张文华，博士，研究员，博士生导师，国家优秀青年基金获得者，南昌大学生物医学创新研究院副院长，江西省脑科学与脑健康重点实验室副主任，江西省“双千计划”创新高端人才，南昌大学青年五四奖章获得者，南昌大学首批“三百人才工程”香樟俊才，南昌大学“215人才工程”赣江青年学者。主要研究方向是利用神经示踪、电生理、光纤记录、光遗传学、化学遗传学等前沿实验技术，在分子、突触、细胞、环路以及动物行为水平等多个层面解析焦虑症、抑郁症等精神疾病的发病机制，并基于中医药活性成分和纳米载药材料建立相应的疾病防治策略。先后以第一/通讯作者在Biological Psychiatry(2021/2019)，Nature Communications (2020)，Science Bulletin (2022)，Advanced Materials (2022/2020)等知名刊物发表学术论文30余篇，论文近5年被引超2000次，单篇最高被引365次（Google Scholar数据），其中1篇论文被Faculty1000列为推荐论文，2篇论文入选ESI高被引论文，1篇论文入选热点论文。部分成果获江西省自然科学奖一等奖（第二完成人）和二等奖（第二完成人）等奖励。
邮箱：whzhang@ncu.edu.cn
教育经历：
· 2007/09 — 2014/06 华中科技大学，生命科学与技术学院， 生物化学与分子生物学 硕士/博士
· 2003/09 — 2007/07 西南大学，生命科学学院，生物科学 学士
工作经历：
· 2022/11 — 至今 南昌大学，生物医学创新研究院，副院长
· 2021/12 — 至今 南昌大学，生物医学创新研究院，研究员
· 2019/12 — 2021/12 南昌大学，生物医学创新研究院，副研究员
· 2014/07 — 2019/12 南昌大学，生物医学创新研究院，助理研究员
学术兼职：
· 中国神经科学学会应激神经生物学分会 委员/副秘书长
· 中国生理学会转化神经科学专业委员会委员
· 中国研究型医院学会神经再生与修复专业委员会委员
· 中国神经科学学会麻醉与脑功能学会（CNSA）青年委员会委员
· 江西省青年科技协会理事、生命科学专委委员
主要科研项目：
· 国家自然科学基金优秀青年基金，200万，2023.1.1-2025.12.31，主持
· 国家自然科学基金面上项目，58万，2020.1.1-2023.12.31，主持
· 国家自然科学基金青年基金项目，17万，2017.1.1-2019.12.31，主持
· 江西省国家级人才创新创业项目，100万，2023.7.1-2026.6.30，主持
· 江西省"双千计划"科技创新高端人才（青年）项目，2020.1.1-2024.12.31，100万元，主持
· 江西省自然科学基金重点项目，20万，2021.1.1-2023.12.31，主持
· 江西省自然科学基金青年重点项目（现江西省杰青项目），20万，2019.7.1-2022.6.30，主持
· 江西省自然科学基金面上项目，6万，2016.1.1-2017.12.31，主持
· 江西省自然科学基金青年基金项目，6万，2017.7.1-2019.6.30，主持
· 江西省教育厅基金一般面上项目，3万，2016.1-2018.12，主持
· 南昌大学学科交叉创新基金重点项目，15万，2021.11.01-2023.10.31, 主持
· 南昌大学交叉学科创新基金项目，50万，2023.01.01-2025.12.31，共同主持
· 国家自然科学基金重点项目，297万，2020.1.1-2024.12.31，参与（排名第二）
· 科技创新2030-“脑科学与类脑研究”重大项目，3900万，2021.12-2026.11，项目骨干
发表论文（#第一作者，*通讯作者，IF为文章发表当年影响因子）
1. Wen-Hua Zhang, Jun-Yu Zhang, Andrew Holmes, Bing-Xing Pan*. Amygdala circuit substrates for stress adaptation and adversity. Biological Psychiatry, 2021, 89(9):847-856 (IF2021=12.81)，一区，Top期刊，（封面文章）
2. Wen-Hua Zhang, Wei-Zhu Liu, Ye He, Wen-Jie You, Jun-Yu Zhang, Hong Xu, Xiao-Li Tian, Bao-Ming Li, Lin Mei, Andrew Holmes, Bing-Xing Pan*. Chronic stress causes projection-specific adaptation of amygdala neurons via small-conductance calcium-activated potassium channel downregulation. Biological Psychiatry, 2019, 85(10):812-828 (IF2019=12.09)，一区，Top期刊，（Preview by Ming-Hu Han, Biological Psychiatry, 85:784-786, 2019）
3. Zhi-Heng Zheng#, Jiang-Long Tu#, Xiao-Han Li, Qing Hua, Wei-Zhu Liu, Yu Liu, Bing-Xing Pan, Ping Hu, Wen-Hua Zhang*. Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala. Brain Behavior and Immunity, 2021, 91:505-518. (IF2021=19.23), 一区，Top期刊，ESI全球1%高被引论文，1‰热点论文
4. Yu Liu#, Ping Hu#, Zhi-Heng Zheng, Da Zhong, Wei-Chang Xie, Zhi-Bo Tang, Bing-Xing Pan*, Jun Luo*, Wen-Hua Zhang*, Xiao-Lei Wang*. Photoresponsive Vaccine-Like CAR-M System with High- Efficiency Central Immune Regulation for Inflammation-related Depression. Advanced Materials, 2022, 34(11):e2108525. (IF2022=29.4)，一区，Top期刊
