2025

70. Enantioselective Synthesis of α-Chiral Sulfonates through Palladium-Catalyzed Tsuji-Trost Sulfonylation with Sulfur Dioxide

Xiaochun He,‡ Fei Zhou,‡ Qingqing Wang, Xiaohong Wang, Zhiqian Chang, Xuemei Zhang*, Zhong Lian* Org. Chem. Front. 2025, DOI: 10.1039/D4QO01887G.

69. Generation of Perthiyl Radicals for the Synthesis of Unsymmetric Disulfides

Fei Zhou,# Xiaochun He,# Mi Zhou, Na Li, Qingqing Wang, Xuemei Zhang*, Zhong Lian* Nat. Commun., 2025, 

2024

68. Palladium-catalyzed difluorocarbene transfer enables access to enantioenriched chiral spirooxindoles

Zhiwen Nie#, Keqin Wu#, Xiaohang Zhan#, Weiran Yang, Zhong Lian, Shaoquan Lin, Shou-Guo Wang and Qin Yin* Nat. Commun., 2024, 15, 8510. 

67. Transition-Metal-Catalyzed Regiodivergent Sulfonylation of Aziridrines for the Synthesis of β‑Amino Sulfones

Qinqiong Zeng,† Yujia Gong,† Xiaochun He,† Xuemei Zhang,* Zhong Lian* Org. Chem. Front. 2024, 11, 6340-6346.

66. Triphasic Hydroxysilylation of Alkenes by Mechanically Piezoelectric Catalysis

Xiaohong Wang,† Xuemei Zhang,† Xiaochun He,† Guangqing Guo, Qian Huang, Fengzhi You, Qingqing Wang, Ruiling Qu, Fei Zhou, Zhong Lian* Angew. Chem. Int. Ed. 2024, e202410334.

65. Brønsted Base Catalyzed Reppe Sulfonylation Reaction

Xiaochun He, Xiaohong Wang, Fei Zhou, Hongzhuo Song, Xuemei Zhang*, Zhong Lian* Org. Chem. Front. 2024, 11, 4740-4747.

64. Organic Reactions Enabled by Mechanical Force-Induced Single Electron Transfer

Ruoxuan Liu,† Xiaochun He,† Tianfen Liu,† Xiaohong Wang,† Qingqing Wang,† Xinzhou Chen, Zhong Lian* Chem. Eur. J. 2024, e202401376. (Invited review)

                                                                                                

63. Access to Chiral Sulfones with An All-Carbon Quaternary Stereocenter from Sulfur Dioxide

Chunxi Huang‡, Xuemei Zhang‡, Liping Luo, Xiuwen Jia, Jian Liao*, Zhong Lian*  Org. Chem. Front. 2024,  11, 4275-4283.

62. Mechanochemical Vicinal Dibromination of Unactivated Alkenes and Alkynes Using Piezoelectric Material as Redox Catalyst

Fengzhi You,† Xuemei Zhang,† Xiaohong Wang, Guangqing Guo, Qingqing Wang, Hongzhuo Song, Ruiling Qu, Zhong Lian* Org. Lett. 2024, 26, 4240-4245.

61. Copper-Catalyzed Sulfonamidation of Enol Silyl Ether via SO₂ Insertion towards the Synthesis of β‑keto Sulfonamides

Qinqiong Zeng,† Yujia Gong,† Xuemei Zhang,†* Zhong Lian* Org. Chem. Front. 2024, 11, 3589.

60. Generation of Sulfamoyl Radical for the Modular Synthesis of Sulfonamides

Haiping Lv,^† Xinzhou Chen,^† Xuemei Zhang,^† Søren Kramer,*  Zhong Lian* ACS Catal. 2024, 14, 6513-6524.

59. Mechanical-Force-Induced Non-spontaneous Dehalogenative Deuteration of Aromatic Iodides Enabled by Using Piezoelectric Materials as a Redox Catalyst

Ruiling Qu, Shan Wan, Xuemei Zhang, Xiaohong Wang, Li Xue, Qingqing Wang, Gui-Juan Cheng,* Lunzhi Dai,* Zhong Lian* Angew. Chem. Int. Ed. 2024. e202400645.

