#contributed equally, *corresponding author
Selected Publications:
1. Lin Zhang, Oliver Einsle*. Architecture of the RNF1 complex that drives biological nitrogen fixation. Nature Chemical Biology. 20, 1078–1085 (2024)
2. Lorena Ilcu, Lukas Denkhaus, Anton Brausemann, Lin Zhang*, Oliver Einsle*. Architecture of the Heme-translocating CcmABCD/E Complex required for Cytochrome c Maturation. Nature Communications. 14, 5190 (2023)
3. Christoph Müller#, Lin Zhang#, Sara Zipfel, Annika Topitsch, Marleen Lutz, Johannes Eckert, Benedikt Prasser, Mohamed Chami, Wei Lü, Juan Du*, Oliver Einsle*. Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature. 608, 626-631 (2022)
4. Lin Zhang, Eckhard Bill, Peter M. H. Kroneck, Oliver Einsle*. Histidine-gated proton-coupled electron transfer to the CuA site of nitrous oxide reductase. Journal of the American Chemical Society. 143, 830-838 (2021)
5. Lin Zhang, Anja Wüst, Benedikt Prasser, Christoph Müller, Oliver Einsle*. Functional assembly of nitrous oxide reductase provides insights into copper site maturation. Proceedings of the National Academy of Sciences. 116, 12822-12827 (2019)
Full Publication List:
32. Lin Zhang, Oliver Einsle*. Architecture of the RNF1 complex that drives biological nitrogen fixation. Nature Chemical Biology. 20, 1078–1085 (2024)
31. Arianna Colcerasa, Florian Friedrich, Jelena Melesina, Patrick Moser, Anja Vogelmann, Pavlos Tzortzoglou, Emilia Neuwirt, Manuela Sum, Dina Robaa, Lin Zhang, Elizabeth Ramos-Morales, Christophe Romier, Oliver Einsle, Eric Metzger, Roland Schüle, Olaf Groß, Wolfgang Sippl, and Manfred Jung*. Structure-activity studies of 1,2,4-oxadiazoles for the inhibition of the NAD+-dependent lysine deacylase Sirtuin 2. Journal of Medicinal Chemistry. 67, 10076-10095 (2024)
30. Tobias Pflüger, Mathias Gschell, Lin Zhang, Volodymyr Shnitsar, Annas J. Zabadné, Paul Zierep, Stefan Günther, Oliver Einsle, Susana L. A. Andrade. How sensor Amt-like proteins integrate ammonium signals. Science Advances. 10, eadm9441 (2024)
29. Sheng Wang, Sebastian Klein, Sylvia Urban, Maximilian Staudt, Nicolas Barthes, Dominica Willmann, Johannes Bacher, Manuela Sum, Helena Bauer, Ling Peng, Georg A. Rennar, Christian Gratzke, Katrin Schüle, Lin Zhang, Oliver Einsle, Holger Greschik, Calum MacLeod, Christopher Thompson, Manfred Jung, Eric Metzger and Roland Schüle*. Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity. Nature Communications. 15, 43 (2024)
28. Laura Sinatra, Anja Vogelmann, Florian Friedrich, Margarita A. Tararina, Emilia Neuwirt, Arianna Colcerasa, Philipp König, Lara Toy, Talha Z. Yesiloglu, Sebastian Hilscher, Lena Gaitzsch, Niklas Papenkordt, Shiyang Zhai, Lin Zhang, Christophe Romier, Oliver Einsle, Wolfgang Sippl, Mike Schutkowski, Olaf Gross, Gerd Bendas, David W. Christianson, Finn K. Hansen, Manfred Jung, and Matthias Schiedel*. Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. Journal of Medicinal Chemistry. 66(21), 14787-14814 (2023)
