2023
38. Organocatalytic Enantioselective Functionalization of Cyclic α-Hydroxyamides: Access to Chiral Cyclic Imides and Azapolycyclic Compounds | Organic Letters (acs.org)
Xiao-Qian Zhang, Yuan-Ren Ma, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.3c03182/asset/images/medium/ol3c03182_0008.gif)
37. Brønsted-Acid-Catalyzed In Situ Formation of Acyclic Tertiary Enamides and Its Application to the Preparation of Diverse Nitrogen-Containing Heterocyclic Compounds | Organic Letters (acs.org)
Yuan-Ren Ma, Xue-Jiao Lv, Qing Dong, Yong-Chao Ming, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.3c01919/asset/images/medium/ol3c01919_0007.gif)
36. Asymmetric iminium ion-catalyzed conjugate addition of 2-hydroxycinnamaldehydes and 2-oxocarboxylic esters: synthesis of chiral polysubstituted bridged bicyclic ketals - Chemical Communications (RSC Publishing)
Yong-Chao Ming, Xue-Jiao Lv, Ying-Han Chen and Yan-Kai Liu*
![Graphical abstract: Asymmetric iminium ion-catalyzed conjugate addition of 2-hydroxycinnamaldehydes and 2-oxocarboxylic esters: synthesis of chiral polysubstituted bridged bicyclic ketals](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D3CC02739B&imageInfo.ImageIdentifier.Year=2023)
35. Triethylamine-Promoted Henry Reaction/Elimination of HNO2/Cyclization Sequence of Functionalized Nitroalkanes and 2-Oxoaldehydes: Diversity-Oriented Synthesis of Oxacycles | Organic Letters (acs.org)
Yu-Xia Lu, Xue-Jiao Lv, Chang Liu, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.3c01158/asset/images/medium/ol3c01158_0006.gif)
34. Asymmetric Retro-Claisen Reaction Catalyzed by Chiral Aza-Bisoxazoline–Zn(II) Complex: Enantioselective Synthesis of α-Arylated Ketones | Organic Letters (acs.org)
Jia-Hui Liu, Xue-Jiao Lv, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.3c00372/asset/images/medium/ol3c00372_0007.gif)
2022
33. Asymmetric Organocatalytic Access to Spiro-fused Heterocyclic Compounds: E1cB Elimination Mediates Formal [4 + 2] Annulation | Organic Letters (acs.org)
Zhi-Hao You* and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.2c02435/asset/images/medium/ol2c02435_0006.gif)
32. Enantioselective Michael Addition/Cyclization/Desymmetrization Sequence of Prochiral Cyclic Hemiacetals and Nitroolefins: Synthesis of Chiral Oxygen-Bridged Bicyclic Compounds | Organic Letters (acs.org)
Yu-Jie Li, Xue-Jiao Lv, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.2c03815/asset/images/medium/ol2c03815_0007.gif)
2021
31. Asymmetric organocatalytic vinylogous Michael addition triggered triple-cascade reactions of 2-hydroxycinnamaldehydes and vinylogous nucleophiles: construction of benzofused oxabicyclo[3.3.1]nonane scaffolds - Chemical Communications (RSC Publishing)
Hui-Chun Wu, Chen Wang, Ying-Han Chen and Yan-Kai Liu*
![Graphical abstract: Asymmetric organocatalytic vinylogous Michael addition triggered triple-cascade reactions of 2-hydroxycinnamaldehydes and vinylogous nucleophiles: construction of benzofused oxabicyclo[3.3.1]nonane scaffolds](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D0CC07761E&imageInfo.ImageIdentifier.Year=2021)
30. Enantioselective organocatalytic sequential Michael-cyclization of functionalized nitroalkanes to 2-hydroxycinnamaldehydes: synthesis of benzofused dioxa[3.3.1] and oxa[4.3.1] methylene-bridged compounds - Organic Chemistry Frontiers (RSC Publishing)
Chen-Jun Peng, Jun-Ping Pei, Ying-Han Chen, Zhi-Yong Wu, Ming Liu and Yan-Kai Liu*
![Graphical abstract: Enantioselective organocatalytic sequential Michael-cyclization of functionalized nitroalkanes to 2-hydroxycinnamaldehydes: synthesis of benzofused dioxa[3.3.1] and oxa[4.3.1] methylene-bridged compounds](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D1QO00501D&imageInfo.ImageIdentifier.Year=2021)
