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成果及论文

1.      Shen M#*, Xiao Y#, Jing D#, Zhang G, Su J, Lin S*, Chen X*, Liu H*. Associations of Combined Lifestyle and Genetic Risks with Incident Psoriasis: A Prospective Cohort Study among UK Biobank Participants of European Ancestry. Journal of the American Academy of Dermatology. 2022;0(0). doi:10.1016/j.jaad.2022.04.006.

2.      Kuang X#, Wang Z#, Luo Z, He Z, Liang L, Gao Q, Li Y, Xia K, Xie Z, Chang R, Wang Y, Liu Y, Zhao S, Su J, Wang Y, Situ W, Chen M, Zhao Y, Chen X*, Xie H*, Liu H*. Ag nanoparticles enhance immune checkpoint blockade efficacy by promoting of immune surveillance in melanoma. Journal of Colloid and Interface Science. 2022; 616:189-200. doi:10.1016/j.jcis.2022.02.050.

3.      Ying Jing #, Xue Chen #, Kunyan Li, Yaoming Liu, Zhao Zhang, Yiqing Chen, Yuan Liu, Yushu Wang, Steven H Lin, Lixia Diao, Jing Wang, Yanyan Lou, Douglas B Johnson, Xiang Chen*, Hong Liu*, Leng Han*. Association of antibiotic treatment with immune-related adverse events in patients with cancer receiving immunotherapy. JITC. 2022 Jan;10(1): e003779.

4.      Ye Youqiong#, Zhang Yongchang#, Yang Nong#, Gao Qian#, Xinyu Ding, Xinwei Kuang, Rujuan Bao, Zhao Zhang, Chaoyang Sun, Bingying Zhou, Li Wang, Qingsong Hu, Chunru Lin, Jianjun Gao, Yanyan Lou, Steven H Lin, Lixia Diao, Liu Hong*, Chen Xiang*, Gordon B.Mills*, HanLeng*. Dynamic profiling of immune features to predict immunotherapy efficacy. The Innovation. 2021.

5.      Jing Y#, Zhang Y#, Wang J#, Li K#, Chen X, Heng J, Gao Q, Ye Y, Zhang Z, Liu Y, Lou Y, Lin SH, Diao L, Liu H*, Chen X*, Mills GB* and Han L*. Association Between Sex and Immune-Related Adverse Events During Immune Checkpoint Inhibitor Therapy. J Natl Cancer Inst 2021

6.      Lau P#, Shen M#, Ma F, Chen Y, Zhang J*, Su J*, Chen X* and Liu H*. A Bayesian network meta-analysis of comparison of cancer therapeutic vaccines for melanoma. J Eur Acad Dermatol Venereol 2021

7.      Li H, Kuang X, Liang L, Ye Y, Zhang Y, Li J, Ma F, Tao J, Lei G, Zhao S, Su J, Yang N, Peng C, Xu X, Hung MC, Han L*, Liu H*, Liu J* and Chen X*. The Beneficial Role of Sunitinib in Tumor Immune Surveillance by Regulating Tumor PD-L1. Adv Sci (Weinh) 2021; 8: 2001596.

8.      Xu Y#, Li Y#, Dong M, Gao Z, Chen X, Liu H* and Shen M*. Association of previous treatment with anti-tumour necrosis factor inhibitors with the effectiveness of secukinumab in the treatment of psoriatic arthritis: systematic review and meta-analysis. Rheumatology (Oxford) 2020; 59: 3657-3665.

9.      Ye Y#, Kuang X#, Xie Z#, Liang L, Zhang Z, Zhang Y, Ma F, Gao Q, Chang R, Lee HH, Zhao S, Su J, Li H, Peng J, Chen H, Yin M, Peng C, Yang N, Wang J, Liu J, Liu H*, Han L*, Chen X*. Small-molecule MMP2/MMP9 inhibitor SB-3CT modulates tumor immune surveillance by regulating PD-L1. Genome Med. 2020 Sep 28;12(1):83. doi: 10.1186/s13073-020-00780-z. PMID: 32988398; PMCID: PMC7523356.

