代表论文： 

15.Zheng M, Lin S, Chen K, Hu R, Wang L*, Zhao Z, Xu H. MetaDegron: multimodal feature-integrated protein language model for predicting E3 ligase targeted degrons. Brief Bioinform. 2024 Sep 23;25(6):bbae519.(共同通讯)，(IF=6.8).

14.Yan C#, Liu X#, Xu H, Wang L*. Cytoplasmic mtDNA clearance suppresses inflammatory immune responses. Trends Cell Biol. 2024 Oct.(IF=13.0).

13.Cao M#, Tang Y#, Luo Y, Gu F, Zhu Y, Liu X, Yan C, Hu W, Wang S, Chao X, Xu H, Chen HB, Wang L*. Natural compounds modulating mitophagy: Implications for cancer therapy. Cancer Lett. 2024 Feb. (IF=9.7).

12.Tang Y#, Wang L#, Qin JJ, Lu Y, Shen HM*, Chen HB*. Targeting Mitophagy to Promote Apoptosis is a Potential Therapeutic Strategy for Cancer. Autophagy, 2023, Mar; 19(3):1031-1033. (IF=13.391, In press).

11. Wang L*, Shen HM*. TMEM251, a new player in lysosomal enzyme trafficking. Life Metabolism. 2022, Dec.

10. Wang L#, Klionsky DJ*, Shen HM*. The emerging mechanisms and functions of microautophagy. Nature Reviews Molecular Cell Biology, 2022, Aug. (IF=113.915).(封面文章).

9. Tang Y#, Wang L#, Yi T, Xu J, Wang J, Qin JJ, Chen Q, Yip KM, Pan YH, Hong P, Lu Y*, Shen HM*, Chen HB*. Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy. Acta Pharmaceutica Sinica B, 2021, Dec; 12: 3966-3982. (IF=14.903).

8. Xu J#, Wang L#, Zhang L, Zheng F, Wang F, Leng J, Wang K, Heroux P, Shen HM, Wu Y*, Xia DJ*. Mono-2-ethylhexyl phthalate drives progression of PINK1-Parkin-mediated mitophagy via increasing mitochondrial ROS to exacerbate cytotoxicity. Redox Biology, 2021 Jan; 38: 101776. (共同一作), (IF=10.21).

7. Wang L*, Shen HM*. Seeing is believing: a novel tool for quantitating mitophagy. Cell Research, 2020 Sep; 30(9): 715-716, (共同通讯), (IF=46.279).

6. Wang L*, Lu G, Shen HM*. The long and the short of PTEN in the regulation of mitophagy. Frontiers in Cell and Developmental Biology, 2020 May; 8(299). (共同通讯), (IF=5.691).

5. Wang L, Qi H, Tang Y, Shen HM*. Post-Translational Modifications of Key Machinery in The Control of Mitophagy. Trends in Biochemical Sciences, 2020 Jan; 45 (1): 58-75. (入选ESI高被引论文), (IF=14.264).

4. Zhang J#, Wang L#, Xu J#, Tang Y, Huang B, Chen Z, Zhang T, Shen HM, Wu Y, Xia DJ*. Bone marrow stromal cell-derived growth inhibitor serves as a stress sensor to induce autophagy. FEBS Letters, 2020 Apr; 594(8): 1248-1260. (共同一作), (IF=3.864).

3. Wang L, Cho YK, Tang Y, Wang J, Park JE, Wu Y, Wang C, Tang Y, Chawla R, Shi Y, Deng S, Zhang J, Lu G, Wu Y, Tan HWS, Pawijit P, Lim G, Chan HY, Zhang J, Fang L, Yu H, Liou YC, Karthik M, Bay BH, Lim KL, Sze SK, Yap CT, Shen HM*. PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. Cell Research, 2018 Jun; 28 (8): 787-802. (封面文章), (IF=46.279).

2. Zhang J#, Sun X#, Wang L#, Wong YK, Lee YM, Zhao T, Yang L, Lu L, Zhong J, Huang D, Wang J*. Artesunate-induced mitophagy alters cellular redox status. Redox Biology, 2018 Aug; 19 (2018): 263-273. (共同一作), (IF=10.21).

1. Wang L, Wang J, Tang Y, Shen HM*. PTEN-L puts a brake on mitophagy. Autophagy, 2018 Sep; 14 (11): 2023-2025. (IF=13.391).