29. Synthesis of Chiral Polycyclic Tetrahydrocarbazoles by Enantioselective Aminocatalytic Double Activation of 2-Hydroxycinnamaldehydes with Dienals | Organic Letters (acs.org)
Yong-Chao Ming, Xue-Jiao Lv, Ming Liu, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.1c02309/asset/images/medium/ol1c02309_0006.gif)
28. Brønsted acid-catalyzed dynamic kinetic resolution of in situ formed acyclic N,O-hemiaminals: cascade synthesis of chiral cyclic N,O-aminals - Organic Chemistry Frontiers (RSC Publishing)
Xue-Jiao Lv, Yong-Chao Ming, Hui-Chun Wu and Yan-Kai Liu*
![Graphical abstract: Brønsted acid-catalyzed dynamic kinetic resolution of in situ formed acyclic N,O-hemiaminals: cascade synthesis of chiral cyclic N,O-aminals](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D1QO01135A&imageInfo.ImageIdentifier.Year=2021)
2020
27. An asymmetric multicatalytic reaction sequence of 2-hydroxycinnamaldehydes and enolic 1,3-dicarbonyl compounds to construct bridged bicyclic acetals - Organic Chemistry Frontiers (RSC Publishing)
Xiao-Qian Zhang, Xue-Jiao Lv, Jun-Ping Pei, Rui Tan and Yan-Kai Liu*
![Graphical abstract: An asymmetric multicatalytic reaction sequence of 2-hydroxycinnamaldehydes and enolic 1,3-dicarbonyl compounds to construct bridged bicyclic acetals](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C9QO01272A&imageInfo.ImageIdentifier.Year=2020)
26. Asymmetric organocatalytic multicomponent reactions for efficient construction of bicyclic compounds bearing bisacetal and isoxazolidine moieties - Chemical Communications (RSC Publishing)
Jun-Ping Pei, Xue-Jiao Lv, Chen-Jun Peng and Yan-Kai Liu*
2019
25. Application of E1cB Elimination in Asymmetric Organocatalytic Cascade Reactions To Construct Polyheterocyclic Compounds | Organic Letters (acs.org)
Zhi-Hao You, Ying-Han Chen, Yu Tang, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.9b03138/asset/images/medium/ol9b03138_0010.gif)
24. Asymmetric construction of polycyclic indole derivatives with different ring connectivities by an organocatalysis triggered two-step sequence - Organic Chemistry Frontiers (RSC Publishing)
Chao-Chao Xie, Rui Tan and Yan-Kai Liu*
![Graphical abstract: Asymmetric construction of polycyclic indole derivatives with different ring connectivities by an organocatalysis triggered two-step sequence](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C8QO01406J&imageInfo.ImageIdentifier.Year=2019)
23. The Quinary Catalyst–Substrate Complex Induced Construction of Spiro-Bridged or Cagelike Polyheterocyclic Compounds via a Substrate-Controlled Cascade Process | Organic Letters (acs.org)
Chen Wang, Ying-Han Chen, Hui-Chun Wu, Cong Wang*, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.9b02375/asset/images/medium/ol9b02375_0007.gif)
22. Aspergiolides A and B: Core Structural Establishment and Synthesis of Structural Analogues | The Journal of Organic Chemistry (acs.org)
Liang Qiao, Zhongwei Duan, Yinghan Chen, Yepeng Luan, Qianqun Gu, Yan-Kai Liu*, and Dehai Li*
![](https://pubs.acs.org/cms/10.1021/acs.joc.8b03185/asset/images/medium/jo-2018-031859_0007.gif)
21. Two Competitive but Switchable Organocatalytic Cascade Reaction Pathways: The Diversified Synthesis of Chiral Acetal-Containing Bridged Cyclic Compounds | Organic Letters (acs.org)
Xue-Jiao Lv, Ying-Han Chen, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.8b03654/asset/images/medium/ol-2018-03654p_0009.gif)
20. Organocatalytic asymmetric synthesis of both cis- and trans-configured pyrano[2,3-b]chromenes via different dehydration pathways - Organic Chemistry Frontiers (RSC Publishing)
Xue-Jiao Lv, Wei-Wei Zhao, Ying-Han Chen, Sheng-Biao Wan and Yan-Kai Liu*