27. Lorena Ilcu, Lukas Denkhaus, Anton Brausemann, Lin Zhang*, Oliver Einsle*. Architecture of the Heme-translocating CcmABCD/E Complex required for Cytochrome c Maturation. Nature Communications. 14, 5190 (2023)
26. Pawel Lycus, Oliver Einsle*, Lin Zhang*. Structural biology of proteins involved in nitrogen cycling. Current Opinion in Chemical Biology. 74, 102278 (2023)
25. Songya Zhang, Lin Zhang, Anja Greule, Julien Tailhades, Edward Marschall, Panward Prasongpholchai, Daniel J. Leng, Jingfan Zhang, Jing Zhu, Joe A. Kaczmarski, Ralf B. Schittenhelm, Oliver Einsle, Colin J. Jackson, Fabrizio Alberti, Andreas Bechthold, Youming Zhang, Manuela Tosin, Tong Si, Max J. Cryle. P450-mediated dehydrotyrosine formation during WS9326 biosynthesis proceeds via dehydrogenation of a specific acylated dipeptide substrate. Acta Pharmaceutica Sinica B. 13(8), 3561-3574 (2023)
24. Christoph Müller#, Lin Zhang#, Sara Zipfel, Annika Topitsch, Marleen Lutz, Johannes Eckert, Benedikt Prasser, Mohamed Chami, Wei Lü, Juan Du*, Oliver Einsle*. Molecular interplay of an assembly machinery for nitrous oxide reductase. Nature. 608, 626-631 (2022)
23. A Vogelmann, M Schiedel, N Wössner, A Merz, D Herp, S Hammelmann, A Colcerasa, G Komaniecki, J Y Hong, M Sum, E Metzger, E Neuwirt, L Zhang, O Einsle, O Groß, R Schüle, H Lin, W Sippl, M Jung*. Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration. RSC Chemical Biology. 3, 468-485 (2022).
22. Anton Brausemann, Lin Zhang, Lorena Ilcu, Oliver Einsle*. Architecture of the membrane-bound cytochrome c heme lyase CcmF. Nature Chemical Biology. 17, 800-805 (2021).
21. Benedikt Prasser, Lisa Schöner, Lin Zhang*, Oliver Einsle*. The copper chaperone NosL forms a heterometal site for Cu delivery to nitrous oxide reductase. Angewandte Chemie International Edition. 60, 18810-18814 (2021).
20. Ahmad Alali, Lin Zhang, Jianyu Li, Chijian Zuo, Dimah Wassouf, Xiaohui Yan, Philipp Schwarzer, Stefan Günther, Oliver Einsle, Andreas Bechthold*. Biosynthesis of the tricyclic aromatic type II polyketide Rishirilide: new potential third ring oxygenation after three cyclization steps. Molecular Biotechnology. 63, 502-514 (2021).
19. Kerstin Schultenkämper, Desirée D Gütle, Marina Gil López, Laura B Keller, Lin Zhang, Oliver Einsle, Jean-Pierre Jacquot, Volker F Wendisch*. Interrogating the role of the two distinct fructose-bisphosphate aldolases of Bacillus methanolicus by site-directed mutagenesis of key amino acids and gene repression by CRISPR interference. Frontiers in Microbiology. 12, 669220 (2021).
18. Lin Zhang, Eckhard Bill, Peter M. H. Kroneck, Oliver Einsle*. A [3Cu:2S] cluster provides insight into the assembly and function of the CuZ site of nitrous oxide reductase. Chemical Science. 12, 3239-3244 (2021).
