8155
中文   |   English 手机浏览
当前位置： 首页   >  成果及论文
成果及论文

代表性论文

  1. T. Hu, Z. Gu, G. R. Williams, M. Strimaite, J. Zha, Z. Zhou, X. Zhang,* C. Tan,* R. Liang,* Layered double hydroxide-based nanomaterials for biomedical applications, Chem. Soc. Rev., 2022, 51, 6126−6176.
  2. R. Gao,# X. Mei,# D. Yan,* R. Liang,* M. Wei, Nano-photosensitizer based on layered double hydroxide and isophthalic acid for singlet oxygenation and photodynamic therapy, Nat. Commun., 2018, 9, 2798.
  3. W. Shen,# T. Hu,# X. Liu, J. Zha, F. Meng, Z. Wu, Z. Cui, Y. Yang, H. Li, Q. Zhang, L. Gu, R. Liang,* C. Tan,* Defect Engineering of Layered Double Hydroxide Nanosheets as Inorganic Photosensitizers for NIR-III Photodynamic Cancer Therapy, Nat. Commun., 2022, 13, 3384.
  4. Z. Zhou,# T. Wang,# T. Hu,# H. Xu, L. Cui, B. Xue, X. Zhao, X. Pan, S. Yu, H. Li, Y. Qin, J. Zhang,* L. Ma,* R. Liang,*  C. Tan,* Synergistic Interaction Between Metal Single-Atoms and Defective WO3-x Nanosheets for Enhanced Sonodynamic Cancer Therapy, Adv. Mater., 2024, 2311002.
  5. T. Hu,# W. Shen,# F. Meng,# S. Yang, S. Yu, H. Li, Q. Zhang, L. Gu,* C. Tan,* R. Liang,* Boosting the sonodynamic cancer therapy performance of 2D layered double hydroxide nanosheet-based sonosensitizers via crystalline-to-amorphous phase transformation, Adv. Mater., 2023, 2209692.
  6. Y. Yang,# T. Hu,# Y. Bian,# F. Meng, S. Yu, H. Li, Q. Zhang, L. Gu, X. Weng,* C. Tan,* R. Liang,* Coupling probiotics with 2D CoCuMo-LDH nanosheets as tumor microenvironment-responsive platform for precise NIR-II photodynamic therapy, Adv. Mater., 2023, 2211205.
  7. W. Liu, S. Xu, S. Guan, R. Liang,* M. Wei,* D. G. Evans, X. Duan, Confined synthesis of carbon nitride in a layered host matrix with unprecedented solid-state quantum yield and stability, Adv. Mater., 2018, 30, 1704376.
  8. Z. Lv, T. Hu, Y. Bian, G. Wang, Z. Wu, H. Li, X. Liu, S. Yang, C. Tan,* R. Liang,* X. Weng*, A MgFe-LDH Nanosheet-Incorporated Smart Thermo-Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration, Adv. Mater., 2023, 35, 2206545.
  9. L. Peng, X. Mei, J. He, J. Xu, W. Zhang,* R. Liang,* M. Wei,* D. G. Evans, X. Duan, Monolayer Nanosheets with an Extremely High Drug Loading toward Controlled Delivery and Cancer Theranostics, Adv. Mater., 2018, 30, 1707389. 
2024年
  1. Z. Zhou,# T. Wang,# T. Hu,# H. Xu, L. Cui, B. Xue, X. Zhao, X. Pan, S. Yu, H. Li, Y. Qin, J. Zhang,* L. Ma,* R. Liang,*  C.    Tan,* Synergistic Interaction Between Metal Single-Atoms and Defective WO3-x Nanosheets for Enhanced Sonodynamic Cancer Therapy, Adv. Mater., 2024, 2311002.
  2. R. Chen,# T. Hu, Yu Lu, S. Yang, M. Zhang, C. Tan,*R. Liang,* and Y. Wang,* PAD4 Inhibitor-Loaded Layered Double HydroxideNanosheets as a Multifunctional Nanoplatform forPhotodynamic Therapy-Mediated Tumor MetastasisTreat, Small 2024, 2404211.
  3. M. Cao, S. Yang, J. Li, Y. Yang, L. Zhan, T. Wang, T. Hu, R. Liang,* Z. Li,* Bifunctional Bismuth-Based Layered Double Hydroxide Sonosensitizer for Magnetic Resonance Imaging-Guided Sonodynamic Cancer Therapy, Small., 2024, 2404475.
