科研项目

[1] 深圳科创委基础研究重点项目（JCYJ20200109142215045），状态：在研，角色：主持。

[2] 国家自然科学基金面上项目（21977120），状态：结题，角色：主持。

[3] 国家自然科学基金面上项目（31770379），状态：结题，角色：主持。

[4] 国家自然科学基金应急项目（81641129），状态：结题，角色：主持。

[5] 国家自然科学基金青年项目（31200258），状态：结题，角色：主持。

[6] 中山大学“百人计划”启动基金（75110-18841218），状态：结题，角色：主持。

[7] 2021年中山大学高校基本科研业务费青年教师团队项目，状态：结题，角色：项目骨干。

[8] 湖北省自然科学基金面上项目（2012FFB02333），状态：结题，角色：主持。

[9] 科技部国家高技术研究发展计划(“863计划”)项目（2014AA022207），状态：结题，角色：主要参与者（第六）。

[10] 科技部国际科技合作与交流专项（2013DFG32950），状态：结题，角色：主要参与者（第三）。

 发明专利

[1] 薛永波，贾舒杰，苏向东，曾子谦，一种真菌来源的聚酮类化合物及其制备方法与应用，申请号：CN 202210626905.4。

[2] 薛永波，吴梅芳，肖柔，苏向东，一种细轴荛花叶提取物的制备方法及其应用，申请号：CN 202110970211.8，授权日：2022.03.02。

[3] 薛永波，苏向东，邓文斌，何鑫，曾子谦，一种彝药齿叶蓼提取物及其制备方法和抗癌应用，申请号：CN 202111002858.8，申请日：2021.08.30。

[4] 薛永波，贾舒杰，苏向东，严文思，一种红千层内生真菌及其应用，申请号：CN 202111239691.7，申请日：2021.10.25。

[5] 张勇慧，薛永波，郭翼，朱虎成，王小川，具有抗阿尔兹海默病活性的化合物及其制备方法和应用，申请号：CN 201810556312.9，授权日：2020.08.04。

[6] 张勇慧，薛永波，郭翼,朱虎成，王小川，贯叶连翘提取物及其制法和制备抗阿尔兹海默病药的应用，申请号：CN 201810556307.8，授权日：2020.07.10。

[7] 张勇慧，薛永波，郭翼，张娜，张锦文，贯叶连翘次生代谢产物中具有乙酰胆碱酯酶抑制作用化合物及分离制备和用途，申请号：CN 201710277708.5，授权日：2020.05.19。

[8] 张勇慧，何艳，乔玉本，李琴，朱虎成，胡正喜，薛永波，汪建平，真菌次生代谢产物中具有抗菌活性化合物的分离制备及用途，申请号：CN 201710951372.6，授权日：2020.07.28。

[9] 张勇慧，齐昌兴，高炜熙，张锦文，薛永波，汪建平，土壤土曲霉次生代谢产物中抗阿尔茨海默病化合物及分离制备，申请号：CN 201610503931.2，授权日：2020.02.14。

[10] 张勇慧，胡琳珍，薛永波，张锦文，王珍珍，地耳草中具有抗EB病毒和抗卡波氏肉瘤相关疱疹病毒作用化合物及其制法及应用，申请号：CN 201610021078.0，授权日：2017.12.12。

[10] 张勇慧，陈春梅，朱虎成，汪建平，薛永波，张锦文，具有肿瘤细胞G1期阻滞作用的化合物及其制备和应用，申请号：CN 201510521102.2，授权日：2017.06.13。

 代表论著（ORCID：0000-0001-9133-6439）

[1].     Peng X, Zeng Z, Hassan S, Xue Y. The potential of marine natural Products: Recent Advances in the discovery of Anti-Tuberculosis agents. Bioorg. Chem. 2024; 151: 107699. Doi: 10.1016/j.bioorg.2024.107699.

[2].     Chen Y, Chen J, Zhong L, Zhang Y, Zhan R, Huang H, Xue Y. Enantioselective synthesis of spirooxindole-pyran derivatives via remote Inverse-Electron-Demand Diels−Alder reaction of β,γ-unsaturated amides. Org. Biomol. Chem. 2024; 22(16): 3198-3203. Doi: 10.1039/d4ob00303a.

