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成果及论文

2023

· Liang Z, Zhao L, Ye AY, Lin SG, Zhang Y, Guo C, Dai HQ, Ba Z, Alt FW. Contribution of the IGCR1 regulatory element and the 3'Igh 

CTCF-binding elements to regulation of Igh V(D)J recombination. Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2306564120. 

doi: 10.1073/pnas.2306564120. Epub 2023 Jun 20. PMID: 37339228; PMCID: PMC10293834.


2022

· Dong Y, Pi X, Bartels-Burgahn F, Saltukoglu D, Liang Z, Yang J, Alt FW, Reth M, Wu H. Structural principles of B cell antigen receptor 

assembly. Nature. 2022 Dec;612(7938):156-161. doi: 10.1038/s41586-022-05412-7. Epub 2022 Oct 13. PMID: 36228656.


2021

· Liang Z, Kumar V, Le Bouteiller M, Zurita J, Kenrick J, Lin SG, Lou J, Hu J, Ye AY, Boboila C, Alt FW, Frock RL. Ku70 suppresses alternative 

end joining in G1-arrested progenitor B cells. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2103630118. 

doi: 10.1073/pnas.2103630118. PMID: 34006647; PMCID: PMC8166026.


2020

· Dai HQ, Liang Z, Chang AN, Chapdelaine-Williams AM, Alvarado B, Pollen AA, Alt FW, Schwer B. Direct analysis of brain phenotypes via 

neural blastocyst complementation. Nat Protoc. 2020 Oct;15(10):3154-3181. doi: 10.1038/s41596-020-0364-y. Epub 2020 Aug 10. 

PMID: 32778838; PMCID: PMC7685531.


2019

· Zhang Y, Zhang X, Ba Z, Liang Z, Dring EW, Hu H, Lou J, Kyritsis N, Zurita J, Shamim MS, Presser Aiden A, Lieberman Aiden E, Alt FW. 

The fundamental role of chromatin loop extrusion in physiological V(D)J recombination. Nature. 2019 Sep;573(7775):600-604. 

doi: 10.1038/s41586-019-1547-y. Epub 2019 Sep 11. PMID: 31511698; PMCID: PMC6867615.


2018

· Chang AN, Liang Z, Dai HQ, Chapdelaine-Williams AM, Andrews N, Bronson RT, Schwer B, Alt FW. Neural blastocyst complementation 

enables mouse forebrain organogenesis. Nature. 2018 Nov;563(7729):126-130. doi: 10.1038/s41586-018-0586-0. Epub 2018 Oct 10. 

PMID: 30305734; PMCID: PMC6588192.

· Chen C, Liang Z, Zhou B, Li X, Lui C, Ip NY, Qu JY. In Vivo Near-Infrared Two-Photon Imaging of Amyloid Plaques in Deep Brain of 

Alzheimer's Disease Mouse Model. ACS Chem Neurosci. 2018 Dec 19;9(12):3128-3136. doi: 10.1021/acschemneuro.8b00306. 

Epub 2018 Aug 16. PMID: 30067906.


2017

· Huang H, Lin X, Liang Z, Zhao T, Du S, Loy MMT, Lai KO, Fu AKY, Ip NY. Cdk5-dependent phosphorylation of liprinα1 mediates neuronal 

activity-dependent synapse development. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6992-E7001. doi: 10.1073/pnas.1708240114. 

Epub 2017 Jul 31. Erratum in: Proc Natl Acad Sci U S A. 2017 Oct 23;: PMID: 28760951; PMCID: PMC5565463.


2016

· Liang Z, Zhan Y, Shen Y, Wong CC, Yates JR 3rd, Plattner F, Lai KO, Ip NY. The pseudokinase CaMKv is required for the activity-dependent 

maintenance of dendritic spines. Nat Commun. 2016 Oct 31;7:13282. doi: 10.1038/ncomms13282. PMID: 27796283; PMCID: PMC5095516.


2015

· Liang Z, Ye T, Zhou X, Lai KO, Fu AK, Ip NY. Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development. J Neurosci. 

2015 Nov 11;35(45):15127-34. doi: 10.1523/JNEUROSCI.1443-15.2015. Erratum in: J Neurosci. 2016 Jan 6;36(1):262. PMID: 26558783; 

PMCID: PMC6605353.

· Lai KO, Liang Z, Fei E, Huang H, Ip NY. Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) 

Is Required for Dendritic Spine Morphogenesis. J Biol Chem. 2015 Jun 5;290(23):14637-46. doi: 10.1074/jbc.M114.627117. 

Epub 2015 Apr 22. PMID: 25903132; PMCID: PMC4505530.

· Chen Y, Liang Z, Fei E, Chen Y, Zhou X, Fang W, Fu WY, Fu AK, Ip NY. Axin Regulates Dendritic Spine Morphogenesis through 

Cdc42-Dependent Signaling. PLoS One. 2015 Jul 23;10(7):e0133115. doi: 10.1371/journal.pone.0133115. PMID: 26204446; 

PMCID: PMC4512687.


2012

· Lai KO, Wong AS, Cheung MC, Xu P, Liang Z, Lok KC, Xie H, Palko ME, Yung WH, Tessarollo L, Cheung ZH, Ip NY. TrkB phosphorylation 

by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci. 2012 Nov;15(11):1506-15. 

doi: 10.1038/nn.3237. Epub 2012 Oct 14. PMID: 23064382; PMCID: PMC7511999.