimeric sesquiterpene lactones in Inula japonica Thunb. by high‐performance liquid chromatography/electrospray ionization with multi‐stage mass spectrometry. Rapid Commun Mass Spectrom 2013; 27(19): 2159-2169. DOI: 10.1002/rcm.6677
13. Jiang-Jiang Qin, S Nag, S Voruganti, W Wang, R Zhang*. Natural product MDM2 inhibitors: anticancer activity and mechanisms of action. Curr Med Chem 2012; 19: 5705-5725. DOI: 10.2174/092986712803988910
12. Jiang-Jiang Qin, Ying Huang, Dan Wang, Xiang-Rong Cheng, Qi Zeng, Shou-De Zhang, Zhen-Lin Hu, Hui-Zi Jin* and Wei-Dong Zhang*. Lineariifolianoids A-D, rare unsymmetrical sesquiterpenoid dimers comprised of xanthane and guaiane framework units from Inula lineariifolia. RSC Adv2012; 2: 1307-1309. https://pubs.rsc.org/en/content/articlelanding/2012/ra/c2ra01014c
11. Jiang-Jiang Qin, Jia-Xian Zhu, Qi Zeng, Xiang-Rong Cheng, Shou-De Zhang, Hui-Zi Jin*, Wei-Dong Zhang*. Sesquiterpene lactones from Inula hupehensis inhibit nitric oxide production in RAW264.7 macrophages. Planta Med 2012; 78: 1002-1009. DOI: 10.1055/s-0031-1298621
10. Jiang-Jiang Qin#, Li Yan Wang#, Jia Xian Zhu, Hui Zi Jin*, Jian Jun Fu, Xiao Feng Liu, Hong Lin Li, Wei Dong Zhang*. Neojaponicone A, a bioactive sesquiterpene lactone dimer with an unprecedented carbon skeleton from Inula japonica. Chem Commun 2011; 47: 1222-1224. DOI: 10.1039/c0cc03572f
9. Jiang-Jiang Qin, Jia-Xian Zhu, Qi Zeng, Xiang-Rong Cheng, Yan Zhu, Shou-De Zhang, Lei Shan, Hui-Zi Jin*, Wei-Dong Zhang*. Pseudoguaianolides and guaianoildes from Inula hupehensis as potential anti-inflammatory agents. J Nat Prod 2011; 74: 1881-1887. DOI: 10.1021/np200319x
8. Jiang-Jiang Qin, Jia-xian Zhu, Yan Zhu, Lan Yan, Hui-zi Jin*, Wei-dong Zhang*. Chemical constituents from the aerial parts of Inula japonica Thunb (旋覆花的化学成分研究). Nat Prod Res Dev (天然产物研究与开发) 2011; 23(6): 999-1001. DOI: 10.3724/SP.J.1009.2011.00115
7. Jiang-Jiang Qin, Hui-Zi Jin*, Jia-Xian Zhu, Jian-Jun Fu, Qi Zeng, Xiang-Rong Cheng, Yan Zhu, Lei Shan, Shou-De Zhang, Yue-Xing Pan, Wei-Dong Zhang*. New sesquiterpenes from Inula japonica Thunb. with their inhibitory activities against LPS-induced NO production in RAW264.7 macrophages. Tetrahedron 2010; 66 (48): 9379-9388. DOI: 10.1016/j.tet.2010.09.091
6. Jiang Jiang Qin, Hui Zi Jin*, Jia Xian Zhu, Jian Jun Fu, Xiao Jia Hu, Xiao Hua Liu, Yan Zhu, Shi Kai Yan, Wei Dong Zhang*. Japonicones E-L, dimeric sesquiterpene lactones from Inula japonica Thunb. Planta Med 2010; 76(3): 278-283. DOI: 10.1055/s-0029-1186065
5. Jiang-Jiang Qin, Jia-Xian Zhu, Yan Zhu, Hui-Zi Jin*, Yonghai Lu, Wei-Dong Zhang*. Flavonoids from the aerial parts of Inula japonica (旋覆花地上部分中的黄酮类化合物). Chin J Nat Med (中国天然药物) 2010; 8(4): 257-259. DOI: 10.3724/SP.J.1009.2010.00257
4. Jiang Jiang Qin, Hui Zi Jin, Jian Jun Fu, Xiao Jia Hu, Yan Wang, Shi Kai Yan*, Wei Dong Zhang*. Japonicones A-D, bioactive dimeric sesquiterpenes from Inula japonica Thunb. Bioorg Med Chem Lett 2009; 19(3): 710-713. Erratum in: Bioorg Med Chem Lett. 2010 Sep 15;20(18):5584. DOI: 10.1016/j.bmcl.2008.12.043
3. Jiang Jiang Qin, Jia Xian Zhu, Wei Dong Zhang*, Yan Zhu, Jian Jun Fu, Xiao Hua Liu, Hui Zi Jin*. A new ent-kaurane type diterpenoid glycoside from Inula japonica Thunb. Arch Pharm Res 2009; 32(10): 1369-1372. DOI: 10.1007/s12272-009-2004-5
2. Jiang Jiang Qin, Hui Zi Jin*, Jian Jun Fu, Xiao Jia Hu, Yan Zhu, Yun Heng Shen, Shi Kai Yan, Wei Dong Zhang. Anthranilic acid derivatives from Inula japonica. Chin Chem Lett 2008; 19: 556-558. DOI: https://doi.org/10.1016/j.cclet.2008.03.026
1. Jiang Jiang Qin, Hui Zi Jin, Jian Jun Fu, Xiao Jia Hu, Yun heng Shen, Shi Kai Yan, Wei Dong Zhang*. Advances in studies on the pharmacological activities of Inula genus plants (旋覆花属植物药理作用研究进展). Nat Prod Res Dev (天然产物研究与开发) 2008; 20: 442-445. (Article in Chinese)