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成果及论文

发表文章:

2022


59. Y. Yang, H. Wang, Z. Sun, X. Li, F. Sun, Q. Liu, L. Zhang,* L. Xu*, and H. Liu*. Palladium-Catalyzed Regiodivergent Arylamination/Aryloxygenation of Allenamide.Org. Chem. Front.2022, accepted. https://doi.org/10.1039/D2QO01271E

58.Yunxia Liu,† Xin Li,† Qing Liu, Xinjin Li, and Hui Liu*.Electromagnetic Mill PromotedMechanochemical Solvent-Free Palladium-Catalyzed Borylation of Aryl Bromides, Org. Lett.2022, accepted. https://doi.org/10.1021/acs.orglett.2c02600


57. X. Li, Y. Liu, L. Zhang, Y. Dong, Q. Liu, D. Zhang, L. Chen, Z. Zhao and H. Liu*. A Novel Electromagnetic Mill Promoted Mechanochemical Solid-State Suzuki–Miyaura Cross-Coupling Reactions Using Ultra-Low Catalyst Loading. Green Chem., 2022, 24, 6026. DOI: https://doi.org/10.1039/D2GC01427K

          


56. X. Dong, X. Sun, Y. Yang, W. Liu, B. Zheng, X. Li, D. Zhang, F. Wang and H. Liu*. Pd/Et3N·HI-Catalyzed Intramolecular C−H Alkylation to Access [a]‑Annulated Indoles via Highly Regioselective Ring-Opening of Epoxides. J. Org. Chem. 2022, , 87, 12, 7995-8004.

            




55. X. Chi,. T. Xia,. Y. Yang,. T. Cao,. D. Zhang* and H. Liu*. Highly diastereoselective synthesis of an octahydro-1H-cyclpenta[c]pyridine skeleton via a Pd/Au-relay catalyzed reaction of (Z)-1-iodo-1,6-diene and alkyne. Org. Chem. Front., 2022, 9, 3186-3191.

             


54. L. Liang, L. Zhang*, Y. Peng*, H. Liu*. Transition-Metal Catalyzed Coupling Reactions of gem-Dibro-moviny Derivatives. Chin. J. Org. Chem. 2022, 42, 10.6023/cjoc202110026.



2021

53. X. Du, H. Zhao, X. Li, L. Zhang, Y. Dong, P. Wang, D. Zhang, Q. Liu, and H. Liu*. Ligand-Regulated Palladium-Catalyzed Regiodivergent Hydroarylation of the Distal Double Bond of Allenamides with Aryl Boronic Acid. J. Org. Chem. 2021, 86, 19, 13276.

                    


52. X. Dong, L.-P. Xu, Y. Yang, Y. Liu, X. Li, Q. Liu, L. Zheng, F. Wang and H. Liu*. A palladium/Et3N·HI-catalyzed highly selective 7-endo alkyl-Heck-type reaction of epoxides and a DFT study on the mechanism. Org. Chem. Front., 2021, 8, 6009-6018. WOS:000693959500001.

       


51. A. Khallaf, P. Wang,* S. Zhuo, H. Zhu, H. Liu*. Synthesis, insecticidal activities, and structure–activity relationships of 1,3,4-oxadiazole-ring-containing pyridylpyrazole-4-carboxamides as novel insecticides of the anthranilic diamide family. J. Heterocyclic Chem. 2021, 58, 2189-2202.

                                                      


50. J. Li, Y. Yang, Y. Liu, Q. Liu, L. Zhang, X. Li, Y. Dong, and H. Liu. Palladium/Norbornene Catalyzed ortho Amination/Cyclization of Aryl Iodide: Process to 3-Methyl-Indole Derivates and Controlla-ble Reductive Elimination against the Second Amination. Org. Lett., 2021, 23, 2988-2993

                   


49. X. Sun, X. Dong, H. Liu and Y. Liu. Recent Progress in Palladium-Catalyzed Radical Reactions. Adv. Synth. Catal. 2021, 363,1527-1558.

                                                   


48. X. Sun, D. Xu, Y. Yang, J. Fu, Y. Wang, Z. Li, Y. Liu  and  H. Liu. Palladium-Catalyzed Cascade 5-Exo-Trig Radical Cyclization/Aromatic C-H Alkylation with Unactivated Alkyl Iodides. Org. Bio. Chem., 2021, 19, 2676-2680.