  4. Y. Bian, T. Hu, K. Zhao, X. Cai, M. Li, C. Tan,* R. Liang,*A LDH-Derived Metal Sulfide Nanosheet-Functionalized Bioactive Glass Scaffold for Vascularized Osteogenesis and Periprosthetic Infection Prevention/Treatment, Adv. Sci. 2024, 2403009.
  5. Y. Bian, K. Zhao, T. Hu, C. Tan,* R. Liang,* X. Weng,* A Se Nanoparticle/MgFe-LDH Composite Nanosheet as a Multifunctional Platform for Osteosarcoma Eradication, Antibacterial and Bone Reconstruction, Adv. Sci. 2024, 2403791.
  6. S. Yang,# T. Hu,# G. Williams, Y. Yang, S. Zhang, J. Shen, M. Chen,* R. Liang,* L. Lyu,* Boosting the sonodynamic performance of CoBiMn-layered double hydroxide nanoparticles via tumor microenvironment regulation for ultrasound imaging-guided sonodynamic therapy, Yang et al. Journal of Nanobiotechnology (2024) 22:317 
  7. D. Zhu,# Y. Lu,# S. Yang,# T. Hu, C. Tan,*R.Liang,* Y. Wang,* PAD4 Inhibitor-Functionalized Layered Double Hydroxide Nanosheets for Synergistic Sonodynamic Therapy/Immunotherapy Of Tumor Metastasis, Adv. Sci., 2024. 2401064.
  8. X. Liu,# T. Hu,# Y. Jia, S. Yang, Y. Yang, Z. Cui, T. Wang, R. Liang,* C. Tan,*  Y. Wang*, A MgAl-LDH-CuS Nanosheet-based    Thermo-Responsive Composite Hydrogel with NIR-Responsive Angiogenesis Inhibitor Releasing Capability for Multimode  Starvation Therapy, J Nanobiotechnol., 2024, 22, 127.
  9. Z. Cui,# T. Hu,# S. Yang, Y. Yang, X. Liu, T. Wang, H. Chen, C. Zeng*, R. Liang*, Y. Zhou*, Amorphous 2D Mn-doped CoMo-layered double hydroxide nanosheets for magnetic resonance imaging-guided sonodynamic cancer therapy. Chem. Eng. J., 2024, 480, 147463.
2023年
  1. T. Hu,# W. Shen,# F. Meng,# S. Yang, S. Yu, H. Li, Q. Zhang, L. Gu,* C. Tan,* R. Liang,* Boosting the sonodynamic cancer therapy performance of 2D layered double hydroxide nanosheet-based sonosensitizers via crystalline-to-amorphous phase transformation, Adv. Mater., 2023, 2209692.
  2. Y. Yang,# T. Hu,# Y. Bian,# F. Meng, S. Yu, H. Li, Q. Zhang, L. Gu, X. Weng,* C. Tan,* R. Liang,* Coupling probiotics with 2D CoCuMo-LDH nanosheets as tumor microenvironment-responsive platform for precise NIR-II photodynamic therapy, Adv. Mater., 2023, 2211205.
  3. Z. Lv, T. Hu, Y. Bian, G. Wang, Z. Wu, H. Li, X. Liu, S. Yang, C. Tan,* R. Liang,* X. Weng*, A MgFe-LDH Nanosheet-Incorporated Smart Thermo-Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration, Adv. Mater., 2023, 35, 2206545.
  4. Y. Bian, X. Cai, Z. Lv, Y. Xu, H. Wang, C. Tan,* R. Liang,* X. Weng,* Layered Double Hydroxides: A Novel Promising 2D             Nanomaterial for Bone Diseases Treatment, Adv. Sci., 2023, 10, 2301806.
  5. G. Wang,# Z. Lv,# T. Wang,# T. Hu, Y. Bian, Y. Yang, R. Liang,* C. Tan,* X. Weng,* Surface Functionalization of Hydroxyapatite Scaffolds with MgAlEu-LDH Nanosheets for High-Performance Bone Regeneration, Adv. Sci., 2023, 10, 2204234.
