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成果及论文

Recent publications（2016-至今；*第一作者，#通讯作者）

  1. Lyu Y*, Fu C*, Ma H*, Su Z#, Sun Z#, Zhou X# (2024). Engineering of a mammalian VMAT2 for cryo-EM analysis results in non-canonical protein folding. Nat Commun, 15:6511. PMID: 39095428.
    DOI: https://doi.org/10.1038/s41467-024-50934-5.
    -- 四川大学生物治疗国重新闻报道：    https://sklb.scu.edu.cn/detail.html?type=articlesDetail&id=101    .
  2. Fu C*, Xiao Y*, Zhou X#, Sun Z# (2024). Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor. Nat Commun, 15:5619. PMID: 38965213.
    DOI: https://doi.org/10.1038/s41467-024-49894-7.
    --《科研留声机》论文解读：https://mp.weixin.qq.com/s/btLAeY3D1tARszkIqKAGrg.
    --《逻辑神经科学》学术新闻报道：https://mp.weixin.qq.com/s/cCyh9sCJcZG-xex1vqrLJQ.
    --《岚翰生命科学》论文解读：https://mp.weixin.qq.com/s/5i57LVo473ONA7OqCjTIbQ.
    --《BioMed科技》学术新闻报道：https://mp.weixin.qq.com/s/MN2RqHt-64Wu5--Sit0G2Q.
  3. Yang L, Ren M, Wang J, He L, Wu S, Yang S, Zhao W, Cheng H, Zhou X, Gou M (2024). A non-viral gene therapy for melanoma by staphylococcal enterotoxin A. Chin Chem Lett, 35:108822.
    DOI: https://doi.org/10.1016/j.cclet.2023.108822.
  4. Zhang S*, Xie Q*, Fu C*, Luo Y, Sun Z#, Zhou X# (2023). Crystal structure of a mammalian CMTM6 and its interaction model with PD-L1. bioRxiv, 2023.01.03.522599. (Preprint)
    DOI: https://doi.org/10.1101/2023.01.03.522599.
  5. Weng J*, Zhou X*, Wiriyasermkul P*, Ren Z, Chen K, Iturbe EG, Zhou M#, Quick M# (2023). Insight into the mechanism of H+-coupled nucleobase transport. Proc Natl Acad Sci USA, 120:e2302799120. PMID: 37549264.
    DOI: https://doi.org/10.1073/pnas.2302799120.
    Preprint (bioRxiv) DOI: https://doi.org/10.1101/2021.12.20.473561.
  6. Wang X, Yang Y, Sun Z#, Zhou X# (2023). Crystal structure of the membrane (M) protein from a bat betacoronavirus. PNAS Nexus, 2:pgad021. PMID: 36874273.
    DOI: https://doi.org/10.1093/pnasnexus/pgad021.
    Preprint (bioRxiv) DOI: https://doi.org/10.1101/2022.06.28.497981.
  7. Zhang S*, Fu C*, Luo Y*, Xie Q*, Xu T, Sun Z#, Su Z#, Zhou X# (2023). Cryo-EM structure of a eukaryotic zinc transporter at a low pH suggests its Zn2+-releasing mechanism. J Struct Biol, 215:107926. PMID: 36464198.
    DOI: https://doi.org/10.1016/j.jsb.2022.107926.
    Priprint (bioRxiv) DOI:     https://doi.org/10.1101/2022.06.29.497979.
  8. Meng F*, Xiao Y*, Ji Y, Sun Z#, Zhou X# (2022). An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway. Nat Commun, 13:1267. PMID: 35273182.
    DOI: https://doi.org/10.1038/s41467-022-28946-w.
    -- 四川大学新闻报道：https://www.scu.edu.cn/info/1207/21282.htm.
    -- 华西医院新闻报道：http://www.wchscu.cn/academic/63065.html.
    -- X-MOL资讯报道：https://www.x-mol.com/news/755069.
    --《今日论文》论文解读：https://mp.weixin.qq.com/s/WrlpzgqeGzLBTX3oyEn0aQ.
    --《岚翰生命科学》论文解读：https://mp.weixin.qq.com/s/iQeZmYvG96J39zN32wDExQ.
    -- 北京生物结构前沿研究中心Journal Club：https://mp.weixin.qq.com/s/cLKsQl4Yu_adiktQOiZsUg.
  9. Fan J*, Xiao Y*, Quick M*, Yang Y, Sun Z#, Javitch JA#, Zhou X# (2021). Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J Biol Chem, 296:100609. PMID: 33811858.