5. Xia Qin, Han-Qing Pan, Shou-He Huang, Jia-Xin Zou, Zhi-Heng Zheng, Xiao-Xuan Liu, Wen-Jie You, Zhi-Peng Liu, Jun-Li Cao, Wen-Hua Zhang*, Bing-Xing Pan*. GABAA(δ) receptor hypofunction in the amygdala-hippocampal circuit underlies stress-induced anxiety. Science Bulletin, 2022, 67(1):97-110 (IF2022=18.9)，一区，Top期刊
6. Wei-Zhu Liu#, Wen-Hua Zhang#, Zhi-Heng Zheng, Jia-Xin Zou, Xiao-Xuan Liu, Shou-He Huang, Wen-Jie You, Ye He, Jun-Yu Zhang, Xiao-Dong Wang, Bing-Xing Pan*. Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety. Nature Communications, 2020, 11:2221 (IF2020=14.92), 一区，Top期刊， Faculty Opinions (原F1000 prime)推荐论文，ESI高被引论文
7. Li-Guo Jin#, Ping Hu#, Yin-Yin Wang, Luo-Jia Wu, Kang Qin, Hao-Xin Cheng, Shu-Hua Wang, Bing-Xing Pan, Hong-Bo Xin, Wen-Hua Zhang*, Xiao-Lei Wang*. Fast-Acting Black-Phosphorus-Assisted Depression Therapy with Low Toxicity. Advanced Materials, 2020, 32(2):e1906050. (IF2020=30.85)，一区，Top期刊
8. Wei-Zhu Liu, Shou-He Huang, Yu Wang, Chun-Yan Wang, Han-Qing Pan, Ke Zhao, Ping Hu, Bing-Xing Pan*, Wen-Hua Zhang*. Medial prefrontal cortex input to basolateral amygdala controls acute stress-induced short-term anxiety-like behavior in mice. Neuropsychopharmacology, 2023, 48:734-744. (IF2023=6.6)，一区，Top期刊
10. Chun-Yan Wang#, Si-Ying Jiang#, Shuang-Mei Liao, Tian-Liu, Qi-Sheng Wu, Han-Qing Pan, Wen-Hua Zhang*, Bing-Xing Pan*, and Wei-Zhu Liu*. Dimethyl fumarate ameliorates chronic stress-induced anxiety-like behaviors by modulating neuroinflammation and neuronal activity in the amygdala. International Immunopharmacology, 2024, 137:112414, (IF2023=4.8), 二区，Top期刊
11. Zhi-Heng Zheng#, Xing-Cheng Lin#, Ying Lu, Shi-Rui Cao, Xu-Kai Liu, Dong Lin, Fan-Hua Yang, Yang-Bo Zhang, Jiang-Long Tu, Bing-Xing Pan, Ping Hu*, Wen-Hua Zhang*. Harmine exerts anxiolytic effects by regulating neuroinflammation and neuronal plasticity in the basolateral amygdala. International Immunopharmacology, 2023, 119:110208, (IF2023=4.8), 二区，Top期刊
12. Jie Chen, Hong Chen, Xia Dong, Tian-Kun Hui, Min Yan, Dong-Yan Ren, Su-Qi Zou, Shunqi Wang, Er-Kang Fei, Wen-Hua Zhang, Xin-Sheng Lai*. Deficiency of skeletal muscle Agrin contributes to the pathogenesis of age-related sarcopenia in mice. Cell Death and Disease, 2024, 15:201. (IF2023=8.1)，一区，Top期刊
13. Ping Hu#, Ying Lu#, Bing-Xing Pan*, Wen-Hua Zhang*. New insights into the pivotal role of the amygdala in inflammation-related depression and anxiety disorder. International Journal of Molecular Sciences, 2022, 23(19):11076 (IF2022=5.6), 二区，Top期刊，Top downloaded papers in 2022
15. Jia-Xin Zou, Guan-Qun Shang, Wei-Zhu Liu, Ye He*, Wen-Hua Zhang*. Connectivity and functional characterization of the mouse contralateral projecting neurons in basolateral amygdala. Stress and Brain, 2022.
