Representative Publications (at NNU)
5篇代表性论文（近3年）：
[1] Regiodivergent and Stereoselective Synthesis of Highly Substituted 1,3-Dienes via Arylative Acyloxy Migration of Propargyl Esters.
Z. Sun, M. Dai (co-first author), C. Ding, S. Chen, and L.-A. Chen*
J. Am. Soc. Chem. 2023, 145, 18115-18125.
[2] Manganese-Catalyzed Redox-Neutral Thiolation of Alkyl Halides with Thioformates.
P. Pei, M. Zhao, D. Lin, Z, Dong, L. Song*, L.-A. Chen*
Angew. Chem. Int. Ed. 2023, 62, e202305510.
[3] Directed Asymmetric Nickel-Catalyzed Reductive 1,2-Diarylation of Electronically Unactivated Alkenes.
Z. Dong, Q. Tang (co-first author), C. Xu, L. Chen, H. Ji, S. Zhou, L. Song*, L.-A. Chen*
Angew. Chem. Int. Ed. 2023, 62, e202218286.
[4] Nickel-Catalyzed Enantioselective Coupling of Acid Chlorides with Bromobenzoates: An Asymmetric Acyloin Synthesis.
H. Ji, D. Lin (co-first author), L. Tai, X. Li, Y. Shi, Q. Han*, L.-A. Chen*
J. Am. Chem. Soc. 2022, 144, 23019-23029.
[5] Palladium-Catalyzed Regiodivergent Synthesis of 1,3-Dienyl and Allyl Esters from Propargyl Esters.
M. Dai, Z. Sun, L.-A. Chen*
Angew. Chem. Int. Ed. 2022, 61, e202203835.
Full Publications (at NNU)
[29] H. Tang, M. Dai, D. Zhou, L, Song*, and L.-A. Chen*, Transition Metal-Catalyzed Redox-Neutral 1,3-Dienylation of Propargylic Esters and Divergent Synthesis (2024 Organic Chemistry Frontiers Review-type Articles), Org. Chem. Front., 2024, DOI: 10.1039/D4QO01407C
[28] M-Y. Zhang, M. Zhang, C. Li, W. Wang, G. Shi, S. Luo, L.-A. Chen*, and Q. Dai*, Advances in the Intermolecular Asymmetric Allylic Functionalization of Unreactive Acyclic Alkenes, Synlett, 2024, DOI: 10.1055/a-2375-7634
[27] C. Zhou, M. Dai, X. Yin, M. Zhang, W. Gu, and L.-A. Chen*, Pd-Catalyzed Dienylation of Propargylic Esters Enabling Highly Stereoselective Synthesis of Danishefsky-type Trisubstituted Dienes, Chin. J. Chem., 2024, 42, 1993-1995 (Emerging Investigator Series)
[26] Z. Dong，C. Xu, J. Chang, S. Zhou, P. Sun, Y. Li*, and L.-A. Chen*, Enantioselective Directed Nickel-Catalyzed Three-Component Reductive Arylalkylation of Alkenes via the Carbometalation/Radical Cross-Coupling Sequence, ACS. Catal., 2024, 14, 4395-4406 (highlighted by 研之成理、化学深耕堂；Most read article in March 2024)
[25] M. Dai，L. Song*, and L.-A. Chen*, Stereoselective Synthesis of Substituted 1,3-Dienes from Propargylic Esters: Electrophilic-Metal or Redox Catalysis? Sci. China Chem. 2024, 67, 1384-1396. (Highlighted by 中国科学化学)
[24] M. Dai，L. F. Kabandula, L. Tai, B. Wu, L. Song*, and L.-A. Chen*, Transition Metal-Catalyzed Synthesis of 1,2,3,4-Tetrasubstituted1,3-Dienes from Propargylic Esters, ChemCatChem, 2024, e202301738, (Invited contribution to special collection "ChineseCatChem", Selected as Best Review-type Article, Highlighted by WileyChem，CBG, )
[23] Z. Sun, M. Dai (co-first author), C. Ding, S. Chen, and L.-A. Chen*, Regiodivergent and Stereoselective Synthesis of Highly Substituted 1,3-Dienes via Arylative Acyloxy Migration of Propargyl Esters, J. Am. Soc. Chem. 2023, 145, 18115-18125.
[22] C, Xu, J. Chang, Z. Dong, L. Song*, L.-A. Chen*, Direct and modular access to allylic amines via nickel-catalyzed three-component coupling, Org. Chem. Front. 2023, 10, 5592-5600
[21] Z, Dong, L. Song*, L.-A. Chen*, Enantioselective Ni-Catalyzed Three-Component Dicarbofunctionalization of Alkenes, ChemCatChem. 2023, 15, e202300803 (Invited Concept, Highlighted by WileyChem).
[20] Y. Chen, D. Lin (co-first author), Z. Yu, Z, Dong, L. Song*, L.-A. Chen*, LiBr-Mediated Cross-Coupling towards α-Trifluoromethylamines, Asian J. Org. Chem. 2023, 12, e202300352.