10.   Liu H#*, Kuang X#, Zhang Y, Ye Y, Li J, Liang L, Xie Z, Weng L, Guo J, Li H, Ma F, Chen X, Zhao S, Su J, Yang N, Fang F, Xie Y, Tao J, Zhang J, Chen M, Peng C, Sun L, Zhang X, Liu J, Han L, Xu X, Hung MC, Chen X*. ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis.Cancer Cell. 2020; 37:324-339.e8.

11.   Ye, Y., Jing, Y., Li, L., Mills, G. B., Diao, L.*, Liu, H.*, & Han, L.* (2020). Sex-associated molecular differences for cancer immunotherapy. Nature communications, 11(1), 1779. https://doi.org/10.1038/s41467-020-15679-x

12.   Guo J#, Zhang J#, Liang L, Liu N, Qi M, Zhao S, Su J, Liu J, Peng C, Chen X*, Liu H*. Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin.J Cell Mol Med.2020.

13.   Zhenwei Tang#, Wenrui Ye#, Haotian Chen, Xinwei Kuang, Jia Guo, Minmin Xiang, Cong Peng, Xiang Chen*, Hong Liu*. Role of purines in regulation of metabolic reprogrammingPurinergic Signalling. 2019 Dec; 15(4): 423–438.

14.   Li H, Liu J, Cao W, Xiao X, Liang L, Liu-Smith F, Wang W, Liu H, Zhou P, Ouyang R, Yuan Z, Liu J, Ye M and Zhang B. C-myc/miR-150/EPG5 axis mediated dysfunction of autophagy promotes development of non-small cell lung cancer. Theranostics 2019; 9: 5134-5148

15.   Liang L, Peng Y, Zhang J, Zhang Y, Roy M, Han X, Xiao X, Sun S, Liu H, Nie L, Kuang Y, Zhu Z, Deng J, Xia Y, Sankaran VG, Hillyer CD, Mohandas N, Ye M*, An X* and Liu J*. Deubiquitylase USP7 regulates human terminal erythroid differentiation by stabilizing GATA1. Haematologica 2019; 104: 2178-2187

16.   Hong Liu, Morayo Adebiyi, Rong Rong Liu, Anren Song, Jeanne Manalo, Yuan Edward Wen, Alexander Q Wen, Tingting Weng, Junsuk Ko, Modupe Idowu, Rodney E Kellems, Holger K Eltzschig , Michael R Blackburn , Harinder S Juneja , Yang Xia*. Elevated ecto-5'-nuleotidase:a missing pathogenic factor and new therapeutic target for sickle cell disease. Blood Advances.2018 2:1957-1968.

17.   Anren Song, Yujin Zhang, Leng Han, Gennady G Yegutkin, Hong Liu, Kaiqi Sun, Angelo D'Alessandro, Jessica Li, Harry Karmouty-Quintana, Takayuki Iriyama , Tingting Weng, Shushan Zhao, Wei Wang, Hongyu Wu , Travis Nemkov , Andrew W Subudhi, Sonja Jameson-Van Houten , Colleen G Julian , Andrew T Lovering, Kirk C Hansen , Hong Zhang, Mikhail Bogdanov , William Dowhan , Jianping Jin , Rodney E Kellems, Holger K Eltzschig, Michael Blackburn , Robert C Roach , Yang Xia*. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 2017;8: 14108.

18.   Aji Huang, Hongyu Wu, Takayuki Iriyama, Yujin Zhang, Kaiqi Sun, Anren Song, Hong Liu, Zhangzhe Peng, Lili Tang, Minjung Lee, Yun Huang, Xin Ni, Rodney E Kellems, Yang Xia*. Elevated adenosine induces placental DNA hypomethylation independent of a2b receptor signaling in preeclampsia. Hypertension. 2017; 70:209-218.

