2090
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◆ 近年承担纵向科研项目情况

[1]     Mengting Gao, Xin Xue, Xuemeng Zhang, Yueyue Chang, Qiulan Zhang, Xin Li, Yifei Wang, Li Zhang, Zhipeng Li(通讯), Haijuan Dong, Wei Wang, Weifeng Yao(通讯) Discovery of potential active ingredients of Er-Zhi-Wan, a famous traditional Chinese formulation, in model rat serum for treating osteoporosis with kidney-yin deficiency by UPLC-Q/TOF-MS and molecular docking[J]. Journal of Chromatography B, 2022, 1208: 123397. (IF= 3.318) 中科院3区

[2]     Yuanyuan Zhai, Xin Li, Yifei Wang, Mengting Gao, Li Feng, Jinjun Shan, Tong Xie, Yudan Cao, Fangfang Cheng, Beihua Bao, Li Zhang, Anwei Ding, Zhipeng Li, Weifeng Yao. Metabolomics combined with proteomics analysis of femur provides a comprehensive interpretation of the changes in postmenopausal osteoporosis under salidroside treatment[J]. Pharmacological Research-Modern Chinese Medicine, 2022, 3: 100079.

[3]     Qiulan Zhang, Xin Liu, Mengting Gao, Xin Li, Yifei Wang, Yueyue Chang, Xuemeng Zhang, Zongli Huo, Li Zhang, Jinjun Shan(通讯), Feng Zhang(通讯), Baoli Zhu(通讯), Weifeng Yao(通讯). The study of human serum metabolome on the health effects of glyphosate and early warning of potential damage[J]. Chemosphere, 2022, 298: 134308. (IF= 8.943) 中科院2区

[4]     Yifeng Wang, Yueyue Chang, Xuemeng Zhang, Mengting Gao, Qiulan Zhang, Xin Li, Li Zhang, Weifeng Yao(通讯). Salidroside protects against osteoporosis in ovariectomized rats by inhibiting oxidative stress and promoting osteogenesis via Nrf2 activation[J]. Phytomedicine, 2022, 99: 154020. (IF= 6.656) 中科院2区

[5]     Shen Song, Rongli Qiu, Xiaodan Jin, Zhuxiu Zhou, Jin Yan, Qiaochan Ou, Xiao Liu, Weidong Li, Yiqing Mao, Weifeng Yao(通讯), Tulin Lu(通讯). Mechanism exploration of ancient pharmaceutic processing (Paozhi) improving the gastroprotective efficacy of Aucklandiae Radix[J]. Journal of Ethnopharmacology, 2022, 287: 114911. (IF= 5.195)中科院2区

[6]     Xin Li, Yifei Wang, Mengting Gao, Beihua Bao, Yudan Cao, Fangfang Cheng, Li Zhang, Zhipeng Li(通讯), Jinjun Shan(通讯), Weifeng Yao(通讯). Metabolomics-driven of relationships among kidney, bone marrow and bone of rats with postmenopausal osteoporosis[J]. Bone, 2022, 156: 116306. (IF= 4.626) 中科院2区

[7]     Li Feng, Mengting Gao, Yuanyuan Zhai, Xin Li, Yifei Wang, Tong Xie, Weifeng Yao(通讯), Jinjun Shan, Li Zhang, Anwei Ding. A novel strategy based on targeted cellular metabolomics for quantitatively evaluating anti-aging effect and screening effective extracts of Erzhi Wan [J]. Journal of Chromatography B, 2021, 1178: 122857. (IF= 3.205) 中科院3区

[8]     Dongjing Jiang, Sijia Guo, An Kang, Yonghui Ju, Jingxian Li, Sheng Yu, Beihua Bao, Yudan Cao, Yuping Tang, Li Zhang(通讯), Weifeng Yao(通讯). Comparison of the short-chain fatty acids in normal rat faeces after the treatment of Euphorbia kansui, a traditional Chinese medicine for edoema [J]. Pharmaceutical Biology, [Y1] 2020, 58(1): 367-373. (IF= 3.503)中科院4区

[9]     Gang Tian, Chao Li, Yuanyuan Zhai, Jia Xu, Li Feng, Weifeng Yao(通讯), Beihua Bao(通讯), Li Zhang, Anwei Ding. GC-MS based metabolomic profiling of lung tissue couple with network pharmacology revealed the possible protection mechanism of Pudilan Xiaoyan Oral Liquid in LPS-induced lung injury of mice [J]. Biomedicine & Pharmacotherapy, 2020, 124: 109833. (IF= 6.529)