[19] P. Pei, M. Zhao, D. Lin, Z, Dong, L. Song*, L.-A. Chen*, Manganese-Catalyzed Redox-Neutral Thiolation of Alkyl Halides with Thioformates. Angew. Chem. Int. Ed. 2023, 62, e202305510. (highlighted by Advances in Engineering as Key Scientific Article)
[18] Z. Dong, Q. Tang (co-first author), C. Xu, L. Chen, H. Ji, S. Zhou, L. Song*, L.-A. Chen*, Directed Asymmetric Nickel-Catalyzed Reductive 1,2-Diarylation of Electronically Unactivated Alkenes. Angew. Chem. Int. Ed. 2023, 62, e202218286. (ESI高被引论文)
[17] D. Lin, Y. Chen, Z, Dong, P. Pei, H. Ji, L. Tai, L.-A. Chen*, General and Modular Access to Enantioenriched Trifluoromethyl Ketones via Nickel-Catalyzed Reductive Trifluoroalkylation. CCS Chem. 2023, 5, 1386-1397. (Highlighted by CCS Chem-Author Spotlight)
[16] L. Tai, L. Chen (co-first author), Y. Shi, L.-A. Chen*, Redox-Active Alkyl Xanthate Esters Enable Practical C–S Cross-Coupling by Nickel Catalysis. Org. Chem. Front. 2023, 10, 2505-2516 (Organic Chemistry Frontiers Emerging Investigator Series).
[15] Y. Qi, D. Lin (co-first author), L.-A. Chen*, Reductive Acylation with Acyl-Ni as a Key Intermediate to Synthesize Ketones. Chin. J. Org. Chem. 2023, 43, 3861-3875 (Invited Review).
[14] H. Ji, D. Lin (co-first author), L. Tai, X. Li, Y. Shi, Q. Han*, L.-A. Chen*, Nickel-Catalyzed Enantioselective Coupling of Acid Chlorides with Bromobenzoates: An Asymmetric Acyloin Synthesis. J. Am. Chem. Soc. 2022, 144, 23019-23029.
[13] M. Dai, Z. Sun, L.-A. Chen*, Palladium-Catalyzed Regiodivergent Synthesis of 1,3-Dienyl and Allyl Esters from Propargyl Esters. Angew. Chem. Int. Ed. 2022, 61, e202203835. (Highlighted by Synfacts)
Before NNU (Post-Doctoral and Graduate Publications)
[12] L.-A. Chen, A. R. Lear, P. Gao, M. K. Brown*, Nickel-Catalyzed Arylboration of Alkenylarenes: Synthesis of Boron-Substituted Quaternary Carbons and Regiodivergent Reactions”. Angew. Chem. Int. Ed. 2019, 58, 10956-10960.
[11] P. Gao-, L.-A. Chen-, M. K. Brown*, Nickel-Catalyzed Stereoselective Diarylation of Alkenylarenes, J. Am. Chem. Soc. 2018, 140, 10653-10657. (-equal contribution, most read articles in August 2018)
[10] L.-A. Chen, M. A. Ashley, J. L. Leighton*, Evolution of an Efficient and Scalable Nine-Step (Longest Linear Sequence) Synthesis of Zincophorin Methyl Ester, J. Am. Chem. Soc. 2017, 139, 4568-4573.
[09] C. N. Foley, L.-A. Chen, D. L. Sackett, J. L. Leighton*, Synthesis and Evaluation of a Linkable Functional Group-Equipped Analogue of the Epothilones, ACS Med. Chem. Lett. 2017, 8, 701-704.
[08] L.-A. Chen, W. Xu, B. Huang, J. Ma, L. Wang, J. Xi, K. Harms, L. Gong*, E. Meggers*, Asymmetric Catalysis with an Inert Chiral-at-Metal Iridium Complex, J. Am. Chem. Soc. 2013, 135, 10598-10601.
[07] L.-A. Chen, X. Tang, J. Xi, W. Xu, L. Gong*, E. Meggers*, Chiral-at-Metal Octahedral Iridium Catalyst for Asymmetric Construction of an All-Carbon Quaternary Stereocenter, Angew. Chem. Int. Ed. 2013, 125, 14271-14275.
[06] L. Gong, L.-A. Chen, E. Meggers*, Asymmetric Catalysis Mediated by the Ligand Sphere of Octahedral Chiral-at-Metal Complexes, Angew. Chem. Int. Ed. 2014, 53, 10868-10874.
[05] C. Wang, L.-A. Chen, H. Huo, X. Shen, K. Harms, L. Gong, E. Meggers*, Asymmetric Lewis Acid Catalysis Directed by Octahedral Rhodium Centrochirality, Chem. Sci. 2015, 6, 1094-1100.
[04] H. Huo, X. Shen, C. Wang, L. Zhang, P. Rose, L.-A. Chen, K. Harms, M. Marsch, G. Hilt, E. Meggers*, Asymmetric Photoredox Transition-Metal Catalysis Activated by Visible Light. Nature 2014, 515, 100-103.
[03] L.-A. Chen, C. F. Wang, M. G. Lin, J. L. Zhang, P.-Q. Huang, A.-E. Wang*, Design and Synthesis of Camphor-derived Chiral [1,2,4]Triazolo[4,3-a]-tetrahydroquinoline N-Heterocyclic Carbene Precursors by Pd-Catalyzed Coupling Reactions of Aryl Hydrazides with a Pyridyl Triflate Derivative. Asian J. Org. Chem. 2013, 294-298.
[02] L.-A. Chen, X. Ding, L. Gong* and E. Meggers*, Thioether-Based Anchimeric Assistance for Asymmetric Coordination Chemistry with Ruthenium(II) and Osmium(II), Dalton Trans. 2013, 42, 5623-5626.
[01] L.-A. Chen, J. Ma, M. A. Celik, H.-L. Yu, Z. Cao, G. Frenking, L. Gong* and E. Meggers*, Active versus Passive Substituent Participation in the Auxiliary-Mediated Asymmetric Synthesis of an Octahedral Metal Complex, Chem. Asian J. 2012, 7, 2523-2526.
