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成果及论文

ŸLiu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ,* Filippov DV.* A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins. Angew Chem Int Ed Engl 2018, 130, 1675. 

ŸLiu Q, Knobloch G, Voorneveld J, Meeuwenoord NJ, Overkleeft HS, van der Marel GA, Andreas G. Ladurner AG,* Filippov DV.* Chemical Synthesis of Linear ADP-ribose Oligomers up to Pentamer and their Binding to the Oncogenic Helicase ALC1. Chem. Sci. 2021 

ŸKliza KW#, Liu Q#, Roosenboom LWM, Jansen PWTC, Filippov DV,* Vermeulen M.* Reading ADP-ribosylation signalling using chemical biology and interaction proteomics. Mol. Cell 2021 

ŸRack JGM#, Liu Q#, Zorzini V, Voorneveld J, Ariza A, Honarmand Ebrahimi K, Reber JM, Krassnig SC, Ahel D, van der Marel GA, Mangerich A, McCullagh JSO, Filippov DV,* Ahel I.* Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal. Nat Commun 2021,12,4581 

ŸLiu Q, Florea BI, Filippov DV.* ADP-Ribosylation Goes Normal: Serine as the Major Site of the Modification. Cell Chem Biol 2017, 24, 431 

ŸLiu Q, Kistemaker HAV, Overkleeft HS, van der Marel GA, Filippov DV.* Synthesis of ribosyl-ribosyl-adenosine-5 ',5 '',5'''(triphosphate)-the naturally occurring branched fragment of poly(ADP ribose). Chem. Commun. 2017, 53, 10255 

§Liu Q#, Qiang X#, Li Y, Sang Z, Li Y, Tan Z, Deng Y. Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer’s disease. Bioorg. Med. Chem. 2015

§Liu Q, van der Marel GA, Filippov DV. Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose. Org Biomol Chem 2019

§Voorneveld J, Rack JGM, van Gijlswijk L, Meeuwenoord NJ, Liu Q, Overkleeft HS, van der Marel GA, Ahel I, Filippov DV. Molecular Tools for the Study of ADP-Ribosylation: A Unified and Versatile Method to Synthesise Native Mono-ADP-Ribosylated Peptides. Chem. Eur. J. 2021 

§Qiang XM, Sang ZP, Yuan W, Li Y, Liu Q, Bai P, Shi YK, Tan ZH, Deng Y. Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease. Eur. J. Med. Chem. 2014

§Sang Z., Qiang X., Li Y., Yuan W., Liu Q., Shi Y., Ang W., Luo Y., Tan Z., Deng Y. Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease. Eur. J. Med. Chem. 2015 

§Sang Z., Li Y., Qiang X., Xiao G., Liu Q., Tan Z., Deng Y. Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease. Bioorg. Med. Chem. 2015