李平教授，1973年生，1995年于山东师范大学获理学学士学位，1998年于西安近代化学研究所获工学硕士学位，2008年于山东师范大学获得理学博士学位，2010年2月-2010年9月赴美国俄亥俄大学访学，现为西北师范大学教授、博士生导师、享受国务院政府特殊津贴、国家百千万人才工程入选者、国家有突出贡献中青年专家、泰山学者、教育部“长江学者和创新团队发展计划”创新团队带头人、教育部“全国高校黄大年式教师团队”骨干成员、山东省有突出贡献的中青年专家、山东省优秀研究生导学团队负责人、山东省高校重点实验室首席专家、山东生物医学工程学会专业委员会委员、山东省科协国家级科技思想库决策咨询专家、AIMS Materials Science编委、中国化学会高级会员、中国致公党山东省第七届委员会委员、中国致公党山东师范大学委员会主任委员。
李平教授多年来致力于疾病相关生物标志物的光学成像分析，探究抑郁症、癌症等重大疾病分子机制及诊疗一体化试剂的开发。主要创新性成果包括：（1）构建成像新材料与新方法，以捕获疾病相关生物标志物，用于抑郁症、癌症等重大疾病发生发展过程中分子机制的探究及早期诊疗研究；（2）基于可逆、特异性的识别反应，实时、原位、高灵敏度地成像分析活细胞及亚细胞器内生物活性分子的动态变化；（3）基于双光子、近红外等功能性光学成像材料，在活体层面实现对生物活性分子的原位成像分析。已主持完成国家重点基础研究发展计划（“973计划”）课题1项、国家自然科学基金面上项目3项、国家重大新药创制课题子课题1项、国家自然科学基金青年基金1项、山东省自然科学基金重大基础研究项目1项及山东省科技攻关项目1项。目前主持国家自然科学基金面上项目1项。相关研究成果已在 Chem. Soc. Rev.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Chem. Sci.、Anal. Chem.、Chem. Commun. 等国际重要的学术刊物上面发表论文80余篇，其中影响因子5.0以上70余篇，10.0以上20余篇，论文总引用达3000余次。作为主要参与者完成的项目，先后荣获国家自然科学二等奖（3/5）、国家科技进步二等奖（8/10），山东省自然科学一等奖（2/4）、山东省自然科学二等奖（1/4）、山东省科技进步一等奖（5/8）、山东省青年科技奖以及山东高等学校优秀科研成果二等奖（1/3）等。此外，李平教授还曾获山东省教育系统女职工建功立业标兵、山东省教书育人楷模、山东省省级教学成果奖一等奖（7/10）、山东省省级教学成果奖一等奖（9/10）、山东师大研究生教育教学成果奖一等奖（9/10）、山东师大优秀教学奖及“青年教学能手”、山东省巾帼建功标兵、山东省优秀研究生导师、齐鲁巾帼科技创新之星荣誉称号。
代表性论文
(1) Wen Zhang, Jihong Liu, Ping Li,* Xin Wang* and Bo Tang.* Reversible Fluorescent Probes for Dynamic Imaging of Liver Ischemia-Reperfusion Injury. Acc. Chem. Res., 2024, 57, 17, 2594–2605.
(2) Xin Wang, Qi Ding, Robin R. Groleau, Luling Wu, Yuantao Mao, Feida Che, Oxana Kotova , Eoin M. Scanlan, Simon E. Lewis,* Ping Li,* Bo Tang,* Tony D. James,* and Thorfinnur Gunnlaugsson.* Fluorescent Probes for Disease Diagnosis. Chem. Rev., 2024, 124, 11, 7106-7164.
(3) Hui Wang,† Xiaoting Zhang,† Ping Li,* Fang Huang, Tiancong Xiu, Hongtong Wang, Wei Zhang, Wen Zhang, and Bo Tang.* Prediction of Early Atherosclerotic Plaques using a Sequence-Activated Fluorescence Probe for the Simultaneous Detection of γ-Glutamyl Transpeptidase and Hypobromous Acid. Angew. Chem. Int. Ed., 2023, e202315861.
(4) Di Su, Ran Zhang, Xin Wang,* Qi Ding, Feida Che, Zhenzhen Liu, Jingwen Xu, Yuying Zhao, Kunqian Ji, Wei Wu,* Chuanzhu Yan,* Ping Li,* and Bo Tang.* Shedding Light on Lysosomal Malondialdehyde Affecting Vitamin B12 Transport during Cerebral Ischemia/Reperfusion Injury. J. Am. Chem. Soc., 2023, 145, 22609-22619.
(5) Jihong Liu, Wen Zhang,* Xin Wang, Qi Ding, Chuanchen Wu, Wei Zhang, Luling Wu,* Tony D. James,* Ping Li,* and Bo Tang.* Unveiling the Crucial Roles of O2•– and ATP in Hepatic Ischemia–Reperfusion Injury Using Dual-Color/Reversible Fluorescence Imaging. J. Am. Chem. Soc., 2023, 145, 36, 19662-19675.
(6) Jihong Liu, Wen Zhang,* Chunmiao Zhou, Mengmei Li, Xin Wang, Wei Zhang, Zhenzhen Liu, Luling Wu,* Tony D. James,* Ping Li,* and Bo Tang.* Precision Navigation of Hepatic Ischemia Reperfusion Injury Guided by Lysosomal Viscosity-Activatable NIR-Ⅱ Fluorescence. J. Am. Chem. Soc., 2022, 144, 30, 13586-13599.
(7) Luling Wu,† Jihong Liu,† Xue Tian,† Robin R. Groleau, Beidou Feng, Yonggang Yang, Adam C. Sedgwick, Hai-Hao Han,* Yang Wang, Han-Min Wang, Fang Huang, Steven D. Bull, Hua Zhang,* Chusen Huang,* Yi Zang, Jia Li, Xiao-Peng He, Ping Li,* Bo Tang, Tony D. James,* and Jonathan L. Sessler*. Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5′-triphosphate in Cellular Applications. J. Am. Chem. Soc., 2022, 144, 174-183.
(8) Luling Wu,†,* Jihong Liu,† Ping Li,* Bo Tang* and Tony D. James*, Two-photon small-molecule fluorescence-based agents for sensing, imaging, and therapy within biological systems. Chem. Soc. Rev., 2021, 50, 702-734.
(9) Qi Ding,† Ying Tian,† Xin Wang,* Ping Li,* Di Su, Chuanchen Wu, Wen Zhang, and Bo Tang*. Oxidative Damage of Tryptophan Hydroxylase‑2 Mediated by Peroxisomal Superoxide Anion Radical in Brains of Mouse with Depression. J. Am. Chem. Soc., 2020, 142, 20735-20743.
(10) Haibin Xiao,† Wen Zhang,† Ping Li,* Wei Zhang, Xin Wang, and Bo Tang*. Versatile fluorescent probes for visualizing superoxide anion in living cells and in vivo. Angew. Chem. Int. Ed., 2020, 132, 4244-4258.
(11) Xin Wang; Ping Li,* Qi Ding; Chuanchen Wu; Wen Zhang; Bo Tang*. Observation of Acetylcholinesterase in Stress-induced Depression Phenotypes by Two-photon Fluorescence Imaging in the Mouse Brain. J. Am. Chem. Soc., 2019, 141(5): 2061-2068.
(12) Xin Wang, Ping Li,* Qi Ding, Chuanchen Wu, Wen Zhang, and Bo Tang*. Illuminating the Function of the Hydroxyl Radical in the Brains of Mice with Depression Phenotypes by Two‐Photon Fluorescence Imaging. Angew. Chem. Int. Ed., 2019, 58, 4674-4678.