其他论文： 

17.Yi J, Wang HL, Lu G, Zhang H, Wang L, Li ZY, Wang L, Wu Y, Xia D, Fang EF, Shen HM. Spautin-1 promotes PINK1-PRKN-dependent mitophagy and improves associative learning capability in an alzheimer disease animal model. Autophagy. 2024 Jul 25.(IF=14.6)

16.Wang TT, Zhang LC, Qin Z, Chen SJ, Zeng JM, Li JY, An L, Wang CY, Gao Y, Wang LM, Zhao ZX, Liu ZQ, Wang SG, Decreased syntaxin17 expression contributes to the pathogenesis of acute pancreatitis in murine models by impairing autophagic degradation, Acta Pharmacol Sin 44(12) (2023) 2445-2454.(IF=8.2)

15. Zhou J, Feng J, Wu Y, Dai HQ, Zhu GZ, Chen PH, Wang LM, Lu G, Liao XW, Lu PZ, Su WJ, Hooi SC, Ye XP, Shen HM, Peng T, Lu GD. Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy. Exp Mol Med. 2022 Nov;54(11):2007-2021.(IF=5.418)

14. Tan HWS, Lu G, Dong H, Cho YK, Natalia A, Wang L, Chan C, Kappei D, Taneja R, Ling SC, Shao H, Tsai SY, Ding WX, Shen HM. A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery. Nature communications. 2022 Jun 28; 13(1): 3720. (IF=17.694).

13. Lu G#, Tan HWS#, Tomas SM, Wang L, Chen J, Cho YL, Chen K, Zhang JZ, He W, Wu Y, Xia D, Zhou J, Fang EF, Fang L, Liu W, Shen HM. WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP. Autophagy, 2022 Apr 7; 1-15. (IF=13.391).

12. Shi Yin#, Ye Zu#, Lu G, Yang N, Zhang J, Wang L, Cui J, Pozo M, Wu Y, Xia D, Shen HM.  Cholesterol-enriched membrane micro-domaindeficiency induces doxorubicin resistancevia promoting autophagy in breast cancer. Molecular Therapy Oncolytics, 2021 Oct; 23: 311-329(IF=6.311).

11. Lu G, Wang L, Zhou J, Shen HM*. A destiny for degradation: interplay between Cullin-RING E3 ligases and autophagy. Trends in Cell Biology, 2021, Jun; 31(6): 432-444. (IF=21.167).

10. Klionsky DJ1,2*, Abdel-Aziz AM, Abdelfatah S, ..., Wang L, ..., Zwerschke W. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition). Autophagy, 2021. Jan; 17(1): 1-382. (IF=13.391).

9. Wu M, Lu G, Lao Y, Zhang H, Zheng D, Zheng Z, Yi J, Xiang Q, Wang L, Tan H, Zhou H, Shen HM*, Xu HX*. Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice. Acta Pharmacologica Sinica, 2021, Feb; 42(2): 199-208. (IF=7.161).

8. Sun X, Shu Y, Xu M, Jiang J, Wang L, Wang J*, Huang D*, Zhang J*. ANXA6 suppresses the tumorigenesis of cervical cancer through autophagy induction. Clinical and Translational Medicine, 2020 Oct; 10(6): e208 (IF=8.554).

7. Chen K, Yang D, Zhao F, Wang S, Ye Y, Sun W, Lu H, Ruan Z, Xu J, Wang T, Lu G, Wang L, Shi Y, Zhang H, Wu H, Lu W, Shen HM*, Xia D*, Wu Y*. Autophagy and Tumor Database: ATdb, a novel database connecting autophagy and tumor. Database (Oxford), 2020, Jan; baaa052. (IF =4.042).

6. Zhang J#, Wang J#, Zhou Z, Park JE, Wang L, Wu S, Sun X, Lu L, Wang T, Lin Q, Sze SK, Huang D, Shen HM*. Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors. Autophagy, 2018 Jul; 14(6): 1043-1059. (IF=13.391).

5. Zhang J#, Wang J#, Wong YK#, Sun X#, Chen Y, Wang L, Yang L, Lu L, Shen HM, Huang D*. Docetaxel enhances lysosomal function through TFEB activation. Cell Death and Disease, 2018 May; 9(6):614. (IF=9.658).

4. Lu G, Yi J, Gubas A, Wang YT, Wu Y, Ren Y, Wu M, Shi Y, Ouyang C, Tan HWS, Wang T, Wang L, Xia D, Chen RH, A.Tooze R, Shen HM*. Suppression of autophagy during mitosis via CRL4s-mediated WIPI2 polyubiquitination and proteasomal degradation. Autophagy, 2019 Nov. 15(11): 1917-1934. (IF=13.391).

3. Niu Y, Sun W, Fu Z, Chen Y, Zhu J, Shi Y, Zhang H, Chen K, Wang L, Shen HM, Xia D, Wu Y*. A Novel Autophagy-Related Gene Pathway-Based Scoring System for Prediction of Chemotherapeutic Outcomes in Advanced Ovarian Cancer Patients. Cancer Epidemiology Biomarkers & Prevention, 2019 Dec; 28(12): 2106-2114. (IF=4.09). 

2. Zhang J, Wang J, Xu J, Lu Y, Jiang J, Wang L, Shen HM*, Xia D*. Curcumin targets the TFEB-lysosome pathway for induction of autophagy. Oncotarget, 2016 Nov; 7(46):75659-75671. 

1. Tang J, Wang L, Xu Q, Yang Z, Zhao J, Sun Q, Feng S, Zhang J, Effects of wetland degradation on bacterial community in the Zoige Wetland of Qinghai-Tibetan Plateau. World J Microbiol Biotechnol, 2012; 28: 649-657. (IF=4.272).