# Co-first authors, * Corresponding authors

1. Yuxuan Xiong^#, Zhengtao Yong^#, Qingfu Zhao, Ao Hua, Xing Wang, Xiang Chen, Xiangliang Yang, Zifu Li^*. Hydroxyethyl starch-based self-reinforced nanomedicine inhibits both glutathione and thioredoxin antioxidant pathways to boost reactive oxygen species-powered immunotherapy. Biomaterials, 2024, 122673

2. Zheng Li^#, Yabo Zhu^#, Zhijie Zhang, Huimin Wang, Chong Wang, Chen Xu, Shiyou Li, Shuya Zhang, Xiangliang Yang, Zifu Li^*. Softness-aided mild hyperthermia boosts stiff nanomedicine by regulating tumor mechanics. Advanced Science, 2024, 2306730, https://onlinelibrary.wiley.com/doi/10.1002/advs.202306730

3. Chen Xiao^#, Jiayuan Li^#, Ao Hua, Xing Wang, Shiyou Li, Zheng Li, Chen Xu, Zhijie Zhang, Xiangliang Yang^*, Zifu Li^*. Hyperbaric oxygen boosts antitumor efficacy of copper-diethyldithiocarbamate nanoparticles against pancreatic ductal adenocarcinoma by regulating cancer stem cell metabolism. Research, 2024, 10.34133/research.0335

4. Qingyuan Deng, Xiangliang Yang, Zifu Li^*. Hyperbaric oxygen: a multifaceted approach in cancer therapy. Medical Gas Research, 2024, (Invited Perspective)

5. Qiang Wang^#, Shiyou Li^#, Chen Xu^#, Xing Wang, Tian Yang, Chong Wang, Yuxuan Xiong, Zhijie Zhang, Xiangliang Yang, Zifu Li^*. Glutaminolysis inhibition boosts photodynamic therapy to eliminate cancer stem cells. Biomaterials, 2024, 306, 122497, https://www.sciencedirect.com/science/article/pii/S0142961224000310

6. Zheng Li, Xiangliang Yang, Zifu Li^*. Tumor mechanics meets nanomedicine mechanical properties. Chemistry of Materials, 2024, 36, 3, 1041-1053, (Invited Perspective, Journal Cover), https://pubs.acs.org/doi/10.1021/acs.chemmater.3c02474

7. Yuxuan Xiong, Zhengtao Yong, Shiyou Li, Qiang Wang, Xiang Chen, Zhijie Zhang, Qingfu Zhao, Qingyuan Deng, Xiangliang Yang, Zifu Li^*. Self-reliant Nanomedicine with Long-lasting Glutathione Depletion Ability Disrupts Adaptive Redox Homeostasis and Suppresses Cancer Stem Cells. Advanced Functional Materials, 2023, 2310158 DOI:10.1002/adfm.202310158

8. Qiang Wang, Tian Yang, Shiyou Li, Chen Xu, Chong Wang, Yuxuan Xiong, Xing Wang, Jiangling Wan, Xiangliang Yang^* and Zifu Li^*. Unimolecular self-assembled hemicyanine-oleic acid conjugate acts as a novel succinate dehydrogenase inhibitor to amplify photodynamic therapy and eliminate cancer stem cells. Research, 2023, https://spj.science.org/doi/10.34133/research.0223

9. Qingfu Zhao^#, Jitang Chen^#, Zhijie Zhang, Chen Xiao, Haowen Zeng, Chen Xu, Xiangliang Yang, Zifu Li^*. Modulating tumor mechanics with nanomedicine for cancer therapy. Biomaterials Science, 2023, 11, 4471-4489, (Emerging Investigator, Invited review), https://doi.org/10.1039/D3BM00363A

10. Yuxuan Xiong^#, Zhengtao Yong^#, Chen Xu^#, Qingyuan Deng, Qiang Wang, Shiyou Li, Chong Wang, Zhijie Zhang, Xiangliang Yang^*, Zifu Li^*. Hyperbaric oxygen activates enzyme‐driven cascade reactions for cooperative cancer therapy and cancer stem cells elimination. Advanced Science, 2023, 2301278, https://doi.org/10.1002/advs.202301278

11. Qiang Wang^#, Shiyou Li^#, Chen Xu, Ao Hua, Chong Wang, Yuxuan Xiong, Qingyuan Deng, Xiang Chen, Tian Yang, Jiangling Wan, Ze-yang Ding, Bi-xiang Zhang, Xiangliang Yang, Zifu Li^*. A novel lonidamine derivative targeting mitochondria to eliminate cancer stem cells by blocking glutamine metabolism. Pharmacological Research, 2023, 190, 106740, https://doi.org/10.1016/j.phrs.2023.106740