                

 

                       


2020

47. C. Cao, Y.Yang, X. Li, Y. Liu, H. Liu, Z. Zhao, and L. Chen. Pd-Catalyzed Cascade Metallo-Ene Cyclization/Metallo-Carbene Coupling of Allenamides. Eur. J. Org. Chem. 2021, 10, 1538-1542.

                

                

 


46. J. Li, L. Meng, Q. Liu, X. Du, L.-P. Xu, L. Zhang, F.-G. Sun, X. Li, D. Zhang, X. Xiao and H. Liu. Palladium-Catalyzed Intramolecular Aerobic Alkenylhydroxylation of Allenamides with Alkenyl Iodides. Org. Chem. Front., 2020, 7, 3880-3886.

     

          

                         


2019

45. X. Dong, H. Wang, H. Liu and F. Wang. Recent Advanced on Transition Metal Migration Involved Reactions. Org. Chem. Front., 2020, 7, 3530-3556.

                                      


44. M. Richard, C. Truillet, V.-L. Tran, H. Liu, K. Porte, D. Audisio, M. Roche, B. Jego, S. Cholet, F. Fenaille, B. Kuhnast, F. Taran and S. Specklin. New fluorine-18 pretargeting PET imaging by Q2 bioorthogonal chlorosydnone–cycloalkyne click reaction. Chem. Commun., 2019, 55, 10400-10403

   

                 

                                  


43. L. Meng, X. Chi, X. Sun, C. Cao, B. Ai, Q. Liu, P. Zhao, Z. Zhao, Y. Dong and H. Liu. An organocatalytic method for constructing pyrroles via the cycloisomerisation of Z-1-iodo-4-N-methylbenzenesulfonyl-1,6-enynes. Org. Biomol. Chem., 2019, 17, 7669-7673.

     

                         

                                 


42. X. Chi, L. Meng, X. Sun, Q. Liu, B. Ai, L. Chen, D. Zhang, P. Zhao, Y. Dong, H. Liu. Palladium-Catalyzed Cycloisomerization of (Z)-1-Iodo-1,6-dienes to 3-Aza-bicyclo[4.1.0]hept-2-enes. Asian J.Org. Chem. 2019, 8, 840-843.

                          


41. J. Song, X. Chi, L. Meng, P. Zhao, F. Sun, D. Zhang, L. Jiao, Q. Liu, Y. Dong, and H. Liu. Pd-Catalyzed Tandem Coupling Reaction of 2-gem-Dibromovinylanilines and N-Tosylhydrazones to Construct 2-(1-phenylvinyl)-indoles. Adv. Synth. Catal. 2019, 361, 3599-3604

                          


40. J. Cui, L. Meng, X. Chi, Q. Liu, P. Zhao, D.Zhang, L. Chen, X. Li, Y. Dong and H. Liu. Palladium-Catalyzed Regiocontrollable Hydroarylation Reaction of Allenamides with B2pin2/H2O. Chem. Commun., 201955, 4355 – 4358

                                          


39. F. Yan, H. Liang, B. Ai, W. Liang, L. Jiao, S. Yao, P. Zhao, Q. Liu, Y. Dong, and H. Liu. Palladium-Catalyzed Intermolecular [4 + 2] Formal Cycloaddition with (Z)-3-Iodo Allylic Nucleophiles and Allenamides. Org. Biomol. Chem., 2019, 17, 2651 - 2656.

                                               


2018

38. J. Cui, J. Song, Q. Liu, H. Liu, and Y. Dong. Transition-Metal-Catalyzed Cyanation by Using an Electrophilic Cyanating Agent, N-Cyano-N-phenyl-p-toluenesulfonamide (NCTS). Chem. Asian J. 2018, 13, 482-495.

                                                                                        


37. J. Li, X. Chi, L. Meng, L. Jiao, W. Shang, P. Wang, D. Zhang, Y. Dong, Q. Liu, and H. Liu. Palladium-Catalyzed Heck-Type Cascade Cyclization of (Z)-1-Iodo-1,6-dienes with N-Tosyl Hydrazones. Org. Biomol. Chem., 2018, 16, 7356-7360.

                                                            


36. H. Liang, L. Meng, X. Chi, S. Yao, H. Chen, L. Jiao, Q. Liu, D. Zhang, H. Liu, and Y. Dong. Palladium/Copper Co-catalyzed Cascade Metallo-ene/Sonogashira Coupling Reaction of Allenamides. Asian J. Org. Chem., 2018, 7, 1793-1796.

