1. Qishu Chen#, Qifan Zhou#, Guanguan Li, Shuo Li, Yingjun Li,* and Xumu Zhang,* Optimized kilogram-scale synthesis and impurity identification of SHEN26 (ATV014) for treating COVID-19. Org. Process Res. Dev. (just accepted)
2. Zhou, Q. F.#; Yang, S. D. #; Cao, L. #; Yang, Y. #; Xu, T. F. #; Chen, Q. S.; Lu, H. Z.; Li, Y. J. *; Guo, D. Y. *; Zhang, X. M. *, Preclinical characterization and anti-SARS-CoV-2 efficacy of ATV014: an oral cyclohexanecarboxylate prodrug of 1 '-CN-4-aza-7,9-dideazaadenosine C-nucleoside. Signal Transduction and Targeted Therapy 2023, 8 (1).
3. Zhou, Q. F. #; Luo, Y. Z. #; Zhu, Y. J. #; Chen, Q. S.; Qiu, J. F.; Cong, F. *; Li, Y. J. *; Zhang, X. M. *, Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses. European Journal of Medicinal Chemistry 2023, 249.
4. Yang, Y. #; Cao, L. #; Yan, M. #; Zhou, J.; Yang, S.; Xu, T.; Huang, S.; Li, K.; Zhou, Q.; Li, G.; Zhu, Y.; Cong, F.; Zhang, H. *; Guo, D. *; Li, Y. *; Zhang, X. *, Synthesis of deuterated S-217622 (Ensitrelvir) with antiviral activity against coronaviruses including SARS-CoV-2. Antiviral research 2023, 213, 105586.
5. Cheng, H. M. #; Fu, L. B. #*; Yang, X. #; Yang, Y. J.; Zhang, Z. N.; Tao, Y.; Wan, J. T.; Tu, Z. C.; Chen, J. X. *; Li, Y. J. *, Screening and identification of 3-aryl-quinolin-2-one derivatives as antiviral agents against influenza A. Journal of Medical Virology 2023, 95 (1).
6. Yang, Y. J. #; Yu, Q. C. #; Hu, L. #; Dai, B. T.; Qi, R. X.; Chang, Y.; Zhang, Q. W. *; Zhang, Z. *; Li, Y. J. *; Zhang, X. M. *, Enantioselective semisynthesis of novel cephalotaxine esters with potent antineoplastic activities against leukemia. European Journal of Medicinal Chemistry 2022, 244.
7. Li, Y. J. #*; Huang, Y. J. #; Cheng, H. M. #; Xu, F.; Qi, R. X.; Dai, B. T.; Yang, Y. J.; Tu, Z. C.; Peng, L. J. *; Zhang, Z. *, Discovery of BRAF/HDAC Dual Inhibitors Suppressing Proliferation of Human Colorectal Cancer Cells. Frontiers in Chemistry 2022, 10.
8. Li, Y. #; Cao, L. #; Li, G.; Cong, F.; Li, Y.; Sun, J.; Luo, Y.; Chen, G.; Li, G.; Wang, P.; Xing, F.; Ji, Y.; Zhao, J.; Zhang, Y.; Guo, D. *; Zhang, X. *, Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models. Journal of Medicinal Chemistry 2022, 65 (4), 2785-2793.
9. Cao, L. #; Li, Y. #*; Yang, S. #; Li, G. #; Zhou, Q. #; Sun, J. #; Xu, T.; Yang, Y.; Liao, R.; Shi, Y.; Yang, Y.; Zhu, T.; Huang, S.; Ji, Y.; Cong, F.; Luo, Y.; Zhu, Y.; Luan, H.; Zhang, H.; Chen, J.; Liu, X.; Luo, R.; Liu, L.; Wang, P.; Yu, Y.; Xing, F.; Ke, B.; Zheng, H.; Deng, X.; Zhang, W.; Lin, C.; Shi, M.; Li, C.-M.; Zhang, Y.; Zhang, L.; Dai, J.; Lu, H.; Zhao, J. *; Zhang, X. *; Guo, D. *, The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants. Science translational medicine 2022, eabm7621-eabm7621.
10. Li, Y. #; Pasunooti, K. K.; Peng, H.; Li, R.-J.; Shi, W. Q.; Liu, W.; Cheng, Z.; Head, S. A.; Liu, J. O. *, Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors. Acs Medicinal Chemistry Letters 2020, 11 (6), 1111-1117.
11. Yang, W. #; Li, Y. #; Ai, Y.; Obianom, O. N.; Guo, D.; Yang, H.; Sakamuru, S.; Xia, M.; Shu, Y. *; Xue, F. *, Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/beta-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation. Journal of Medicinal Chemistry 2019, 62 (24), 11151-11164.
12. Li, Y. #; Pasunooti, K. K. #; Li, R.-J.; Liu, W.; Head, S. A.; Shi, W. Q.; Liu, J. O. *, Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition. Journal of Medicinal Chemistry 2018, 61 (24), 11158-11168.
13. 氮杂并环衍生物、其药物组合物及其用途. 李迎君;薛晓纤;王萍;李潮;张绪穆. 发明专利, 申请,2023-01-12, 中国, 2023100398982.
国际专利:2023-07-20, WIPO, WO2023134713A1.
14. 一种治疗病毒感染的核苷类化合物及其用途. 张绪穆;郭德银;李官官;曹流;李迎君;徐铁凤;冀彦锡;周启璠;杨彧鉴;朱调珍. 发明专利, 申请,2021-09-15, 中国, 2021110837309.
国际专利:2021-09-15, WIPO, WO2022142477A1.
印度专利:2021-09-15, Indian Application No. 202134041493.
15. 丁克, 李迎君, 程辉敏, 任小梅, 张章, 庄晓曦, 龙活尤, 涂正超, 磺酰胺基芳基炔类化合物及其用途. 发明专利, 授权, 2014-12-9, 中国, 201410753013.6.
16. Itraconazole Analogs and Use Thereof. Jun Liu; Yingjun Li; Kalyan Kumar; Wukun Liu; Wei Shi; Ruojing Li; Sarah A Head. 发明专利, 授权, 2018-10-04, USA, US11028078B2.
国际专利:2021-09-15, WIPO, WO2020072830A1.
中国专利:2021-07-23 CN113164472A