12. Zheng Li, Yabo Zhu, Haowen Zeng, Chong Wang, Chen Xu, Qiang Wang, Huimin Wang, Shiyou Li, Jitang Chen, Chen Xiao, Xiangliang Yang, Zifu Li*. Mechano-boosting nanomedicine antitumour efficacy by blocking the reticuloendothelial system with stiff nanogels. Nature Communications, 2023, 14, 1437 https://doi.org/10.1038/s41467-023-37150-3

13. Yuxuan Xiong^#, Wei Wang^#, Qingyuan Deng, Zhijie Zhang, Qiang Wang, Zhengtao Yong, Chaoyang Sun*, Xiangliang Yang, Zifu Li*. Mild photothermal therapy boosts nanomedicine antitumor efficacy by disrupting DNA damage repair pathways and modulating tumor mechanics. Nano Today, 2023, 101767 https://doi.org/10.1016/j.nantod.2023.101767

14. Wei Wang^#, Yuxuan Xiong^#, Xingyuan Hu, Funian Lu, Tianyu Qin, Li Zhang, Ensong Guo, Bin Yang, Yu Fu, Dianxing Hu, JunPeng Fan, Xu Qin, Chen Liu, RouRou Xiao, Gang Chen, Zifu Li*, Chaoyang Sun*. Codelivery of adavosertib and olaparib by tumor-targeting nanoparticles for augmented efficacy and reduced toxicity. Acta Biomaterialia, 2023, 157, 428-441 https://doi.org/10.1016/j.actbio.2022.12.021

15. Chen Xu, Shiyou Li, Jitang Chen, Huimin Wang, Zheng Li, Qingyuan Deng, Jiayuan Li, Xing Wang, Yuxuan Xiong, Zhijie Zhang, Xiangliang Yang, Zifu Li*. Doxorubicin and erastin co-loaded hydroxyethyl starch-polycaprolactone nanoparticles for synergistic cancer therapy. Journal of Controlled Release, 2023, 356, 256-271 https://doi.org/10.1016/j.jconrel.2023.03.001

16. Chen Xiao^#, Jiayuan Li^#, Xing Wang^#, Shiyou Li, Chen Xu, Zhijie Zhang, Ao Hua, Ze-yang Ding, Bi-xiang Zhang, Xiangliang Yang, Zifu Li^*. Hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanocrystals for cancer therapy. Journal of Controlled Release, 2023, 356, 288-305 https://doi.org/10.1016/j.jconrel.2023.02.043

17. Chong Wang^#, Qiang Wang^#, Huimin Wang^#, Zheng Li, Jitang Chen, Zhijie Zhang, Haowen Zeng, Ximiao Yu, Xiaoquan Yang, Xiangliang Yang, Zifu Li*. Hydroxyethyl starch-folic acid conjugates stabilized theranostic nanoparticles for cancer therapy. Journal of Controlled Release, 2023, 353, 391-410, https://doi.org/10.1016/j.jconrel.2022.11.059

18. Chong Wang^#, Huimin Wang^#, Hai Yang^#, Chen Xu, Qiang Wang, Zheng Li, Zhijie Zhang, Jiankun Guan, Ximiao Yu, Xiaoquan Yang, Xiangliang Yang, Zifu Li*. Targeting cancer-associated fibroblasts with hydroxyethyl starch nanomedicine boosts cancer therapy. Nano Research, 2023 https://doi.org/10.1007/s12274-023-5394-7

19. Zhijie Zhang^#, Zibing Wang^#, Yuxuan Xiong^#, Chong Wang, Qingyuan Deng, Tian Yang, Qingqing Xu, Zhengtao Yong, Xiangliang Yang, Zifu Li*. A two-pronged strategy to alleviate tumor hypoxia and potentiate photodynamic therapy by mild hyperthermia. Biomaterials Science, 2023, 11, 108-118 (Back Cover), DOI: https://doi.org/10.1039/D2BM01691E

20. Zhijie Zhang^#, Qingyuan Deng^#, Chen Xiao, Zifu Li*, Xiangliang Yang*. Rational design of nanotherapeutics based on five features principle for potent elimination of cancer stem cells. Accounts of Chemical Research, 2022, 55, 526-536, (Invited review) https://pubs.acs.org/doi/full/10.1021/acs.accounts.1c00635

