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成果及论文

[18] Lijie Lv, Jia Zheng, Yijie Xiao, Dan Ni, Zhangshun Luo, Yunyun Gao, Yue Wei, Yi He*, and Shenyou Nie*. [4 + 2] Cyclization or Lossen Rearrangement: Rhodium-Catalyzed Divergent Synthesis of Carboline Derivatives with Anticancer Activity. Org. Lett.  2024, 26, 4212-4217. (IF= 5.2, JCR 1 区)

https://pubs.acs.org/doi/10.1021/acs.orglett.4c01050


[17] Boyi Zhang#, Hui Bai#, Beibei Zhan#,* Kaihang Wei, Shenyou Nie*, Xiaheng Zhang*. Deacylative arylation and alkynylation of unstrained ketones. Sci. Adv. 2024, 10, eado0225. (IF= 13.6, JCR 1 区)

https://www.science.org/doi/10.1126/sciadv.ado0225


[16] Feiyu Gao#, Chenxin Yin#, Yi He#,* Shuang Zhao, Mengxiao Chen, Jia Zheng, Dan Ni, Houhua Yin, Xian Fu, Xiaoyong Zhang* , Shenyou Nie*. Visible-light mediated Ugi-type reaction for the synthesis of 3,3-disubstituted phthalides. Adv. Synth. Catal. 2024, DOI: 10.1002/adsc.202400040. (IF= 5.4, JCR 1 区)

https://doi.org/10.1002/adsc.202400040


[15] Shuang Zhao#, Mengxiao Chen#, Wenlu Zhou, Dan Ni, Zhenghua Li, Shenyou Nie*, Yi He*. Green synthesis for diverse bioactive benzo-fused spiroindolines through DBU-catalysed post-Ugi double cyclization. Chem. Commun. 2024, DOI: 10.1039/D4CC00846D. (IF= 4.9, JCR 2 区)

https://doi.org/10.1039/D4CC00846D


[14] Yijie Xiao#, Lijie Lv#, Nanxuan Luo, Peirui Zhao, Yao Chen, Zhangshun Luo, Houhua Yin, Yi He*, Shenyou Nie*. Rhodium-catalysed homo-coupling of terminal alkynes: divergent synthesis of bioactive 1,3-diyne and conjugated enediynes. New J. Chem. 2024, 48, 7517–7523.  (IF= 3.3, JCR 2 区)

Graphical abstract: Rhodium-catalysed homo-coupling of terminal alkynes: divergent synthesis of bioactive 1,3-diynes and conjugated enediynes

https://doi.org/10.1039/D4NJ00366G


[13] Xin Li#; Xiaowei Wu#; Shenyou Nie; Jidong Zhao; Yuan Yao; Fangrui Wu; Chandra Bhushan Mishra; Md Ashraf-Uz-Zaman; Bala Krishna Moku; Yongcheng Song*. Discovery, Structure–Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein–Protein Interactions between AF9/ENL and AF4 or DOT1L. Cancers 2023, 15, 5283. (IF= 5.2, JCR 2 区)

Cancers 15 05283 ch001

https://doi.org/10.3390/cancers15215283


[12] Shuang Zhao#, Yi He#,*, Feiyu Gao#, Yue Wei, Jiawei Zhang, Mengxiao Chen, Yunyun Gao, Yuan Zhang, Jun-yan Liu, Zufeng Guo, Zhenghua Li*, Shenyou Nie*. Rapid access to C2-quaternary 3-methyleneindolines via base-mediated post-Ugi Conia-ene cyclization. Chem. Commun. 2023, 59, 3099–3102. (IF= 6.065, JCR 2 区)

Graphical abstract: Rapid access to C2-quaternary 3-methyleneindolines via base-mediated post-Ugi Conia-ene cyclization

https://doi.org/10.1039/D2CC06281J


[11] Shenyou Nie#, Fangrui Wu#, Jingyu Wu#, Xin Li#, Chao Zhou, Yuan Yao, and Yongcheng Song*. Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP. Eur. J. Med. Chem. 2022, 237, 114407. (IF= 7.088, JCR 1 区)

Image 1

https://doi.org/10.1016/j.ejmech.2022.114407


[10] Jin-Pin Liu, Si-Yu Cen, Zian Xue, Tian-Xiang Wang, Yun Gao, Jia Zheng, Cheng Zhang, Junchi Hu, Shenyou Nie, Yue Xiong, Kun-Liang Guan, and Hai-Xin Yuan*. A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4. ACS Chem. Biol. 2022, 17, 3389–3406 (IF= 4.63, JCR 2 区)

