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成果及论文

1: Li, L.; Williams, P.; Ren, W.; Wang, M.; Gao, Z.; Miao, W.; Huang, M.; Song, J.; and Wang, Y. YY1 Interacts with Guanine Quadruplexs to Regulate DNA Looping and Gene Expression. Nat Chem Biol. 2021 Feb; 17(2):161-168.

2: Li, L.; Williams, P.; Gao, Z.; and Wang, Y. VEZF1-Guanine Quadruplex DNA Interaction Regulates Alternative Splicing. Nucleic Acids Res. 2020 Dec 2;48(21):11994-12003

3: Li, L.; Miao, W.; Williams, P.; Guo, C.; and Wang, Y. SLIRP Interacts with Helicases to Facilitate 2'-O-Methylation of rRNA and to Promote Translation. J. Am. Chem. Soc. 2019; 141:10958-10961.

4: Li, L.; Miao, W.; Huang, M.; Williams, P.; and Wang, Y. Integrated Genomic and Proteomic Analyses Reveal Novel Mechanisms of the Methyltransferase SETD2 in Renal Cell Carcinoma Development. Mol Cell Proteomics. 2019;18:437-447.

5: Williams, P.#; Li, L.#; Dong, X.; and Wang, Y. Identification of SLIRP as a G Quadruplex-Binding Protein. J. Am. Chem. Soc. 2017;139:12426-12429. (co-first author).

6: Li, L.; and Wang, Y. Cross-talk between the H3K36me3 and H4K16ac histone epigenetic marks in DNA double-strand break repair. J Biol Chem. 2017;292:11951-11959.

7: Wu, J.#; Li, L. #; Wang, P.; You, C.; Williams, NL.; and Wang, Y. Translesion synthesis of O4-alkylthymidine lesions in human cells. Nucleic Acids Res. 2016;44:9256-9265.

8: Chen, X.#; Li, L. #; Xu, B.; Zhao, S.; Lu, P.; He, Y.; Ye, T.; Feng, YQ.; and Wu, Y. Phosphatidylinositol-specific phospholipase C2 functions in auxin-modulated root development. Plant Cell Environ. 2019;42:1441-1457. (co-first author).

9: Li, L.; He, Y.; Wang, Y.; Zhao, S.; Chen, X.; Ye, T.; Wu, Y.; and Wu, Y. Arabidopsis PLC2 is involved in auxin-modulated reproductive development. Plant J. 2015;84:504-15. Impact factor: 5.78; Citation: 22.

10: Miao, W.; Li, L.; Liu, X.; Qi, T.; Guo, L.; Huang, M.; and Wang, Y. A Targeted Quantitative Proteomic Method Revealed a Substantial Reprogramming of Kinome during Melanoma Metastasis. Sci Rep. 2020; 10:2485.

11: Dai, X.; Gonzalez, G.; Li, L.; Li, J.; You, C.; Miao, W.; Hu, J.; Fu, L.; Zhao, Y.; Li. R.; Chen, X.; Xu, Y.; Gu, W.; and Wang, Y. YTHDF2 Binds to 5-Methylcytosine in RNA and Modulates the Maturation of Ribosomal RNA. Anal Chem. 2020; 92:1346-1354.

12: Liu, X.; Miao, W.; Huang, M.; Li, L.; Dai, X.; and Wang, Y. Elevated Hexokinase II Expression Confers Acquired Resistance to 4-Hydroxytamoxifen in Breast Cancer Cells. Mol Cell Proteomics. 2019. pii: mcp.RA119.001576.

13: Miao, W.; Li, L.; and Wang, Y. High-Throughput Targeted Quantitative Analysis of the Interaction between HSP90 and Kinases. Anal Chem. 2019;91:11507-11509.

14: Miao, W.; Li, L.; Zhao, Y.; Dai, X.; Chen, X.; and Wang, Y. HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N(6)-methyladenosine. Nat Commun. 2019;10:3613.

15: Wu, J.; Du, H.; Li, L.; Price, NE.; Liu, X.; and Wang, Y. The Impact of Minor-Groove N(2)-Alkyl-2'-deoxyguanosine Lesions on DNA Replication in Human Cells. ACS Chem Biol. 2019;14:1708-1716.

16: Miao, W.; Yuan, J.; Li, L.; and Wang, Y. Parallel-Reaction-Monitoring-Based Proteome-Wide Profiling of Differential Kinase Protein Expression during Prostate Cancer Metastasis in Vitro. Anal Chem. 2019; 91:9893-9900.

17: Du, H.; Wang, P.; Li, L.; and Wang, Y. Repair and translesion synthesis of O(6)-alkylguanine DNA lesions in human cells. J Biol Chem. 2019; 294:11144-11153.

18: Tang. F.; Liu, S.; Li, QY.; Yuan, J.; Li, L.; Wang, Y.; Yuan, BF.; and Feng, YQ. Location analysis of 8-oxo-7,8-dihydroguanine in DNA by polymerase-mediated differential coding. Chem Sci. 2019; 10:4272-4281.

19: Su, Y.; Ghodke, PP.; Egli, M.; Li, L.; Wang, Y.; and Guengerich, FP. Human DNA polymerase η has reverse transcriptase activity in cellular environments. J Biol Chem. 2019; 294:6073-6081.

