Selected Publications

Therapeutic science:

1. Lo, H. S., Hui, K. P. Y., Lai, H.-M., He, X., Khan, K. S., Kaur, S., Huang, J., Li, Z., Chan, A. K. N., Cheung, H. H.-Y., Ng, K.-C., Ho, J. C. W., Chen, Y. W., Ma, B., Cheung, P. M.-H., Shin, D., Wang, K., Lee, M.-H., Selisko, B., Eydoux, C., Guillemot, J.-C., Canard, B., Wu, K.-P., Liang, P.-H., Dikic, I., Zuo, Z., Chan, F. K. L., Hui, D. S. C., Mok, V. C. T., Wong, K.-B., Mok, C. K. P., Ko, H., Aik, W. S., Chan, M. C. W.# & Ng, W.-L.# Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir. ACS Cent Sci (2021) In press. doi: 1021/acscentsci.0c01186. First available on bioRxiv, doi: 10.1101/2020.05.26.116020. (#Corresponding authors)

2. Le, T.K., Paris, C., Khan, K.S., Robson, F., Ng, W.-L.# & Rocchi, P.# Nucleic acid-based technologies targeting coronaviruses. Trends Biochem Sci 46, 351-365 (2021). (#Corresponding authors)

*This article was selected as a cover art.

3. Robson, F., Khan, K.S., Le, T.K., Paris, C., Demirbag, S., Barfuss, P., Rocchi, P., Ng, W.-L.# Coronavirus RNA proofreading: molecular basis and therapeutic targeting. Mol Cell 79, 710-727 (2020). (#Corresponding author)

4. Li, F.*, Ng, W.-L.*, Luster, T. A., Hu, H., Sviderskiy, V.O., Dowling, C.M., Hollinshead, K.E.R., Zouitine, P., Zhang, H., Huang, Q., Ranieri, M., Wang, W., Fang, Z., Chen, T., Deng, J., Zhao, K., So, H.C., Khodadadi-Jamayran, A., Xu, M., Karatza, A., Pyon, V., Li, S., Pan, Y., Labbe, K., Almonte, C., Poirier, J.T., Miller, G., Possemato, R., Qi, J. & Wong, K.K. Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer. Cancer Res 80, 3556-3567 (2020).

*Co-first authorship; #This article was selected as a cover art.

5. Li, F., Huang, Q., Luster, T. A., Hu, H., Zhang, H., Ng, W.-L., Khodadadi-Jamayran, A., Wang, W., Chen, T., Deng, J., Ranieri, M., Fang, Z., Pyon, V., Dowling, C. M., Bagdatlioglu, E., Almonte, C., Labbe, K., Silver, H., Rabin, A. R., Jani, K., Tsirigos, A., Papagiannakopoulos, T., Hammerman, P. S., Velcheti, V., Freeman, G. J., Qi, J., Miller, G. & Wong, K.-K. In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in lung adenocarcinoma. Cancer Discov 10, 270-287 (2020).

*This article was highlighted in the spotlight, see Cancer Discov 10, 179-181 (2020).

Medicinal chemistry:

6. Ng, W.-L. & Shing, T. K. M. Synthetic and biological studies of carbasugar SGLT2 inhibitors. Syn. Org. Chem. Jpn., 1215-1222 (2018).

*This is an invited review article.

7. Ng, W.-L., Li, H. C., Lau, K. M., Chan, A. K. N., Lau, C. B. & Shing, T. K. M. Concise and stereodivergent synthesis of carbasugars reveals unexpected structure-activity relationship (SAR) of SGLT2 inhibition. Sci Rep 7, 5581 (2017).

8. Ng, W.-L., Lau, K. M., Lau, C. B. & Shing, T. K. M. Palladium-catalyzed arylation of carbasugars enables the discovery of potent and selective SGLT2 inhibitors. Angew Chem Int Ed 55, 13818-13821 (2016).

*This article was highlighted in Synfacts, 2017, 13, 17.

9. Shing, T. K. M., Ng, W.-L., Chan, J. Y. & Lau, C. B. Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors. Angew Chem Int Ed 52, 8401-8405 (2013).

*This article was highlighted in Synfacts, 2013, 9, 1147

Chemical biology:

10. Imiolek, M., Isenegger, P., Ng, W.-L., Khan, A., Gouverneur, V. & Davis, B. G. Residue-selective protein C-formylation via sequential difluoroalkylation-hydrolysis. ACS Cent Sci 7, 145-155 (2021).

11. Galan, S. R. G., Wickens, J. R., Dadova, J., Ng, W.-L., Zhang, X., Simion, R. A., Quinlan, R., Pires, E., Paton, R. S., Caddick, S., Chudasama, V. & Davis, B. G. Post-translational site-selective protein backbone alpha-deuteration. Nat Chem Biol 14, 955-963 (2018).

12. Imiolek, M., Karunanithy, G., Ng, W.-L., Baldwin, A. J., Gouverneur, V. & Davis, B. G. Selective radical trifluoromethylation of native residues in proteins. J Am Chem Soc 140, 1568-1571 (2018).

13. Wright, T. H., Bower, B. J., Chalker, J. M., Bernardes, G. J., Wiewiora, R., Ng, W.-L., Raj, R., Faulkner, S., Vallee, M. R., Phanumartwiwath, A., Coleman, O. D., Thezenas, M. L., Khan, M., Galan, S. R., Lercher, L., Schombs, M. W., Gerstberger, S., Palm-Espling, M. E., Baldwin, A. J., Kessler, B. M., Claridge, T. D., Mohammed, S. & Davis, B. G. Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity. Science 354, 597 (2016).

*This article was highlighted in C&EN News, 2016, vol. 94, issue 38, and was also featured in Science, 2016, 354, 553 & Nature Method, 2016, 13, 907

Other collaborative works:

14. Zhao, L., Li, Z., Vong, J. S. L., Chen, X., Lai, H.-M., Yan, L. Y. C., Huang, J., Sy, S. K. H., Tian, X., Huang, Y., Chan, H. Y. E., So, H.-C., Ng, W.-L., Tang, Y., Lin, W.-J., Mok, V. C. T. & Ko, H. Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain. Nat Commun 11, 4413 (2020).

15. Zhao, J., Cheng, S. W., Ng, W.-L., Zhang, Y., Shek, T. L., Ren, T., Yan, X., Li, K., Wang, J. & Zuo, Z. Identification of the in vivo relevant dissolution media for the three active components in EGb 761 tablet for better correlation with their pharmacokinetics in healthy subjects. Eur J Pharm Sci 154, 105515 (2020).

16. Lai, H. M., Ng, W.-L., Gentleman, S. M. & Wu, W. Chemical probes for visualizing intact animal and human brain tissue. Cell Chem Biol 24, 659-672 (2017).

17. Lai, H. M., Liu, A. K., Ng, W.-L., DeFelice, J., Lee, W. S., Li, H., Li, W., Ng, H. M., Chang, R. C., Lin, B., Wu, W. & Gentleman, S. M. Rationalisation and validation of an acrylamide-free procedure in three-dimensional histological imaging. PLoS One 11, e0158628 (2016).