21. Xiaoxian Wang^#, Ningbing Ye^#, Chen Xu^#, Chen Xiao^#, Zhijie Zhang^#, Qingyuan Deng, Shiyou Li, Jiayuan Li, Zifu Li*, Xiangliang Yang. Hyperbaric oxygen regulates tumor mechanics and augments Abraxane and gemcitabine antitumor effects against pancreatic ductal adenocarcinoma by inhibiting cancer-associated fibroblasts. Nano Today, 2022, 101458 https://doi.org/10.1016/j.nantod.2022.101458

22. Qiang Wang^#, Chong Wang^#, Shiyou Li^#, Yuxuan Xiong, Huimin Wang, Zheng Li, Jiangling Wan, Xiangliang Yang, Zifu Li*. Influence of Linkers within Stimuli-Responsive Prodrugs on Cancer Therapy: A Case of Five Doxorubicin Dimer-Based Nanoparticles. Chemistry of Materials, 2022, 34, 5, 2085-2097, https://doi.org/10.1021/acs.chemmater.1c03346

23. Yuxuan Xiong^#, Zibing Wang^#, Qiang Wang, Qingyuan Deng, Jitang Chen, Jianshuang Wei, Xiaoquan Yang, Xiangliang Yang, Zifu Li*. Tumor-specific activatable biopolymer nanoparticles stabilized by hydroxyethyl starch prodrug for self-amplified cooperative cancer therapy. Theranostics, 2022, 12, 944-962, https://www.thno.org/v12p0944.htm

24. Hang Hu^#, Xin Liu^#, Jun Hong^#, Ningbing Ye, Chen Xiao, Jianhao Wang*, Zifu Li*, Defeng Xu*. Mesoporous polydopamine-based multifunctional nanoparticles for enhanced cancer phototherapy. Journal of Colloid and Interface Science, 2022, 612, 246-260, https://www.sciencedirect.com/science/article/pii/S002197972102316X

25. Jitang Chen, Zhijie Zhang, Nining Li, Haowen Zeng, Zheng Li, Chong Wang, Chen Xu, Qingyuan Deng, Qiang Wang, Xiangliang Yang, Zifu Li*. Precise fibrin decomposition and tumor mechanics modulation with hydroxyethyl starch-based smart nanomedicine for enhanced antitumor efficacy. J. Mater. Chem. B, 2022, 10, 8193-8210, DOI: 10.1039/D2TB01812H

26. Xin Liu^#, Ningbing Ye^#, Chen Xiao, Xiaoxian Wang, Shiyou Li, Yihan Deng, Xiaoquan Yang, Zifu Li*, Xiangliang Yang. Hyperbaric oxygen regulates tumor microenvironment and boosts commercialized nanomedicine delivery for potent eradication of cancer stem-like cells. Nano Today, 2021, 101248, https://doi.org/10.1016/j.nantod.2021.101248

27. Xin Liu^#, Ningbing Ye^#, Sha Liu^#, Jiankun Guan, Qingyuan Deng, Zhijie Zhang, Chen Xiao, Ze-yang Ding, Bi-xiang Zhang, Xiao-ping Chen, Zifu Li*, Xiangliang Yang. Hyperbaric Oxygen Boosts PD-1 Antibody Delivery and T Cell Infiltration for Augmented Immune Responses Against Solid Tumors. Advanced Science, 2021, 2100233, https://doi.org/10.1002/advs.202100233

28. Jiankun Guan^#, Yuxin Wu^#, Xin Liu^#, Huimin Wang, Ningbing Ye, Zheng Li, Chen Xiao, Zhijie Zhang, Zifu Li*, Xiangliang Yang. A novel prodrug and its nanoformulation suppress cancer stem cells by inducing immunogenic cell death and inhibiting indoleamine 2, 3-dioxygenase. Biomaterials, 2021, 121180, https://doi.org/10.1016/j.biomaterials.2021.121180

29. Jiankun Guan^#, Yuxin Wu^#, Huimin Wang, Haowen Zeng, Zifu Li*, Xiangliang Yang. DiR loaded tumor targeting theranostic cisplatin-icodextrin prodrug nanoparticle for imaging guided chemo-photothermal cancer therapy. Nanoscale, 2021, 13, 19399-19411 (Back Cover, 2021 Nanoscale HOT Article Collection) https://doi.org/10.1039/D1NR05824J

