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成果及论文

回国后发表论文:

Chen Y, Sun J, Ju Z, Wang ZQ,Li T* (通讯作者). Nbs1-mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis. Cell Prolif. 54:e12972 (2021).

Zhou ZW, Kirtay M, Schneble N, Yakoub G, Ding M, Rüdiger T, Siniuk K, Lu R, Jiang YN,Li T, Kaether C, Barzilai A,Wang ZQ*. NBS1 interacts with Notch signaling in neuronal homeostasis.Nucleic Acids Res. 4;48(19):10924-10939 (2020).

Wan X, Zhu X, Wang H, Feng Y, Zhou W, Liu P, Shen W, Zhang L, Liu L,Li T, et al. PGC1α protects against hepatic steatosis and insulin resistance via enhancing IL10‐mediated anti‐inflammatory response. FASEB J.4(8):10751-10761 (2020).

Zhu X, Shen W, Yao K, Wang H,Li T, Song L, Diao D, Mao G, et al. Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity. CirculationRes. 125 (7), 707-719 (2019).

Diao D#, Wang H#,Li T# (共同第一), et al. Telomeric epigenetic response mediated by Gadd45a regulates stem cell aging and lifespan. EMBO Rep. 19: e45494 (2018).

Han X, Wei Y, Wang H, Wang F, Ju ZY,Li T* (通讯作者). Nonsense -mediated mRNA decay: a ‘nonsense’ pathway makes sense in stem cell biology.Nucleic Acids Res. 46 (3), 1038–1051 (2018).

Liu X, Zong W,Li T,Wang Y, Xu X, Zhou ZW, Wang ZQ. The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1‐βTrCP2‐Cdc25A‐mediated mitotic entry to ensure neurogenesis. EMBO J. 36 (24), 3666-3681 (2017).

Li T* (通讯作者), Zhou ZW, Ju Z, Wang ZQ. DNA damage response in hematopoietic stem cell ageing.Genomics, Proteomics & Bioinformatics.14(3): 147-154 (2016).

Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Rudolph KL, Liu G,Li T, Ju Z. SIRT6 maintains hematopoietic stem cell homeostasis through the epigenetic regulation of Wnt signaling.Cell Stem Cell.18: 495-507 (2016).


博士后期间工作

Li T, Shi Y, Wang P, Guachalla LM, Sun B, Joerss T, Chen YS, Groth M, Krueger A, Platzer M, Yang YG, Rudolph KL, Wang ZQ. Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay. EMBO J.34:1630-1647 (2015). (当期亮点文章:Highlighted in Lou et al. EMBO J, 34: 1606-1608.)

Zhou ZW, Liu C,Li T, et al. An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.PLoS Genet.9(8):e1003702 (2013).

Li T,Wang ZQ. Point mutation at the Nbs1 Threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 phosphorylation after DNA damage.Mech Ageing Dev.132(8-9):382-8 (2011).

Saidi A#,Li T# (共同第一), et al. Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development.Mol Cell Biol.30(23):5572-81 (2010).