 

58. Three-Component Radical Cross-Coupling: Asymmetric Vicinal Sulfonyl-Esterification of Alkenes Involving Sulfur Dioxide

Zhiqian Chang,‡ Xuemei Zhang,‡ Haiping Lv, Haotian Sun, Zhong Lian* Adv. Sci. 2024, 2309069.

57. Access to Chiral β-Amino Sulfones from Acrylamides and Sulfur Dioxide by Iron Catalysis

Liping Luo†, Xuemei Zhang†, Chunxi Huang, Zhong Lian* Org. Chem. Front. 2024, 11, 1678-1684.

2023

56. Cross-Electrophile Coupling Between Two Different Tosylates Enabled by Nickel/Palladium Cooperative Catalysis

Ruiling Qu,† Jinyu Zhang,† Zhong Lian* Eur.  J. Org. Chem. 2023,  e202300874.

55. Recent advances in nickel catalyzed carbonylative reactions via the insertion of Carbon Monoxide

Xinzhou Chen,† Gang Chen,† Zhong Lian* Chin. J. Chem. 2024, 42, 177-189. (Invited review)

54. Mechanochemical Synthesis of Aryl Fluorides by Using Ball Milling and a Piezoelectric Material as the Redox Catalyst

Xiaohong Wang, Xuemei Zhang, Li Xue, Qingqing Wang, Fengzhi You, Lunzhi Dai, Jiagang Wu, Søren Kramer,* Zhong Lian* 

Angew. Chem. Int. Ed. 2023,  e202307054.

53. Copper-Catalyzed 1,4-Trifluoromethylthio-Arylsulfonylation of 1,3-Enynes via the Insertion of Sulfur Dioxide

Hongzhuo Song, Xuemei Zhang, Gang Chen, Xiaochun He, Zhong Lian*  Org. Lett. 2023, 5916-5921.

52. Metal-Free Defluorinative Silylation of α-CF₃-Styrenes with Silyl Carboxylic Acid by Photo-Redox Catalysis

Xiong Li, Mi Zhou, Zhong Lian* Tetrahedron Lett. 2023, 10.1016/j.tetlet.2023.154611. (Invited paper to special issue)

51. Palladium-Catalyzed Cross-Electrophile Coupling Reaction involving Sulfur Dioxide for the Direct Synthesis of Diverse Functionalized Sulfones

Baojian Xiong, Jinyu Zhang, Ting Wang, Xuemei Zhang, Gui-juan Cheng,* Zhong Lian* Org. Chem. Front. 2023, 10, 3567-3576.

50. Copper-Catalyzed Ring-Open Sulfonylation of Cyclopropanols via the Insertion of Sulfur Dioxide toward the Synthesis of γ-Keto Aryl Sulfones              

Lin Shen, Xuemei Zhang, Zhong Lian* Org. Chem. Front. 2023, 10, 3239-3244.

49. Thiophene, 2,3,4,5-tetrabromo-,1,1-dioxide (SOgen)

Gang Chen, Zhong Lian* e-EROS 2023, accepted.

48. Application Progress of Silyl Carboxylic Acid in Organic Synthesis 

Guangqing Guo, Zhong Lian* Chin. J. Org. Chem. 2023, 10.6023/cjoc202303030 (Invited review to special issue: 有机硅化学)

47. Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1

Wang, C.; Yu, L.-Y.; Zhang, YY; Zhou, YX; Sun, B;Xiao, QJ; Zhang, MH; Liu, HY; Li, JH; Li, JH; Luo, YZ; Xu, J; Lian, Z; Lin, JW; Wang, X; Zhang, P; Guo, L; Ren, RB; Deng, D.* Nat. Commun. 2023, 1727.