[10]     Li Feng, Yuanyuan Zhai, Jia Xu, Weifeng Yao(通讯), Hui Li, Yudan Cao, Fangfang Cheng, Beihua Bao, Li Zhang(通讯). A review on traditional uses, phytochemistry and pharmacology of Eclipta prostrata (L.) L [J]. Journal of Ethnopharmacology, 2019, 245: 112109. (IF= 3.69)

[11]     Jia Xu, Yuanyuan Zhai, Li Feng, Tong Xie, Weifeng Yao(通讯), Jinjun Shan(通讯), Li Zhang. An optimized analytical method for cellular targeted quantification of primary metabolites in tricarboxylic acid cycle and glycolysis using gas chromatography-tandem mass spectrometry and its application in three kinds of hepatic cell lines. Journal of Pharmaceutical and Biomedical Analysis,. (IF= 3.209)

[12]     Yuanyuan Zhai, Jia Xu, Li Feng, Qinan Liu, Weifeng Yao(通讯), Hui Li, Yudan Cao, Fangfang Cheng, Beihua Bao, Li Zhang(通讯). Broad range metabolomics coupled with network analysis for explaining possible mechanisms of Er-Zhi-Wan in treating liver-kidney Yin deficiency syndrome of Traditional Chinese medicine. Journal of Ethnopharmacology, 2019, 234: 57-66. (IF= 3.69)

[13] Yi Zhang, Jing Gao, Qiao Zhang, Kan Wang, WeiFeng Yao(通讯), Beihua Bao, Li Zhang(通讯), Yuping Tang. Interpretation of Euphorbia Kansui Stir-Fried with Vinegar Treating Malignant Ascites by a UPLC-Q-TOF/MS Based Rat Serum and Urine Metabolomics Strategy Coupled with Network Pharmacology. Molecules, 2018, 23(12): 3246. (IF= 3.06)

[14] Ying Nie, Weifeng Yao(通讯). A Comprehensive Quality Evaluation Method Based on C30-HPLC and an Analytic Hierarchy Process for the Chinese Herbal Formula, Erzhiwan. Molecules, 2018, 23(8): 2045. (IF= 3.06)

[15] Shen Song, WeiFeng Yao(通讯), Xiaobin Cui, Xiao Liu, RongLi Qiu. Spectrum-effect relationship analysis by binary chromatographic fingerprint to identify components responsible for the antibacterial activity of the essential oil from Curcumae wenyujin. International Journal of Food Properties, 2018, 21(1): 546-556. (IF= 1.398)

[16] Hui Li, Weifeng Yao, Qinan Liu, Jia Xu, Beihua Bao, Mingqiu Shan, Yudan Cao, Fangfang Cheng, Anwei Ding, Zhang, Li. Application of UHPLC-ESI-Q-TOF-MS to Identify Multiple Constituents in Processed Products of the Herbal Medicine Ligustri Lucidi Fructus. Molecules. 2017; 22(5):689. (IF= 3.098)

[17] Weifeng Yao, Hui Li, Qinan Liu, Ye Gao, Jin Dai, Beihua Bao, Li Zhang, Anwei Ding, Yuping Tang, Jinao Duan. Simultaneous quantitation and comparison of eight components in Jiao-ai decoction and Si-wu decoction byultra high performance liquid chromatography with triple quadrupole tandem mass spectrometry. Journal of Separation Science, 2016, 39(17): 3311–3317. (IF=2.741)

[18] Weifeng Yao, Hui Li, Qinan Liu, Ye Gao, Jin Dai, Beihua Bao, Li Zhang, Anwei Ding. Cellular Metabolomics Revealed the Cytoprotection of Amentoflavone, a Natural Compound, in Lipopolysaccharide-Induced Injury of Human Umbilical Vein Endothelial Cells. International Journal of Molecular Sciences. 2016; 17(9):1514. (IF= 3.226)

[19] Weifeng Yao, Jin Dai, Chuanzhu Zheng, Beihua Bao, Haibo Cheng, Li Zhang, Anwei Ding, Wei Li. Quality assessment of Fructus Ligustri Lucidi by the simultaneous determination of six compounds and chemometric analysis. Journal of Separation Science, 2015, 38(11): 1822–1827. (IF= 2.741)

