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成果及论文

2023

38. Organocatalytic Enantioselective Functionalization of Cyclic α-Hydroxyamides: Access to Chiral Cyclic Imides and Azapolycyclic Compounds | Organic Letters (acs.org)

Xiao-Qian Zhang, Yuan-Ren Ma, and Yan-Kai Liu*


37. Brønsted-Acid-Catalyzed In Situ Formation of Acyclic Tertiary Enamides and Its Application to the Preparation of Diverse Nitrogen-Containing Heterocyclic Compounds | Organic Letters (acs.org)

Yuan-Ren Ma, Xue-Jiao Lv, Qing Dong, Yong-Chao Ming, and Yan-Kai Liu*


36. Asymmetric iminium ion-catalyzed conjugate addition of 2-hydroxycinnamaldehydes and 2-oxocarboxylic esters: synthesis of chiral polysubstituted bridged bicyclic ketals - Chemical Communications (RSC Publishing)

Yong-Chao Ming, Xue-Jiao Lv, Ying-Han Chen and Yan-Kai Liu*

Graphical abstract: Asymmetric iminium ion-catalyzed conjugate addition of 2-hydroxycinnamaldehydes and 2-oxocarboxylic esters: synthesis of chiral polysubstituted bridged bicyclic ketals

 

35. Triethylamine-Promoted Henry Reaction/Elimination of HNO2/Cyclization Sequence of Functionalized Nitroalkanes and 2-Oxoaldehydes: Diversity-Oriented Synthesis of Oxacycles | Organic Letters (acs.org)

Yu-Xia Lu, Xue-Jiao Lv, Chang Liu, and Yan-Kai Liu*

 

34. Asymmetric Retro-Claisen Reaction Catalyzed by Chiral Aza-Bisoxazoline–Zn(II) Complex: Enantioselective Synthesis of α-Arylated Ketones | Organic Letters (acs.org)
Jia-Hui Liu, Xue-Jiao Lv, and Yan-Kai Liu*


 

2022

 

33. Asymmetric Organocatalytic Access to Spiro-fused Heterocyclic Compounds: E1cB Elimination Mediates Formal [4 + 2] Annulation | Organic Letters (acs.org)

Zhi-Hao You* and Yan-Kai Liu*

 

32. Enantioselective Michael Addition/Cyclization/Desymmetrization Sequence of Prochiral Cyclic Hemiacetals and Nitroolefins: Synthesis of Chiral Oxygen-Bridged Bicyclic Compounds | Organic Letters (acs.org)

Yu-Jie Li, Xue-Jiao Lv, and Yan-Kai Liu*

 

2021


31. Asymmetric organocatalytic vinylogous Michael addition triggered triple-cascade reactions of 2-hydroxycinnamaldehydes and vinylogous nucleophiles: construction of benzofused oxabicyclo[3.3.1]nonane scaffolds - Chemical Communications (RSC Publishing)

Hui-Chun Wu, Chen Wang, Ying-Han Chen and Yan-Kai Liu*

Graphical abstract: Asymmetric organocatalytic vinylogous Michael addition triggered triple-cascade reactions of 2-hydroxycinnamaldehydes and vinylogous nucleophiles: construction of benzofused oxabicyclo[3.3.1]nonane scaffolds


30. Enantioselective organocatalytic sequential Michael-cyclization of functionalized nitroalkanes to 2-hydroxycinnamaldehydes: synthesis of benzofused dioxa[3.3.1] and oxa[4.3.1] methylene-bridged compounds - Organic Chemistry Frontiers (RSC Publishing)

Chen-Jun Peng, Jun-Ping Pei, Ying-Han Chen, Zhi-Yong Wu, Ming Liu and Yan-Kai Liu*

Graphical abstract: Enantioselective organocatalytic sequential Michael-cyclization of functionalized nitroalkanes to 2-hydroxycinnamaldehydes: synthesis of benzofused dioxa[3.3.1] and oxa[4.3.1] methylene-bridged compounds

 

29. Synthesis of Chiral Polycyclic Tetrahydrocarbazoles by Enantioselective Aminocatalytic Double Activation of 2-Hydroxycinnamaldehydes with Dienals | Organic Letters (acs.org)  
Yong-Chao Ming, Xue-Jiao Lv, Ming Liu, and Yan-Kai Liu*

 

28. Brønsted acid-catalyzed dynamic kinetic resolution of in situ formed acyclic N,O-hemiaminals: cascade synthesis of chiral cyclic N,O-aminals - Organic Chemistry Frontiers (RSC Publishing)
Xue-Jiao Lv, Yong-Chao Ming, Hui-Chun Wu and Yan-Kai Liu*

Graphical abstract: Brønsted acid-catalyzed dynamic kinetic resolution of in situ formed acyclic N,O-hemiaminals: cascade synthesis of chiral cyclic N,O-aminals

 

2020


27. An asymmetric multicatalytic reaction sequence of 2-hydroxycinnamaldehydes and enolic 1,3-dicarbonyl compounds to construct bridged bicyclic acetals - Organic Chemistry Frontiers (RSC Publishing)