46. Multicomponent Reactions Based on SO₂ Surrogates: Recent Advances

Gang Chen, Zhong Lian* Eur.  J. Org. Chem. 2023, e202300217. (Invited Review)

 

45. Enantioselective Intermolecular Radical Amidation and Amination of Benzylic C–H Bondsvia Dual Copper and Photocatalysis 

Xuemeng Chen, Zhong Lian,* Søren Kramer* Angew. Chem. Int. Ed. 2023,  e202217638.

44. Palladium-Catalyzed Carbonylative Hiyama-Denmark Reaction Towardthe Synthesis of Aryl Carbonyl-Containing Oxindoles

Xiong Li, Xuemei Zhang, Baojian Xiong, Zhong Lian*  J. Org. Chem. 2023, 88, 5226-5230. (Invited paper to special issue: C1 Chemistry)

2022

43. Carbonylative Cross-Electrophile Coupling Between Aryl Bromides and Aryl Triflates Enabled by Palladium and Rhodium Cooperative Catalysis and CO as Reductant        Gang Chen, Ruoxin Zhou, Xuemei Zhang, Xue Xiao, Søren Kramer,* Gui-Juan Cheng* and Zhong Lian* ACS Catal. 2022, 12, 14582-14591.

42. Iron-Catalyzed Sulfonylthiocyanation of α, β-Unsaturated Amides/Esters via the Insertion of Sulfur Dioxide                                                                                       Xiuwen Jia, Liping Luo, Chunxi Huang, Xuemei Zhang,* and Zhong Lian* Org. Lett. 2022, 24, 7560-7565.

41. Enantioselective Four-Component Arylsulfonylcyanation of Vinylarenes via the Insertion of Sulfur Dioxide Enabled by Using SOgen as SO₂ surrogate.                   Lei Chen, Xuemei Zhang, Mi Zhou, Lin Shen, Søren Kramer* and Zhong Lian*  ACS Catal. 2022, 12, 10764-10770.

40. Copper Catalyzed Cyano-Sulfonylation of Allenes via the Insertion of Sulfur Dioxide Toward the Synthesis of (E)-α-Cyanomethyl Vinylsulfones.                                Yue Li, Xuemei Zhang,* and Zhong Lian* Org. Chem. Front. 2022, 9, 5141-5146.

39. Palladium-Catalyzed Domino Cyclization/Direct Aminosulfonylation between Aryl Iodides and Amines via the Insertion of Sulfur Dioxide.

Haiping Lv, Xiaochun He, Lin Shen, Xuemei Zhang,* Zhong Lian* Adv. Synth. Catal. 2022, 364, 2729-2734.

38. Metal- and Base-Free Tandem Sulfonylation/Cyclization of 1,5-Dienes with Aryldiazonium Salts via the Insertion of Sulfur Dioxide.

Xiaohong Wang, Fengzhi You, Baojian Xiong, Lei Chen, Xuemei Zhang,^* Zhong Lian^* RSC Adv. 2022, 12, 16745-16750.

 

37. Nickel-Catalyzed Cross-Electrophile Coupling Reactions between Allylic Acetates and gem-Difluorovinyl Tosylate.

Xiaochun He, Jiangjun Liu, Gang Chen, Baojian Xiong, Xue Xiao, Lei Chen, Xuemei Zhang, Lin Dong, Xuelei Ma,* Zhong Lian* 

Org. Lett. 2022, 24, 3538–3543.

36. Palladium-Catalysed Difluoroolefination of Benzyl Tosylates Toward the Synthesis of gem-Difluoro-2-trifluromethyl Styrene Derivatives.

Jie Xu, Jiangjun Liu, Gang Chen, Baojian Xiong, Xuemei Zhang, Zhong Lian*, RSC Adv. 2022, 12, 12983–12987.

35. Copper-Catalyzed Trifluoromethylthio-Arylsulfonylation of Styrene Derivatives via the Insertion of Sulfur Dioxide.

Gang Chen, Jie Xu, Baojian Xiong, Hongzhuo Song, Xuemei Zhang, Xuelei Ma,* Zhong Lian* Org. Lett. 2022, 24, 1207-1212.

34. Cross-Electrophile Coupling between Aryl/Vinyl Triflates and Vinyl Tosylates for the Synthesis of gem-Difluoroalkenes via Ni/Pd Cooperative Catalysis. 