16. Han-Qing Pan, Xiao-Xuan Liu, Ye He, Jin Zhou, Cai-Zhi Liao, Wen-Jie You, Si-Ying Jiang, Xia Qin, Wen-Bing Chen, Er-Kang Fei, Wen-Hua Zhang, Bing-Xing Pan*. Prefrontal GABAA(δ)R promotes fear extinction through enabling the plastic regulation of neuronal intrinsic excitability. Journal of Neuroscience, 2022, 42(29):5755-5770 (IF2022=5.3), 一区，Top期刊, Featured article
17. Xia Qin, Xiao-Xuan Liu, Yu Wang, Dan Wang, Ying Song, Jia-Xin Zou, Han-Qing Pan, Xiao-Zhou Zhai, Yong-Mei Zhang, Yang-Bo Zhang, Ping Hu*, Wen-Hua Zhang*. Early life stress induces anxiety-like behavior during adulthood through dysregulation of neuronal plasticity in the basolateral amygdala. Life Sciences, 2021, 285:119959 (IF2021=6.78)，二区，Top期刊
18. Wen-Jie You#, Ye He#, Wei-Zhu Liu, Yu-Ge Zhu, Ping Hu, Bing-Xing Pan, Wen-Hua Zhang*. Exposure to single prolonged stress fails to induce anxiety-like behavior in mice. Stress and Brain, 2021, 1(2):145-159.
19. Yun-Yun Wang#, Si-Yu Gai#, Wen-Hua Zhang, Xue-Tao Huang, Shu-Min Ma, Yu-Jia Huo, Yi-Chen Wu, Hai-Jun Tu, Jean-Philippe Pin, Philippe Rondard, Chan-Juan Xu*, Jian-Feng Liu*. The GABAB receptor mediates neuroprotection by coupling to G13. Science Signaling, 2021, 14(705):eaaz4112 (IF2021=9.52)，一区，Top期刊
21. Han-Qing Pan#, Wen-Hua Zhang#*, Cai-Zhi Liao, Ye He, Zhi-Ming Xiao, Xia-Qin, Wei-Zhu Liu, Na Wang, Jia-Xin Zou, Xiao-Xuan Liu, Bing-Xing Pan*. Chronic stress oppositely regulates tonic inhibition in Thy1-expressing and non-expressing neurons in amygdala. Frontiers in Neuroscience, 2020, 14:299 (IF2020=4.68)，二区，Top期刊
22. Wen-Bing Chen#, Han-Qing Pan#, Ye He, Xue-Hui Wang, Wen-Hua Zhang, Bing-Xing Pan*. Rap1b but not Rap1a in the forebrain is required for learned fear. Cell and Bioscience, 2020, 10:107 (IF2020=7.13)，二区
24. Wen-Hua Zhang#, Ke-Xin Cao#, Zeng-Bo Ding, Jian-Li Yang, Bing-Xing Pan*, Yan-Xue Xue*. Role of prefrontal cortex in the extinction of drug memories. Psychopharmacology, 2019, 236:463-477 (IF2019=3.13)，三区
25. Yong-Jian Hu#, Qian Sun#, Wen-Hua Zhang, Yu-Jia Huo, Chan-Juan Xu, Jian-Feng Liu. Specific activation of mGlu2 induced IGF-1R transactivation through FAK phosphorylation. Acta Pharmacologica Sinica, 2019, 40(4):460-467 (IF2019=5.06)，二区
26. Ye He#, Zhi-Heng Zheng#, Jin Zhou, Ping Hu, Bo-Wei Huang, Wei-Zhu Liu, Wen-Jie You, Han-Qing Pan, Bing-Xing Pan, Wen-Hua Zhang*. Gender-dependent regulation of anxiety-like behavior by δ subunit containing GABAA receptor during postnatal development. NeuroReport, 2019, 30:753-759 (Cover paper)（IF2019=1.39），四区
