费尔康，博士，副研究员，“香江学者”，南昌大学“215人才工程”赣江青年学者。

邮箱：fek@ncu.edu.cn

教育经历：

• 2003/09 — 2008/03  中国科学技术大学，生命科学学院，神经生物学  博士

• 1999/09 — 2003/07  安徽大学，生命科学学院，生物技术  学士

工作经历：

• 2021/12 — 至今          南昌大学，生物医学创新研究院，副研究员

• 2014/03 — 2021/12   南昌大学，生物医学创新研究院，助理研究员

• 2011/11 — 2013/11   香港科技大学，理学院生命科学部，香江学者

• 2008/03 — 2011/10   中国科学技术大学，生命科学学院，博士后

学术兼职：

• 江西省神经科学学会 理事

主要科研项目：

• 国家自然科学基金面上项目：精神分裂症易感基因DGCR2在突触形成中的功能与机制（31771142），57万元，2018.1-2021.12，主持

• 国家自然科学基金地区科学基金项目：精神分裂症相关蛋白dysbindin的磷酸化修饰调节其功能并参与精神分裂症发病（81460215），47万元，2015.1-2018.12，主持

• 国家自然科学基金青年科学基金项目：SUMO化修饰影响fALS相关蛋白SOD1聚集的机制研究（30900412），22万元，2010.1-2012.12，主持

• 第四批中国博士后科学基金特别资助金：Cdk5活性诱导的基因表达在树突和突触发育中作用的研究（201104330），10万元，2011.09-2013.08，主持

• 第三批中国博士后科学基金特别资助金：精神分裂症相关蛋白dysbindin 核内功能的研究（201003324），10万元，2010.09-2012.08，主持

• 第四十五批中国博士后科学基金二等资助金：严重抑郁症相关蛋白DCNP1 核内功能的研究（20090450808），3万元，2009.09-2011.08，主持

• 中国科学院王宽诚博士后工作奖励基金：精神分裂症相关蛋白dysbindin 功能的研究，2万元，2008，主持

发表论文：(*共第一作者；#通讯作者)

Dong Lin*, Lu-Hui Li*, Wen-Bing Chen*, Jiang Chen, Dong-Yan Ren, Zhi-Heng Zheng, Chang-Qin Zhao, Yan-Zi Zhong, Bin Luo, Hong-Yang Jing, Peng Chen, Su-Qi Zou, Xin-Sheng Lai, Tian Zhou, Ning Ding, Lei Li, Bing-Xing Pan#, Er-Kang Fei#. LHPP, a risk factor for major depressive disorder, regulates stress-induced depression-like behaviors through its histidine phosphatase activity. Molecular Psychiatry, 2022. 

• Chen, P.*, Liu, Z.*, Zhang, Q., Lin, D., Lu, S., Liu, J., Jiao, H. F., Lai, X., Zou, S., Wang, S., Zhou, T., Li, B. M., Zhu, L.#, Pan, B. X.#, Fei, E.# (2021). DSCAM deficiency leads to premature spine maturation and autism-like behaviors. J Neurosci 2021, Advance online publication. https://doi.org/10.1523/JNEUROSCI.1003-21.2021

• Chen, P.*; Jing, H.*; Xiong, M.; Zhang, Q.; Lin, D.; Ren, D.; Wang, S.; Yin, D., Chen, Y., Zhou, T.; Li, B.; Fei, E.#; Pan, B.X.# Spine impairment in mice high-expressing neuregulin 1 due to LIMK1 activation. Cell Death Dis 2021, 12: 403, doi:10.1038/s41419-021-03687-8 

• Luo. B.*; Liu. Z.Y.*; Lin, D.; Chen, W.B.; Ren, D.Y; Yu, Z.; Xiong, M.T.; Zhao, C.Q.; Fei, E.#; Li, B.M.# ErbB4 promotes inhibitory synapse formation by cell adhesion, independent of its kinase activity. Transl Psychiatry 2021, 11: 361, doi:10.1038/s41398-021-01485-6
  

• Hui, T.K.; Lai, X.; Dong, X.; Jing, H.;  Liu, Z.Y.;  Fei, E.K.; Chen, W.B.; Wang, S.; Ren, D.; Zou, S.#, Wu, H.T.#, Pan, B.X.#. Ablation of Lrp4 in Schwann Cells Promotes Peripheral Nerve Regeneration in Mice. Biology (Basel) 2021, 10:452.