Baojian Xiong, Yue Li, Jinyu Zhang, Jiangjun Liu, Xuemei Zhang,* Zhong Lian* Adv. Synth. Catal. 2022, 364, 1009-1015.   

                                                                

33. gem-Difluorovinylation of Alkynyl Bromoarenes via Dual Nickel-/Palladium-Catalyzed Cross-Electrophile Coupling. 

Haotian Sun, Baojian Xiong, Yuan Yang, Jiangjun Liu, Xuemei Zhang,* Zhong Lian* Org. Chem. Front. 2022, 9, 305-310. 

                                                                 

    

2021      

32. Stereoselective gem-Difluorovinylation of gem-Difluorinated Cyclopropanes Enabled by Ni/Pd Cooperative Catalysis.

Baojian Xiong, Xuemeng Chen, Jiangjun Liu, Xuemei Zhang,* Ying Xia, Zhong Lian* ACS Catal. 2021, 11960–11965.

31. Copper-Catalyzed Chloro-Arylsulfonylation of Styrene Derivatives via the Insertion of Sulfur Dioxide.

Yue Li, Ling Shen, Mi Zhou, Baojian Xiong, Xuemei Zhang,* Zhong Lian* Org. Lett. 2021, 23, 5880-5884.

30. Metal-Free Sulfonylative Annulations of Alkyl Diiodides with Sulfur Dioxide: Synthesis of Cyclic Aliphatic Sulfones.

Xiuwen Jia, Chunxi Huang, Xuemei Zhang,* Zhong Lian* Org. Chem. Front. 2021,8, 5310-5315.

29. Metal- and Base-Free C(sp2)–H Arylsulfonylation of Enamides for Synthesis of E-β-Amidovinyl Sulfones via the Insertion of Sulfur Dioxide.

Lei Chen, Mi Zhou, Lin Shen, Xiaochun He, Xiong Li, Xuemei Zhang,* Zhong Lian* Org. Lett. 2021, 23, 4991-4996.

28. Copper-Catalyzed Alkynylation of Benzylic C–H Bonds with Alkynylboronic Esters. 

Buendia, M.B.; Balin, J.G.; Andersen, M.E.; Lian, Z.; Kramer, S.^* Synlett  2021, 33,150-154.

27. Design and Applications of a SO₂ Surrogate in Palladium-Catalyzed Direct Aminosulfonylation between Aryl Iodides and Amines.

Jia, X. W.; Kramer, S.; Skrydstrup, T.; Lian, Z.* Angew. Chem. Int. Ed. 2021, 60, 7353-7359.

2020

26. Nickel-Catalyzed Cross-Electrophile Coupling Reactions for the Synthesis of gem-Difluorovinyl Arenes.

Xiong, B. J.; Wang, T.; Sun, H. T.; Li, Y.; Kramer, S.;* Cheng, G.-J.;* Lian, Z.* ACS Catal. 2020, 10, 13616−13623.

25. Catalytic AgF-Initiated Intramolecular 1,3-Sulfonyl Migration of gem-Difluorovinyl Sulfonates to α,α-Difluoro-β-ketosulfones.

Xiong, B. J.; Chen, L.; Xu, J.; Sun, H. T.; Li, X.; Li, Y.; Lian, Z.^* Org. Lett. 2020, 22, 9263–9268.

24. Dual Nickel-/Palladium-Catalyzed Reductive Cross-Coupling Reactions between Two Phenol Derivatives.

Xiong, B. J.; Li, Y.; Wei, Y.; Kramer, S.^*; Lian, Z.^* Org. Lett. 2020, 22, 6334−6338.

23. Silylcarboxylic Acids as Bifunctional Reagents: Application in Palladium‐Catalyzed External‐CO‐Free Carbonylative Cross‐Coupling Reactions.

Li, X.; Xu, J.; Li, Y.;  Kramer, S.; Skrydstrup, T.;  Lian, Z.* Adv. Synth. Catal. 2020, 362, 4078-4083.

