Dr. Lyu’s Group has been mostly focusing on the method innovations and translational applications of functional metabolomics in the interdisciplinary sciences of life and health. The academic achievements of the candidate can be summarized as the follows: 1) definition and development of novel methods and strategies of functional metabolomics, such as precision-modification metabolomics and spatial temporal operative real metabolomics (STORM). 2) elucidation of the new regulatory-mechanism of siderophore biosynthesis on the virulence formation of pathogenic Escherichia coli; 3) clarification of novel mechanism of biofilm formation in pathogenic Escherichia coli at a functional-metabolism level, conserving novel strategy to tangle all the harmful impact of biofilms by targeting functional metabolites, which are extremely threaten-microorganisms mostly accounted for high-frequency drug resistance, air pollution and food contamination. 4) identification of novel metabolite biomarkers that can facilitate the diagnosis and metastasis monitoring of pancreatic cancer, as well as characterization of novel metabolic targets for disease therapy. Currently, Dr. Lyu’s Group further studies the novel methods of next-generation functional metabolomics (STORM+) aiming at promoting the interdisciplinary applications of life and health sciences by the discovery of poly-functional metabolites.
Secured Research Grants (PI)
16) Project title: Development of novel strategy for life-omics innovations
Grant Number: SHM-C 2023-12-01C
Funding Body: Shenzhen Science and Technology Commission (Shenzhen, China)
Expected Period: 2024-2026
Total Funding: US $ 500,000.00
Role: Chief Investigator (Dr. Haitao Lu)
15) Project title: Development of novel strategy for life-omics innovations
Grant Number: SKL-GRF 2024-01
Funding Body: State Key Lab of Environmental and Biological Analysis (Hong Kong, China)
Expected Period: 2024-2026
Total Funding: US $ 150,000.00
Role: Chief Investigator (Dr. Haitao Lu)
14) Project title: Development of novel strategy for life-omics innovations
Grant Number: NSLDO-2024-0105
Funding Body: National Laboratory of Diseases and Omics (Shanghai, China)
Expected Period: 2023-2026
Total Funding: US $ 80,000.00
Role: Chief Investigator (Dr. Haitao Lu)
13) Project title: STORM strategy innovated molecular diagnosis and therapeutic targets of
pancreatic cancer
Grant Number: NRCTM(SH)-2021-07
Funding Body: National Research Center for Translational Medicine (Shanghai, China)
Expected Period: 2022-2025
Total Funding: US $ 65,000.00
Role: Chief Investigator (Dr. Haitao Lu)
12) Project title: Investigating the mechanism of siderophore biosynthesis regulating
biofilm formation in Escherichia coli
Grant Number: 21ZR1431600
Funding Body: Shanghai Natural Science Foundation of China
Expected Period: 2021-2024
Total Funding: US $ 40,000.00
Role: Chief Investigator (Dr. Haitao Lu)
11) Project title: STORM strategy innovated therapeutic discovery of pancreatic cancer
Grant Number: 2021-2-4620
Funding Body: Agilent-Applications and Core Technology-University Research Fund
Expected Period: 2021-2022
Total Funding: US $ 35,000.00
Role: Chief Investigator (Dr. Haitao Lu)
10) Project title: Metabolic Phenotyping and Metabolically Modulatory Mechanisms of
Multiple-Organs Metastasis of Pancreatic Cancer
Grant Number: 2017YFC1038
Funding Body: National Key Projects for Research and Innovation of China
Expected Period: 2017-2021
Total Funding: US $ 600,000.00
Role: Chief Investigator (Dr. Haitao Lu)
9) Project title: Pathogenic Escherichia coli guided the discovery and characterization of
novel functional-secondary compounds
Grant Number: 31670031
Funding Body: National Natural Science Foundation of China
Expected Period: 2017-2020
Total Funding: US $ 120,000.00
Role: Chief Investigator (Dr. Haitao Lu)
8) Project title: Development and Applications of Precision-Modification Metabolomics
Grant Number: WF220441502
Funding Body: The Professorship Startup Grant provided by SJTU
Expected Period: 2016-2019
Total Funding: US $ 200,000.00
Role: Chief Investigator (Dr. Haitao Lu)
7) Project title: Discovery and functional characterization of novel siderophores
Grant Number: 106112015CDJZR468808
Funding Body: The Fundamental Research Funds for Then Central Universities Key Grant
Expected Period: 2015-2017
Total Funding: US $ 80,000.00
Role: Chief Investigator (Dr. Haitao Lu)
6) Project title: Metabolomics driven translational research of TCM, Panax Ginseng
against Type 2 Diabetes
Grant Number: CQDXWL-2014-Z002
Funding Body: The Fundamental Research Funds for The Central Universities
Expected Period: 2014-2017
Total Funding: US $ 60,000.00
Role: Chief Investigator (Dr. Haitao Lu)
5) Project title: Metabolomics identifies functional small molecules of Panax Ginseng
against Type 2 Diabetes
Grant Number: CSTC2014JCYIA10109
Funding Body: Natural Science Foundation of Chongqing in China
Expected Period: 2014-2017
Total Funding: US $ 10,000.00
Role: Chief Investigator (Dr. Haitao Lu)
4) Project title: Professional visit as an effort to build collaboration between QUT and
Chongqing University in China
Grant Number: ECARD/VCRF2013-2013
Funding Body: QUT ECARD/VCRF Travel Fellowship
Expected Period: 2013-2014
Total Funding: AU $ 7 K
Role: Chief Investigator (Dr. Haitao Lu)
3) Project title: Identification of key metabolite biomarkers and associated metabolic
pathways for monitoring musculoskeletal injury
Grant Number: 150410-0070/08
Funding Body: QUT Vice Chancellor Research Fellowship
Expected Period: 2013-2014
Total Funding: US $ 250,000.00
Role: Principal Investigator (Dr. Haitao Lu)
2) Project title: Metabolomics identifies bioactive components and associated therapeutic
mechanisms of Pyrrosla lingua (Thunb) at a metabolic level.
Grant Number: 81274175
Funding Body: National Natural Science Foundation of China
Expected Period: 2013-2016
Total Funding: US $ 150,000.00
Role: Chief Investigator (Dr. Haitao Lu)
1) Project title: Development of Integrated Omics Platform and its application to
translational research of the complex diseases
Grant Number: 0236011104401
Funding Body: Chongqing University “Young-100 Talents” Professorship Foundation
Expected Period: 2013-2016
Total Funding: US $ 300,000.00
Role: Principal Investigator (Dr. Haitao Lu)