[20] Weifeng Yao, HaiweiGu, Jiangjiang Zhu, Gregory Barding, Haibo Cheng, Beihua Bao, Li Zhang, Anwei Ding, Wei Li. Integrated Plasma and Urine Metabolomics Coupled with HPLC/QTOF-MS and Chemometric Analysis on Potential Biomarkers in Liver Injury and Hepatoprotective Effects of Er-Zhi-Wan[J]. Analytical and Bioanalytical Chemistry, 2014, 406(28):7367-7378. (IF=3.578)

[21] Weifeng Yao, Mu He, Yejuan Jiang, Li Zhang, Anwei Ding, Yuzhu Hu. Integrated LC/MS and GC/MS Metabolomics Data for the Evaluation of Protection Function of Fructus LigustriLucidi on Mouse Liver [J]. Chromatographia, 2013, 76(17-18): 1171-1179. (IF=1.37)

[22] Weifeng Yao, Xiaoying Yin, Yuzhu Hu. A new algorithm of piecewise automated beam search for peak alignment of chromatographic fingerprints [J]. Journal of Chromatography A, 2007, 1160(1-2): 254–262.

[23] Weifeng Yao, Xuefang Luo, Yuzhu Hu. Determination of amantadine sulfate in chloride sodium injection by capillary gas chromatography [J]. PDA Journal of Pharmaceutical Science and Technology, May/June, 2006, 60: 138-143.

[24]   王乙妃,李鑫,高梦婷,夏文余,姚卫峰.福多司坦对肺癌细胞黏蛋白MUC1和MUC5AC的抑制作用研究[J].中国现代应用药学,2022,39(7):868-877.

[25]   王乙妃,张其乐,李鑫,高梦婷,张丽,丁安伟,夏文余,姚卫峰.福多司坦干预炎症微环境下肺癌细胞的代谢组学研究[J].药学学报,2022,57(02):419-427.

[26]   冯丽,王乙妃,高梦婷,李鑫,姚卫峰,张丽.二至丸及不同极性部位含药血清对H_2O_2诱导的肝细胞衰老的保护作用及物质基础研究[J].药学学报,2021,56(04):1137-1146.

[27]   李硕,常月月,程芳芳,包贝华,曹雨诞,姚卫峰,张丽,丁安伟.多模板分子印迹固相萃取及其在中药多组分提取分离中的应用[J].药学学报,2021,56(03):751-760.

[28]   田刚,李超,翟园园,冯丽,徐佳,包贝华,姚卫峰,张丽,丁安伟.基于血清靶向代谢组学研究蒲地蓝消炎口服液对脂多糖诱导的急性肺炎小鼠能量代谢的影响[J].南京中医药大学学报,2021,37(01):120-125.

[29]   田刚,胡远卓,李超,翟园园,包贝华,姚卫峰,张丽,丁安伟.基于生物网络和代谢组学研究蒲地蓝消炎口服液抗LPS诱导小鼠急性呼吸道感染的作用机制[J].药学学报,2021,56(03):816-822.

[30]   宗阳,姚卫峰,居文政.以白介素6为受体挖掘中药单体治疗新型冠状病毒肺炎引发的细胞因子风暴的干预作用[J].中国医院药学杂志,2020,40(11):1182-1188.

[31]   宗阳,姚卫峰,居文政.基于细胞因子风暴和中医“湿毒犯肺”理论挖掘抗新型冠状病毒肺炎中药[J].药学学报,2020,55(06):1091-1097.

[32]   翟园园,李鑫,高梦婷,王乙妃,冯丽,姚卫峰,包贝华,曹雨诞,张丽,丁安伟.基于分子对接技术筛选二至丸治疗骨质疏松的活性成分及验证[J].药学学报,2020,55(06):1222-1228.

[33]   宗阳,姚卫峰,单进军,汪受传.基于网络药理学和分子对接法探寻清宣止咳颗粒治疗儿童新型冠状病毒肺炎活性化合物[J].世界中医药,2020,15(04):477-483.