22. Nickel-Catalyzed Intramolecular Desulfitative C—N Coupling: A Synthesis of Aromatic Amines.

Liu, J. J.; Jia, X. W.; Chen, X. M.; Sun, H. T.; Li, Y.; Kramer. S.; Lian, Z.* J. Org. Chem. 2020, 85, 5702-5711.

21. Nickel-Catalyzed Inter- and Intramolecular Aryl Thioether Metathesis by Reversible Arylation.

Delcaillau, T.; Bismuto, A.; Lian, Z.; Morandi, B.* Angew. Chem. Int. Ed. 2020, 59, 2110-2114.

2019

20. Transition-Metal-Catalyzed Transformation of Sulfonates via S–O Bond Cleavage: Synthesis of Alkyl Aryl Ether and Diaryl Ether.

Chen, X. M.; Xiao, X.; Sun, H. T.; Li, Y.; Cao, H. L.; Zhang, X. M.; Yang, S. Y.; Lian, Z.* Org. Lett. 2019, 21, 8879-8883.

19. Metal-Free Aerobic Oxidative Selective C–C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols.

Xia, A. J.; Qi, X. Y.; Mao, X.; Wu, X. A.; Yang, X.; Zhang, R.; Xiang, Z. Y.; Lian, Z.; Chen, Y. C.; Yang, S. Y.* Org. Lett. 2019, 21, 3028-3033.

18. Iron‐Catalyzed Ring‐Closing C−O/C−O Metathesis of Aliphatic Ethers.

Biberger, T.; Makai, S.; Lian, Z.; Morandi, B.* Angew. Chem. Int. Ed. 2018, 57, 6940-6944.

Before SCU （研究生和博后）

17. Lian, Z.; Bhawal, B. N.; Yu, P.; Morandi, B.* Science 2017, 356, 1059.

16. Lian, Z.; Nielsen, D. U.; Lindhardt, A. L.; Daasbjerg, K.; Skrydstrup, T. ^*Nat. Commun. 2016, 7, 13782.

15. Lian, Z.; Friis, S. D.; Skrydstrup, T.^* Angew. Chem. Int. Ed. 2014, 53, 9582.

14. Lian, Z.; Yin, H. F.; Friis, S. D.; Skrydstrup, T.* Chem. Commun. 2015, 51, 7831-7834.

13. Lian, Z.; Friis, S. D.; Skrydstrup, T.^* Chem. Commun. 2015, 51, 3600-3603.

12. Lian, Z.; Friis, S. D.; Skrydstrup, T.^* Chem. Commun. 2015, 51, 1870-1873.

11. Lian, Z.; Friis, S. D.; Lindhardt, A. T.; Skrydstrup, T.^* Synlett 2014, 25, 1241.

10. Lian, Z.; Shi, M.^* Org. Biomol. Chem. 2012, 10, 8048. 

9. Lian, Z.; Zhao, Q. Y.; Wei, Y.; Shi, M.^* Eur. J. Org. Chem. 2012, 3338.

8. Lian, Z.; Wei, Y.; Shi, M.^* Tetrahedron 2012, 2401.

7. Lian, Z.; Shi, M.^* Eur. J. Org. Chem. 2012, 581.

6. Lian, Z.; Guan, X. Y.; Shi, M.^* Tetrahedron 2011, 2018.

5. Nielsen, D. U.; Lian, Z.; Lindhardt, A. T.; Skrydstrup, T.* Topics in Heterocyclic Chemistry 2016, 44, 88-99.

4. Wang, Q.; Lian, Z.; Xu, Q.; Shi, M.^* Adv. Synth. Catal. 2013, 3344.

3. Zhao, Q. Y.; Lian, Z.; Wei, Y.; Shi, M.^* Tetrahedron 2012, 4899.

2. Zhao, Q. Y.; Lian, Z.; Wei, Y.; Shi, M.^* Chem. Commun. 2012, 48, 1724.

1. Pei, C. K.; Wu, L.; Lian, Z.; Shi, M.^* Org. Biomol. Chem. 2012, 10, 171.