![Graphical abstract: Organocatalytic asymmetric synthesis of both cis- and trans-configured pyrano[2,3-b]chromenes via different dehydration pathways](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C9QO00366E&imageInfo.ImageIdentifier.Year=2019)
19. Asymmetric Organocatalyzed Reaction Sequence To Synthesize Chiral Bridged and Spiro-Bridged Benzofused Aminals via Divergent Pathways | Organic Letters (acs.org)
Ying-Han Chen, Xue-Jiao Lv, Zhi-Hao You, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.9b01874/asset/images/medium/ol-2019-01874a_0010.gif)
18. Asymmetric organocatalyzed reaction sequence of 2-hydroxy cinnamaldehydes and acyclic N-sulfonyl ketimines to construct diverse chiral bridged polycyclic aminals - Organic Chemistry Frontiers (RSC Publishing)
Ying-Han Chen, Xue-Jiao Lv, Zhi-Hao You and Yan-Kai Liu*
![Graphical abstract: Asymmetric organocatalyzed reaction sequence of 2-hydroxy cinnamaldehydes and acyclic N-sulfonyl ketimines to construct diverse chiral bridged polycyclic aminals](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C9QO01116A&imageInfo.ImageIdentifier.Year=2019)
2018
17. Organocatalytic Asymmetric Synthesis of Spiro-Bridged and Spiro-Fused Heterocyclic Compounds Containing Chromane, Indole, and Oxindole Moieties | Organic Letters (acs.org)
Zhi-Hao You, Ying-Han Chen, Yu Tang, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.8b02731/asset/images/medium/ol-2018-027316_0008.gif)
16. Different hybridized oxygen atoms controlled chemoselective formation of oxocarbenium ions: synthesis of chiral heterocyclic compounds - Organic & Biomolecular Chemistry (RSC Publishing)
Xiao-Na Wu, Zhi-Hao You and Yan-Kai Liu*
![Graphical abstract: Different hybridized oxygen atoms controlled chemoselective formation of oxocarbenium ions: synthesis of chiral heterocyclic compounds](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C8OB01743C&imageInfo.ImageIdentifier.Year=2018)
15. Organocatalytic Diversity-Oriented Asymmetric Synthesis of Structurally and Stereochemically Complex Heterocycles | Organic Letters (acs.org)
Liang Qiao, Zhong-Wei Duan, Xiao-Na Wu, De-Hai Li*, Qian-Qun Gu, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.8b00377/asset/images/medium/ol-2018-00377u_0007.gif)
14. Asymmetric Organocatalytic Sequential Reaction of Structurally Complex Cyclic Hemiacetals and Functionalized Nitro-olefins To Synthesize Diverse Heterocycles | Organic Letters (acs.org)
Jun-Ping Pei, Ying-Han Chen, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.8b01386/asset/images/medium/ol-2018-01386e_0009.gif)
13. Diversified Synthesis of Chiral Chromane-Containing Polyheterocyclic Compounds via Asymmetric Organocatalytic Cascade Reactions | ACS Omega
Ying-Han Chen, De-Hai Li*, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acsomega.8b02891/asset/images/medium/ao-2018-02891p_0004.gif)
2017
12. Enantio- and diastereoselective synthesis of tetrahydrofuro[2,3-b]furan-2(3H)-one derivatives and related oxygen heterocycles via an asymmetric organocatalytic cascade process - Organic Chemistry Frontiers (RSC Publishing)
Wei-Wei Zhao and Yan-Kai Liu*
![Graphical abstract: Enantio- and diastereoselective synthesis of tetrahydrofuro[2,3-b]furan-2(3H)-one derivatives and related oxygen heterocycles via an asymmetric organocatalytic cascade process](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C7QO00621G&imageInfo.ImageIdentifier.Year=2017)
11. Lactols in Asymmetric Sequential Organo‐ and Gold‐Catalysis: Synthesis of Densely Functionalized Epimeric Bicyclic O,O‐Acetals - You - 2017 - Advanced Synthesis & Catalysis - Wiley Online Library
Zhi-Hao You, Ying-Han Chen, Xiao-Na Wu, Yan-Kai Liu*
![image](https://onlinelibrary.wiley.com/cms/asset/b4f7fc6c-46fe-4a32-911b-9b7beb360362/adsc201701071-toc-0001-m.png)