27. Jun-Yu Zhang#, Tao-Hui Liu#, Ye He, Han-Qing Pan, Wen-Hua Zhang, Xiao-Li Tian, Xiao-Ping Yin, Bao-Ming Li, Xiao-Dong Wang, Andrew Holmes, Ti-Fei Yuan, Bing-Xing Pan*. Chronic stress remodels synapses in an amygdala circuit-specific manner. Biological Psychiatry, 2019, 85:189-201 (IF2019=12.09)，一区Top期刊
28. Xiao-Bin Xu*, Shi-Jun Fan, Ruei Tian, Jun-Yu Zhang, Wen-Hua Zhang, Bing-Xing Pan*, Nobumasa Kato. The effects of perinatal bisphenol A exposure on thyroid hormone homeostasis and glucose metabolism in the prefrontal cortex and hippocampus of rats. Brain and Behavior, 2019, e01225 (IF2019=2.09)，四区
29. Wei-Zhu Liu, Bo-Wei Huang, Wen-Jie You, Ping Hu, Xue-Hui Wang, Jun-Yu Zhang, Xiao-Bin Xu, Zong-Yong Zhang, Bing-Xing Pan, Wen-Hua Zhang*. Harmine enhances GABAergic transmission onto basoamygdala projection neurons in mice. Brain Research Bulletin, 2018, 137:294-300 (IF2018=3.10)，三区
30. Shi-Yong Wu#, Wen-Hua Zhang#, Shu-Min Ma, Bin Li, Chan-Juan Xu*, Ping Yi*. ERK1/2 and JNK Signaling Synergistically Modulate Mitogenic Effect of Fibroblast Growth Factor 2 on Liver Cell. Cell Biology International, 2018, 42:1511-1522 (IF2018=2.13)，四区
31. Jun-Yu Zhang, Xia Qin, Wen-Hua Zhang, Bing-Xing Pan. Role of amygdala in anxiety disorders by chronic stress exposure. Research Signpost Publisher, 2018, Chapter 12: 299~322. (Books)
32. Wen-Hua Zhang, Jin Zhou, Han-Qing Pan, Xiao-Yang Wang, Wei-Zhu Liu, Jun-Yu Zhang, Xiao-Ping Ying, Bing-Xing Pan*. δ subunit-containing GABAA receptor prevents overgeneralization of fear in adult mice. Learning Memory, 2017, 24:381-384 (IF2017=2.67)，三区
33. Chen Song#, Wen-Hua Zhang#, Xue-Hui Wang, Jun-Yu Zhang, Xiao-Li Tian, Xiao-Ping Yin, Bing-Xing Pan*. Acute stress enhances the glutamatergic transmission onto basoamygdala neurons embedded in distinct microcircuits. Molecular Brain, 2017,10:3 (*co-first authors) (IF2017=3.45)，二区
34. Jing-Jing He#, Wen-Hua Zhang#, Shi-Ling Liu, Yi-Fang Chen, Chen-Xi Liao, Qian-Qing Shen, Ping Hu*. Activation of β2 adrenergic receptor promotes cellular proliferation in human glioblastoma. Oncology Letters, 2017, 14(3):3846-3852 (IF2017=1.66)，四区
35. Zhi-Peng Liu#, Qing-Hai He#, Han-Qing Pan, Xiao-Bin Xu, Wen-Bing Chen, Ye He, Jin Zhou, Wen-Hua Zhang, Jun-Yu Zhang, Xiao-Ping Ying, Ren-Wen Han, Bao-Ming Li, Tian-Ming Gao, Bing-Xing Pan*. Delta subunit-containing gamma-aminobutyric acid a receptor disinhibits lateral amygdala and facilitates fear expression in mice. Biological Psychiatry, 2017, 81(12):990-1002 (IF2017=11.98)，一区，Top期刊
36. Xiao-Bin Xu*, Shi-Jun Fan, Ye He, Xin Ke, Chen Song, Yao Xiao, Wen-Hua Zhang, Jun-Yu Zhang, Xiao-Ping Yin, Nobumasa Kato, Bing-Xing Pan*. Loss of hippocampal oligodendrocytes contributes to the deficit of contextual fear learning in adult rats experiencing early bisphenol A exposure. Molecular Neurobiology, 2017, 54(6):4524-4536 (IF2017=5.08)，二区