17. Lin Zhang, Eckhard Bill, Peter M. H. Kroneck, Oliver Einsle*. Histidine-gated proton-coupled electron transfer to the CuA site of nitrous oxide reductase. Journal of the American Chemical Society. 143, 830-838 (2021)
16. Yucong Yu, Huimin Wang, Biao Tang, Junheng Liang, Lin Zhang, Hongkuan Wang, Xiaoying Bian, Yue-Zhong Li, Youming Zhang, Guo-Ping Zhao*, Xiaoming Ding*. Reassembly of the biosynthetic gene cluster enables high epothilone yield in engineered Schlegelella brevitalea. ACS Synthetic Biology. 9, 2009-2022 (2020)
15. Nathalie Wössner, Zayan Alhalabi, Jessica González, Sören Swyter, Jin Gan, Karin Schmidtkunz, Lin Zhang, Alejandro Vaquero, Huib Ovaa, Oliver Einsle, Wolfgang Sippl, Manfred Jung*. Sirtuin 1 inhibiting thiocyanates (S1th) - a new class of isotype selective inhibitors of NAD+ dependent lysine deacetylases. Frontiers in Oncology. 10, 657 (2020)
14. Christoph W Grathwol, Nathalie Wössner, Steven Behnisch-Cornwell, Lukas Schulig, Lin Zhang, Oliver Einsle, Manfred Jung, Andreas Link*. Activation of Sirtuin 2 inhibitors employing photoswitchable geometry and aqueous solubility. ChemMedChem. 15, 1480-1489 (2020)
13. Lin Zhang, Anja Wüst, Benedikt Prasser, Christoph Müller, Oliver Einsle*. Functional assembly of nitrous oxide reductase provides insights into copper site maturation. Proceedings of the National Academy of Sciences. 116, 12822-12827 (2019)
12. Miaomiao Li, Christoph Müller, Klemens Fröhlich, Oliver Gorka, Lin Zhang, Olaf Groß, Oliver Schilling, Oliver Einsle, Claudia Jessen-Trefzer*. Detection and characterization of a Mycobacterial L-arabinofuranose ABC transporter identified with a rapid lipoproteomics protocol. Cell Chemical Biology. 26, 852-862.e6 (2019)
11. Lin Zhang, Christian Trncik, Susana L.A. Andrade, Oliver Einsle*. The flavinyl transferase ApbE of Pseudomonas stutzeri matures the NosR protein required for nitrous oxide reduction, Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1858, 95-102 (2017)
10. Jing Chen, Hui Yuan, Lin Zhang, Haiyun Pan, Rongyan Xua, Yang Zhong, Jiakuan Chen, Peng Nan*. Cloning, expression and purification of isoflavone-2’-hydroxylase from Astragalus membranaceus Bge. Var. mongolicus (Bge.) Hsiao. Protein Expression and Purification. 107, 83-89 (2015)
9. Lisa K. Schneider, Anja Wüst, Anja Pomowski, Lin Zhang, Oliver Einsle*. No laughing matter: the unmaking of the greenhouse gas dinitrogen monoxide by N2O reductase. In Metal Ions in Life Science. 14, 177-210 (2014)
8. Lin Zhang, Binyan Zhu, Ruixue Dai, Guoping Zhao*, Xiaoming Ding*. Control of directionality in Streptomyces phage fBT1 integrase-mediated site-specific recombination. PLoS ONE. 8, e80434 (2013)
7. Bo Zhang#, Lin Zhang#, Ruixue Dai, Meiying Yu, Guoping Zhao*, Xiaoming Ding*. An efficient procedure for marker-free mutagenesis of S. coelicolor by site-specific recombination for secondary metabolite overproduction. PLoS ONE. 8, e55906 (2013) (co-first author)
6. Lin Zhang, Guoping Zhao*, Xiaoming Ding*. Tandem assembly of the epothilone biosynthetic gene cluster by in vitro site-specific recombination. Scientific Reports. 1, 141 (2011)
5. Lin Zhang, Guoping Zhao*, Xiaoming Ding*. Site-specific recombination systems: mechanisms and applications. SCIENTIA SINICA Vitae. 40, 1090-1111 (2010)
5. 张霖，赵国屏*，丁晓明*，位点特异性重组系统的机理和应用，中国科学：生命科学，40, 1090-1111 (2010)
4. Lin Zhang, Lu Wang, Jin Wang, Xijun Ou, Guoping Zhao*, Xiaoming Ding*. DNA cleavage is independent of synapsis during Streptomyces phage fBT1 integrase-mediated site-specific recombination. Journal of Molecular Cell Biology. 2, 264-275 (2010)
3. Xijun Ou, Bo Zhang, Lin Zhang, Guoping Zhao*, Xiaoming Ding*. Characterization of rrdA, a TetR family protein gene involved in the regulation of secondary metabolism in Streptomyces coelicolor. Applied and Environmental Microbiology. 75, 2158-2165 (2009)
2. Xijun Ou, Bo Zhang, Lin Zhang, Kai Dong, Chun Liu, Guoping Zhao*, Xiaoming Ding*. SarA influences the sporulation and secondary metabolism in Streptomyces coelicolor M145. Acta Biochimica et Biophysica Sinica. 40, 877-882 (2008).
1. Lin Zhang, Xijun Ou, Guoping Zhao*, Xiaoming Ding*. Highly efficient in vitro site-specific recombination system based on Streptomyces phage fBT1 integrase. Journal of Bacteriology. 190, 6392-6397 (2008).