  6. T. Hu, B. Xue, F. Meng, L. Ma, Y. Du, S. Yu, R. Ye, H. Li, Q. Zhang, L. Gu, Z. Zhou,* R. Liang,* C. Tan,* Preparation of 2D polyaniline/MoO3-x superlattice nanosheets via intercalation-induced morphological transformation for efficient chemodynamic therapy, Adv. Healthcare Mater., 2023, 2202911.
  7. J. Zhang,# Y. Yang,# F. Qin,# T. Hu, X. Zhao, S. Zhao, Y. Cao, Z. Gao, Z. Zhou,* R. Liang,* C. Tan,* Y. Qin, Catalyzing Generation and Stabilization of Oxygen Vacancies on CeO2-x Nanorods by Pt Nanoclusters as Nanozymes for Catalytic Therapy, Adv. Healthcare Mater., 2023, 12, 2302056.
  8. S. Wang,# S. Yang,# Z. Cui, X. Liu, Y. Yang, T. Wang, W. Ma, Y. Zhou, R. Liang,* D. Yan,* H. Chen,* In-situ Activation of CuAl-LDH Nanosheets to Catalyze Bioorthogonal Chemistry in vivo in Tumor Microenvironment for Precise Chemotherapy and Chemodynamic Therapy, Chem. Eng. J., 2023, 457, 141186.
  9. Z. Zhou,# T. Wang,# T. Hu,# C. Cheng, S. Yu, H. Li, S. Liu, L. Ma,* M. Zhao,* R. Liang,* C. Tan*, Facile synthesis of 2D Al-TCPP MOF nanosheets for efficient sonodynamic cancer therapy, Mater. Chem. Front., 2023,7, 1684-1693.
  10. Z. Cao,# Y. Bian,# T. Hu, Y. Yang, Z. Cui , T. Wang, S. Yang, X. Weng,* R. Liang,* C. Tan,* Recent advances in two-dimensional nanomaterials for bone tissue engineering, J. Materiomics, 2023, 9, 930-958
  11. Y. Bian,# T. Hu,# Z. Lv, Y. Xu, Y. Wang, H. Wang, W. Zhu, B. Feng, R. Liang,* C. Tan,* X. Weng,* Bone tissue engineering for treating osteonecrosis of the femoral head, Exploration, 2023, 3, 20210105
2022年
  1. T. Hu, Z. Gu, G. R. Williams, M. Strimaite, J. Zha, Z. Zhou, X. Zhang,* C. Tan,* R. Liang,* Layered double hydroxide-based nanomaterials for biomedical applications, Chem. Soc. Rev., 2022, 51, 6126−6176.
  2. W. Shen,# T. Hu,# X. Liu, J. Zha, F. Meng, Z. Wu, Z. Cui, Y. Yang, H. Li, Q. Zhang, L. Gu, R. Liang,* C. Tan,* Defect Engineering of Layered Double Hydroxide Nanosheets as Inorganic Photosensitizers for NIR-III Photodynamic Cancer Therapy, Nat. Commun., 2022, 13, 3384.
  3. T. Hu,# Q. Liu,# Z. Zhou,# W. Zhao, H. Huang, F. Meng, W. Liu, Q. Zhang, L. Gu, R. Liang,* C. Tan,* Preparation of Dye Molecule-Intercalated MoO3 Organic/Inorganic Superlattice Nanoparticles for Fluorescence Imaging-Guided Catalytic Therapy, Small，2022, 18, 2200595.
  4. J. Wu, T. Hu, G. Zhao,* A. Li,* R. Liang,* Two-dimensional transition metal chalcogenide nanomaterials for cancer diagnosis and treatment, Chin. Chem. Lett., 2022, 33, 4437–4448.
  5. T. Hu,# Z. Zhou,# J. Zha, G. R. Williams, Z. Wu, W. Zhao, W. Shen, H. Li, X. Weng,* R. Liang,* C. Tan*, Ternary NiCoTi-layered double hydroxide nanosheets as a pH-responsive nanoagent for photodynamic/chemodynamic synergistic therapy, Fundam. Res., 2022, DOI: 10.1016/j.fmre.2022.06.001.
  6. Z. Zhou, X. Li, T. Hu, B. Xue, H. Chen, L. Ma, R. Liang,* C. Tan,* Molybdenum-based nanomaterials for photothermal cancer therapy, Adv. NanoBiomed Res., 2022, 2, 2200065.
