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成果及论文

  1. Chune Peng , Qingbin Wang , Runmiao Jiao , Yingying Xu , Naihan Han, Wenshuang Wang, Changxiang Zhu, Fuchuan Li * A novel chondroitin sulfate E from Dosidicus gigas cartilage and its antitumor metastatic activity Carbohydr Polym. 2021;262:117971

  2.  Qingdong Zhang, Hai-Yan Cao, Lin Wei, Danrong Lu, Min Du, Min Yuan, Deling Shi, Xiangxue Chen, Peng Wang, Xiu-Lan Chen, Lianli Chi, Yu-zhong Zhang*, and Fuchuan Li*. Discovery of exolytic heparinases and their catalytic mechanism and potential application. Nat. Commun. 2021, 12.1263

  3. Wenshuang Wang, Cédric Przybylski, Xiaojuan Cai, Chrystel Lopin-Bon, Runmiao Jiao, Liran Shi, Kazuyuki Sugahara, José L. Neira, Régis Daniel*, and Fuchuan Li*. Investigation of Action Pattern of a Novel Chondroitin Sulfate/Dermatan Sulfate 4-O-Endosulfatase. Biochem. J. 2021.478(2):281-298.

  4. Wenshuang Wang, Liran Shi, Yong Qin and Fuchuan Li*. Research and application of chondroitin sulfate/dermatan sulfate-degrading enzymes. Front. Cell Dev. Biol. 2020,10.3389/fcell.2020.560442.

  5. Wenshuang Wang, Nanhan Han, Yingying Xu, Yunxue Zhao, Liran Shi, Jorge Filmus, and Fuchuan Li*. Assembling Custom Side Chains on Proteoglycans to Interrogate Their Function in Living Cells. Nat. Commun. 2020, 11:5915. 

  6. Qingdong Zhang, Danrong Lu, Shumin Wang, Lin Wei, Wenshuang Wang, and Fuchuan Li*.Identification and biochemical characterization of a novel chondroitin sulfate/dermantan sulfate lyase from Photobacterium sp. Int. J. Biol. Macromol. 2020, 165: 2314-2325. 6

  7. Danrong   Lu, Qingdong   Zhang, Shumin   Wang , Jingwen   Guan , Runmiao    Jiao , Naihan Han, Wenjun Han, and Fuchuan Li*. Biochemical characteristics and synergistic effect of two novel alginate lyases from Photobacterium sp. FC615. Biotechnol. Biofuels. 2019, 12:260. 6

  8. Shumin Wang, Tiantian Su, Qingdong Zhang, Jingwen Guan, Jing He, Lichuan Gu, and Fuchuan Li*. Comparative Study of Two Chondroitin Sulfate/Dermatan Sulfate 4-O-Sulfatases With High Identity. Front. Microbiol. 2019, 10:1309.

  9. Shumin Wang, Jingwen Guan, Qingdong Zhang, Xiangxue Chen, and Fuchuan Li*. Identification and Signature Sequences of Bacterial Δ4,5Hexuronate-2-O-Sulfatases. Front. Microbiol. 2019, 10: 704. 

  10. Chune Peng, Qingbin Wang, Shumin Wang, Wenshuang Wang, Runmiao Jiao, Wenjun Han, and Fuchuan Li*. A chondroitin sulfate and hyaluronic acid lyase with poor activity to glucuronyl 4,6- O-disulfated N-acetylgalactosamine (E-type)-containing structures. J. Biol. Chem. 2018, 293(12):4230-4243. 

  11. Chune Peng, Qingbin Wang, Danrong Lu, Wenjun Han, and Fuchuan Li*. A Novel Bifunctional Endolytic Alginate Lyase with Variable Alginate-Degrading Modes and Versatile Monosaccharide- Producing Properties. Front. Microbiol. 2018, 9:167. 

  12. Naihan Han, Wenshuang Wang, Danrong Lu, Han Wang, Xinying Ma, Xiaopeng Fan, and Fuchuan Li*. A novel, rapid, and sensitive homogeneous sandwich detection method of Glypican-3 as a serum marker for hepatocellular carcinoma. Chem. Commun (Camb)., 2017, 53(90):12209-12212.

  13.  Wenshuang Wang, Xiaojuan Cai, Naihan Han, Wenjun Han, Kazuyuki Sugahara, and Fuchuan Li*. Sequencing of chondroitin sulfate oligosaccharides using a novel exolyase from a marine bacterium that degrades hyaluronan and chondroitin sulfate/dermatan sulfate. Biochem. J., 2017, 474(22):3831-3848. 

  14. Wenshuang Wang, Junhong Wang, and Fuchuan Li*. Hyaluronidase and Chondroitinase. Adv. Exp.Med. Biol., 2017, 925:75-87. 

  15. Shumin Wang, Kazuyuki Sugahara, and Fuchuan Li*. Chondroitin sulfate/dermatan sulfate sulfatases from mammals and bacteria. Glycoconj. J., 2016, 33(6):841-851. 

  16. Xiaoru Zhang, Ruijuan Li, Yuanyuan Chen, Shusheng Zhang, Wenshuang Wang, and Fuchuan Li*. Applying DNA rolling circle amplification in fluorescence imaging of cell surface glycans labeled by a metabolic method. Chem. Sci., 2016, 7, 6182-6189. 

  17. Wenjun Han, Yuanyuan Cheng, Dandan Wang, Shumin Wang, Huihui Liu, Jingyan Gu, Zhihong Wu, and Fuchuan Li *. Biochemical Characteristics and Substrate Degradation Pattern of a Novel Exo-Type β-Agarase from the Polysaccharide-Degrading Marine Bacterium Flammeovirga sp. Strain MY04. Appl. Environ. Microbiol. 2016, pii: AEM.00393-16. 