• Chen, J.*; Zhou, T.*; Guo, A.M.; Chen, W.B.; Lin, D.; Liu, Z.Y.; Fei, E.K.# Metformin Ameliorates Lipopolysaccharide-Induced Depressive-Like Behaviors and Abnormal Glutamatergic Transmission. Biology (Basel) 2020, 9, doi:10.3390/biology9110359.

• Chen, W.B.; Chen, J.; Liu, Z.Y.; Luo, B.; Zhou, T.; Fei, E.K.# Metformin Enhances Excitatory Synaptic Transmission onto Hippocampal CA1 Pyramidal Neurons. Brain Sci 2020, 10, doi:10.3390/brainsci10100706.

• Fei, E.; Xiong, W.C.; Mei, L.# Ephrin-B3 recruits PSD-95 to synapses. Nat Neurosci 2015, 18, 1535-1537, doi:10.1038/nn.4147

• Yan, M.; Guo, A.; Chen, P.; Jing, H.; Ren, D.; Zhong, Y.; Wu, Y.; Fei, E.; Lai, X.; Zou, S., et al. LRP4 LDLalpha repeats of astrocyte enhance dendrite arborization of the neuron. Mol Brain 2020, 13, 166, doi:10.1186/s13041-020-00708-z.

• Yu, Z.; Lin, D.; Zhong, Y.; Luo, B.; Liu, S.; Fei, E.; Lai, X.; Zou, S.; Wang, S.# Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus. Cell Biosci 2019, 9, 9, doi:10.1186/s13578-019-0272-4.

• Yan, M.; Liu, Z.; Fei, E.; Chen, W.; Lai, X.; Luo, B.; Chen, P.; Jing, H.; Pan, J.X.; Rivner, M.H., et al. Induction of Anti-agrin Antibodies Causes Myasthenia Gravis in Mice. Neuroscience 2018, 373, 113-121, doi:10.1016/j.neuroscience.2018.01.015.

• Wang, Y.N.; Figueiredo, D.; Sun, X.D.; Dong, Z.Q.; Chen, W.B.; Cui, W.P.; Liu, F.; Wang, H.S.; Li, H.W.; Robinson, H., et al. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. Proc Natl Acad Sci U S A 2018, 115, 2508-2513, doi:10.1073/pnas.1716322115.

• Wang, H.; Liu, F.; Chen, W.; Sun, X.; Cui, W.; Dong, Z.; Zhao, K.; Zhang, H.; Li, H.; Xing, G., et al. Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice. Proc Natl Acad Sci U S A 2018, 115, 13105-13110, doi:10.1073/pnas.1811287115.

• Chen, D.; Li, Y.P.; Yu, Y.X.; Zhou, T.; Liu, C.; Fei, E.K.; Gao, F.; Mu, C.C.; Ren, H.G.; Wang, G.H.# Dendritic cell nuclear protein-1 regulates melatonin biosynthesis by binding to BMAL1 and inhibiting the transcription of N-acetyltransferase in C6 cells. Acta Pharmacol Sin 2018, 39, 597-606, doi:10.1038/aps.2017.163.

• Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Acevedo Arozena, A.; Adachi, H.; Adams, C.M.; Adams, P.D.; Adeli, K., et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016, 12, 1-222, doi:10.1080/15548627.2015.1100356.

• Lai, K.O.#; Liang, Z.; Fei, E.; Huang, H.; Ip, N.Y.# Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis. J Biol Chem 2015, 290, 14637-14646, doi:10.1074/jbc.M114.627117.

• Chen, Y.#; Liang, Z.; Fei, E.; Chen, Y.; Zhou, X.; Fang, W.; Fu, W.Y.; Fu, A.K.; Ip, N.Y.# Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling. PLoS One 2015, 10, e0133115, doi:10.1371/journal.pone.0133115.

• Wang, X.; Guo, J.; Fei, E.; Mu, Y.; He, S.; Che, X.; Tan, J.; Xia, K.; Zhang, Z.; Wang, G., et al. BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PLoS One 2014, 9, e86276, doi:10.1371/journal.pone.0086276.

• Li, B.; Hu, Q.; Xu, R.; Ren, H.; Fei, E.; Chen, D.; Wang, G.# Hax-1 is rapidly degraded by the proteasome dependent on its PEST sequence. BMC Cell Biol 2012, 13, 20, doi:10.1186/1471-2121-13-20.

• Hu, Q.; Li, B.; Xu, R.; Chen, D.; Mu, C.; Fei, E.; Wang, G.# The protease Omi cleaves the mitogen-activated protein kinase kinase MEK1 to inhibit microglial activation. Sci Signal 2012, 5, ra61, doi:10.1126/scisignal.2002946.