                                       


35. J. Song, J. Cui, H. Liang, Q. Liu, Y. Dong, and H. Liu. Palladium-Catalyzed Direct Oxidative Esterification of Indoles at the C3 Position: A Novel Prospect for C(sp2)-H Acyloxylation. Asian J. Org. Chem., 2018, 7, 341-345.

                      


2017

34. J. Song, Q. Liu, H. Liu, and X. Jiang. Recent Advances in Palladium-Catalyzed Carboxylation with CO2. Eur. J. Org. Chem., 2018, 6696-713.

                                                                                     


33. X. Dong, J. Cui, J. Song, Y. Han, Q. Liu, Y. Dong and Hui Liu. Palladium-catalyzed intramolecular reductive olefin hydrocarbonation: benzylic hydrogen serving as a new hydrogen donor. Chem. Commun., 2017, 53, 4903-4906.

                                                      



32. F. Yan, H. Liang, J. Song, J. Cui, Q. Liu, S. Liu, P. Wang, Y. Dong and H. Liu. Palladium-Catalyzed Cyclization-Heck Reaction of Allenamides: An Approach to 3-Methylene-5-phenyl-1,2,3,4-tetrahydropyridine Derivatives. Org. Lett., 2017, 19, 86-89.

                                                       


31. H. Liang,  F. Yan,   X. Dong,   Q. Liu,   X. Wei,   S. Liu,   Y. Dong,    H. Liu. Palladium-Catalyzed Cascade Metallo-Ene/Suzuki Coupling Reaction of AllenamidesChem. Commun., 2017, 53, 3138-3141.

                                 


30. J. Li, Y. Hu, D. Zhang, Q. Liu, Y. Dong and H. Liu. Transition-Metal- Catalyzed Reactions Involving Oximes. Adv. Synth. Catal., 2017, 359, 710-771.

                             


29. X. Dong, Q. Liu, Y. Dong and H. Liu, Transition-Metal-Catalyzed Electrophilic Amination: Application of O-Benzoylhydroxylamines in the Construction of the C-N Bond. Chem. Eur. J., 2017, 23, 2481-2511.

                                         


28. J. Cui, H. Wang, J. Song, X. Chi, L. Meng, Q. Liu, D. Zhang, Y. Dong and H. Liu. Copper(I)-Catalyzed 5-exo-trig Radical Cyclization/Borylation of Alkyl Halides: Access to Functionalized Pyrrolidine Derivates. Org. Biomol. Chem., 2017, 15, 8508-8512.

                            


27. X. Dong, Y. Hou, F. Meng, H-B. Liu and H. Liu. Recent Advances on Alkyl-Heck Reaction. Chin. J. Org. Chem., 2017, 37, 1088-1098.

                                                


2016

26. H. Liu, D. Audisio, L. Plougastel, E. Decuypere, V. Gouverneur, and F. Taran. Ultrafast Click Chemistry with Fluorosydnones. Angew. Chem. Int. Ed., 2016, 55, 12073-12077.

                                


25. J. Li, W. Yang, F. Yan, Q. Liu, P. Wang, Y. Li, Y. Zhao, Y. Dong and H. Liu. Pd-Catalyzed Oxidative Isomerization of Propargylic Acetates: Highly Efficient Access to α-Acetoxyenones via Alkenyl Csp2-O Bond-Forming Reductive Elimination from PdIV. Chem.Comm., 2016, 52, 10644-10647.

                     


24. X. Dong, Y. Han, F. Yan, Q. Liu, P. Wang, K. Chen, Y. Li, Z. Zhao, Y. Dong, and H. Liu. Palladium-Catalyzed 6Endo Selective Alkyl-Heck Reactions: Access to 5Phenyl-1,2,3,6-tetrahydropyridine Derivatives. Org. Lett., 2016, 18, 3774-3777.

                        


23. H. Liang, H. Liu and X. Jiang. Research on the Conversion of α-Hydroxy Ketones into 1,2-Diketones and Subsequent Transformations. Synlett, 2016, 27, 2774-2782.

                                        


2015

22. Q. Liu, X. Dong, J. Li, J. Xiao, Y. Dong and H. Liu. Recent Advances on Palladium Radical Involved Reactions. ACS Catal., 2015, 5, 6111-6137.