(13) Wei Zhang, Jun Lu, Xiaonan Gao, Ping Li,* Wen Zhang, Yu Ma, Hui Wang, Bo Tang*. Enhanced Photodynamic Therapy by Reduced Levels of Intracellular Glutathione Obtained By Employing a Nano-MOF with CuII as Active Center. Angew. Chem. Int. Ed., 2018, 57, 4891-4896.
(14) Ping Li, Lu Liu, Haibin Xiao, Wei Zhang, Lulin Wang, and Bo Tang*. A New Polymer Nanoprobe Based on Chemiluminescence Resonance Energy Transfer (CRET) for Ultrasensitive Imaging of Intrinsic Superoxide Anion in Mice. J. Am. Chem. Soc., 2016, 138, 2893-2896.
(15) Wei Zhang, Wei Liu, Ping Li,* Haibin Xiao, Hui Wang, and Bo Tang*. A Fluorescence Nanosensor for Glycoproteins with Activity Based on the Molecularly Imprinted Spatial Structureof the Target and Boronate Affinity. Angew. Chem. Int. Ed., 2014, 53, 12489-12493.
(16) Wen Zhang,† Ping Li,† Fan Yang, Xiufen Hu, Chuanzhi Sun, Wei Zhang, Dezhan Chen, and Bo Tang*. Dynamic and Reversible Fluorescence Imaging of Superoxide Anion Fluctuations in Live Cells and in Vivo. J. Am. Chem. Soc., 2013, 135, 14956-14959.
主要论文
2024年
(122) Jihong Liu, Dongni Yin, Wen Zhang, Xin Wang, Tony D. James, Ping Li* and Bo Tang. A multifunctional “three-in-one” fluorescent theranostic system for hepatic ischemia–reperfusion injury. Chem. Sci., 2024, 10.1039/d4sc04962d.
(121) Feida Che, Xiaoming Zhao, Qi Ding, Xiwei Li, Wen Zhang, Ping Li,* Xin Wang* and Bo Tang. A versatile fluorescent probe for hydrogen peroxide in serotonergic neurons of living brains of mice with depression. J. Mater. Chem. B, 2024, 12, 10241-10247.
(120) Wen Zhang, Min Zhang, Mengmei Li, Xin Wang, Ping Li* and Bo Tang.* Glutathione and viscosity double-locked response fluorescent probe for imaging and surgical navigation of hepatocellular carcinoma. Chem. Commun., 2024, 60, 10021-10024.
(119)Wen Zhang, Jihong Liu, Ping Li,* Xin Wang* and Bo Tang.* Reversible Fluorescent Probes for Dynamic Imaging of Liver Ischemia-Reperfusion Injury. Acc. Chem. Res., 2024, 57, 17, 2594–2605.
(118) Xin Wang, Qi Ding, Robin R. Groleau, Luling Wu, Yuantao Mao, Feida Che, Oxana Kotova , Eoin M. Scanlan, Simon E. Lewis,* Ping Li,* Bo Tang,* Tony D. James,* and Thorfinnur Gunnlaugsson.* Fluorescent Probes for Disease Diagnosis. Chem. Rev., 2024, 124, 11, 7106-7164.
(117) Yuantao Mao, Chuanchen Wu, Xin Wang,* Fanghui Zhang, Xinru Qi, Xia Li, Ping Li,* and Bo Tang.* Fluorescence Imaging Sheds Light on the Immune Evasion Mechanisms of Hepatic Stellate Cells Mediated by Superoxide Anion. Commun. Biol., 2024, 7, 558.
(116) Chuanchen Wu, Yuantao Mao, Xinru Qi, Xin Wang, Ping Li,* Wen Zhang, and Bo Tang.* Tracking Interactions between TAMs and CAFs Mediated by Arginase‐Induced Proline Production During Immune Evasion of HCC. Aggregate, 2024, e530.
(115) Jin Li, Jiheng Xu, Ruize Zhao, Wei Zhang, Ping Li, Wen Zhang, Hui Wang, and Bo Tang.* Progress of Fluorescent Probes for Protein Phosphorylation and Glycosylation in Atherosclerosis. Chem. Eur. J., 2024, e202303778.
(114) Hui Wang,* Xiaoting Zhang, Tiancong Xiu, Hongtong Wang, Ping Li,* and Bo Tang,* Fluorescence Probes for Sensing and Imaging within Golgi Apparatus. Coordin. Chem. Rev., 2024, 502, 215618.
(113) Hui Wang,* Na Wen, Ping Li,* Tiancong Xiu, Shuqi Shang, Wei Zhang, Wen Zhang, Junnan Qiao, and Bo Tang,* Treatment Evaluation of Rheumatoid Arthritis by in Situ Fluorescence Imaging of the Golgi Cysteine. Talanta, 2024, 270, 125532.
2023年
(112) Jun Lu,† Zongying Li,† Mengmeng Lu, Nannan Fan, Wei Zhang,* Ping Li, Yue Tang,* Xia Yin, Wen Zhang, Hui Wang, and Bo Tang.* Assessing early Atherosclerosis by Detecting and Imaging of Hypochlorous acid and Phosphorylation using Fluorescence Nanoprobe. Adv. Mater., 2023, 2307008.
(111) Hui Wang,† Xiaoting Zhang,† Ping Li,* Fang Huang, Tiancong Xiu, Hongtong Wang, Wei Zhang, Wen Zhang, and Bo Tang.* Prediction of Early Atherosclerotic Plaques using a Sequence-Activated Fluorescence Probe for the Simultaneous Detection of γ-Glutamyl Transpeptidase and Hypobromous Acid. Angew. Chem. Int. Ed., 2023, e202315861.
(110) Xin Wang,† Feida Che,† Xin Zhang, Ping Li,* Wen Zhang, and Bo Tang.* Tracing Superoxide Anion in Serotonergic Neurons of Living Mouse Brains with Depression by Small-Molecule Fluorescence Probes. Anal. Chem., 2023, 95, 42, 15614-15620.
(109) Di Su, Ran Zhang, Xin Wang,* Qi Ding, Feida Che, Zhenzhen Liu, Jingwen Xu, Yuying Zhao, Kunqian Ji, Wei Wu,* Chuanzhu Yan,* Ping Li,* and Bo Tang.* Shedding Light on Lysosomal Malondialdehyde Affecting Vitamin B12 Transport during Cerebral Ischemia/Reperfusion Injury. J. Am. Chem. Soc., 2023, 145, 22609-22619.
(108) Xiaoting Zhang,† Tiancong Xiu,† Hui Wang, Hongtong Wang, Ping Li,* and Bo Tang.* Recent progress in the development of small-molecule double-locked logic gate fluorescence probes. Chem. Commun. 2023,59, 11017-11027.
(107) Di Su,† Ran Zhang,† Xin Wang,* Qi Ding, Feida Che, Wen Zhang, Wei Wu,* Ping Li,* and Bo Tang.* A New Multi-Parameter Imaging Platform for in Vivo Drug Efficacy Evaluation of Ischemic Stroke. Talanta, 2024, 266, 125133.
(106) Jihong Liu, Wen Zhang,* Xin Wang, Qi Ding, Chuanchen Wu, Wei Zhang, Luling Wu,* Tony D. James,* Ping Li,* and Bo Tang.* Unveiling the Crucial Roles of O2•– and ATP in Hepatic Ischemia–Reperfusion Injury Using Dual-Color/Reversible Fluorescence Imaging. J. Am. Chem. Soc., 2023, 145, 36, 19662-19675.