37. Ping Hu#, Wen-Hua Zhang#, Hong-Bo Xin and Glenn Deng*. Single cell isolation and analysis. Frontiers in Cell and Developmental Biology, 2016,4:116 (他引365次)
38. Ping Hu, Jing-Jing He, Shi-Ling Liu, Meng Wang, Bing-Xing Pan, Wen-Hua Zhang*. β2-adrenergic receptor activation promotes the proliferation of A549 lung cancer cells via the ERK1/2/CREB pathway. Oncology Reports, 2016, 36(3):1757-1763 (IF2016=2.66)，三区
39. Wen-Hua Zhang#, Chan-Juan Xu#*, Hai-Jun Tu#, Yun-Yun Wang, Qian Sun, Ping Hu, Yong-Jian Hu, Philippe Rondard, Jian-Feng Liu*. GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Scientific Reports, 2015, 5:10468 (IF2015=5.23)，二区
40. Zong-Yong Zhang#, Wen-Hua Zhang#, Si-Luo Huang#*, Qian Sun, Yun-Yun Wang, Yong-Jian Hu, Ning-Hua Sun, Yi-Lei Zhang, Zhi-Hua Jiang, Li Su*, Jian-Feng Liu*. GABAB receptor promotes its own surface expression by recruiting a Rap1-dependent signaling cascade. Journal of Cell Science, 2015, 128(12):2302-2313 (IF2015=4.71)，二区
41. Min Wan#, Wen-Hua Zhang#, Yang-Li Tian, Chan-Juan Xu, Tao Xu, Jian-Feng Liu*, Rong-Ying Zhang*. Unraveling a molecular determinant for clathrin-independent internalization of the M2 muscarinic acetylcholine receptor. Scientific Reports, 2015, 5:11408 (IF2015=5.23)，二区
42. Chan-Juan Xu, Wen-Hua Zhang, Philippe Rondard, Jean Philippe Pin, Jian-Feng Liu*. Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor. Frontiers in Pharmacology. 2014; 5:12
43. Ping Hu, Bin Li, Wen-Hua Zhang, Yi-Jian Li, Guang Li, Xin-Nong Jiang, Joanna Wdzieczak-Bakala, Jian-Miao Liu*. AcSDKP regulates cell proliferation through PI3KCA/Akt signaling pathway. PLoS ONE, 2013, 8(11): e79321 (IF=3.73)
44. Guillaume A. Baloucoune#, Lei Chun#, Wen-Hua Zhang#, Chan-Juan Xu, Si-Luo Huang, Qian Sun, Yun-Yun Wang, Hai-Jun Tu, Jian-Feng Liu*. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation. PLoS ONE, 2012, 7(6):e39698 (IF2012=4.09)
45. Lei Chun, Wen-Hua Zhang, Jian-Feng Liu*. Structure and ligand recognition of class C GPCRs. Acta Pharmacologica Sinica, 2012, 33:312-323 (IF2012=2.35)
46. Xin Lin#, Xin Li#, Ming Jiang#, Lin-Hai Chen#, Chan-Juan Xu, Wen-Hua Zhang, Han Zhao, Bing Sun, Xiao-Li Xu, Fa-Jun Nan*, Jian-Feng Liu*. An activity-based probe reveals dynamic protein-protein interactions mediate IGF-1R transactivation by GABAB receptor in neurons. Biochemical Journal, 2012, 443.627-634 (IF2012=4.65)
47. Hai-Jun Tu#, Chan-Juan Xu#, Wen-Hua Zhang, Qiu-Yao Liu, Philippe Rondard, Jean-Philippe Pin, Jian-Feng Liu*. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. Journal of Neuroscience. 2010, 30(2):749-59 (IF2010=7.27)