2021年
  1. Y. Wang, S. Shen T. Hu, G. R. Williams, Y. Bian, B. Feng, R. Liang,* X. Weng,* Layered Double Hydroxide Modified Bone Cement Promoting Osseointegration via Multiple Osteogenic Signal Pathways, ACS Nano, 2021, 15, 9732−9745.
  2. J. Wu, G. R. Williams, Y. Zhu, T. Hu, H. Wang, W. Zhao, R. Liang,* X. Weng,* M. Wei,* Ultrathin Chalcogenide Nanosheets for Photoacoustic Imaging-Guided Synergistic Photothermal/Gas Therapy, Biomaterials, 2021, 273, 120807.
  3. S. Wang, T. Hu, G. Wang, Z. Wang, D. Yan*, R. Liang,* C. Tan,* Ultrathin CuFe2S3 nanosheets derived from CuFe-layered double hydroxide as an efficient nanoagent for synergistic chemodynamic and NIR-II photothermal therapy, Chem. Eng. J., 2021, 419, 129458.
  4. T. Hu,# L. Yan,# Z. Wang, W. Shen, R. Liang,* D. Yan,* M. Wei,* A pH-responsive Ultrathin Cu-based Nanoplatform for Specific Photothermal and Chemodynamic Synergistic Therapy, Chem. Sci., 2021, 12, 2594–2603.
  5. T. Hu, Z. Wang, W. Shen, R. Liang,* D. Yan,* M. Wei,* Recent advances in innovative strategies for enhanced cancer photodynamic therapy, Theranostics, 2021, 11, 3278−3300.
  6. Z. Wang,# L. Fu,# Y. Zhu, S. Wang, G. Shen, L. Jin,* R. Liang,* Chemodynamic/photothermal synergistic therapy based on Ce-doped Cu-Al layered double hydroxide, J. Mater. Chem. B, 2021, 9, 710–718.
2020年
  1. Y. Zhu,# Y. Wang,# G. R. Williams, L. Fu, J. Wu, H. Wang, R. Liang,* X. Weng,* M. Wei,* Multicomponent Transition Metal Dichalcogenide Nanosheets for Imaging-Guided Photothermal and Chemodynamic Therapy, Adv. Sci., 2020, 7, 2000272. (Front Cover)
  2. A. Wang, W. Yang, X. Yang, X. Mei, T. Hu, R. Liang,* D. Meng,* D. Yan,* MgAl monolayer hydrotalcite increases the hypoglycemic effect of berberine by enhancing its oral bioavailability, Biomed. Pharmacother., 2020, 127, 110140.
  3. X. Mei, T. Hu, Y. Wang, X. Weng,* R. Liang,* M. Wei,* Recent advancements in two-dimensional nanomaterials for drug delivery, WIREs Nanomed Nanobiotechnol., 2020, 12, e1596.
  4. X. Mei,# T. Hu,# H. Wang, R. Liang,* W. Bu,* M. Wei,* Highly dispersed Nano-enzyme Triggered Intracellular Catalytic Reaction toward Cancer Specific Therapy, Biomaterials, 2020, 258, 120257.
  5. J. Wu,# S. Zhang,# X. Mei, N. Liu, T. Hu, R. Liang,* D. Yan,* M. Wei,* Ultrathin Transition Metal Chalcogenide Nanosheets Synthesized via Topotactic Transformation for Effective Cancer Theranostics, ACS Appl. Mater. Interfaces, 2020, 12, 48310−48320.
  6. Y. Wang, X. Mei, Y. Bian, T. Hu, X. Weng,* R. Liang,* M. Wei,* Magnesium-based layered double hydroxides nanosheets: a new bone repair material with unprecedented osteogenic differentiation performance, Nanoscale, 2020, 12, 19075−19082. (Front Cover)
  7. L. Yan,# Y. Wang,# T. Hu,# X. Mei, X. Zhao, Y. Bian, L. Jin, R. Liang,* X. Weng,* M. Wei,* Layered Double Hydroxides Nanosheets: toward Ultrasensitive Tumor Microenvironment Responsive Synergetic Therapy, J. Mater. Chem. B, 2020, 8, 1445−1455.
