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成果及论文

一、承担课题:

2020/01—2022/12   江西省双千计划科技创新高端人才青年类项目

100万元,在研,主持

2018/01—2021/12   PAQR7在精子响应孕酮能力下降的男性不育症中的作用机制

国家自然科学基金面上项目,批准号:81771644,获批经费:55万元,主持,在研。

2017/01—2019/12   CatSper相互作用膜蛋白与人精子功能调控

江西省自然科学基金青年重点项目,批准号:20171ACB2100620万,主持,结题。

2016/09—2018/08   利用CatSper电流缺失病例研究人精子中CatSper功能

5国家人口和计划生育委员会计划生育药具重点实验室开放课题,批准号:2016KF077.5万元,主持,结题。

2016/07—2020/12   避孕节育及兼有治疗作用的新药具研发

科技部国家重点研发计划中生殖健康及重大出生缺陷防控研究专项,批准号:2016YFC100090510万,任务负责人,在研。

2016/01—2018/12   己烯雌酚抑制人成熟精子功能的胞内信号机制

江西省自然科学基金面上项目,批准号:20161BAB2041675万,主持,结题。

2015/10—2020/10   南昌大学“215人才工程赣江青年学者奖励计划

10万元,主持,在研。

2015/01—2019/12   LncRNA及互作复合体在男性不育中的作用

科技部重大科学研究计划(973课题),参与,结题。

2015/01—2018/12   利用跨种“囊胚补充”技术在小鼠与大鼠或猴嵌合体动物种生成跨物种异源卵巢的实验研究

国家自然科学基金,批准号:31460307,参与,结题。

2015/01—2017/12   弱精症相关hPAQR7受体在人成熟精子孕酮信号转导中的作用机制

国家自然科学基金青年科学基金项目,批准号:31400996,获批经费:25 万,主持,结题。

2014/01—2016/12   hPAQR7蛋白在人精子孕酮非基因组效应中的功能研究

江西省青年科学基金计划,批准号:20142BAB215050,获批经费:5 万,主持,结题。

2013/01—2017/12   精子功能调控的膜蛋白机制研究

国家自然科学基金重点项目,批准号:31230034,参与,结题。

2013/01—2015/12   苦参碱对小鼠精子抑制作用的机制研究

江西省教育厅青年科学基金项目,批准号:GJJ13021,获批经费:1 万,主持,结题。

2011/01—2013/12   活性氧分子调节Slo3通道和精子钾电流的生物物理机制研究

国家自然科学基金面上项目,批准号:31070767,参与,结题。


二、学术期刊任职

2019/01—至今      学术任职

担任国家自然科学基金委同行评议专家、江西省科技专家库专家、湖南省科技专家库专家、山西省科技专家库专家、妇幼健康研究会安全避孕专业委员会委员、中国药理学会生殖药理专业委员会委员、中华医学会计划生育学分会交叉前沿学组委员、中国细胞生物学学会会员、中国生理学学会会员、中国药理学会会员和中国神经科学学会会员。

2019/01—至今      期刊任职

担任《Frontiers in Physiology》、《Theriogenology》、《Andrologia》、《Reproduction in Domestic Animals》、《Current Pharmaceutical Design》、《Systems Biology in Reproductive Medicine》、《Molecular Biology Reports》等SCI期刊特约审稿人。


三、奖励/专利

2019/05   第十六届挑战杯南昌大学大学生课外学术科技作品竞赛一等奖,指导教师

2018/08   19罗恩国际研究奖(Royan International Research Award)提名奖

2017/11   2017年硕士研究生国家一等奖学金,指导教师

2017/04   海智惠赣鄱第二届江西国际合作教育与科研大讲堂活动本科生科研论文演讲比赛二等奖,指导教师

2015/12   2015 年硕士研究生国家一等奖学金,指导教师

2015/04   第十四届挑战杯南昌大学大学生课外学术科技作品竞赛一等奖,指导教师

2016/06   曾旭辉, 郑莉萍, 罗韬等. 中国发明专利用于制备LRRC52多克隆抗体的免疫原”. 专利申请日: 2014/06/27. 专利号: ZL201410295554.9,已授权

2019/06   罗韬,曾旭辉,陈厚仰等. 中国发明专利用于制备mPRa单克隆抗体的免疫原”. 专利申请日: 2019/06/24. 专利号: 201910552308.X

2019/06   陈厚仰,汤育新,曾旭辉,罗韬,孙捷,王共先. 中国发明专利一种用于诊断弱精子症的生物标记物”.专利申请日:2019/06/22. 专利号:201910546487.6

2019/06   陈厚仰,曾旭辉,汤育新,罗韬,孙捷,王共先. 中国发明专利“TAT-TDRG1制备成治疗弱精子症药物中的应用”.专利申请日:2019/06/22. 专利号:201910546587.9.