    DOI: https://doi.org/10.1016/j.jbc.2021.100609.
  10. Wang X*, Lyu Y*, Ji Y, Sun Z#, Zhou X# (2021). An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter. Acta Cryst D, D77:108-116. PMID: 33404530.
    DOI: https://doi.org/10.1107/S205979832001517X.
    -- I3DC论文解读: http://proteopedia.org/w/Journal:Acta_Cryst_D:S205979832001517X.
  11. Wang X*, Lyu Y*, Ji Y, Sun Z#, Zhou X# (2021). The substrate binding in the bile acid transporter ASBTYf of Yersinia frederiksenii. Acta Cryst D, D77:117-125. PMID: 33404531.
    DOI: https://doi.org/10.1107/S2059798320015004.
    -- I3DC论文解读: http://proteopedia.org/w/Journal:Acta_Cryst_D:S2059798320015004.
  12. Zhu Y, Mészáros J, Walle R, Fan R, Sun Z, Dwork AJ, Trifilieff P, Javitch JA (2020). Detecting GPCR Complexes in Postmortem Human Brain with Proximity Ligation Assay and A Bayesian Classifier. Biotechniques, 68:122-129. PMID: 31859535.
    DOI: https://doi.org/10.2144/btn-2019-0083.
  13. Mukai J, Cannavo E, Crabtree GW, Sun Z, Diamantopoulou A, Thakur P, Chang CY, Cai Y, Lomvardas S, Takata A, Xu B, Gogos JA (2019). Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice. Neuron, 104:1-17. PMID: 31606247.
    DOI: https://doi.org/10.1016/j.neuron.2019.09.014.
  14. Sun Z#, Williams DJ, Xu B, Gogos JA# (2018). Altered function and maturation of primary cortical neurons from a 22q11.2 deletion mouse model of schizophrenia. Transl Psychiatry, 8:85. PMID: 29666363.
    DOI: https://doi.org/10.1038/s41398-018-0132-8.
  15. Fan J*, Wang X*, Sun Z#, Zhou X# (2018). Membrane Asymmetry and Phospholipid Translocases in Eukaryotic Cells, in Advances in Membrane Proteins (eds Y. Cao), Springer Nature, Singapore.
    DOI: https://doi.org/10.1007/978-981-13-0532-0_3.
  16. Crabtree GW*, Sun Z*, Kvajo M*, Broek J, Fenelon K, McKellar H, Xiao L, Xu B, Bahn S, O'Donnell JM, Gogos JA# (2017). Alteration of neuronal excitability and short-term synaptic plasticity in the prefrontal cortex of a mouse model of mental illness. J Neurosci, 37:4158-4180. PMID: 28283561.
    DOI: https://doi.org/10.1523/JNEUROSCI.4345-15.2017.
  17. Diamantopoulou A, Sun Z, Mukai J, Xu B, Felenon K, Karayiorgou M, Gogos JA (2017). Loss-of-function mutation in Mirta22/Emc10 rescues specific schizophrenia-related phenotypes in a mouse model of the 22q11.2 deletion. Proc Natl Acad Sci USA, 114:E6127-E6136. PMID:28696314.
    DOI: https://doi.org/10.1073/pnas.1615719114.
  18. Qi Y, Zhang XJ, Renier N, Wu Z, Atkin T, Sun Z, Ozair MZ, Tchieu J, Zimmer B, Fattahi F, Ganat Y, Azevedo R, Zeltner N, Brivanlou AH, Karayiorgou M, Gogos JA, Tomishima M, Tessier-Lavigne M, Shi SH, Studer L (2017). Combined small-molecule inhibition accelerates the derivation of functional, early-born, cortical neurons from human pluripotent stem cells. Nat Biotechnol, 35:154-163. PMID:28112759.
    DOI: https://doi.org/10.1038/nbt.3777.

Prior publications（2003-2015；*第一作者，#通讯作者）

  1. Zhou X*, Levin EJ*, Pan Y, Sharma R, Kloss B, Bruni R, Quick M#, Zhou M# (2014). Structural basis of the alternating-access mechanism in a bile acid transporter. Nature, 505:569-573. PMID: 24317697.
    DOI: https://doi.org/10.1038/nature12811.
  2. Zhou X*, Sebastian TT*, Graham TR# (2013). Auto-inhibition of Drs2p, a yeast phospholipid flippase, by its carboxyl-terminal tail. J Biol Chem, 288:31807-31815. PMID: 24045945.