20: Du, H.; Wang, P.; Li, L.; Amato, NJ.; and Wang, Y. Cytotoxic and Mutagenic Properties of C1' and C3'-Epimeric Lesions of 2'-Deoxyribonucleosides in Human Cells. ACS Chem Biol. 2019; 14:478-485.

21: Miao, W.; Li, L.; and Wang, Y. Identification of Helicase Proteins as Clients for HSP90. Anal Chem. 2018; 90:11751-11755.

22: Huang, M.; Qi, TF.; Li, L.; Zhang, G.; and Wang, Y. A Targeted Quantitative Proteomic Approach Assesses the Reprogramming of Small GTPases during Melanoma Metastasis. Cancer Res. 2018; 78:5431-5445.

23: Du, H.; Leng, J.; Wang, P.; Li, L.; and Wang, Y. Impact of tobacco-specific nitrosamine-derived DNA adducts on the efficiency and fidelity of DNA replication in human cells. J Biol Chem. 2018; 293:11100-11108.

24: Miao, W.; Li, L.; and Wang, Y. A Targeted Proteomic Approach for Heat Shock Proteins Reveals DNAJB4 as a Suppressor for Melanoma Metastasis. Anal Chem. 2018; 90:6835-6842.

25: Wu, J.; Wang, P.; Li, L.; You, C.;and Wang, Y. Cytotoxic and mutagenic properties of minor-groove O(2)-alkylthymidine lesions in human cells. J Biol Chem. 2018; 293:8638-8644.

26: Tam, LM.; Jiang, J.; Wang, P.; Li, L.; Miao, W.; Dong, X.; and Wang, Y. Arsenite Binds to the Zinc Finger Motif of TIP60 Histone Acetyltransferase and Induces Its Degradation via the 26S Proteasome. Chem Res Toxicol. 2017; 30:1685-1693.

27: Liu, Y.; Perez, L.; Gill, AD.; Mettry, M.; Li, L.; Wang, Y.; Hooley, RJ.; and Zhong, W. Site-Selective Sensing of Histone Methylation Enzyme Activity via an Arrayed Supramolecular Tandem Assay. J. Am. Chem. Soc. 2017; 139:10964-10967.

28: Jiang, J.; Bellani, M.; Li, L.; Wang, P.; Seidman, MM.; and Wang, Y. Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair. ACS Chem Biol. 2017; 12:1858-1866.

29: Wu, J.; Wang, P.; Li, L.; Williams, NL.; Ji, D.; Zahurancik, WJ,; You, C.;Wang, J.; Suo, Z.; and Wang, Y. Replication studies of carboxymethylated DNA lesions in human cells. Nucleic Acids Res. 2017; 45:7276-7284.

30: Price, NE.; Li, L.; Gates, KS.; and Wang, Y. Replication and repair of a reduced 2΄-deoxyguanosine-abasic site interstrand cross-link in human cells. Nucleic Acids Res. 2017; 45:6486-6493.

31: Liu, S.; Jiang, J.; Li, L.; Amato, NJ.; Wang, Z.; and Wang, Y. Arsenite Targets the Zinc Finger Domains of Tet Proteins and Inhibits Tet-Mediated Oxidation of 5-Methylcytosine. Environ Sci Technol. 2015; 49:11923-31.

32: Zhang, ZM.; Rothbart, SB.; Allison, DF.; Cai, Q.; Harrison, JS.; Li, L.; Wang, Y.; Strahl, BD.; Wang, GG.; and Song, J. An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Cell Rep. 2015; 12:1400-6.

33: Zhao, S.; Wu, Y.; He, Y.; Wang, Y.; Xiao, J.; Li, L.; Wang, Y.; Chen, X.; Xiong, W.; and Wu, Y. RopGEF2 is involved in ABA-suppression of seed germination and post-germination growth of Arabidopsis. Plant J. 2015; 84:886-99.

34: Wang, Y.; Li, L.; Ye, T.; Lu, Y.; Chen, X.; and Wu, Y. The inhibitory effect of ABA on floral transition is mediated by ABI5 in Arabidopsis. J Exp Bot. 2013; 64:675-84.

35: Wang, Y.; Li, L.; Ye, T.; Zhao, S.; Liu, Z.; Feng, YQ.; and Wu Y. Cytokinin antagonizes ABA suppression to seed germination of Arabidopsis by downregulating ABI5 expression. Plant J. 2011; 68:249-61.

36: Bade, D., Cai, Q., Li, L., Yu, K., Dai, X., Miao, W., and Wang, Y. (2021). Modulation of N-terminal methyltransferase 1 by an N(6)-methyladenosine-based epitranscriptomic mechanism. Biochem Biophys Res Commun 546, 54-58.

37: Liu, X., Gonzalez, G., Dai, X., Miao, W., Yuan, J., Huang, M., Bade, D., Li, L., Sun, Y., and Wang, Y. (2020). Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism. Mol Ther 28, 2593-2604.

38: Yang, Y.Y., Yu, K., Li, L., Huang, M., and Wang, Y. (2020). Proteome-wide Interrogation of Small GTPases Regulated by N(6)-Methyladenosine Modulators. Anal Chem 92, 10145-10152.