30. Jitang Chen^#, Si Li^#, Xin Liu, Sha Liu, Chen Xiao, Zhijie Zhang, Shiyou Li, Zifu Li*, Xiangliang Yang. Transforming growth factor-β blockade modulates tumor mechanical microenvironment for enhanced antitumor efficacy of photodynamic therapy. Nanoscale, 2021, 13, 9989-10001 (Inside Back Cover, 2021 Nanoscale HOT Article Collection) https://doi.org/10.1039/D1NR01552D

31. Yuxuan Xiong^#, Chen Xiao^#, Zifu Li*, Xiangliang Yang. Engineering nanomedicine for glutathione depletion-augmented cancer therapy. Chemical Society Reviews, 2021, 50, 6013-6041 (Invited review) https://doi.org/10.1039/D0CS00718H

32. Huimin Wang^#, Hang Hu^#, Hai Yang, Zifu Li*. Hydroxyethyl starch based smart nanomedicine. RSC Advances 2021,11, 3226-3240 (Invited review) https://doi.org/10.1039/D0RA09663F

33. Jitang Chen^#, Ze-yang Ding^#, Si Li^#, Sha Liu^#, Chen Xiao, Zifu Li*, Bi-xiang Zhang*, Xiao-ping Chen, Xiangliang Yang*. Targeting transforming growth factor-β signaling for enhanced cancer chemotherapy. Theranostics, 2021, 11, 1345-1363 (Invited review) https://www.thno.org/v11p1345.htm

34. Xiaoxian Wang, Si Li, Xin Liu, Xian Wu, Ningbing Ye, Xiangliang Yang, Zifu Li*. Boosting Nanomedicine Efficacy with Hyperbaric Oxygen Therapy. Bio-Nanomedicine for Cancer Therapy 2021 pp 77-95 (Invited review) https://link.springer.com/chapter/10.1007%2F978-3-030-58174-9_4

35. Qiang Wang, Jiankun Guan, Jiangling Wan, Zifu Li*. Disulfide based prodrugs for cancer therapy. RSC Advances 2020,10, 24397-24409 (Invited review) https://doi.org/10.1039/D0RA04155F

36. Zheng Li^#, Chen Xiao^#, Tuying Yong^#, Zifu Li*, Lu Gan*, Xiangliang Yang*. Influence of nanomedicine mechanical properties on tumor targeting delivery. Chemical Society Reviews, 2020, 49, 2273-2290 (Inside Front Cover, Invited review) https://doi.org/10.1039/C9CS00575G

37. Zhijie Zhang^#, Chen Xiao^#, Tuying Yong^#, Xiangliang Yang, Lu Gan*, Zifu Li*. Cellular microparticles for tumor targeting delivery: from bench to bedside. Chemical Communications, 2020, 56, 6171-6188 (Inside Back Cover, Invited review) https://doi.org/10.1039/D0CC02333G

38. Zifu Li, Chunzhi Di, Suping Li*, Xiangliang Yang*, Guangjun Nie*. Smart Nanotherapeutic Targeting of Tumor Vasculature. Accounts of Chemical Research, 2019, 52, 2703-2712 (Invited review) https://pubs.acs.org/doi/10.1021/acs.accounts.9b00283

39. Yihui Li^#, Yuxin Wu^#, Jitang Chen^#, Jiangling Wan^#, Chen Xiao, Jiankun Guan, Xianlin Song, Shiyou Li, Mengmeng Zhang, Huangchen Cui, Tiantian Li, Xiaoquan Yang, Zifu Li*, Xiangliang Yang*. A Simple Glutathione-Responsive Turn-On Theranostic Nanoparticle for Dual-Modal Imaging and Chemo-Photothermal Combination Therapy. Nano Letters, 2019, 19, 5806-5817 https://pubs.acs.org/doi/10.1021/acs.nanolett.9b02769

40. Yuxuan Xiong, Zushun Xu*, Zifu Li*. Polydopamine-Based Nanocarriers for Photosensitizer Delivery. Frontiers in Chemistry 2019 (Invited review) https://doi.org/10.3389/fchem.2019.00471

41. Hang Hu^#, Jitang Chen^#, Hai Yang^#, Xuetao Huang, Honglian Wu, Yuxin Wu, Fenfang Li, Yunfei Yi, Chen Xiao, Yihui Li, Yuxiang Tang, Zifu Li*, Bixiang Zhang*, Xiangliang Yang*. Potentiating photodynamic therapy of ICG-loaded nanoparticles by depleting GSH with PEITC. Nanoscale 2019, 11, 6384-6393 https://doi.org/10.1039/C9NR01306G