(105) Wen Zhang,† Wenjie Fan,† Xin Wang, Ping Li,* Wei Zhang, Hui Wang, and Bo Tang.* Uncovering Endoplasmic Reticulum Superoxide Regulating Hepatic Ischemia-Reperfusion Injury by Dynamic Reversible Fluorescence Imaging. Anal. Chem., 2023, 95, 21, 8367-8375.
(104) Chuanchen Wu, Yuantao Mao, Fanghui Zhang, Xin Wang, Nannan Fan, Wen Zhang, Ping Li,* and Bo Tang.* Uncovering the Mechanism of Cancer-Associated Fibroblasts Induced Immune Evasion of Hepatocellular Carcinoma Cells via in Situ Fluorescence Imaging. Sensor. Actuat. B-Chem., 2023, 389, 15, 133891.
(103) Ning Wen, Jin Li, Wei Zhang, Ping Li, Xia Yin, Wen Zhang, Hui Wang, and Bo Tang.* Monitoring the Progression of Early Atherosclerosis Using a Fluorescence Nanoprobe for the Detection and Imaging of Phosphorylation and Glucose Levels. Angew. Chem. Int. Ed., 2023, e202302161.
(102) Kai Wang, Ruixiao Zhang, Xiujie Zhao,* Yan Ma, Lijuan Ren, Youxiao Ren, Gaofei Chen, Dingming Ye, Jinfang Wu, Xinyuan Hu, Yuanqiang Guo, Rimo Xi, Meng Meng, Qingqiang Yao,* Ping Li,* Qixin Chen,* and Tony D. James.* Reversible Recognition-Based Boronic Acid Probes for Glucose Detection in Live Cells and Zebrafish. J. Am. Chem. Soc. 2023, 145, 15, 8408-8416.
(101) Wen Zhang,† Mengmei Li,† Xin Wang, Wei Zhang, Hui Wang, Ping Li,* and Bo Tang.* Precision Navigation of Venous Thrombosis Guided by Viscosity-Activatable Near-Infrared Fluorescence. Anal. Chem. 2023, 95, 4, 2382-2389.
(100) Jin Li, Na Zhao, Wei Zhang,* Ping Li, Xia Yin, Wen Zhang, Hui Wang, and Bo Tang.* Assessing the Progression of Early Atherosclerosis Mice Using a Fluorescence Nanosensor for the Simultaneous Detection and Imaging of pH and Phosphorylation. Angew. Chem. Int. Ed., 2023, 62, 3, e202215178.
2022年
(99) Hanchuang Zhu, Pan Jia, Xin Wang, Ying Tian, Caiyun Liu, Xiwei Li, Kun Wang, Ping Li,* Baocun Zhu*, and Bo Tang*. In Situ Observation of Lysosomal Hypobromous Acid Fluctuations in the Brain of Mice with Depression Phenotypes by Two-Photon Fluorescence Imaging. Anal. Chem. 2022, 94, 34, 11783–11790.
(98) Fuyan Tang,† Chuanchen Wu,† Zhaodong Zhai, Kai Wang, Xueli Liu, Haibin Xiao,* Shuping Zhuo,* Ping Li,* and Bo Tang. Recent progress in small-molecule fluorescent probes for endoplasmic reticulum imaging in biological systems. Analyst, 2022,147, 987-1005.
(97) Wen Zhang,† Chunmiao Zhou,† Ping Li,* Jihong Liu, Xin Wang, Wei Zhang, Hui Wang, and Bo Tang*. Quantitative Fluorescence Imaging of the Intracellular Redox State by Real-Time Spatial and Temporal Simultaneous Analysis of O2•− Levels and Keap1 Translocation. Anal. Chem., 2022, 94, 36, 12352-12359.
(96) Wen Zhang,† Mengmei Li,† Xin Wang, Ping Li,* and Bo Tang*. Application of Near-Infrared Fluorescence Imaging in Thrombosis Detection. Anal. Sens., 2022, e202200045.
(95) Xin Wang,† Di Su,† Chunyu Liu, Ping Li,* Ran Zhang, Wen Zhang, Wei Zhang, and Bo Tang*. Janus-Faced Fluorescence Imaging Agent for Malondialdehyde and Formaldehyde in Brains. Anal. Chem., 2022, 94, 43, 14965-14973.
(94) Hui Wang, Junwei Nie, Ping Li,* Xiaoting Zhang, Yu Wang, Wei Zhang, Wen Zhang, and Bo Tang*. Exploring Idiopathic Pulmonary Fibrosis Biomarker by Simultaneous Two-Photon Fluorescence Imaging of Cysteine and Peroxynitrite. Anal. Chem., 2022, 94, 32, 11272–11281.
(93) Jihong Liu, Wen Zhang,* Chunmiao Zhou, Mengmei Li, Xin Wang, Wei Zhang, Zhenzhen Liu, Luling Wu,* Tony D. James,* Ping Li,* and Bo Tang.* Precision navigation of hepatic ischemia reperfusion injury guided by lysosomal viscosity-activatable NIR-Ⅱ fluorescence. J. Am. Chem. Soc., 2022, 144, 30, 13586–13599.
(92) Nannan Fan, Yongqing Zhou, Lijie Wu, Xin Wang, Ping Li,* Zhenzhen Liu, Wen Zhang, Wei Zhang, Bo Tang*. Probing Iron-Mediated Synergistic Change of Cl− and HClO in Liver Cancer Cells with a Dual-Color Fluorescence Reporter. Anal. Chem., 2022, 94, 30, 10659–10668.
(91) Li Yang,‡ Mengqi Wang,‡ Xiaoyu Gu,‡ Wei Zhang,* Ping Li, Wen Zhang, Hui Wang and Bo Tang*, One-step synthesis of carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice. Front. Chem. Sci. Eng. 2022, Accepted.
(90) Nannan Fan, Ping Li,* Yongqing Zhou, Chuanchen Wu, Xin Wang, Zhenzhen Liu, Bo Tang*. Demystifying Lysosomal α-L-Fucosidase in Liver Cancer-Bearing Mice by Specific Two-Photon Fluorescence Imaging. ACS Sensors, 2022, 7, 71-81.
(89) Xin Wang,‡ Ruiyuan Wang,‡ Qi Ding, Wei Wu,* Feida Che, Ping Li,* Wen Zhang, Wei Zhang, Zhenzhen Liu, and Bo Tang.* Hypochlorous Acid-Activated Multifunctional Fluorescence Platform for Depression Therapy and Antidepressant Efficacy Evaluation. Anal. Chem., 2022, 94, 27, 9811–9818.
(88) Hui Wang,‡* Cuifang Liu,‡ Xiaoting Zhang, Tiancong Xiu, Ping Li,* Wei Zhang, Wen Zhang, Xin Wang, Zhenzhen Liu, Bo Tang*. Simultaneous fluorescence imaging of Golgi O2•−and Golgi H2O2 in mice with hypertension. Biosens. Bioelectron., 2022, 213, 114480.
(87) Xue Wang,† Jin Li,† Wei Zhang,* Ping Li, Wen Zhang, Hui Wang, and Bo Tang* Evaluating diabetic ketoacidosis via a MOF sensor for fluorescence imaging of phosphate and pH, Chem. Commun., 2022, 58, 3023-3026.