    DOI: https://doi.org/10.1074/jbc.M113.481986.
  3. Sun Z, Risner ML, van Asselt JB, Zhang DQ, Kamermans M, McMahon DG# (2012). Physiological and molecular characterization of connexin hemichannels in zebrafish retinal horizontal cells. J Neurophysiol, 107:2624-2632. PMID:22357795.
    DOI: https://doi.org/10.1152/jn.01126.2011.
  4. Zhou X, Natarajan P, Muthusamy BP, Graham TR#, Liu K (2011). Coupling Drs2p to phospholipid translocation, membrane asymmetry, and vesicle budding, in Transmembrane Dynamics of Lipids (eds P. F. Devaux and A. Herrmann), John Wiley & Sons, Inc., Hoboken, NJ, USA.
    DOI: https://doi.org/10.1002/9781118120118.ch9.
  5. Klaassen LJ, Sun Z, Steijaert MN, Bolte P, Fahrenfort I, Sjoerdsma T, Klooster J, ClaassenY, Shields CR, Ten Eikelder HM, Janssen-Bienhold U, Zoidl G, McMahon DG, KamermansM (2011). Synaptic transmission from horizontal cells to cones is impaired by loss of connexin hemichannels. PLoS Biol, 9:e1001107. PMID: 21811399.
    DOI: https://doi.org/10.1371/journal.pbio.1001107.
  6. Zhou X, Graham TR# (2009). Reconstitution of phospholipid translocase activity with purified Drs2p, a type-IV P-type ATPase from budding yeast. Proc Natl Acad Sci USA, 106:16586-16591. PMID: 19805341.
    DOI: https://doi.org/10.1073/pnas.0904293106.
  7. Sun Z, Zhang DQ, McMahon DG# (2009). Zinc modulation of hemi-gap-junction channel currents in retinal horizontal cells. J Neurophysiol, 101:1774-1780. PMID: 19176613.
    DOI: https://doi.org/10.1152/jn.90581.2008.
  8. Muthusamy BP, Natarajan P, Zhou X, Graham TR (2009). Linking phospholipid flippases to vesicle-mediated protein transport. Biochim Biophys Acta, 1791:612-619. PMID: 19286470.
    DOI: https://doi.org/10.1016/j.bbalip.2009.03.004.
  9. Zhang DQ, Sun Z, McMahon DG (2006). Modulation of A-type potassium currents in retinal horizontal cells by extracellular calcium and zinc. Vis Neurosci, 23:825-832. PMID: 17020637.
    DOI: https://doi.org/10.1017/S0952523806239993.
  10. Zhou H, Sun Z, Hoshi T, Kashiwagi Y, Anzai J, Li G (2005). Electrochemical studies of danthron and the DNA-danthron interaction. Biophys Chem, 114:21-26. PMID: 15792857.
    DOI: https://doi.org/10.1016/j.bpc.2004.11.001.
  11. Liu X, Shang L, Sun Z, Li G (2005). Direct electrochemistry of hemoglobin in dimethyldioctadecyl ammonium bromide film and its electrocatalysis to nitric oxide. J Biochem Biophys Methods, 62:143-151. PMID: 15680284.
    DOI: https://doi.org/10.1016/j.jbbm.2004.10.005.
  12. Sun Z, Zheng X, Hoshi T, Kashiwagi Y, Anzai J, Li G# (2004). The electrochemistry and determination of Ligustrazine hydrochloride. Anal Bioanal Chem, 380:545-550. PMID: 15322795.
    DOI: https://doi.org/10.1007/s00216-004-2782-z.
  13. Sun Z, Ma Z, Zhang W, Wang X, Fan C, Li G# (2004). Electrochemical investigations of baicalin and DNA-Baicalin interactions. Anal Bioanal Chem, 379:283-286. PMID: 14991219.
    DOI: https://doi.org/10.1007/s00216-004-2542-0.
  14. Sun Z, Liu L, Zheng X, Fan C, Wang Q, Li G# (2004). An easy and rapid method to determine aristolochic acid I and II with high sensitivity. Anal Bioanal Chem, 378:388-390. PMID: 13680054.
    DOI: https://doi.org/10.1007/s00216-003-2209-2.
  15. Shang L, Sun Z, Wang X, Li G (2003). Enhanced peroxidase activity of hemoglobin in a DNA membrane and its application to an unmediated hydrogen peroxide biosensor. Anal Sci, 19:1537-1539. PMID: 14640454.
    DOI: https://doi.org/10.2116/analsci.19.1537.