                                                                                


21. E. Decuypere, S. Specklin, S. Gabillet, D. Audisio, H. Liu, L. Plougastel, S. Kolodych, F. Taran. Copper(I)-Catalyzed Cycloaddition of 4-Bromosydnones and Alkynes for the Regioselective Synthesis of 1,4,5-Trisubstituted Pyrazoles. Org. Lett., 2015, 17, 362-365.

                                            


2014年以前

20. H. Liu, J. Wei, Z. Qiao, Y. Fu, X. Jiang. Palladium-Catalyzed Intramolecular Reductive Cross-Coupling of Csp2-Csp3 Bond Formation. Chem. Eur. J., 2014, 20, 8308-8313.

                        


19. H. Liu, M. Feng, X. Jiang. Unstrained Carbon-Carbon Bond Cleavage. Chem. Asian J., 2014, 9, 3360-3382.

                                                  


18. H. Liu, X. Jiang . Pd-Catalyzed Reactions from Unactivated Csp3-I Bond. Pure and Applied Chemistry, 2014, 85, PAC.2014.5032.

                            


17. Z. Qiao, H. Liu,X. Xiao, Y. Fu, J. Wei, Y. Li and X. Jiang. Efficient Access to 1, 4-Benzothiazine: Palladium-Catalyzed Double C-S Bond Formation Using. Org. Lett. 2013, 15, 11, 2594–2597.

                           


16. H. Liu, Z. Gu and X. Jiang. Direct Trifluoromethylation of C-H Bond. Adv. Synth. Catal., 2013, 355, 617-626.

                                  


15. H. Liu, Xuefeng Jiang. Transfer of Sulfur: From Simple to Diverse. Chem. Asian J., 20138, 2546-2563.

                                                  


14. H. Liu, X. Jiang. Mechanistic Insight to the Reaction Pathway of Aerobic Oxidative C-C Bond Cleavage of α-Hydroxy Ketones. Synlett, 2013, 24, 1311-1315.

                         


13. L. Wang, J. Huang, S. Peng, H. Liu, X. Jiang and J. Wang. Palladium-Catalyzed Oxidative Cycloaddition via C–H/N–H Activation: Access to Benzazepines. Angew. Chem. Int. Ed., 2013, 52, 1768-1772.

              


12. H. Liu, C. Dong, Z. Zhang, P. Wu and X. Jiang. Transition-Metal-Free Aerobic Oxidative Cleavage of C-C Bonds in α-Hydroxy Ketones and Mechanistic Insight to the Reaction Pathway. Angew. Chem. Int. Ed., 2012, 51, 12570-12574.

                                         


11. H. Liu, Z. Qiao and X. Jiang. Palladium-Catalyzed Atom Transfer Radical Cyclization of Unactivated Alkyl Iodide. Org. Biomol. Chem., 2012, 10, 7274-7277.

                                                             


10. X. Jiang, H. Liu and Z. Gu. Carbon-Halogen Bond Formation by the Reductive Elimination of PdII Species. Asian J. Org. Chem., 2012, 1, 16-24.

                                    


9. K. Li, J. Hu, H. Liu and X. Tong. Amine-catalyzed formal (3+3) annulations of 2-(acetoxymethyl)buta-2,3-dienoate with sulfur ylides: synthesis of 4H-pyrans bearing a vinyl sulfide group. Chem. Commun., 2012, 48, 2900-2902.

                 


8. W. Li, H. Liu, X. Jiang, J. Wang. Enantioselective Organocatalytic Conjugate Addition of Nitroalkanes to Electrophilic 2-Iminochromenes. ACS Catal., 2012, 2, 1535-1538.

             



7. X. Jiang, L. Shi, H. Liu, Akbar H. Khan and Jason S. Chen. Gas Extrusion in Natural Products Total Synthesis. Org. Biomol. Chem., 2012, 10, 8383-8392.

    


6. P. Wu, H. Liu, X. Tong. Synthesis of 3-pyrroline via domino Heck-aza-Michael reaction. Tetrahedron Lett., 2012, 53, 4673-4675.

 


5 .Q. Ren, J. Huang, L. Wang, W. Li, H. Liu, X. Jiang and J. Wang. Highly Efficient Assembly of 3Hydroxy Oxindole Scaffold via a Catalytic Decarboxylative [1,2]-Addition Strategy. ACS Catalysis, 2012, 2, 2622-2625.