Abstract Image

https://doi.org/10.1021/acschembio.2c00445


[9] Jia Zheng#, Wei Zhang#, Linfeng Li#, Yi He, Yue Wei, Yongjun Dang, Shenyou Nie*, and Zufeng Guo*. Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review. Front. Chem. 2022, 10, 860985. (IF= 5.45, JCR 2区)

https://doi.org/10.3389/fchem.2022.860985


[8] Shenyou Nie#, Yuan Yao#, Fangrui Wu#, Xiaowei Wu, Jidong Zhao, Yuanda Hua, Jingyu Wu, Tong Huo, Yi-Lun Lin, Alexander R. Kneubehl, Megan B. Vogt, Josephine Ferreon, Rebecca Rico-Hesse, and Yongcheng Song*. Synthesis, Structure-Activity Relationships and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease. J. Med. Chem. 2021, 64, 2777–2800. (IF= 8.04, JCR 1 区)

Abstract Image

https://doi.org/10.1021/acs.jmedchem.0c02070


[7] Fangrui Wu#, Shenyou Nie#, Yuan Yao#, Tong Huo#, Xin Li, Xiaowei Wu, Jidong Zhao, Yi-Lun Lin, Yinjie Zhang, Qiangxing Mo, Yongcheng Song*. Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth. Theranostics, 2021, 11, 8172-8184. (IF= 11.556, JCR 1 区)

Graphic abstract

https://doi.org/10.7150/thno.56737


[6] Shenyou Nie#, Jidong Zhao#, Xiaowei Wu#, Yuan Yao#, Fangrui Wu, Yi-Lun Lin, Xin Li, Alexander R. Kneubehl, Megan B. Vogt, Rebecca Rico-Hesse, and Yongcheng Song*.Synthesis, Structure-Activity Relationship and Antiviral Activity of Indole-Containing Inhibitors of Flavivirus NS2B-NS3 protease. Eur. J. Med. Chem. 2021, 225, 113767. (IF= 6.514, JCR 1 区)

https://doi.org/10.1016/j.ejmech.2021.113767


[5] Shenyou Nie, Wei Li and Biao Yu*. Total Synthesis of Nucleoside Antibiotic A201A. J. Am. Chem. Soc. 2014, 136, 4157-4160. (IF= 12.113, JCR 1 区)

Abstract Image

https://doi.org/10.1021/ja501460j


[4] Yuan Yao#, Tong Huo#, Yi-Lun Lin#, Shenyou Nie#, Fangrui Wu#, Yuanda Hua, Jingyu Wu, Alexander R. Kneubehl, Megan B. Vogt, Rebecca Rico-Hesse, Yongcheng Song*. Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease. J. Am. Chem. Soc. 2019141, 6832-6836. (IF= 14.612, JCR 1 区)

Abstract Image

https://doi.org/10.1021/jacs.9b02505


[3] Shenyou Nie, Xiaoping Chen, Yuyong Ma, Wei Li*, Biao Yu*. An unexpected rearrangement of pent-4-enofuranosides to cyclopentanones upon hydrogenolysis of the anomeric benzyl group. Carbohydr. Res. 2016, 432, 36-40. (IF= 1.817, JCR 3 区)

https://doi.org/10.1016/j.carres.2016.06.006


[2] Fangrui Wu, Yuanda Hua, Salma Kaochar, Shenyou Nie, Yi-Lun Lin, Yuan Yao, Jingyu Wu, Xiaowei Wu, Xiaoyong Fu, Rachel Schiff, Christel M. Davis, Matthew Robertson, Erik A. Ehli, Cristian Coarfa, Nicholas Mitsiades, Yongcheng Song*. Discovery, Structure− Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP. J. Med. Chem. 202063, 4716-4731. (IF= 6.205, JCR 1 区)

Abstract Image

https://doi.org/10.1021/acs.jmedchem.9b02164


[1] Arun K. Ghosh*, Anne M. Veitschegger, Shenyou Nie, Nicola Relitti, Andrew J. MacRae, and Melissa S. Jurica.Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in vitro Splicing Inhibition. J. Org. Chem. 2018, 83, 5187-5198. (IF= 4.805, JCR 2 区) 

https://doi.org/10.1021/acs.joc.8b00593