• Fu, K.; Ren, H.; Wang, Y.; Fei, E.; Wang, H.; Wang, G.# DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Oncogene 2012, 31, 1311-1322, doi:10.1038/onc.2011.315.

• Wang, P.; Li, B.; Zhou, L.; Fei, E.#; Wang, G.# The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins. Neuroscience 2011, 190, 43-55, doi:10.1016/j.neuroscience.2011.06.008.

• Ma, X.; Fei, E.; Fu, C.; Ren, H.; Wang, G.# Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53. Mol Psychiatry 2011, 16, 1105-1116, doi:10.1038/mp.2011.43.

• Li, B.; Hu, Q.; Wang, H.; Man, N.; Ren, H.; Wen, L.; Nukina, N.; Fei, E.; Wang, G.# Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases. Cell Death Differ 2010, 17, 1773-1784, doi:10.1038/cdd.2010.55.

• Fei, E.; Ma, X.; Zhu, C.; Xue, T.; Yan, J.; Xu, Y.; Zhou, J.; Wang, G.# Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression. J Biol Chem 2010, 285, 38630-38640, doi:10.1074/jbc.M110.107912.

• Ying, Z.; Wang, H.; Fan, H.; Zhu, X.; Zhou, J.; Fei, E.; Wang, G.# Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation. Hum Mol Genet 2009, 18, 4268-4281, doi:10.1093/hmg/ddp380.

• Tao, R.S.; Fei, E.K.#; Ying, Z.; Wang, H.F.; Wang, G.H. Casein kinase 2 interacts with and phosphorylates ataxin-3. Neurosci Bull 2008, 24, 271-277, doi:10.1007/s12264-008-0605-5.

• Jia, N.L.; Fei, E.K.#; Ying, Z.; Wang, H.F.; Wang, G.H.# PolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner. Neurosci Bull 2008, 24, 201-208, doi:10.1007/s12264-008-0326-9.

• Fan, J.; Ren, H.; Jia, N.; Fei, E.; Zhou, T.; Jiang, P.; Wu, M.; Wang, G.# DJ-1 decreases Bax expression through repressing p53 transcriptional activity. J Biol Chem 2008, 283, 4022-4030, doi:10.1074/jbc.M707176200.

• Fan, J.; Ren, H.; Fei, E.; Jia, N.; Ying, Z.; Jiang, P.; Wu, M.; Wang, G.# Sumoylation is critical for DJ-1 to repress p53 transcriptional activity. FEBS Lett 2008, 582, 1151-1156, doi:10.1016/j.febslet.2008.03.003.

• Zhang, T.; Jia, N.; Fei, E.; Wang, P.; Liao, Z.; Ding, L.; Yan, M.; Nukina, N.; Zhou, J.; Wang, G.# Nurr1 is phosphorylated by ERK2 in vitro and its phosphorylation upregulates tyrosine hydroxylase expression in SH-SY5Y cells. Neurosci Lett 2007, 423, 118-122, doi:10.1016/j.neulet.2007.06.041.

• Wang, H.; Jia, N.; Fei, E.; Wang, Z.; Liu, C.; Zhang, T.; Fan, J.; Wu, M.; Chen, L.; Nukina, N., et al. p45, an ATPase subunit of the 19S proteasome, targets the polyglutamine disease protein ataxin-3 to the proteasome. J Neurochem 2007, 101, 1651-1661, doi:10.1111/j.1471-4159.2007.04460.x.

• Liu, C.; Fei, E.; Jia, N.; Wang, H.; Tao, R.; Iwata, A.; Nukina, N.; Zhou, J.; Wang, G.# Assembly of lysine 63-linked ubiquitin conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis. J Biol Chem 2007, 282, 14558-14566, doi:10.1074/jbc.M700422200.

• Fei, E.; Jia, N.; Zhang, T.; Ma, X.; Wang, H.; Liu, C.; Zhang, W.; Ding, L.; Nukina, N.; Wang, G.# Phosphorylation of ataxin-3 by glycogen synthase kinase 3beta at serine 256 regulates the aggregation of ataxin-3. Biochem Biophys Res Commun 2007, 357, 487-492, doi:10.1016/j.bbrc.2007.03.160.

• Fei, E.; Jia, N.; Yan, M.; Ying, Z.; Sun, Q.; Wang, H.; Zhang, T.; Ma, X.; Ding, H.; Yao, X., et al. SUMO-1 modification increases human SOD1 stability and aggregation. Biochem Biophys Res Commun 2006, 347, 406-412, doi:10.1016/j.bbrc.2006.06.092