Xiao-Qian Zhang, Xue-Jiao Lv, Jun-Ping Pei, Rui Tan and Yan-Kai Liu*

Graphical abstract: An asymmetric multicatalytic reaction sequence of 2-hydroxycinnamaldehydes and enolic 1,3-dicarbonyl compounds to construct bridged bicyclic acetals

 

26. Asymmetric organocatalytic multicomponent reactions for efficient construction of bicyclic compounds bearing bisacetal and isoxazolidine moieties - Chemical Communications (RSC Publishing)

Jun-Ping Pei, Xue-Jiao Lv, Chen-Jun Peng and Yan-Kai Liu*

Graphical abstract: Asymmetric organocatalytic multicomponent reactions for efficient construction of bicyclic compounds bearing bisacetal and isoxazolidine moieties


2019

 

25. Application of E1cB Elimination in Asymmetric Organocatalytic Cascade Reactions To Construct Polyheterocyclic Compounds | Organic Letters (acs.org)

Zhi-Hao You, Ying-Han Chen, Yu Tang, and Yan-Kai Liu*

 

24. Asymmetric construction of polycyclic indole derivatives with different ring connectivities by an organocatalysis triggered two-step sequence - Organic Chemistry Frontiers (RSC Publishing)

Chao-Chao Xie, Rui Tan and Yan-Kai Liu*

Graphical abstract: Asymmetric construction of polycyclic indole derivatives with different ring connectivities by an organocatalysis triggered two-step sequence

 

23. The Quinary Catalyst–Substrate Complex Induced Construction of Spiro-Bridged or Cagelike Polyheterocyclic Compounds via a Substrate-Controlled Cascade Process | Organic Letters (acs.org)

Chen Wang, Ying-Han Chen, Hui-Chun Wu, Cong Wang*, and Yan-Kai Liu*


22. Aspergiolides A and B: Core Structural Establishment and Synthesis of Structural Analogues | The Journal of Organic Chemistry (acs.org)

Liang Qiao, Zhongwei Duan, Yinghan Chen, Yepeng Luan, Qianqun Gu, Yan-Kai Liu*, and Dehai Li*

 

21. Two Competitive but Switchable Organocatalytic Cascade Reaction Pathways: The Diversified Synthesis of Chiral Acetal-Containing Bridged Cyclic Compounds | Organic Letters (acs.org)
Xue-Jiao Lv, Ying-Han Chen, and Yan-Kai Liu*

 

20. Organocatalytic asymmetric synthesis of both cis- and trans-configured pyrano[2,3-b]chromenes via different dehydration pathways - Organic Chemistry Frontiers (RSC Publishing)

Xue-Jiao Lv, Wei-Wei Zhao, Ying-Han Chen, Sheng-Biao Wan and Yan-Kai Liu*

Graphical abstract: Organocatalytic asymmetric synthesis of both cis- and trans-configured pyrano[2,3-b]chromenes via different dehydration pathways

 

19. Asymmetric Organocatalyzed Reaction Sequence To Synthesize Chiral Bridged and Spiro-Bridged Benzofused Aminals via Divergent Pathways | Organic Letters (acs.org)
Ying-Han Chen, Xue-Jiao Lv, Zhi-Hao You, and Yan-Kai Liu*

 

18. Asymmetric organocatalyzed reaction sequence of 2-hydroxy cinnamaldehydes and acyclic N-sulfonyl ketimines to construct diverse chiral bridged polycyclic aminals - Organic Chemistry Frontiers (RSC Publishing)

Ying-Han Chen, Xue-Jiao Lv, Zhi-Hao You and Yan-Kai Liu*

Graphical abstract: Asymmetric organocatalyzed reaction sequence of 2-hydroxy cinnamaldehydes and acyclic N-sulfonyl ketimines to construct diverse chiral bridged polycyclic aminals

 

2018

 

17. Organocatalytic Asymmetric Synthesis of Spiro-Bridged and Spiro-Fused Heterocyclic Compounds Containing Chromane, Indole, and Oxindole Moieties | Organic Letters (acs.org)

Zhi-Hao You, Ying-Han Chen, Yu Tang, and Yan-Kai Liu*

 

16. Different hybridized oxygen atoms controlled chemoselective formation of oxocarbenium ions: synthesis of chiral heterocyclic compounds - Organic & Biomolecular Chemistry (RSC Publishing)

Xiao-Na Wu, Zhi-Hao You and Yan-Kai Liu*

Graphical abstract: Different hybridized oxygen atoms controlled chemoselective formation of oxocarbenium ions: synthesis of chiral heterocyclic compounds

 

15. Organocatalytic Diversity-Oriented Asymmetric Synthesis of Structurally and Stereochemically Complex Heterocycles | Organic Letters (acs.org)

Liang Qiao, Zhong-Wei Duan, Xiao-Na Wu, De-Hai Li*, Qian-Qun Gu, and Yan-Kai Liu*

 