[34]   姚卫峰,翟园园,林丽丽,杨斌,庄莉,张丽,谢彤,赵霞,单进军,汪受传.融合“成分-靶点-共有通路”网络和分子对接技术的清肺口服液抗新型冠状病毒肺炎的活性成分初探[J].南京中医药大学学报,2020,36(02):174-178.

[35]   徐佳,刘其南,翟园园,冯丽,谢彤,姚卫峰,张丽.二至丸抗大鼠肾细胞衰老的GC-MS代谢组学研究[J].南京中医药大学学报,2019, 35(4):458-464.

[36]   庄莉,翟园园,姚卫峰,徐佳,冯丽,包贝华,曹雨诞,张丽,丁安伟.基于网络药理学的二至丸对肾脏保护作用的机制研究[J]. 药学学报2019, 54(5):877-885.

[37]   徐森楠, 庄莉, 翟园园, 姚卫峰, 徐佳, 刘其南, 包贝华, 曹雨诞, 张丽, 丁安伟. 基于网络药理学研究二至丸防治骨质疏松症的物质基础与作用机制. 中国药学杂志, 2018, 53(21):40-47.

[38]   徐佳,刘其南,翟园园,单进军,姚卫峰(通讯),张丽.细胞代谢组学样品前处理研究进展[J].中国细胞生物学学报, 2018, 40(3): 418-425.

[39]   刘其南,徐佳,翟园园,姚卫峰(通讯),张丽,曹雨诞,包贝华,丁安伟.二至丸对D-半乳糖诱导大鼠肾细胞衰老的保护作用[J].南京中医药大学学报,2018,34(01):81-86.

[40]   翟园园,刘其南,徐佳,姚卫峰(通讯),包贝华,曹雨诞,张丽,丁安伟. 基于网络药理学的二至丸保肝作用机制研究[J]. 药学学报, 2018,53(4):567-573.

[41]   李慧,刘其南,张丽,姚卫峰(通讯),丁安伟. 基于层次分析法及多指标正交试验优选酒炖女贞子炮制工艺[J]. 中草药,2016,47(16):2832-2837.

[42]   李慧,刘其南,高叶,何睦,姚卫峰(通讯),张丽,丁安伟. 二至丸干预大鼠急性酒精肝损伤的尿液代谢组学研究[J]. 中国医院药学杂志,2016,36(19):46-50.

[43]   姚卫峰, 周丽娜, 张丽, 丁安伟, 李伟. 细胞代谢组学及其应用[J]. 中国临床药理学与治疗学, 2014,19(3): 334-340.

[44]   姚卫峰,何睦,蒋叶娟,丁安伟,张丽. 基于多指标加权评分的中药复方二至丸提取工艺研究[J]. 中成药, 2013, 35(7): 1414-1418.

[45]   姚卫峰, 蒋叶娟, 蔡秀江, 何睦, 丁安伟. 二至丸对四氯化碳致大鼠急性肝损伤血浆代谢组学研究[J]. 中国药学杂志,2013, 48 (10):808-813.

[46]   姚卫峰, 耿婷, 丁安伟, 张丽. 荆芥内酯在大鼠体内的排泄研究.中国药学杂志, 2012, 47(16): 1318-1322.

[47]   姚卫峰, 陈汀, 张丽, 丁安伟. 女贞子醇提物不同极性部位的体外抗氧化活性研究[J]. 中国实验方剂学杂志, 2011, 17(22): 138-140.

[48]   姚卫峰, 曹琳琳, 单鸣秋, 张丽, 丁安伟. 基于主成分降维和神经网络模型识别不同产地的荆芥穗. 中国中药杂志, 2010, 35(14):1815-1817.

[49]   姚卫峰, 刘卉, 陈汀, 张丽, 丁安伟. 基于UPLC-TOF-MS基峰强度色谱图轮廓的香丹注射液快速质量分析. 中国药房, 2010, 21(47): 4468-4470.

[50]   姚卫峰, 胡育筑, 牟玲丽, 余伯阳. 基于最小二乘支持向量机的色谱指纹图预测银杏叶总抗氧化活性[J]. 分析化学, 2009, 37(3):383-388. (SCI)


◆ 近年获批专利情况

[1] 中药复方的质量控制和评价方法.    证书号: 4674608. 专利号: ZL201810519735.3授权公告日:2021.9.14,南京中医药大学. 姚卫峰;张丽;包贝华;曹雨诞;刘其南.