(86) Wei Zhang, Jin Li, Na Zhao, Ping Li, Wen Zhang, Hui Wang, Bo Tang* Ratiometric fluorescence biosensor for imaging of protein phosphorylation levels in atherosclerosis mice. Anal. Chim. Acta, 2022, 1208, 339825.
(85) Xin Wang,‡ Qi Ding,‡ Ying Tian, Wei Wu,* Feida Che, Ping Li,* Wen Zhang, Wei Zhang and Bo Tang*. In situ fluorescence imaging reveals that mitochondrial H2O2 mediates lysosomal dysfunction in depression. Chem. Commun., 2022, 58, 6320–6323.
(84) Luling Wu,† Jihong Liu,† Xue Tian,† Robin R. Groleau, Beidou Feng, Yonggang Yang, Adam C. Sedgwick, Hai-Hao Han,* Yang Wang, Han-Min Wang, Fang Huang, Steven D. Bull, Hua Zhang,* Chusen Huang,* Yi Zang, Jia Li, Xiao-Peng He, Ping Li,* Bo Tang, Tony D. James,* and Jonathan L. Sessler*. Dual-Channel Fluorescent Probe for the Simultaneous Monitoring of Peroxynitrite and Adenosine-5′-triphosphate in Cellular Applications. J. Am. Chem. Soc., 2022, 144, 174-183.
(83) Yongqing Zhou, Wen Zhang,* Xin Wang, Ping Li,* Bo Tang.* Recent Progress in Small-Molecule Fluorescence and Photoacoustic Dual-Modal Probes for the In-Vivo Detection of Bioactive Molecules. Chemistry-An Asian Journal, 2022, 17, 10, e202200155.
(82) Di Su, Xin Wang, Wen Zhang, Ping Li*, Bo Tang*. Fluorescence imaging for visualizing the bioactive molecules of lipid peroxidation within biological systems. Trend. Anal. Chem., 2022, 146,116484.
(81) Chuanchen Wu,† Yuantao Mao,† Xin Wang, Ping Li,* and Bo Tang*. Deep-Tissue Fluorescence Imaging Study of Reactive Oxygen Species in a Tumor Microenvironment. Anal. Chem., 2022, 94, 165-176.
(80) Jun Lu, Zhongyao Jiang, Jie Ren, Wei Zhang,* Ping Li, Zhenzhen Chen, Wen Zhang, Hui Wang, and Bo Tang* One-Pot Synthesis of Multifunctional Carbon-Based Nanoparticle-supported Dispersed Cu2+ Disrupts Redox Homeostasis to Enhance CDT. Angew. Chem. Int. Ed. 2022, 61, e202114373.
(79) Yongqing Zhou, Xin Wang, Wei Zhang*, Bo Tang, Ping Li*. Recent advances in small molecule fluorescent probes for simultaneous imaging of two bioactive molecules in live cells and in vivo. Front. Chem. Sci. Eng., 2022, 16, 4-33.
2021年
(78) Hui Wang,†* Xiaoting Zhang,† Mingyan Dong, Wei Zhang, Wen Zhang, Ping Li,* and Bo Tang. Evaluation of Effectiveness of Antiarthritic Treatment by in situ Ratiometric Fluorescence Imaging of the Endoplasmic Reticulum pH. Sensors and Actuators B: Chemical, 2021, 349, 130786.
(77) Hui Wang,a Xin Wang,a Ping Li,*a Mingyan Dong,a Shao Q. Yao *b and Bo Tang *a. Fluorescent probes for visualizing ROS-associated proteins in disease. Chem. Sci., 2021, 12, 11620-11646.
(76) Zhenzhen Liu†, Xiaoning Liu†, RuiCheng Fan†, Yuping Jia†, Qingke Zhang, Xin qing Gao, Yu-Qing Wang, Yu-Qing Wang, Meng-Qing Yang, Li-Zhen Ji, Yong Qing Zhou, Hong Li Li*, Ping Li*, Bo Tang*. Identification of pimavanserin tartrate as a potent Ca2+-calcineurin-NFAT pathway inhibitor for glioblastoma therapy. Acta Pharmacol Sin. 2021, 42, 1860-1874.
(75) Wei Zhang, Jie Ren, Jun Lu, Ping Li, Wen Zhang, Hui Wang, and Bo Tang*. Elucidating the Relationship between ROS and Protein Phosphorylation through In Situ Fluorescence Imaging in the Pneumonia Mice. Anal. Chem., 2021, 93, 31, 10907–10915.
(74) Hui Wang*,1, Hongtong Wang1, Xiaoting Zhang, Mingyan Dong, Fang Huang*, Ping Li*, Bo Tang. A two-photon fluorescent probe for imaging of mitochondrial cysteine in λ-carrageenan induced arthritis. Sensors and Actuators B: Chemical, 2021, 338, 129749.
(73) Yongqing Zhou, Chuanchen Wu, Xin Wang, Ping Li*, Nannan Fan, Wei Zhang, Zhenzhen Liu, Wen Zhang, Bo Tang*. Exploring the Changes of Peroxisomal Polarity in the Liver of Mice with Nonalcoholic Fatty Liver Disease. Anal. Chem., 2021, 93, 9609-9620.
(72) Hui Wang, Mingyan Dong, Hongtong Wang, Fang Huang, Ping Li,* Wei Zhang, Wen Zhang and Bo Tang*. Ultrasensitive and ratiometric two-photon fluorescence imaging of Golgi polarity during drug-induced acute kidney injury. Chem. Commun., 2021, 57, 5838–5841.
(71) Nannan Fan, Chuanchen Wu, Yongqing Zhou, Xin Wang, Ping Li,* Zhenzhen Liu, and Bo Tang*. Rapid Two-Photon Fluorescence Imaging of Monoamine Oxidase B for Diagnosis of Early-Stage Liver Fibrosis in Mice. Anal. Chem. 2021, 93, 7110-7117.
(70) Yongqing Zhou, Zhenzhen Liu, Guangming Qiao, Bo Tang, Ping Li.* Visualization of endoplasmic reticulum viscosity in the liver of mice with nonalcoholic fatty liver disease by a near-infrared fluorescence probe. Chin. Chem. Lett., 2021. 32, 3641-3645.
(69) Hui Wang,† Cuifang Liu,† Zixu He, Ping Li,* Wei Zhang, Wen Zhang, and Bo Tang*. Dual-Colored Fluorescence Imaging of Mitochondrial HNO and Golgi-HNO in Mice with DILI. Anal. Chem., 2021, 93, 6551–6558.
(68) Wen Zhang, Simin Bi, Ping Li,* Jihong Liu, Chunmiao Zhou, Xin Wang, Wei Zhang, Hui Wang, and Bo Tang*. In Situ Observation of mtDNA Damage during Hepatic Ischemia-Reperfusion. Anal. Chem. 2021, 93, 14, 5782–5788.
(67) Luling Wu,†,* Jihong Liu,† Ping Li,* Bo Tang* and Tony D. James*, Two-photon small-molecule fluorescence-based agents for sensing, imaging, and therapy within biological systems. Chem. Soc. Rev., 2021, 50, 702-734.
(66) Nannan Fan, Ping Li,* Chuanchen Wu, Xin Wang, Yongqing Zhou, and Bo Tang*. ALP-Activated Chemiluminescence PDT Nano-Platform for Liver Cancer-Specific Theranostics. ACS Appl. Bio Mater. 2021, 4, 1740-1748.
(65) Haibin Xiao, Ping Li,* Bo Tang. Recent progresses in fluorescent probes for detection of polarity. Coordin. Chem. Rev., 2021, 427, 213528.
