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成果及论文

(1)Lian, X.; Mao, Y.; Fu, Z.; Zhang, W.; Chen, J.; Zhuo, D.; Zheng, M.; Wu, J.; Liao, C. Siteselective and Enantiocomplementary C(Sp3)–H Oxyfunctionalization for Synthesis of α-Hydroxy Acids. ACS Catal. 2024https://doi.org/10.1021/acscatal.4c00398.

(2)Luo, Z.; Li, Q.; Yang, H.; Li, Y.; Liu, Y.; Tang, C.; Liu, J.; Ke, C.; Ye, Y.; Zhang, R.; Liao, C. Vicinal Diones and α-Keto Esters as Electrophiles of Aldolases for Stereoselective Construction of Tertiary Alcohols. ChemCatChem 2024https://doi.org/10.1002/cctc.202400337.

(3) Zhang, R.; Zhang, C.; Tan, J.; He, Y.; Zhuo, D.; Zhang, J.; Luo, Z.; Li, Q.; Yao, J.; Ke, C.; Tang, C.; Ye, Y.; He, S.; Sheng, X.; Liao, C. Enzymatic Synthesis of Noncanonical α‐Amino Acids Containing γ‐Tertiary Alcohols. Angewandte Chemie 2023. https://doi.org/10.1002/anie.202318550.

(4) Liu, Y.; Fu, Z.; Dong, H.; Zhang, J.; Mao, Y.; Zheng, M.; Liao, C. Asymmetric C1 Extension of Aldehydes through Biocatalytic Cascades for Stereodivergent Synthesis of Mandelic Acids. Angewandte Chemie 2023. https://doi.org/10.1002/anie.202300906.

(5)Mao, Y.; Zhang, W.; Fu, Z.; Liu, Y.; Chen, L.; Lian, X.; Zhuo, D.; Wu, J.; Zheng, M.; Liao, C. Versatile Biocatalytic C(Sp3)−H Oxyfunctionalization for the Site‐ Selective and Stereodivergent Synthesis of α‐ and β‐Hydroxy Acids. Angewandte Chemie 2023. https://doi.org/10.1002/anie.202305250.

(6)Chen, L.; Zhang, Z.; Li, Z.; Li, R.; Huo, R.; Chen, L.; Wang, D.; Luo, X.; Chen, K.; Liao, C.; Zheng, M. Learning Protein Fitness Landscapes with Deep Mutational Scanning Data from Multiple Sources. Cell Syst. 2023. https://doi.org/10.1016/j.cels.2023.07.003.

(7)Zhang, R.; Tan, J.; Luo, Z.; Dong, H.; Ma, N.; Liao, C. Stereo-Selective Synthesis of Non-Canonical γ-Hydroxy-α-Amino Acids by Enzymatic Carbon–Carbon Bond Formation. Catal. Sci. Technol. 2021. https://doi.org/10.1039/d1cy00955a.

(8)Peng, J.; Liao, C.; Bauer, C.; Seebeck, F. P. FluorinatedS‐Adenosylmethionine as a Reagent for Enzyme‐Catalyzed Fluoromethylation. Angewandte Chemie 2021. https://doi.org/10.1002/anie.202108802.

(9)Liao, C.; Seebeck, F. P. Asymmetric β-Methylation of l- and d-α-Amino Acids by a Self-Contained Enzyme Cascade. Angew. Chem. Int. Ed. 2020. https://doi.org/10.1002/anie.201916025.

(10)Goncharenko, K. V.; Flückiger, S.; Liao, C.; Lim, D.; Stampfli, A. R.; Seebeck, F. P. Selenocysteine as a Substrate, an Inhibitor and a Mechanistic Probe for Bacterial and Fungal Iron-Dependent Sulfoxide Synthases. Chem. Eur. J. 2020. https://doi.org/10.1002/chem.201903898.

(11)Liao, C.; Seebeck, F. P. S -Adenosylhomocysteine as a Methyl Transfer Catalyst in Biocatalytic Methylation Reactions. Nat. Catal. 2019. https://doi.org/10.1038/s41929-019-0300-0.

(11)Liao, C.; Seebeck, F. P. In Vitro Reconstitution of Bacterial DMSP Biosynthesis. Angewandte Chemie 2019. https://doi.org/10.1002/anie.201814662.

(12)Gamage, A. M.; Liao, C.; Cheah, I. K.; Chen, Y.; Lim, D. R. X.; Ku, J. W. K.; Chee, R. S. L.; Gengenbacher, M.; Seebeck, F. P.; Halliwell, B.; Gan, Y.-H. The Proteobacterial Species Burkholderia Pseudomallei Produces Ergothioneine, Which Enhances Virulence in Mammalian Infection. FASEB J. 2018. https://doi.org/10.1096/fj.201800716.

(13)Liao, C.; Seebeck, F. P. Convergent Evolution of Ergothioneine Biosynthesis in Cyanobacteria. ChemBioChem 2017. https://doi.org/10.1002/cbic.201700354.

(14)Ruan, J.; Liao, C.; Ye, Y.; Lin, G. Lack of Metabolic Activation and Predominant Formation of an Excreted Metabolite of Nontoxic Platynecine-Type Pyrrolizidine Alkaloids. Chem. Res. Toxicol. 2013. https://doi.org/10.1021/tx4004159.

(15)Liao, C.-S.; Tang, C.-P.; Yao, S.; Ye, Y. Humulane-Type Sesquiterpenoids from Pilea Cavaleriei Subsp. Crenata†. Org. Biomol. Chem. 2013. https://doi.org/10.1039/c3ob40872h.