10. Asymmetric Organocatalytic One-Pot, Two-Step Sequential Process to Synthesize Chiral Acetal-Containing Polycyclic Derivatives from Cyclic Hemiacetals and Enones | The Journal of Organic Chemistry (acs.org)
Chao Liu and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.joc.7b01915/asset/images/medium/jo-2017-019155_0009.gif)
9. Lactols in an asymmetric aldol-desymmetrization sequence: access to tetrahydro-4H-furo[2,3-b]pyran-2-one and tetrahydro-4H-furo[2,3-b]furan-2-one derivatives - Organic & Biomolecular Chemistry (RSC Publishing)
Ji-Yao Li, Ke-Wei Yu, Chao-Chao Xie and Yan-Kai Liu*
![Graphical abstract: Lactols in an asymmetric aldol-desymmetrization sequence: access to tetrahydro-4H-furo[2,3-b]pyran-2-one and tetrahydro-4H-furo[2,3-b]furan-2-one derivatives](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C6OB02420C&imageInfo.ImageIdentifier.Year=2017)
8. Diversity-Oriented One-Pot Synthesis to Construct Functionalized Chroman-2-one Derivatives and Other Heterocyclic Compounds | The Journal of Organic Chemistry (acs.org)
Ying-Han Chen, Xue-Li Sun, Hua-Shi Guan, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.joc.7b00461/asset/images/medium/jo-2017-004618_0009.gif)
2016
7. From racemic precursors to fully stereocontrolled products: one-pot synthesis of chiral α-amino lactones and lactams - Organic & Biomolecular Chemistry (RSC Publishing)
Zhi-Hao You, Ying-Han Chen and Yan-Kai Liu*
![Graphical abstract: From racemic precursors to fully stereocontrolled products: one-pot synthesis of chiral α-amino lactones and lactams](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C6OB00953K&imageInfo.ImageIdentifier.Year=2016)
6. Substrate-Controlled, One-Pot Synthesis: Access to Chiral Chroman-2-one and Polycyclic Derivatives | Organic Letters (acs.org)
Xue-Li Sun, Ying-Han Chen, Dan-Yang Zhu, Yan Zhang, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.6b00160/asset/images/medium/ol-2016-001603_0007.gif)
5. Catalysts | Free Full-Text | Organocatalytic, Asymmetric [2+2+2] Annulation to Construct Six-Membered Spirocyclic Oxindoles with Six Continuous Stereogenic Centers (mdpi.com)
Zhi-Long Li, Chao Liu, Rui Tan,* Zhi-Ping Tong,* andYan-Kai Liu*
![](https://pub.mdpi-res.com/catalysts/catalysts-06-00065/article_deploy/html/images/catalysts-06-00065-ag-550.jpg?1581058292)
4. One-pot, highly efficient, asymmetric synthesis of ring-fused piperidine derivatives bearing N,O- or N,N-acetal moieties - Organic & Biomolecular Chemistry (RSC Publishing)
Ji-Yao Li, Zhi-Long Li, Wei-Wei Zhao, Yan-Kai Liu,* Zhi-Ping Tong and Rui Tan*
![Graphical abstract: One-pot, highly efficient, asymmetric synthesis of ring-fused piperidine derivatives bearing N,O- or N,N-acetal moieties](https://pubs.rsc.org/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C5OB02571K&imageInfo.ImageIdentifier.Year=2016)
3. The Attractive Application of Lactol Chemistry: From Racemic Lactol to Natural Product Skeleton
Pin-Wen Cai, Zhi-Hao You, Liang-Hui Xie, Rui Tan*, Zhi-Ping Tong*, Yan-Kai Liu*
![](https://www.thieme-connect.de/media/synthesis/201616/i_c0029_ga_10-1055_s-0035-1561972.gif)
2015
2. Open–Close: An Alternative Strategy to α-Functionalization of Lactone via Enamine Catalysis in One Pot under Mild Conditions | Organic Letters (acs.org)
Yan-Kai Liu*, Zhi-Long Li, Ji-Yao Li, Huan-Xi Feng, and Zhi-Ping Tong
![](https://pubs.acs.org/cms/10.1021/acs.orglett.5b00794/asset/images/medium/ol-2015-00794n_0006.gif)
1. An Efficient One-Pot Approach to the Construction of Chiral Nitrogen-Containing Heterocycles under Mild Conditions | Organic Letters (acs.org)
Huan-Xi Feng, Rui Tan, and Yan-Kai Liu*
![](https://pubs.acs.org/cms/10.1021/acs.orglett.5b01772/asset/images/medium/ol-2015-017725_0002.gif)