(64) Luling Wu,† Jihong Liu,† Xue Tian, Robin R. Groleau, Steven D. Bull, Ping Li,* Bo Tang*, Tony D. James*. Fluorescent probe for the imaging of superoxide and peroxynitrite during drug-induced liver injury. Chem. Sci., 2021, 12, 3921-3928.
2020年
(63) Qi Ding,† Ying Tian,† Xin Wang,* Ping Li,* Di Su, Chuanchen Wu, Wen Zhang, and Bo Tang*. Oxidative Damage of Tryptophan Hydroxylase‑2 Mediated by Peroxisomal Superoxide Anion Radical in Brains of Mouse with Depression. J. Am. Chem. Soc., 2020, 142, 20735–20743.
(62) Wei Zhang, Hui Zhang, Mengqi Wang, Ping Li, Caifeng Ding, Wen Zhang, Hui Wang, and Bo Tang*. Copolymer-Based Fluorescence Nanosensor for In Situ Imaging of Homocysteine in the Liver and Kidney of Diabetic Mice. Anal. Chem., 2020, 92, 16221-16228.
(61) Yongqing Zhou, Ping Li,* Xin Wang, Chuanchen Wu, Nannan Fan, Xiaoning Liu, Lijie Wu, Wei Zhang, Wen Zhang, Zhenzhen Liu and Bo Tang*. In situ visualization of peroxisomal viscosity in the liver of mice with non-alcoholic fatty liver disease by near-infrared fluorescence and photoacoustic imaging. Chem. Sci., 2020, 11, 12149.
(60) Xin Wang,† Xiaoyi Bai,† Di Su, Yandi Zhang, Ping Li,* Shuyi Lu, Yulin Gong, Wen Zhang, and Bo Tang*. Simultaneous Fluorescence Imaging Reveals N‑Methyl‑D‑aspartic Acid Receptor Dependent Zn2+/H+ Flux in the Brains of Mice with Depression. Anal. Chem., 2020, 92, 4101−4107.
(59) Wei Zhang, Xiaolei Liu, Ping Li, Wen Zhang, Hui Wang, and Bo Tang*. In Situ Fluorescence Imaging of the Levels of Glycosylation and Phosphorylation by a MOF-Based Nanoprobe in Depressed Mice. Anal. Chem., 2020, 92, 3716−3721.
(58) Hui Wang,*,† Yuyun Yang,† Fang Huang, Zixu He, Ping Li,* Wei Zhang, Wen Zhang, and Bo Tang*. In Situ Fluorescent and Photoacoustic Imaging of Golgi pH to Elucidate the Function of Transmembrane Protein 165. Anal. Chem., 2020, 92, 3103−3110.
(57) Di Su,† Ping Li,† Xin Wang, Wei Zhang, Yandi Zhang, Chuanchen Wu, Wen Zhang, Yan Li, Wenjun Tai, and Bo Tang*. Observing Malondialdehyde-Mediated Signaling Pathway in Cerebral Ischemia Reperfusion Injury with a Specific Nanolight. Anal. Chem., 2020, 92, 2748-2755.
(56) Jiheng Xu,† Hui Zhang,† Wei Zhang*, Ping Li, Wen Zhang, Hui Wang and Bo Tang*. Fluorescence nanosensor for in situ detection of phosphate and alkaline phosphatase in parathyroid dysfunction mice. Chem. Commun., 2020, 56, 2431-2434.
(55) Lijie Wu,† Qi Ding,† Xin Wang, Ping Li,* Nannan Fan, Yongqing Zhou, Lili Tong, Wen Zhang, Wei Zhang, and Bo Tang*. Visualization of Dynamic Changes in Labile Iron (Ⅱ) Pools in Endoplasmic Reticulum Stress-Mediated Drug-Induced Liver Injury. Anal. Chem., 2020, 92, 1245-1251.
(54) Haibin Xiao,† Wen Zhang,† Ping Li,* Wei Zhang, Xin Wang, and Bo Tang*. Versatile fluorescent probes for visualizing superoxide anion in living cells and in vivo. Angew. Chem. Int. Ed., 2020, 132, 4244-4258.
2019年
(53) Chuanchen Wu,† Ping Li,† Nannan Fan, Jianjun Han, Wei Zhang, Wen Zhang, and Bo Tang*. A Dual-Targeting Functionalized Graphene Film for Rapid and Highly Sensitive Fluorescence Imaging Detection of Hepatocellular Carcinoma Circulating Tumor Cells. ACS Appl. Mater. Inter., 2019, 11, 44999-45006.
(52) Hui Wang,† Zixu He,† Yuyun Yang, Jiao Zhang, Wei Zhang, Wen Zhang, Ping Li* and Bo Tang*. Ratiometric Fluorescence Imaging of Golgi H₂O₂ Reveals a Correlation between Golgi Oxidative Stress and Hypertension. Chem. Sci., 2019, 10, 10876-10880.
(51) Wen Zhang,† Jihong Liu,† Ping Li,* Xin Wang, Simin Bi, Jiao Zhang, Wei Zhang, Hui Wang, and Bo Tang*. In situ and real-time imaging of superoxide anion and peroxynitrite elucidating arginase 1 nitration aggravating hepatic ischemia-reperfusion injury. Biomaterials, 2019, 225, 119499.
(50) Wen Zhang,† Di Su,† Ping Li,* Jiao Zhang, Jihong Liu, Hui Wang, Wei Zhang and Bo Tang*. Two-photon fluorescence imaging of mitochondrial superoxide anion transport mediating liver ischemia-reperfusion injury in mice. Chem. Commun., 2019, 55, 10740-10743.
(49) Jun Lu, Wei Zhang*, Ping Li, Xiaonan Gao, Wen Zhang, Hui Wang and Bo Tang*. Photodynamic therapy for hypoxic solid tumors via Mn-MOF as a photosensitizer. Chem. Commun., 2019, 55, 10792-10795.
(48) Hui Wang,† Yixin Zhang,† Yuyun Yang, Zixu He, Chuanchen Wu, Wei Zhang, Wen Zhang, Ju Liu, Ping Li* and Bo Tang*. In situ photoacoustic imaging of cysteine to reveal the mechanism of limited GSH synthesis in pulmonary fibrosis. Chem. Commun., 2019, 55, 9685-9688.
(47) Yandi Zhang,† Xin Wang,† Xiaoyi Bai, Ping Li,* Di Su, Wen Zhang, Wei Zhang, and Bo Tang*. Highly Specific Cys Fluorescence Probe for Living Mouse Brain Imaging via Evading Reaction with Other Biothiols. Anal. Chem., 2019, 91, 8591-8594.
(46) Yongqing Zhou,† Ping Li,† Nannan Fan, Xin Wang, Xiaoning Liu, Lijie Wu, Wen Zhang, Wei Zhang, Changle Ma* and Bo Tang*. In situ visualization of peroxisomal peroxynitrite in liver of mice with acute liver injury induced by carbon tetrachloride using a new two-photon fluorescent probe. Chem. Commun., 2019, 55, 6767-6770.
(45) Ping Li,† Xiaomeng Guo,† Xiaoyi Bai, Xin Wang, Qi Ding, Wen Zhang, Wei Zhang, and Bo Tang*. Golgi Apparatus Polarity Indicates Depression-like Behaviours of Mice Using in vivo Fluorescence Imaging. Anal. Chem., 2019, 91, 3382-3388.