四、期刊论文(原文请见https://www.researchgate.net/profile/Tao_Luo25/research)

1.             Cheng Y-M, Peng Z, Chen H-Y, Pan T-T, Hu X-N, Wang F, Luo T*. (2020) Posttranslational lysine 2-hydroxyisobutyrylation of human sperm tail proteins affects motility. Hum Reprod https://doi:10.1093/humrep/dez296.

2.             Sun X-Y, Chen W-Q, Weng S-Q, Pan T-T, Hu X-N, Wang F, Xia T-X-Y, Chen H-Y, Luo T*. (2020) Effects of the environmental endocrine disruptors di-2-ethylhexyl phthalate and mono-2-ethylhexyl phthalate on human sperm function in vitro. Reprod Fertil Dev https://doi.org/10.1071/RD19164.

3.             Yang Y, Chen H-Y, Weng S-Q, Pan T-T, Chen W-Q, Wang F, Luo T*, Tang Y-X*. (2020) In vitro exposure to metformin activates human spermatozoa at therapeutically relevant concentrations. Andrology 00, 1–8. https://doi.org/10.1111/andr.12755.

4.             Luo T, Wang F, Weng S-Q, Chen H-Y, Kang H, Wang J, Luo S*. (2020) Anethole compromises human sperm function by affecting the sperm intracellular calcium concentration and tyrosine phosphorylation. Reprod Toxicol 93, 99-105.

5.             Cheng Y-M, Hu X-N, Peng Z, Pan T-T, Wang F, Chen H-Y, Chen W-Q, Zhang Y, Zeng X-H & Luo T. (2019) Lysine glutarylation in human sperm is associated with progressive motility. Hum Reprod 34(7), 1186-1194.

6.             Luo T, Chen H-Y, Zou Q-X, Wang T, Cheng Y-M, Wang H-F, Wang F, Jin Z-L, Chen Y, Weng S-Q & Zeng X-H. (2019) A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters. Hum Reprod 34(3), 414-423.

7.             Xie F, Chen X, Weng S, Xia T, Sun X, Luo T & Li P. (2019) Effects of two environmental endocrine disruptors di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) on human sperm functions in vitro. Reprod Toxicol 83, 1-7.

8.             Yuan Y, Ding X, Cheng Y, Kang H, Luo T, Zhang X, Kuang H, Chen Y, Zeng X & Zhang D. (2019) PFOA evokes extracellular Ca2+ influx and compromises progesterone-induced response in human sperm. Chemosphere 241, 125074.

9.             Chen H, Luo T, Chen T & Wang G. (2018) Seminal bacterial composition in patients with obstructive and non-obstructive azoospermia. Exp Ther Med 15, 2884-2890.

10.          Chen W, Weng S-Q, Lv M-G, Chen W-Q, Bi Z-F, Chen H-Y, Luo T, Hu H & Liao W-B. (2018) β-Elemene Inhibits Human Sperm Function by Affecting Sperm Vitality and Intracellular Calcium. Cell Physiol Biochem 51, 2019-2029.

11.           Luo S, Luo T, Liu Y, Li Z, Fan S & Wu C. (2018) N-terminus plus linker domain of Mg-chelatase D subunit is essential for Mg-chelatase activity in Oryza sativa. Biochem Biophys Res Commun 497, 749-755.

12.          Lv M-G, Chen W-Q, Weng S-Q, Chen H-Y, Cheng Y-M & Luo T. (2018) Rosmarinic acid compromises human sperm functions by an intracellular Ca2+ concentration-related mechanism. Reprod Toxicol 81, 58-63.

13.          Wang H-F, Chang M, Peng T-T, Yang Y, Li N, Luo T, Cheng Y-M, Zhou M-Z, Zeng X-H & Zheng L-P. (2017) Exposure to Cadmium Impairs Sperm Functions by Reducing CatSper in Mice. Cell Physiol Biochem 42, 44-54.

