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成果及论文

2020年至今代表性论文:

(13)  Fang, Shanfang; Kang, W. T.; Li, Haizhou; Cai, Qiongna; Liang, Wanxin; Zeng, Minghui; Yu, Qian; Zhong, Rongcui; Tao, Yiwen; Liu, Shouping*; Lin, Shuimu*. Development of cannabidiol derivatives as potent broad-spectrum antibacterial agents with membrane-disruptive mechanism. Eur. J. Med. Chem. 2024, 266, 116149. (中科院一区)

(12) Yu, Qian; Cai, Qiongna; Liang, Wanxin; Zhong, Kewen; Liu, Jiayong; Li, Haizhou; Chen, Yongzhi; Li, Hongxia; Fang, Shanfang; Zhong, Rongcui; Liu, Shouping*Lin, Shuimu*. Design of phenothiazine-based cationic amphiphilic derivatives incorporating arginine residues: Potential membrane-active broad-spectrum antimicrobials combating pathogenic bacteria in vitro and in vivo. Eur. J. Med. Chem. 2023, 260, 115733. (中科院一区)

(11)   Cai, Qiongna; Yu, qian; Liang, Wanxin; Li, Haizhou; Liu, Jiayong; Li, Hongxia; Chen, Yongzhi; Fang, Shanfang; Zhong, Rongcui; Liu, Shouping*; Lin, Shuimu*. Membrane-active nonivamide derivatives as effective broad-spectrum antimicrobials: Rational design, synthesis, and biological evaluation. Journal of Medicinal Chemistry, 2022, 65, 16754-16773. (中科院一区)

(10)   Liang, Wanxin; Yu, qian; Zheng, Zixian; Liu, Jiayong; Cai, Qiongna; Liu, Shouping*; Lin, Shuimu*; Design and synthesis of phenyl sulfide-based cationic amphiphiles as membrane-targeting antimicrobial agents against Gram-positive pathogens, Journal of Medicinal Chemistry, 2022, 65(20):14221-14236. (中科院一区)

(9)  Liu, Jiayong; Li, Hongxia; He, Qile; Chen, Kaiting; Chen, Yongzhi; Zhong, Rongcui; Li, Haizhou; Fang, Shanfang; Liu, Shouping*; Lin, Shuimu*; Design, synthesis, and biological evaluation of tetrahydroquinoline amphiphiles as membrane-targeting antimicrobials against pathogenic bacteria and fungi, European Journal of Medicinal Chemistry, 2022, 243: 114734. (中科院一区)

(8)   Liu, Jiayong#; Li, Hongxia#; Li, Haizhou; Fang, Shanfang; Shi, Jinguo; Chen, Yongzhi; Zhong, Rongcui; Liu, Shouping*; Lin, Shuimu*; Rational design of dipicolylamine-containing carbazole amphiphiles combined with Zn2+ as potent broad-spectrum antibacterial agents with a membrane-disruptive mechanism, Journal of Medicinal Chemistry, 2021, 64(14): 10429-10444. (中科院一区)

(7)   Lin, Shuimu*; Wade, John D. *; Liu, Shouping*; De novo design of flavonoid-based mimetics of cationic antimicrobial peptides: Discovery, development, and applications, Accounts of Chemical Research, 2021, 54(1): 104-119. (中科院一区)

(6)   Li, Hongxia#; Liu, Jiayong#; Liu, Chuan-Fa; Li, Haizhou; Luo, Jiachun; Fang, Shanfang; Chen, Yongzhi; Zhong, Rongcui; Liu, Shouping*; Lin, Shuimu*; Design, Synthesis, and Biological Evaluation of Membrane-Active Bakuchiol Derivatives as Effective Broad-Spectrum Antibacterial Agents, Journal of Medicinal Chemistry, 2021, 64(9): 5603-5619. (中科院一区)

(5)  Chen, Yongzhi; Li, Hongxia; Liu, Jiayong; Zhong, Rongcui; Li, Haizhou; Fang, Shanfang; Liu, Shouping*; Lin, Shuimu*; Synthesis and biological evaluation of indole-based peptidomimetics as antibacterial agents against Gram-positive bacteria, European Journal of Medicinal Chemistry, 2021, 226: 113813. (中科院一区)

(4)  Zhong, Rongcui#; Li, Haizhou#; Li, Hongxia; Fang, Shanfang; Liu, Jiayong; Chen, Yongzhi; Liu, Shouping*; Lin, Shuimu*; Development of Amphiphilic Coumarin Derivatives as Membrane-Active Antimicrobial Agents with Potent In Vivo Efficacy against Gram-Positive Pathogenic Bacteria., ACS Infectious Diseases, 2021, 7(10): 2864-2875. (中科院二区)

(3)   Lin, Shuimu; Li, Hongxia; Tao, Yiwen; Liu, Jiayong; Yuan, Wenchang; Chen, Yongzhi; Liu, Ying; Liu, Shouping*; In Vitro and in Vivo Evaluation of Membrane-Active Flavone Amphiphiles: Semisynthetic Kaempferol-Derived Antimicrobials against Drug-Resistant Gram-Positive Bacteria, Journal of Medicinal Chemistry, 2020, 63(11): 5797-5815. (中科院一区

(2)   Lin, Shuimu; Liu, Jiayong; Li, Hongxia; Liu, Ying; Chen, Yongzhi; Luo, Jiachun; Liu, Shouping*; Development of Highly Potent Carbazole Amphiphiles as Membrane-Targeting Antimicrobials for Treating Gram-Positive Bacterial Infections, Journal of Medicinal Chemistry, 2020, 63(17): 9284-9299. (中科院一区)

(1)  Lin, Shuimu#; Chen, Yongzhi#; Li, Hongxia; Liu, Jiayong; Liu, Shouping*; Design, synthesis, and evaluation of amphiphilic sofalcone derivatives as potent Gram-positive antibacterial agents, European Journal of Medicinal Chemistry, 2020, 202: 112596. (中科院一区

2020年至今授权专利:

1林水木刘寿平,栗宏霞,江鸿;补骨脂酚衍生物、其药学上可接受的盐及其制备方法和应用;中国授权号:ZL202011152645.9,授权日:2022-11-15。同时申请国际PCT专利,申请号:PCT/CN2020/125481,申请日期:2020-10-27。(已转让)

2林水木刘寿平,栗宏霞;黄酮类化合物及其制备方法和应用;授权号:ZL201911257926.8,授权日:2023-2-17

3林水木刘寿平,梁婉欣;二苯硫醚化合物、抗菌药物及制备方法与应用;授权号:ZL202210322575.X;授权日:2023-6-6

4林水木刘寿平,刘家勇;氯福克酚衍生物、抗菌药物及制备方法与应用;申请号:202210427128.0;申请日期:2022-04-22。(同时提交国际PCT发明专利申请,申请号:PCT/CN2022/088513,申请日期:2022-04-22。)

5林水木刘寿平,栗宏霞,江鸿;补骨脂酚衍生物、其药学上可接受的盐及其制备方法和应用;美国授权号:US 11,912,650B2,授权日:2024-02-27

6林水木刘寿平,栗宏霞,江鸿;补骨脂酚衍生物、其药学上可接受的盐及其制备方法和应用;韩国授权号:10-2630858,授权日:2024-01-24