19.   Sun K, D'Alessandro A, Ahmed MH, Zhang Y, Song A, Ko TP, Nemkov T, Reisz JA, Wu H, Adebiyi M, Peng Z, Gong J, Liu H, Huang A, Wen YE, Wen AQ, Berka V, Bogdanov MV, Abdulmalik O, Han L, Tsai AL, Idowu M, Juneja HS, Kellems RE, Dowhan W, Hansen KC, Safo MK, Xia Y*. Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease. Sci Rep. 2017 Nov 10;7(1):15281. doi: 10.1038/s41598-017-13667-8. PMID: 29127281; PMCID: PMC5681684.

20.   Kaiqi Sun, Hong Liu, Anren Song, Jeanne M Manalo, Angelo D'Alessandro, Kirk C Hansen, Rodney E Kellems, Holger K Eltzschig, Michael R Blackburn, Robert C Roach, Yang Xia*. Erythrocyte purinergic signaling components underlie hypoxia adaptation. J Appl Physiol (1985). 2017,123:951- 956.

21.   Liu H, Zhang Y, Wu H, D'Alessandro A, Yegutkin GG, Song A, Sun K, Li J, Cheng NY, Huang A, Edward Wen Y, Weng TT, Luo F, Nemkov T, Sun H, Kellems RE, Karmouty-Quintana H, Hansen KC, Zhao B, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Eltzschig HK, Blackburn MR, Roach RC, Xia Y*. Beneficial role of erythrocyte adenosine a2b receptormediated AMP-activated protein kinase activation in high-altitude hypoxia. Circulation. 2016; 134:405-421.

22.   19.Sun K, Zhang Y, D'Alessandro A, Nemkov T, Song A, Wu H, Liu H, Adebiyi M, Huang A, Wen YE, Bogdanov MV, Vila A, O'Brien J, Kellems RE, Dowhan W, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Safo M, Hansen KC, Roach RC, Xia Y*. Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia. Nat Commun. 2016; 7:12086.

23.   20.Hu X, Adebiyi MG, Luo J, Sun K, Le TT, Zhang Y, Wu H, Zhao S, KarmoutyQuintana H, Liu H, Huang A, Wen YE, Zaika OL, Mamenko M, Pochynyuk OM, Kellems RE, Eltzschig HK, Blackburn MR, Walters ET, Huang D, Hu H, Xia Y*. Sustained elevated adenosine via adora2b promotes chronic pain through neuro-immune interaction. Cell Rep. 2016; 16:106-119.

24.   D'Alessandro A*, Nemkov T, Sun K, Liu H, Song A, Monte AA, Subudhi AW, Lovering AT, Dvorkin D, Julian CG, Kevil CG, Kolluru GK, Shiva S, Gladwin MT, Xia Y, Hansen KC, Roach RC. AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia. J Proteome Res. 2016 Oct 7;15(10):3883-3895. doi: 10.1021/acs.jproteome.6b00733. Epub 2016 Sep 27. PMID: 27646145; PMCID: PMC5512539.

25.   21.Luo F, Le NB, Mills T, Chen NY, Karmouty-Quintana H, Molina JG, Davies J, Philip K, Volcik KA, Liu H, Xia Y, Eltzschig HK, Blackburn MR*. Extracellular adenosine levels are associated with the progression and exacerbation of pulmonary fibrosis.6 FASEB J. 2016;30:874-883.

26.   Sun K, Liu H, Song A, Manalo JM, D'Alessandro A, Hansen KC, Kellems RE, Eltzschig HK, Blackburn MR, Roach RC, Xia Y. Erythrocyte purinergic signaling components underlie hypoxia adaptation. J Appl Physiol (1985). 2017 Oct 1;123(4):951-956. doi: 10.1152/japplphysiol.00155.2017. Epub 2017 Jun 1. PMID: 28572494; PMCID: PMC5668449.

27.   Liu H, Xia Y*. Beneficial and detrimental roles of adenosine signaling in diseases and therapy. Journal of Applied Physiology. 2015.119; 1173-1182.