4.H. Liu, C. Li, D. Qiu and X. Tong. Palladium-Catalyzed Cycloisomerizations of (Z)-1-Iodo-1,6-dienes: Iodine Atom Transfer and Mechanistic Insight to Alkyl Iodide Reductive Elimination. J. Am. Chem. Soc., 2011, 133, 6187-6193.

         


3. H. Liu, C. Chen, L. Wang and X. Tong. Pd(0)-Catalyzed Iodoalkynation of Norbornene Scaffolds: The Remarkable Solvent Effect on Reaction Pathway. Org. Lett., 2011, 13, 5072-5075.

    


2.H. Liu, L. Wang and X. Tong. Palladium-Catalyzed Heck-type Reaction of Oxime Ether Bearing a Pendant Vinyl Iodide Moiety. Chem.Comm., 2011, 47, 12206-12208.

    


1. H. Liu, J. Yu, L. Wang, X. Tong. Cyclization–oxidation of 1,6-enyne derivatived from Baylis–Hillman adducts via Pd(II)/Pd(IV)-catalyzed reactions: stereoselective synthesis of multi-substituted bicyclo[3.1.0] hexanes and insight into reaction pathways. Tetrahedron Lett., 2008, 49, 6924-6928.

    


授权专利:

1. 姜雪峰,汪舰,刘会,李文军,3,3-二取代-2-氧化吲哚类化合物的不对称合成方法。专利授权号:ZL 2012 1 0093045.9

2.姜雪峰,刘会,乔宗君,一种2,3-二氢-[1,4]-苯并噻嗪类化合物的合成方法。专利授权号:ZL 2013 1 0028082.6

3. 刘会,刘青,董云会,李峻,胡义甜,朱玉花,一种多取代的α-乙酰氧基-α,β-烯酮类化合物的合成方法。专利授权号:ZL 2016 1 0310198.2

4. 刘会,韩颖,董旭,刘青,董云会,许正帅,白占猛,曹风亮,一种3-甲基-1-对甲苯磺酰基四氢吡咯类化合物的合成方法。专利授权号:ZL 2016 1 0455519.8

5. 刘会,闫法超,董旭,董云会,刘青,王平,梁寒冰,一种3-苯基-哌啶类衍生物合成方法。专利授权号:ZL 2016 1 0518448.1

6. 刘青,董云会,刘会,李峻,董旭,闫法超,一种5,10-二氢吲哚[3,2-b]吲哚类化合物的合成方法。专利授权号:ZL 2015 1 0911887.4

7. 刘会,刘青,董云会,董旭,韩颖,许正帅,白占猛,曹风亮,一种5-苯基-1,2,3,6-四氢吡啶衍生物的合成方法。专利授权号:ZL 2016 1 0310197.8

8. 刘会,崔洁,孟龙,迟晓晨,孙曦,曹成强,刘青,李新进,周振,董云会,一种4-甲基-N-苯基-N-(2-苯基丙-1-烯基)本磺酰胺类化合物的合成方法。专利授权号:ZL 2018 1 1432287.X

9. 刘会,崔洁,迟晓晨,孟龙,曹成强,孙曦,刘青,周振,孙丰钢,董云会,一种4-甲基-N-苯基-N-(2-苯基丙-1-烯丙基)苯磺酰胺类化合物的合成方法。专利授权号:ZL 2018 1 1432269.1

10. 刘会,宋键,迟晓晨,孟龙,史亚菲,王新源,梁文静,姚树志,刘青,董云会。一种吲哚C-2位置烯基化的方法。专利授权号:ZL 2018 1 1193563.1


著作:

1. Hui Liu, X. Jiang*.

Application of Zinc catalysts in Total Synthesis in Zinc Catalysis-Applications in Organic Synthesis Ed. Stephan Enthaler and Xiao-Feng Wu, Wiley-VCH, 2014, 219-273.

2.X. Jiang*, Hui LiuElectrophilic Cyclizations in Comprehensive Organic Synthesis 2nd Edition, Ed. Gary Molander and Paul Knochel, Oxford: Elsevier, 2014, Vol 4, 412-497.

3. Xu Dong, Hui Liu*Science of Synthesis Knowledge Updates, Ed. X. Jiang et al., Thieme, 2019, 3, 1-88.