14. Asymmetric Organocatalytic Sequential Reaction of Structurally Complex Cyclic Hemiacetals and Functionalized Nitro-olefins To Synthesize Diverse Heterocycles | Organic Letters (acs.org)

Jun-Ping Pei, Ying-Han Chen, and Yan-Kai Liu*

 

13. Diversified Synthesis of Chiral Chromane-Containing Polyheterocyclic Compounds via Asymmetric Organocatalytic Cascade Reactions | ACS Omega

Ying-Han Chen, De-Hai Li*, and Yan-Kai Liu*

 

2017

 

12. Enantio- and diastereoselective synthesis of tetrahydrofuro[2,3-b]furan-2(3H)-one derivatives and related oxygen heterocycles via an asymmetric organocatalytic cascade process - Organic Chemistry Frontiers (RSC Publishing)

Wei-Wei Zhao and Yan-Kai Liu*

Graphical abstract: Enantio- and diastereoselective synthesis of tetrahydrofuro[2,3-b]furan-2(3H)-one derivatives and related oxygen heterocycles via an asymmetric organocatalytic cascade process

 

11. Lactols in Asymmetric Sequential Organo‐ and Gold‐Catalysis: Synthesis of Densely Functionalized Epimeric Bicyclic O,O‐Acetals - You - 2017 - Advanced Synthesis & Catalysis - Wiley Online Library

Zhi-Hao You, Ying-Han Chen, Xiao-Na Wu, Yan-Kai Liu*

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10. Asymmetric Organocatalytic One-Pot, Two-Step Sequential Process to Synthesize Chiral Acetal-Containing Polycyclic Derivatives from Cyclic Hemiacetals and Enones | The Journal of Organic Chemistry (acs.org)

Chao Liu and Yan-Kai Liu*

 

9. Lactols in an asymmetric aldol-desymmetrization sequence: access to tetrahydro-4H-furo[2,3-b]pyran-2-one and tetrahydro-4H-furo[2,3-b]furan-2-one derivatives - Organic & Biomolecular Chemistry (RSC Publishing)

Ji-Yao Li, Ke-Wei Yu, Chao-Chao Xie and Yan-Kai Liu*

Graphical abstract: Lactols in an asymmetric aldol-desymmetrization sequence: access to tetrahydro-4H-furo[2,3-b]pyran-2-one and tetrahydro-4H-furo[2,3-b]furan-2-one derivatives

 

8. Diversity-Oriented One-Pot Synthesis to Construct Functionalized Chroman-2-one Derivatives and Other Heterocyclic Compounds | The Journal of Organic Chemistry (acs.org)

Ying-Han Chen, Xue-Li Sun, Hua-Shi Guan, and Yan-Kai Liu*

 

2016

 

7. From racemic precursors to fully stereocontrolled products: one-pot synthesis of chiral α-amino lactones and lactams - Organic & Biomolecular Chemistry (RSC Publishing)

Zhi-Hao You, Ying-Han Chen and Yan-Kai Liu*

Graphical abstract: From racemic precursors to fully stereocontrolled products: one-pot synthesis of chiral α-amino lactones and lactams

 

6. Substrate-Controlled, One-Pot Synthesis: Access to Chiral Chroman-2-one and Polycyclic Derivatives | Organic Letters (acs.org)

Xue-Li Sun, Ying-Han Chen, Dan-Yang Zhu, Yan Zhang, and Yan-Kai Liu*

 

5. Catalysts | Free Full-Text | Organocatalytic, Asymmetric [2+2+2] Annulation to Construct Six-Membered Spirocyclic Oxindoles with Six Continuous Stereogenic Centers (mdpi.com)

Zhi-Long Li, Chao Liu, Rui Tan,* Zhi-Ping Tong,* andYan-Kai Liu*

 

4. One-pot, highly efficient, asymmetric synthesis of ring-fused piperidine derivatives bearing N,O- or N,N-acetal moieties - Organic & Biomolecular Chemistry (RSC Publishing)

Ji-Yao Li, Zhi-Long Li, Wei-Wei Zhao, Yan-Kai Liu,* Zhi-Ping Tong and Rui Tan*

Graphical abstract: One-pot, highly efficient, asymmetric synthesis of ring-fused piperidine derivatives bearing N,O- or N,N-acetal moieties

 

3. The Attractive Application of Lactol Chemistry: From Racemic Lactol to Natural Product Skeleton

Pin-Wen Cai, Zhi-Hao You, Liang-Hui Xie, Rui Tan*, Zhi-Ping Tong*, Yan-Kai Liu*

 

2015

 

2. Open–Close: An Alternative Strategy to α-Functionalization of Lactone via Enamine Catalysis in One Pot under Mild Conditions | Organic Letters (acs.org)

Yan-Kai Liu*, Zhi-Long Li, Ji-Yao Li, Huan-Xi Feng, and Zhi-Ping Tong

 

1. An Efficient One-Pot Approach to the Construction of Chiral Nitrogen-Containing Heterocycles under Mild Conditions | Organic Letters (acs.org)

Huan-Xi Feng, Rui Tan, and Yan-Kai Liu*