  18. Wenjun Han, Jingyan Gu, Yuanyuan Cheng, Huihui Liu, Yuezhong Li, and Fuchuan Li*. Novel Alginate Lyase (Aly5) from a Polysaccharide-Degrading Marine Bacterium, Flammeovirga sp. Strain MY04: Effects of Module Truncation on Biochemical Characteristics, Alginate Degradation Patterns, and Oligosaccharide-Yielding Properties. Appl. Environ. Microbiol. 2015, 82(1):364-74.

  19. Wenshuang Wang, Naihan Han, Ruijuan Li, Wenjun Han, Xiaoru Zhang, and Fuchuan Li*. Supercharged Fluorescent Protein as a Versatile Probe for the Detection of Glycosaminoglycans in Vitro and in Vivo. Anal. Chem. 2015, 87(18):9302-7. 

  20. Wenshuang Wang, Wenjun Han, Xingya Cai, Xiaoyu Zheng, Kazuyuki Sugahara, and Fuchuan Li*. Cloning and characterization of a novel chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from a marine bacterium. J. Biol. Chem. 2015, 290(12):7823-32.

  21.  Wenjun Han, Wenshuang Wang, Mei Zhao, Kazuyuki Sugahara, and Fuchuan Li*. A novel liminase from a marine bacterium that degrades hyaluronan and chondroitin sulfate. J. Biol. Chem. 2014, 289(40):27886-98. 

  22. Fuchuan Li, Wen Shi, Mariana I Capurro and Jorge Filmus. Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating hedgehog signaling. J. Cell Biol., 2011, 192(4):691-704. 

  23. Fuchuan Li, Chilkunda D. Nandini, Tomohide Hattori, Xingfeng Bao, Daisuke Murayama, Toshikazu Nakamura, Nobuhiro Fukushima, and Kazuyuki Sugahara. Structure of pleiotrophin- and hepatocyte growth factor-binding sulfated hexasaccharide determined by biochemical and computational approaches. J. Biol. Chem., 2010, 285(36):27673-85. 

  24. Mariana I Capurro, Fuchuan Li and Jorge Filmus. Overgrowth of a mouse model of Simpson- Golabi-Behmel syndrome is partly mediated by Indian hedgehog. EMBO Rep., 2009, 10(8):901-7.

  25. Fuchuan Li, Gerdy B. ten Dam, Sengottuvelan Murugan, Shuhei Yamada, Taishi Hashiguchi, Shuji Mizumoto, Kayoko Oguri, Minoru Okayama, Toin H. van Kuppevelt, and Kazuyuki Sugahara. Involvement of Highly Sulfated Chondroitin Sulfate in the Metastasis of the Lewis Lung Carcinoma Cells. J. Biol. Chem., 2008, 283(49):34294-304. 

  26. Mariana I Capurro, Ping Xu, Wen Shi, Fuchuan Li, Angela Jia and Jorge Filmus. Glypican-3 Inhibits Hedgehog Signaling During Development by Competing with Patched for Hedgehog Binding. Dev. Cell, 2008,14(5):700-11. 

  27. Fuchuan Li, Ajaya Kumar Shetty and Kazuyuki Sugahara. Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways. J. Biol. Chem., 2007, 282(5): 2956-2966. 

  28. Meiyu Geng1, Fuchuan Li1, Xianliang Xin, Jing Li, Zuowei Yan, and Huashi Guan. The potential molecular targets of marine sulfated polymannuroguluronate interfering with HIV-1 entry. Interaction between SPMG and HIV-1 rgp120 and CD4 molecule. Antiviral. Res. 2003, 59(2):127-135. 

  29. 一种难以降解CS-E 的糖胺聚糖裂解酶及其编码基因与应用，李福川，彭春娥，王庆彬等， 国家发明专利，专利号：ZL201710544077.9

  30. 一种外切型糖胺聚糖裂解酶及其编码基因与应用，李福川，蔡晓娟，王文爽等，国家发明专利，专利号：ZL201610227396.2

  31. 一株弧菌 FC509 菌株及其培养方法与应用，李福川，韩文君，王文爽等，国家发明专利， 专利号：ZL201410159983.3

  32. 一种内切型硫酸软骨素硫酸皮肤素 4-O-硫酸酯酶及其编码基因与应用，李福川，王文爽， 郑小煜等，国家发明专利，专利号：ZL201410209975.5

  33. 一种糖胺聚糖降解酶及其编码基因与应用，李福川，韩文君，王文爽等，国家发明专利， 专利号：ZL2014101,60095.3

  34. 一种高表达水溶性肝素酶 I 融合蛋白及其编码基因， 李福川，赵梅，韩文君等，国家发明专利，专利号：ZL201410246947.0

  35. 一种外切型琼胶酶及其编码基因与应用，李福川，韩文君等，国家发明专利，专利号：ZL201410396060.X

  36. 高正电荷荧光蛋白在糖胺聚糖分析检测中的应用，李福川，王文爽等，国家发明专利，专利号：ZL201510044900.0

  37. 一种用于蛋白聚糖高灵敏度检测的试剂盒及其制备方法，李福川，韩乃寒等，国家发明专利，专利号：ZL201610143751.8

  38. 一种内切型褐藻胶裂解酶及其编码基因与应用，李福川，韩文君等，国家发明专利，专利号：ZL2014104698614

  39. 一种高硫酸化硫酸软骨素及其制备方法与应用，李福川，王庆彬等，国家发明专利，专利号：ZL201610323540.2

  40. 一种外切型糖胺聚糖裂解酶及其编码基因与应用，李福川，王文爽等，国家发明专利，专利号：ZL2016102273962