14.          Zou Q-X, Peng Z, Zhao Q, Chen H-Y, Cheng Y-M, Liu Q, He Y-Q, Weng S-Q, Wang H-F, Wang T, Zheng L-P & Luo T. (2017) Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa. Hum Reprod 32(2), 290-298.

15.          He Y, Zou Q, Chen H, Weng S, Luo T & Zeng X. (2016) Lead Inhibits Human Sperm Functions by Reducing the Levels of Intracellular Calcium, cAMP, and Tyrosine Phosphorylation. Tohoku J Exp Med 238, 295-303.

16.          He Y, Zou Q, Li B, Chen H, Du X, Weng S, Luo T & Zeng X. (2016) Ketamine inhibits human sperm function by Ca(2+)-related mechanism. Biochem Biophys Res Commun 478, 501-506.

17.          Li Z, Zhang D, He Y, Ding Z, Mao F, Luo T & Zhang X. (2016) Lipopolysaccharide Compromises Human Sperm Function by Reducing Intracellular cAMP. Tohoku J Exp Med 238, 105-112.

18.          Luo S, Luo T, Peng P, Li Y & Li X. (2016) Disturbance of chlorophyll biosynthesis at Mg branch affects the chloroplast ROS homeostasis and Ca2+ signaling in Pisum sativum. Plant Cell, Tissue and Organ Culture (PCTOC) 127, 729-737.

19.          Luo T, Zou Q-X, He Y-Q, Wang H-F, Wang T, Liu M, Chen Y & Wang B. (2016) Matrine compromises mouse sperm functions by a [Ca(2+)]i-related mechanism. Reprod Toxicol 60, 69-75.

20.          Tan Z, Zhou J, Chen H, Zou Q, Weng S, Luo T & Tang Y. (2016) Toxic effects of 2,4-dichlorophenoxyacetic acid on human sperm function in vitro. J Toxicol Sci 41, 543-549.

21.          Wang H-F, Liu M, Li N, Luo T, Zheng L-P & Zeng X-H. (2016) Bisphenol A Impairs Mature Sperm Functions by a CatSper-Relevant Mechanism. Toxicol Sci 152, 145-154.

22.          Luo T, Li N, He Y-q, Weng S-q, Wang T, Zou Q-x & Zeng X-h. (2015) Emodin inhibits human sperm functions by reducing sperm [Ca(2+)]i and tyrosine phosphorylation. Reprod Toxicol 51, 14-21.

23.          Luo T, Zou Q-x, He Y-q, Wang H-f, Li N & Zeng X-h. (2015) Matrine inhibits mouse sperm function by reducing sperm [Ca2+]i and phospho-ERK1/2. Cell Physiol Biochem 35, 374-385.

24.          Xiang C, Li J, Hu L, Huang J, Luo T, Zhong Z, Zheng Y & Zheng L. (2015) Hippo signaling pathway reveals a spatio-temporal correlation with the size of primordial follicle pool in mice. Cell Physiol Biochem 35, 957-968.

25.          Luo T, Luo S, Araújo WL, Schlicke H, Rothbart M, Yu J, Fan T, Fernie AR, Grimm B & Luo M. (2013) Virus-induced gene silencing of pea CHLI and CHLD affects tetrapyrrole biosynthesis, chloroplast development and the primary metabolic network. Plant Physiol Biochem 65, 17-26.

26.          Ouyang J-X, Luo T, Sun H-Y, Huang J, Tang D-F, Wu L, Zheng Y-H & Zheng L-P. (2013) RNA interference mediated pten knock-down inhibit the formation of polycystic ovary. Mol Cell Biochem 380, 195-202.

27.          Xu J, Xiong W, Cao B, Yan T, Luo T, Fan T & Luo M. (2013) Molecular characterization and functional analysis of "fruit-weight 2.2-like" gene family in rice. Planta 238, 643-655.

28.          Luo T, Fan T, Liu Y, Rothbart M, Yu J, Zhou S, Grimm B & Luo M. (2012) Thioredoxin redox regulates ATPase activity of magnesium chelatase CHLI subunit and modulates redox-mediated signaling in tetrapyrrole biosynthesis and homeostasis of reactive oxygen species in pea plants. Plant Physiol 159, 118-130.

29.    Huang X-S, Luo T, Fu X-Z, Fan Q-J & Liu J-H. (2011) Cloning and molecular characterization of a mitogen-activated protein kinase gene from Poncirus trifoliata whose ectopic expression confers dehydration/drought tolerance in transgenic tobacco. J Exp Bot 62, 5191-5206.