(44) Ping Li,† Jijuan Wang,† Xin Wang, Qi Ding, Xiaoyi Bai, Yandi Zhang, Di Su, Wei Zhang, Wen Zhang and Bo Tang*. In situ visualization of ozone in the brains of mice with depression phenotypes by using a new near-infrared fluorescence probe. Chem. Sci., 2019, 10, 2805-2810.
(43) Wen Zhang,† Jiao Zhang,† Ping Li,* Jihong Liu, Di Su and Bo Tang*. Two-photon fluorescence imaging reveals a Golgi apparatus superoxide anion-mediated hepatic ischaemia-reperfusion signalling pathway. Chem. Sci., 2019, 10, 879-883.
(42) Ping Li,*† Xiaohui Shi,† Haibin Xiao, Qi Ding, Xiaoyi Bai, Chuanchen Wu, Wen Zhang and Bo Tang*. Two-photon imaging of the endoplasmic reticulum thiol flux in the brains of mice with depression phenotypes. Analyst, 2019, 144, 191-196.
(41) Xin Wang; Ping Li,* Qi Ding; Chuanchen Wu; Wen Zhang; Bo Tang*. Observation of Acetylcholinesterase in Stress-induced Depression Phenotypes by Two-photon Fluorescence Imaging in the Mouse Brain. J. Am. Chem. Soc., 2019, 141(5): 2061~2068.
(40) Xin Wang, Ping Li,* Qi Ding, Chuanchen Wu, Wen Zhang, and Bo Tang*. Illuminating the Function of the Hydroxyl Radical in the Brains of Mice with Depression Phenotypes by Two‐Photon Fluorescence Imaging. Angew. Chem. Int. Ed., 2019, 58, 4674-4678.
2018年
(39) Xueting Liu,† Nannan Fan,† Lijie Wu, Chuanchen Wu, Yongqing Zhou, Ping Li* and Bo Tang*. Lighting up alkaline phosphatase in drug-induced liver injury using a new chemiluminescence resonance energy transfer nanoprobe. Chem. Commun., 2018, 54, 12479-12482.
(38) Haibin Xiao,† Ruilin Zhang,† Chuanchen Wu, Ping Li,* Wen Zhang*, Bo Tang. A new pH-sensitive fluorescent probe for visualization of endoplasmic reticulum acidification during stress. Sensor Actuat B-Chem., 2018, 273, 1754-1761.
(37) Wei Zhang*, Jiheng Xu, Ping Li, Xiaonan Gao, Wen Zhang, Hui Wang and Bo Tang*. Treatment of hyperphosphatemia based on specific interaction between phosphorus and active center Zr(IV) of nano-MOFs. Chem. Sci., 2018, 9, 7483-7487.
(36) Wei Zhang, Jun Lu, Xiaonan Gao, Ping Li,* Wen Zhang, Yu Ma, Hui Wang, Bo Tang*. Enhanced Photodynamic Therapy by Reduced Levels of Intracellular Glutathione Obtained By Employing a Nano-MOF with CuII as Active Center. Angew. Chem. Int. Ed., 2018, 57, 4891-4896.
(35) Haibin Xiao, Chuanchen Wu, Ping Li,* and Bo Tang*. Simultaneous Fluorescence Visualization of Endoplasmic Reticulum Superoxide Anion and Polarity in Myocardial Cells and Tissue. Anal. Chem., 2018, 90, 6081-6088.
(34) Wei Zhang*, Ruixia Wang, Wei Liu, Xin Wang, Ping Li,* Wen Zhang, Hui Wang and Bo Tang*. Te-containing carbon dots for fluorescence imaging of superoxide anion in mice during acute strenuous exercise or emotional changes. Chem. Sci., 2018, 9, 721-727.
2017年
(33) Wei Zhang, Jiaoyang Wang, Ping Li,* Chuanchen Wu, Hongyan Zhang, Wen Zhang, Hui Wang and Bo Tang*. Transferrin-navigation Nano Artificial Antibody Fluorescence Recognition of Circulating Tumor Cells. Sci. Rep., 2017, 7,10142.
(32) Haibin Xiao, Chuanchen Wu, Ping Li,* Wen Gao, Wen Zhang, Wei Zhang, Lili Tong and Bo Tang*. Ratiometric photoacoustic imaging of endoplasmic reticulum polarity in injured liver tissues of diabetic mice. Chem. Sci., 2017, 8, 7025-7030.
(31) Wen Zhang, Xin Wang, Ping Li,* Haibin Xiao, Wei Zhang, Hui Wang, and Bo Tang*. Illuminating Superoxide Anion and pH Enhancements in Apoptosis of Breast Cancer Cells Induced by Mitochondrial Hyperfusion Using a New Two-Photon Fluorescence Probe. Anal. Chem., 2017, 89, 6840-6845.
(30) Haibin Xiao, Xiao Liu, Chuanchen Wu, Yaohuan Wu, Ping Li,* Xiaomeng Guo, Bo Tang*. A new endoplasmic reticulum-targeted two-photon fluorescent probe for imaging of superoxide anion in diabetic mice. Biosens. Bioelectron., 2017, 91, 449-455.
2016年
(29) Ping Li, Lu Liu, Haibin Xiao, Wei Zhang, Lulin Wang, and Bo Tang*. A New Polymer Nanoprobe Based on Chemiluminescence Resonance Energy Transfer (CRET) for Ultrasensitive Imaging of Intrinsic Superoxide Anion in Mice. J. Am. Chem. Soc., 2016, 138, 2893-2896.
(28) Baocun Zhu,† Ping Li,† Wei Shu, Xin Wang, Caiyun Liu, Yue Wang, Zuokai Wang, Yawei Wang, and Bo Tang*. Highly Specific and Ultrasensitive Two-photon Fluorescence Imaging of Native HOCl in Lysosomes and Tissues Based on Thiocarbamate Derivatives. Anal. Chem., 2016, 88,12532-12538.
(27) Wei Zhang, Junqing Kang, Ping Li,* Lu Liu, Hui Wang and Bo Tang*. Two-photon fluorescence imaging of sialylated glycans in vivo based on a sialic acid imprinted conjugated polymer nanoprobe. Chem. Commun., 2016, 52, 13991-13994.
(26) Haibin Xiao, Ping Li,* Shan Zhang, Wei Zhang, Wen Zhang and Bo Tang*. Simultaneous fluorescence visualization of mitochondrial hydrogen peroxide and zinc ions in live cells and in vivo. Chem. Commun., 2016, 52, 12741-12744.
(25) Haibin Xiao, Ping Li,* Xiufen Hu, Xiaohui Shi, Wen Zhang and Bo Tang*. Simultaneous fluorescence imaging of hydrogen peroxide in mitochondria and endoplasmic reticulum during apoptosis. Chem. Sci., 2016, 7, 6153-6159.
(24) Haibin Xiao,† Ping Li,† Wei Zhang and Bo Tang*. An ultrasensitive near-infrared ratiometric fluorescent probe for imaging mitochondrial polarity in live cells and in vivo. Chem. Sci., 2016, 7, 1588-1593.
2015年
(23) Wei Zhang, Wei Liu, Ping Li,* Fang Huang, Hui Wang, and Bo Tang*. Rapid-Response Fluorescent Probe for Hydrogen Peroxide in Living Cells Based on Increased Polarity of C-B Bonds. Anal. Chem., 2015, 87, 9825-9828.
(22) Wei Zhang, Junqing Kang, Ping Li,* Hui Wang, and Bo Tang*. Dual Signaling Molecule Sensor for Rapid Detection of Hydrogen Sulfide Based on Modified Tetraphenylethylene. Anal. Chem., 2015, 87, 8964-8969.