  8. Z. Wang, T. Hu, R. Liang,* M. Wei,* Application of Zero-Dimensional Nanomaterials in Biosensing, Front. Chem., 2020, 8, 00320.
  9. X. Liu, T. Hu, G. Lin, X. Wang, Y. Zhu, R. Liang,* W. Duan,* M. Wei, The synthesis of a DHAD/ZnAlTi-LDH composite with advanced UV blocking and antibacterial activity for skin protection, RSC Adv., 2020, 10, 9786−9790.
  10. Y. Wang, Y. Bian, L. Zhou, B. Feng,* X. Weng,* R. Liang,* Biological evaluation of bone substitute, Clinica Chimica Acta, 2020, 510, 544–555.
2019年
  1. T. Hu, X. Mei, Y. Wang, X. Weng,* R. Liang,* M. Wei,* Two-Dimensional Nanomaterials：Fascinating Materials in Biomedical Field, Sci. Bull., 2019, 64, 1707−1727.
  2. L. Fu, H. Liu, L. Yan, Y. Fu, Y. Zhu, L. Jin,* R. Liang,* Fabrication of CuNCs/LDHs Films with Excellent Luminescent Properties and Exploration of Thermosensitivity, Ind. Eng. Chem. Res., 2019, 58, 8009−8015.
2018年
  1. R. Gao,# X. Mei,# D. Yan,* R. Liang,* M. Wei, Nano-photosensitizer based on layered double hydroxide and isophthalic acid for singlet oxygenation and photodynamic therapy, Nat. Commun., 2018, 9, 2798.
  2. W. Liu, S. Xu, S. Guan, R. Liang,* M. Wei,* D. G. Evans, X. Duan, Confined synthesis of carbon nitride in a layered host matrix with unprecedented solid-state quantum yield and stability, Adv. Mater., 2018, 30, 1704376.
  3. L. Peng, X. Mei, J. He, J. Xu, W. Zhang,* R. Liang,* M. Wei,* D. G. Evans, X. Duan, Monolayer Nanosheets with an Extremely High Drug Loading toward Controlled Delivery and Cancer Theranostics, Adv. Mater., 2018, 30, 1707389. 
  4. X. Mei, W. Wang, L. Yan, T. Hu, R. Liang,* D. Yan,* M. Wei,* David G. Evans, Xue Duan, Hydrotalcite Monolayer toward High Performance Synergistic Dual-modal Imaging and Cancer Therapy, Biomaterials, 2018, 165, 14−24.
  5. X. Mei, S. Xu, T. Hu, L. Peng, R. Gao, R. Liang,* M. Wei,* D. G. Evans, X. Duan, Layered double hydroxide monolayers for controlled loading and targeted delivery of anticancer drugs, Nano Res., 2018, 11, 195–205.
  6. T. Hu, J. He, S. Zhang, X. Mei, W. Zhang,* R. Liang,* M. Wei,* D. G. Evans, X. Duan, An ultrathin photosensitizer for simultaneous fluorescence imaging and photodynamic therapy, Chem. Commun., 2018, 54, 5760−5763.
  7. X. Mei, J. Ma, X. Bai, X. Zhang, S. Zhang, R. Liang,* M. Wei,* D. G. Evans, X. Duan, A bottom-up synthesis of rare-earth-hydrotalcite monolayer nanosheets toward multimode imaging and synergetic therapy, Chem. Sci., 2018, 9, 5630−5639.
2017年
  1. S. Guan, Y. Weng, M. Li, R. Liang,* C. Sun,* X. Qu,* S. Zhou, An NIR-sensitive layered supramolecular nanovehicle for combined dual-modal imaging and synergistic therapy, Nanoscale, 2017, 9, 10367–10374.
  2. W. Liu, S. Xu, R. Liang,* M. Wei,* D. G. Evans, X. Duan, In situ synthesis of nitrogen-doped carbon dots in the interlayer region of a layered double hydroxide with tunable quantum yield, J. Mater. Chem. C, 2017, 5, 3536−3541.
  3. X. Mei, R. Liang,* L. Peng, T. Hu, M. Wei,* Layered double hydroxide bio-composites toward excellent systematic anticancer therapy, J. Mater. Chem. B, 2017, 5, 3212−3216.
