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Congratulations on the publication in Trends in Cancer, about p53 regulation and implications in cancer immunotherapy!
发布时间:2020-11-27



Highlights (https://www.sciencedirect.com/science/article/abs/pii/S240580332030279X)

The tumor-suppressor protein p53 plays a crucial role in cell fate decision-making. Mild and short-term DNA damage leads to p53 activation of pro-survival mechanisms, allowing the cells to repair and recover from the damage. Intensive and prolonged DNA damage triggers p53-dependent cell death to avoid the accumulation of genomic mutations.

The life and death decision-making by p53 is influenced by multiple mechanisms, including p53 post-translational modification, different binding affinities for p53 response elements, p53 threshold levels and dynamic patterns, and p53 regulation of miRNAs.

Wild-type p53 enhances antitumor immunity by sensitizing cells to immunogenic cell death, whereas mutant p53 increases mutational burden and promotes neoantigenesis.

p53-dependent anticancer immunity represents a promising direction for the development of cancer therapeutic strategies.

                  p53 Fine-Tunes Immune Homeostasis. p53, either wild type or mutants, enhance anti-cancer immunotherapy by increasing neoantigens.