(21) Lu Li,† Ping Li,† Juan Fang, Qingling Li, Haibin Xiao, Hui Zhou, and Bo Tang*. Simultaneous Quantitation of Na+ and K+ in Single Normal and Cancer Cells Using a New Near-Infrared Fluorescent Probe. Anal. Chem., 2015, 87, 6057-6063.
(20) Wei Zhang, Wei Liu, Ping Li,* Junqing Kang, Jiaoyang Wang, Hui Wang and Bo Tang*. Reversible two-photon fluorescent probe for imaging of hypochlorous acid in live cells and in vivo. Chem. Commun., 2015, 51, 10150-10153.
(19) Wen Zhang, Xin Wang, Ping Li,* Fang Huang, Hui Wang, Wei Zhang and Bo Tang*. Elucidating the relationship between superoxide anion levels and lifespan using an enhanced two-photon fluorescence imaging probe. Chem. Commun., 2015, 51, 9710-9713.
2014年
(18) Wei Zhang, Wei Liu, Ping Li,* Haibin Xiao, Hui Wang, and Bo Tang*. A Fluorescence Nanosensor for Glycoproteins with Activity Based on the Molecularly Imprinted Spatial Structureof the Target and Boronate Affinity. Angew. Chem. Int. Ed., 2014, 53, 12489-12493.
(17) Ping Li, Shan Zhang, Nannan Fan, Haibin Xiao, Wen Zhang, Wei Zhang, Hui Wang, and Bo Tang*. Quantitative Fluorescence Ratio Imaging of Intralysosomal Chloride Ions with Single Excitation/Dual Maximum Emission. Chem. Eur. J., 2014, 20, 11760-11767.
(16) Wen Gao, Wenhua Cao, Huaibin Zhang, Ping Li, Kehua Xu and Bo Tang*. Targeting lysosomal membrane permeabilization to induce and image apoptosis in cancer cells by multifunctional Au-ZnO hybrid nanoparticles. Chem. Commun., 2014, 50, 8117-8120.
(15) Ping Li, Haibin Xiao, Yinfang Cheng, Wen Zhang, Fang Huang, Wei Zhang, Hui Wang and Bo Tang*. A near-infrared-emitting fluorescent probe for monitoring mitochondrial pH. Chem. Commun., 2014, 50, 7184-7187.
2013年
(14) Wen Zhang,† Ping Li,† Fan Yang, Xiufen Hu, Chuanzhi Sun, Wei Zhang, Dezhan Chen, and Bo Tang*. Dynamic and Reversible Fluorescence Imaging of Superoxide Anion Fluctuations in Live Cells and in Vivo. J. Am. Chem. Soc., 2013, 135, 14956-14959.
(13) Ping Li, Wen Zhang, Kexiang Li, Xiao Liu, Haibin Xiao, Wei Zhang, and Bo Tang*. Mitochondria-Targeted Reaction-Based Two-Photon Fluorescent Probe for Imaging of Superoxide Anion in Live Cells and in Vivo. Anal. Chem., 2013, 85, 9877-9881.
(12) Xi-Feng Shi,Na Li, Ke Zhao, Guan-Wei Cui, Ying-Qiang Zhao, Ming-Yue Ma, Ke-Hua Xu, Ping Li, Yu-Bin Dong*, Bo Tang*. A dye-sensitized FeOOH-CNT photocatalyst with threeelectron transfer channels regulated by hydrogen bonding. Appl. Catal. B. Environ., 2013, 136-137, 334-340.
2012年
(11) Ping Li, TingXie, Nannan Fan, Kexiang Li and Bo Tang*. Ratiometric fluorescence imaging for distinguishing chloride concentration between normal and ischemic ventricular myocytes. Chem. Commun., 2012, 48, 2077-2079.
(10) Wen Gao, LifeiJi, Lu Li, Guanwei Cui, Kehua Xu, Ping Li, Bo Tang*. Bifunctional combined Au-Fe2O3 nanoparticles for induction of cancer cell-specific apoptosis and real-time imaging. Biomaterials, 2012, 33, 3710-3718.
2011年
(9) Ping Li, Xia Duan, Zhenzhen Chen, Ying Liu, Ting Xie, Libo Fang, Xiaorui Li, Miao Yin and Bo Tang*. A near-infrared fluorescent probe for detecting copper (II) with high selectivity and sensitivity and its biological imaging applications. Chem.Commun., 2011, 47, 7755-7757.
(8) Kehua Xu, Lulu Wang, Mingming Qiang, Liyong Wang, Ping Li and Bo Tang*. A selective near-infrared fluorescent probe for singlet oxygen in living cells. Chem. Commun., 2011, 47, 7386-7388.
(7) Ping Li, Libo Fang, Hui Zhou, Wen Zhang, Xu Wang, Na Li, Hongbo Zhong, and Bo Tang*. A New Ratiometric Fluorescent Probe for Detection of Fe2+ with High Sensitivity and Its Intracellular Imaging Applications. Chem. Eur. J., 2011, 17,10520-10523.
2011年之前
(6) Ping Li, TingXie, Xia Duan, Fabiao Yu, Xu Wang and Bo Tang*. A New Highly Selective and Sensitive Assay for Fluorescence Imaging of OH in Living Cells: Effectively Avoiding the Interference of Peroxynitrite. Chem. Eur. J., 2010, 16, 1834-1840.
(5) Bo Tang*, Fabiao Yu, Ping Li, Lili Tong, Xia Duan, Ting Xie, and Xu Wang. A Near-Infrared Neutral pH Fluorescent Probe for Monitoring Minor pH Changes: Imaging in LivingHepG2 and HL-7702 Cells. J. Am. Chem. Soc., 2009, 131, 3016-3023.
(4) Fabiao Yu, Wenshen Zhang, Ping Li, Yanlong Xing, Lili Tong, Jianping Ma and Bo Tang*. Cu2+-selective naked-eye and fluorescent probe: its crystal structure and application in bioimaging. Analyst, 2009, 134, 1826-1833.
(3) Ping Li, Bo Tang*, Yanlong Xing, Puming Li, Guiwen Yang and Liang Zhang. A near-infrared fluorescent probe for lipid hydroperoxides in living cells. Analyst, 2008, 133, 1409-1415.
(2) Bo Tang*, Yanlong Xing, Ping Li, Ning Zhang, Fabiao Yu, and Guiwen Yang. A Rhodamine-Based Fluorescent Probe Containing a Se-N Bond for Detecting Thiols and Its Application in Living Cells. J. Am. Chem. Soc., 2007, 129, 11666-11667.
(1) Kehua Xu, Bo Tang*, Hui Huang, Guiwen Yang, Zhenzhen Chen, Ping Li and Liguo An. Strong Red Fluorescent Probes Suitable for Detecting Hydrogen Peroxide Generated by Mice Peritoneal Macrophages. Chem. Commun., 2005, 5974-5976.