[3].     Zeng Z, Jia S, Jin Y, Gu P, Yang J, Chen Z, Deng W, Xue Y. Colletotrikalactones A and B, Unusual Tricyclic Polyketides from Mangrove Associated Fungus Colletotrichum sp. J065. New J. Chem. 2024; 48: 16806-16812. Doi: 10.1039/D4NJ02991G.

[4].     Wang B, Wan AH, Xu Y, Zhang RX, Zhao BC, Zhao XY, Shi YC, Zhang X, Xue Y, Luo Y, Deng Y, Neely GG, Wan G, Wang QP. Identification of indocyanine green as a STT3B inhibitor against mushroom α-amanitin cytotoxicity. Nat. Commun. 2023; 14(1): 2241. doi: 10.1038/s41467-023-37714-3.

[5].     Xue Y, Savchenko AI, Agnew-Francis KA, Miles JA, Holt T, Lu H, Chow S, Forster PI, Boyle GM, Ross BP, Fischer K, Kutateladze AG, Williams CM. seco-Pregnane Glycosides from Australian Caustic Vine (Cynanchum viminale subsp. australe). J. Nat. Prod. 2023; 86(3): 490-497. Doi: 10.1021/acs.jnatprod.2c01037.

[6].     Wu Y, Su X, Lu J, Wu M, Yang SY, Mai Y, Deng W, Xue Y. In Vitro and in Silico Analysis of Phytochemicals From Fallopia dentatoalata as Dual Functional Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease. Front. Pharmacol. 2022; 13: 905708. Doi: 10.3389/fphar.2022.905708.

[7].     Jia S, Su X, Yan W, Wu M, Wu Y, Lu J, He X, Ding X, Xue Y. Acorenone C: A New Spiro-Sesquiterpene from a Mangrove-Associated Fungus, Pseudofusicoccum sp. J003. Acorenone C: A New Spiro-Sesquiterpene from a Mangrove-Associated Fungus, Pseudofusicoccum sp. J003. Front. Chem. 2021; 9: 780304. DOI: 10.3389/fchem.2021.780304

[8].     Su X, Wu Y, Wu M, Lu J, Jia S, He X, Liu S, Zhou Y, Xing H, Xue Y. Regioisomers Salviprolin A and B, Unprecedented Rosmarinic Acid Conjugated Dinorditerpenoids from Salvia przewalskii Maxim. Molecules. 2021; 26(22): 6955. DOI: 10.3390/molecules26226955.

[9].     Zhang N, Shi Z, Guo Y, Xie S, Qiao Y, Li XN, Xue Y, Luo Z, Zhu H, Chen C, Hu L, Zhang Y: The Absolute Configurations of Hyperilongenols A–C: Rare 12,13-Seco-Spirocyclic Polycyclic Polyprenylated Acylphloroglucinols with Enolizable β,β′-Tricarbonyl Systems from Hypericum longistylum Oliv. Org. Chem. Front. 2019; 6: 1491–502. DOI:10.1039/C9QO00245F.

[10].    Guo Y, Tong Q, Zhang N, Duan X, Cao Y, Zhu H, Xie S, Yang J, Zhang J, Liu Y, Xue Y, Zhang Y: Highly functionalized cyclohexanone-monocyclic polyprenylated acylphloroglucinols from Hypericum perforatum induce leukemia cell apoptosis. Org. Chem. Front. 2019; 6: 871–24. DOI:10.1039/C8QO01268G.

[11].    Xie S, Wu Y, Qiao Y, Guo Y, Wang J, Hu Z, Zhang Q, Li X, Huang J, Zhou Q, Luo Z, Liu J, Zhu H, Xue Y, Zhang Y: Protoilludane, Illudalane, and Botryane Sesquiterpenoids from the Endophytic Fungus Phomopsis sp. TJ507A. J. Nat. Prod. 2018; 81: 1311–20. DOI:10.1021/acs.jnatprod.7b00889.

[12].    Li H, Sun W, Deng M, Qi C, Chen C, Zhu H, Luo Z, Wang J, Xue Y, Zhang Y: Asperversins A and B, Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor. Mar. Drugs 2018; 16: 177. DOI:10.3390/md16060177.