28.   Liu H, Ding D, Sun H, Jiang H, Wu X, Roth JA, Salvi R*. Cadmium-induced ototoxicity in rat cochlear organotypic cultures. Neurotox Res. 2014 Aug;26(2):179-89. doi: 10.1007/s12640-014-9461-4. Epub 2014 Feb 28. PMID: 24577639.

29.   Hong Liu, Dalian Ding, Haiyan Jiang, Richard Salvi. (2011) Ototoxic destruction by co-administration of kanamycin and ethacrynic acid in rats. J Zhejiang Univ Sci B.12 (10): P.853-61

30.   Hong Liu, Hong Sun, Richard Salvi Dalian Ding. (2011) Review: Cadmium poisoning and ototoxicity of cadmium. Chinese Journal of Otology. 9 (1): 50-53.

31.   Hong Liu, Dalian DingHong Sun, Richard Salvi. (2011). Measure of sensory epithelium of the inner ear in CBA mice. Chinese Journal of Otology.9(2): 224-231

32.   Xuewen Wu, Dalian Ding, Haiyan Jiang, Xiaowei Xing, Suping Huang, Hong Liu, Zhedong Chen, Hong Sun. Transfection using hydroxyapatite nanoparticles in the inner ear via an intact round window membrane in chinchilla. J Nanopart Res 14, 708 (2012)

33.   Xuewen Wu, Dalian Ding, Hong Sun, Hong Liu, Haiyan Jiang, Richard Salvi, Neurotoxicity of lead in rat cochlear organotypic cultures. Journal of Otology 6(2); 43-50 (2011)

34.   Xuewen Wu, Dalian Ding, Hong Sun, Hong Liu. (2011) Noise-induced the change of auditory brain response. Chinese Journal of EENT, (2); 72-76

35.   ADORA1在制备PD-L1/PDD-1单抗肿瘤免疫治疗药物中的应用,发明专利,ZL 2019 1 1361623.0

36.   DPCPX抑制剂在制备PD-L1/PD-1单抗肿瘤免疫治疗药物中的应用,发明专利,ZL 2019 1 1359805.4

37.   ATF3在制备PD-L1/PD-1单抗肿瘤免疫治疗药物中的应用,发明专利,ZL 2019 1 1361595.2

38.   用于评估肿瘤IBC疗法的疗效的生物标志物、系统、方法及试剂盒,发明专利,202210344394.70

39.   一种新型免疫刺激纳米药物及其在黑素瘤治疗中的应用,发明专利,202211128629.50

40.   黑磷纳米药物Apt@SCH@BPs的构建方法及应用,发明专利,202210961968.50

41.   PF543在制备PD-L1/PD-1单抗肿瘤免疫治疗药物中的应用,发明专利,202111634204.70

42.   MTA3在制备PD-L1/PD-1单抗肿瘤免疫治疗用药中的应用,发明专利,202111633758.50

43.   SPHK1在制备PD-L1/PD-1单抗肿瘤免疫治疗药物中的应用,发明专利,202111634200.90

44.   一种专门用于小鼠背部皮肤光照治疗的固定器,发明专利,ZL 2021 2 1286376.5

45.   一种银屑病小鼠模型制作用膏药敷贴,发明专利,ZL.2021 2 1215866.6

46.   黑磷在促进伤口愈合药物研制中的应用,发明专利,202110681866.30

47.    一种专门用于小鼠背部皮肤光照治疗的固定器[P]. ,发明专利,CN215584462U,2022-01-21.

48.   一种银屑病小鼠模型制作用膏药敷贴,发明专利,CN215585225U,2022-01-21

49.   一种动物实验中肠道炎造模用小鼠灌肠装置,发明专利,CN215584469U,2022-01-21.

50.    一种搭载咪喹莫特用于小鼠银屑病模型构建的药贴,发明专利,CN215584885U,2022-01-21.

51.   灵芝酸A在治疗银屑病药物中的应用,发明专利,CN113813265A,2021-12-21.

52.    黑磷在促进伤口愈合药物研制中的应用,发明专利,CN113262238A,2021-08-17.