授权发明专利
(1) 唐波，李平，肖海滨，张雯，具有大斯托克斯位移的近红外荧光染料及合成方法与应用，2014.10.31，中国，ZL201410606444.X
(2) 唐波，李平，肖海滨，一种对环境极性敏感的近红外荧光探针及其合成方法和应用，2015.4.30，中国，ZL201510218987.9
(3) 唐波，李平，张彦笛，王昕，张雯，一种特异性双光子成像荧光探针及制备方法与应用，2019.07.23，中国，CN 110041296 A
(4) 唐波，李平，吴丽杰，范楠楠，近红外荧光化合物与制备方法及其检测亚铁离子的应用，2019.12.13，中国，CN 110563702 A
(5) 唐波，李平，白晓艺，王昕，张雯，一种检测锌离子和pH的荧光探针、其制备方法与应用，2020.09.29，中国，CN 110698493 В
(6) 唐波，丁琪，李平，王昕，一种双色荧光探针及其合成方法与应用，2020.11.20，中国， CN 110963995 В
(7) 唐波，王慧，李平，杨玉云，花菁类化合物及制备方法与在检测高尔基体pH中的应用，2020.11.20，中国，CN 110551056 B
(8) 唐波，丁琪，李平，王昕，张彦笛，一种检测抑郁症小鼠脑内Cys的近红外荧光探针及其合成方法与应用，2021.02.23，中国，CN 111057047 B
(9) 唐波，丁琪，李平，王昕，一种检测过氧化物酶体中超氧阴离子自由基的荧光探针及其应用，2021.08.17，中国，CN 111100184 B
(10) 唐波，李平，苏迪，张雯，王昕，一种双光子荧光碳点材料及合成方法与应用，2021.11.09，中国，CN 110041924 B
(11) 唐波，李平，白晓艺，王昕，张雯，郭笑萌，一种定位高尔基体近红外荧光探针及其合成方法与应用，2022.02.08，中国，CN 110093153 B
承担项目
已主持完成国家重点基础研究发展计划（“973计划”）课题1项、国家自然科学基金面上项目3项、国家重大新药创制课题子课题1项、国家自然科学基金青年基金1项、山东省自然科学基金重大基础研究项目1项及山东省科技攻关项目1项。目前主持国家自然科学基金面上项目2项：
(1) 国家自然科学基金面上项目（No. 22377070）， 肝癌免疫检查点阻断疗法耐药性相关代谢活性分子的荧光成像研究， 2024.01-2027.12， 50 万，主持，在研。
(2) 国家自然科学基金面上项目（No. 22074083），基于活性氧自由基调控的抑郁症成像诊疗一体化研究，2021.01-2024.12，63万，主持，在研。
(3) 国家科技重大专项（重大新药创制）子课题（2017ZX09301030004），免疫稳态因素分子纳米探针荧光可视化示踪技术的中医药应用，2017.01-2020.12，124.17万，主持，结题。
(4) 国家自然科学基金面上项目（No. 21675105），活体内抑郁症相关活性分子的双光子荧光成像研究，2017.01-2020.12，65万，主持，结题。
(5) 国家重点基础研究发展计划（973）课题（2013CB933804），重大疾病相关的若干重要难检活性小分子细胞内纳米传感研究，2013.01-2017.08，140万，主持，结题。
(6) 国家自然科学基金面上项目（No. 21475079），高灵敏成像检测慢性炎症介导的癌变细胞及活体内活性氧自由基变化的功能纳米荧光探针研究，2015.01-2018.12，90万，主持，结题。
(7) 国家自然科学基金面上项目（No. 20975063），活细胞内活性氧和功能性阳离子区域定位识别的近红外荧光探针的设计、合成及其可视化成像分析，2010.01-2012.12, 36万，主持，结题。
(8) 国家自然科学基金青年基金（No. 21205073），基于发光与定位双功能荧光团检测亚细胞器内活性小分子荧光探针的设计合成及成像可视化研究，2013.01-2015.12, 27万，主持，结题。
(9) 山东省自然科学基金重大基础研究项目（ZR2017ZC0225），基于分子探针技术的循环肿瘤细胞精准分选与分析研究及试剂盒研发，2017.08-2019.07，120万，主持，结题。
(10) 山东省科技攻关项目（No. 2010G0020243），细胞内阴离子区域定位识别荧光探针的设计合成及其可视化成像研究，2010.01-2013.12，40万，主持，结题。
荣誉称号
(1) 第十一届山东省优秀科技工作者，山东省科学技术协会，2023
(2) 山东省巾帼建功标兵，山东省妇联，2023
(3) 山东省优秀研究生导师，山东省教育厅，2023
(4) 齐鲁巾帼科技创新之星，山东省妇女联合会、山东省科学技术厅、山东省科学技术协会，2022
(5) 山东省教书育人楷模，中共山东省委宣传部，山东省教育厅，2021
(6) 山东省优秀研究生导学团队，山东省教育厅，2021
(7) 山东省教育系统女职工建功立业标兵，山东省教育工会委员会，2021
(8) 山东师范大学第三届研究生“五导”卓越导学团队，山东师范大学，2020
(9) 百千万人才工程国家级人选，国家有突出贡献中青年专家，中华人民共和国人力资源与社会保障部，2019
(10) 泰山学者特聘专家，山东省人民政府，2017
(11) 山东省有突出贡献的中青年专家，山东省人民政府，2015
获奖情况
(1) 李平(3/5)，细胞稳态调控活性分子的荧光成像研究，中华人民共和国国务院，国家自然科学奖，二等奖，2018（唐波，董育斌，李平，李娜，王鹏）
(2) 李平(8/10)，重要农药、医药中间体的绿色化工生产技术集成，中华人民共和国国务院，国家科技进步奖，二等奖，2007（唐波，董育斌，王春先，张立省，崔官伟，陈德展，王子明，李平，陈蓁蓁，王洪鉴）
(3) 李平(2/4)，与重大疾病相关的细胞内活性分子的荧光传感分析，山东省人民政府，山东省自然科学奖，一等奖，2015（唐波，李平，李娜，王栩）
(4) 李平(1/4)，氧化应激相关生物活性小分子的荧光成像研究，山东省人民政府，山东省自然科学奖，二等奖，2019（李平，张卫，张雯，肖海滨）
(5) 李平(1/1)，山东省青年科技奖，中共山东省委组织部、山东省人力资源与社会保障厅、山东省科学技术协会，2015（李平）
(6) 李平(5/8)，催化法生产农药、医药中间体绿色化工新工艺，山东省政府，山东省科技进步奖，一等奖，2004（唐波，董育斌，崔官伟，王春先，李平，李家瀚，陈蓁蓁，张立省）
(7) 李平(1/3)，细胞及活体内超氧阴离子自由基的荧光成像可视化分析，山东省教育厅，山东高等学校优秀科研成果奖，二等奖，2014（李平，唐波，张卫）
(8) 李平(7/10)，分析化学研究生创新能力培养的“教-研-用”一体化育人模式探索与实践，山东省省级教学成果奖评审委员会，山东省省级教学成果奖，一等奖，2022（唐波、王栩、崔官伟、张春阳、李娜、王金山、李平、李璐、高雯、陈蓁蓁）
(9) 李平(9/10)，基于“三位一体”高水平人才培养平台，促进研究生科技创新能力的培养，山东省省级教学成果奖评审委员会，山东省省级教学成果奖，一等奖，2018（毕华林，张春阳，董育斌，王金山，崔官伟，刘金凯，陈蓁蓁，李娜，李平，王栩）
(10) 李平(9/10)，基于“三位一体”高水平人才培养平台，促进研究生科技创新能力的培养，山东师范大学，第三届研究生教育教学成果奖，一等奖，2018（毕华林，张春阳，董育斌，王金山，崔官伟，刘金凯，陈蓁蓁，李娜，李平，王栩）
(11) 李平(3/4)，一种农药、医药中间体的生产工艺，济南市人民政府，济南市专利奖，三等奖，2006（唐波，崔官伟，李平，范玲超）