42. Yuxiang Tang^#, Yihui Li^#, Si Li^#, Hang Hu, Yuxin Wu, Chen Xiao, Zhiqin Chu, Zifu Li*, Xiangliang Yang. Transformable nanotherapeutics enabled by ICG: towards enhanced tumor penetration under NIR light irradiation. Nanoscale 2019, 11, 6217-6227 https://doi.org/10.1039/C9NR01049A

43. Chen Xiao^#, Hang Hu^#, Hai Yang^#, Si Li, Hui Zhou, Jian Ruan, Yuting Zhu, Xiangliang Yang, Zifu Li*. Colloidal hydroxyethyl starch for tumor-targeted platinum delivery. Nanoscale Advances 2019, 1, 1002-1012 https://doi.org/10.1039/C8NA00271A

44. Xian Wu^#, Yanhong Zhu^#, Wei Huang, Jingqiu Li, Bixiang Zhang, Zifu Li*, Xiangliang Yang*. Hyperbaric Oxygen Potentiates Doxil Antitumor Efficacy by Promoting Tumor Penetration and Sensitizing Cancer Cells. Advanced Science, 2018, 5, 1700859 https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201700859

45. Qing Zhou^#, Yihui Li^#, Yanhong Zhu^#, Chan Yu, Haibo Jia, Binghao Bao, Hang Hu, Chen Xiao, Jianqi Zhang, Xiaofan Zeng, Ying Wan, Huibi Xu, Zifu Li*, Xiangliang Yang*. Co-delivery nanoparticle to overcome metastasis promoted by insufficient chemotherapy. Journal of Controlled Release, 2018, 275, 67-77 https://doi.org/10.1016/j.jconrel.2018.02.026

46. Yuxiang Tang^#, Yihui Li^#, Rong Xu^#, Si Li, Hang Hu, Chen Xiao, Honglian Wu, Lin Zhu, Jiaxiong Ming, Zhiqin Chu, Huibi Xu, Xiangliang Yang*, Zifu Li*. Self-assembly of folic acid dextran conjugates for cancer chemotherapy. Nanoscale 2018, 10, 17265-17274 https://doi.org/10.1039/C8NR04657C

47. Hang Hu^#, Jiangling Wan^#, Xuetao Huang^#, Yuxiang Tang, Chen Xiao, Huibi Xu, Xiangliang Yang*, Zifu Li*. iRGD-decorated reduction-responsive nanoclusters for targeted drug delivery. Nanoscale 2018 10, 10514–10527 https://doi.org/10.1039/C8NR02534G

48. Honglian Wu^#, Hang Hu^#, Jiangling Wan^#, Yaming Li, Yuxin Wu, Yuxiang Tang, Chen Xiao, Huibi Xu, Xiangliang Yang, Zifu Li*. Hydroxyethyl starch stabilized polydopamine nanoparticles for cancer chemotherapy. Chemical Engineering Journal, 2018 349, 129-145 https://doi.org/10.1016/j.cej.2018.05.082

49. Hang Hu^#, Chen Xiao^#, Honglian Wu, Yihui Li, Qing Zhou, Yuxiang Tang, Chan Yu, Xiangliang Yang*, Zifu Li*. Nanocolloidosomes with Selective Drug Release for Active Tumor-Targeted Imaging-Guided Photothermal/Chemo Combination Therapy. ACS Applied Materials & Interfaces, 2017, 9, 42225–42238 https://pubs.acs.org/doi/10.1021/acsami.7b14796

50. Yihui Li, Hang Hu, Qing Zhou, Yanxiao Ao, Chen Xiao, Jianglin Wan, Ying Wan, Huibi Xu, Zifu Li*, Xiangliang Yang*. α-Amylase- and Redox-Responsive Nanoparticles for Tumor-Targeted Drug Delivery. ACS Applied Materials & Interfaces, 2017, 9, 19215-19230 https://pubs.acs.org/doi/10.1021/acsami.7b04066

51. Hang Hu, Yihui Li, Qing Zhou, Yanxiao Ao, Chan Yu, Ying Wan, Huibi Xu, Zifu Li*, Xiangliang Yang*. Redox-Sensitive Hydroxyethyl Starch–Doxorubicin Conjugate for Tumor Targeted Drug Delivery. ACS Applied Materials & Interfaces, 2016, 8, 30833-30844 https://pubs.acs.org/doi/10.1021/acsami.6b11932