[13].    Zhu H, Chen C, Tong Q, Yang J, Wei G, Xue Y, Wang J, Luo Z, Zhang Y: Asperflavipine A: A Cytochalasan Heterotetramer Uniquely Defined by a Highly Complex Tetradecacyclic Ring System from Aspergillus flavipes QCS12. Angew. Chem. Int. Ed. 2017; 129: 5242–46. DOI:10.1002/ange.201701125.

[14].    Guo Y, Zhang N, Chen C, Huang J, Li XN, Liu J, Zhu H, Tong Q, Zhang J, Luo Z, Xue Y, Zhang Y: Tricyclic Polyprenylated Acylphloroglucinols from St John’s Wort, Hypericum perforatum. J. Nat. Prod. 2017; 80: 1493–504, DOI:10.1021/acs.jnatprod.6b01178.

[15].    Hu Z, Wu Y, Xie S, Sun W, Guo Y, Li XN, Liu J, Li H, Wang J, Luo Z, Xue Y, Zhang Y: Phomopsterones A and B, Two Highly Functionalized Ergostane-type Steroids from the Endophytic Fungus Phomopsis sp. TJ507A, Org. Lett. 2017; 19(1): 258–61. DOI: 10.1021/acs.orglett.6b03557.

[16].    He Y, Hu Z, Sun W, Li Q, Li XN, Zhu H, Huang J, Liu J, Wang J, Xue Y, Zhang Y: Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp. TJ23. J. Org. Chem. 2017; 82(6): 3125–31. DOI:10.1021/acs.joc.7b00056.

[17].    Tang Y, Xue Y, Du G, Wang J, Liu J, Sun B, Li XN, Yao G, Luo Z, Zhang Y: Structural revisions of a class of natural products: scaffolds of aglycon analogs of fusicoccins and cotylenins isolated from fungi. Angew. Chem. Int. Ed. 2016; 55: 4069–73. DOI: 10.1002/anie.201600313.

[18].    Zhu H, Chen C, Tong Q, Li XN, Yang J, Xue Y, Luo Z, Wang J, Yao G, Zhang Y: Epicochalasines A and B, Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes. Angew. Chem. Int. Ed. 2016; 47: 3486–90. DOI:10.1002/anie.201511315.

[19].    Qi C, Bao J, Wang J, Zhu H, Xue Y, Wang X, Li H, Sun W, Gao W, Lai Y, Chen JG, Zhang Y: Asperterpenes A and B, Two Unprecedented Meroterpenoids from Aspergillus terreus with BACE1 Inhibitory Activities. Chem. Sci. 2016; 7: 6563–72. DOI:10.1039/C6SC02464E.

[20].    Qiao Y, Xu Q, Hu Z, Li XN, Xiang M, Liu J, Huang J, Zhu H, Wang J, Luo Z, Xue Y, Zhang: Diterpenoids of the Cassane Type from Caesalpinia decapetala. J. Nat. Prod. 2016; 79 (12): 3134–42. DOI: 10.1021/acs.jnatprod.6b00910.

[21].    Zhu H, Chen C, Xue Y, Tong Q, Li XN, Chen X, Wang J, Yao G, Luo Z, Zhang Y: Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, from Aspergillus flavipes. Angew. Chem. Int. Ed. 2015; 54: 13374–8. DOI: 10.1002/anie.201506264.

[22].    Chen C, Zhu H, Li XN, Yang J, Wang J, Li G, Li Y, Tong Q, Yao G, Luo Z, Xue Y, Zhang Y.: Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum. Org. Lett. 2015; 17(3): 644–7. DOI: 10.1021/ol503666b.

[23].    Xue Y, Li X, Du X, Li X, Wang W, Yang J, Chen J, Pu J, Sun H: Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis. Phytochemistry 2015; 116: 253–61. DOI: 10.1016/j.phytochem.2015.03.009.

[24].    Zhu H, Chen C, Yang J, Li XN, Liu J, Sun B, Huang SX, Li D, Yao G, Luo Z, Li Y, Zhang J, Xue Y, Zhang Y: Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum sampsonii. Org. Lett. 2014; 16: 6322–5. DOI: 10.1021/ol5030579.

[25].    Xue Y-B, Yang JH, Li XN, Du X, Pu JX, Xiao WL, Su J, Zhao W, Li Y, Sun HD: Henrischinins A–C: three new triterpenoids from Schisandra henryi. Org. Lett. 2011; 13: 1564–7. DOI: 10.1021/ol200283y.