  4. S. Guan, R. Liang,* C. Li, M. Wei,* A supramolecular material for dual-modal imaging and targeted cancer therapy, Talanta, 2017, 165, 297–303.
  5. 梅旭安, 彭刘琪, 梁瑞政,* 卫敏,* LDHs生物医学复合材料的制备及其在药物输送和诊疗方面的应用,中国科学.化学, 2017, 47, 431−441.
2016年
  1. C. Li, R. Liang,* R. Tian, S. Guan, D. Yan, Ji. Luo,* M. Wei,* D. G. Evans, X. Duan, A targeted agent with intercalation structure for cancer near-infrared imaging and photothermal therapy, RSC Adv., 2016, 6, 16608–16614.
  2. W. Liu, S. Xu, Z. Li, R. Liang,* M. Wei,* D. G. Evans, X. Duan, Layer-by-Layer Assembly of Carbon Dots-Based Ultrathin Films with Excellent Quantum Yield and Temperature Sensing Performance, Chem. Mater., 2016, 28, 5426−5431.
  3. R. Tian, D. Yan, C. Li, S. Xu, R. Liang,* L. Guo, M. Wei,* D. G. Evans, X. Duan, Surface-confined fluorescence enhancement of Au nanoclusters anchoring to a two-dimensional ultrathin nanosheet toward bioimaging, Nanoscale, 2016, 8, 9815–9821.
  4. S. Guan, R. Liang,* C. Li, D. Yan,* M. Wei,* D. G. Evans, X. Duan, A layered drug nanovehicle toward targeted cancer imaging and therapy, J. Mater. Chem. B, 2016, 4, 1331–1336.
  5. M. Li, R. Tian, D. Yan, R. Liang,* M. Wei,* D. G. Evans, X. Duan, A luminescent ultrathin film with reversible sensing toward pressure, Chem. Commun., 2016, 52, 4663–4666.
2015年
  1. R. Liang, S. You, L. Ma, C. Li, L. Zhang, M. Wei*, D. Yan*, M. Yin*, W. Yang, D. G. Evans, X. Duan, A Supramolecular Nanovehicle toward Systematic and Targeted Cancer Therapy, Chem. Sci., 2015, 6, 5511−5518.
2014年
  1. R. Liang, M. Wei,* D. G. Evans, X. Duan, Inorganic nanomaterials for bioimaging, targeted drug delivery and therapeutics, Chem. Commun., 2014, 50, 14071−14081.
  2. R. Liang, L. Ma, L. Zhang, C. Li, W. Liu, M. Wei*, D. Yan*, D. G. Evans, X. Duan, A Monomeric Photosensitizer for Targeted Cancer Therapy, Chem. Commun., 2014, 50, 14983−14986.
  3. R. Liang, R. Tian, Z. Liu, D. Yan,* M. Wei, Preparation of Monodisperse Ferrite Nanocrystals with Tunable Morphology and Magnetic Properties, Chem. Asian J., 2014, 9, 1161–1167.
  4. R. Liang, R. Tian, L. Ma, L. Zhang, Y. Hu, J. Wang, M. Wei,* D. Yan,* D. G. Evans, X. Duan, A Supermolecular Photosensitizer with Excellent Anticancer Performance in Photodynamic Therapy, Adv. Funct. Mater., 2014, 24, 3144−3151.
  5.  R. Liang, D. Yan, R. Tian, X. Yu, W. Shi, C. Li, M. Wei*, D. G. Evans, X. Duan, Quantum Dots-Based Flexible Films and Their Application as the Phosphor in White Light-Emitting Diodes, Chem. Mater., 2014, 26, 2595−2600.
2013年
  1. R. Liang, R. Tian, W. Shi, Z. Liu, D. Yan, M. Wei*, David G. Evans, Xue Duan, A temperature sensor based on CdTe quantum dots−layered double hydroxide ultrathin films via layer-by-layer assembly, Chem. Commun., 2013, 49, 969−971.
2012年
  1. R. Liang, S. Xu, D. Yan, W. Shi, R. Tian, H. Yan, M. Wei,* D. G. Evans, X. Duan, CdTe Quantum Dots/Layered Double Hydroxide Ultrathin Films with Multicolor Light Emission via Layer-by-Layer Assembly, Adv. Funct. Mater., 2012, 22, 4940−4948.