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成果及论文

2024

13. Qiao, S.; Cheng, Z.; Li, F.*  Chemoenzymatic Synthesis of Macrocyclic Peptides and Polyketides via Thioesterase-catalyzed Macrocyclization. Beilstein J. Org. Chem. 2024, 20, 721–733.   (Invited review for the thematic issue "Young investigators in natural products chemistry, biosynthesis, and enzymology") 

2023

12. Li, F.; Deng, H.; Renata, H.* Chemoenzymatic Approaches for Exploring Structure–Activity Relationship Studies of Bioactive Natural Products. Nat. Synth. 2023, 2, 708–718.

11. Jeong, J.-H.; Zhong, S.; Li, F.; Huang, C.; Chen, X.; Liu, Q.; Peng, S.; Park, H.; Lee, Y. M.; Dhillon, J.; Luo, J.-L.Tumor-derived OBP2A Promotes Prostate Cancer Castration Resistance. J. Exp. Med. 2023, 3, e20211546. 


Pior to 2022

10. Li, F.#; Deng, H.#; Renata, H.* Remote B-Ring Oxidation of Sclareol with an Engineered P450 Facilitates Divergent Access to Complex Terpenoids. J. Am. Chem. Soc. 2022, 144, 7616. (# equal contribution)

9. Li, F.; Renata, H.* A Chiral-Pool-Based Strategy to Access Trans-Syn-Fused Drimane Meroterpenoids: Chemoenzymatic Total Syntheses of Polysin, N-Acetyl-Polyveoline and the Chrodrimanins. J. Am. Chem. Soc. 2021, 143, 18280.

8. Li, F.#; Yang, L.-C.#; Zhang, J.; Chen. J. S.; Renata, H.* Stereoselective Synthesis of β-Branched α-Amino Acids via a Biocatalytic Dynamic Kinetic Resolution. Angew. Chem. Int. Ed. 2021, 60, 17680. (# equal contribution, Hot paper)

7. Li, J.#; Li, F.#; King-Smith, E.#; Renata, H.* “Merging Chemoenzymatic and Radical-Based Retrosynthetic Logic for Rapid and Modular Synthesis of Oxidized Meroterpenoids.” Nat. Chem. 2020, 12, 173. (# equal contribution)

6. Li, F.#; Zhang, X.#; Renata, H.* “Enzymatic C–H Functionalizations for Natural Product Synthesis.” Curr. Opin. Chem. Biol. 2019, 49, 25. (# equal contribution)

5. Li, F.; Tu, Q.; Chen. S.; Zhu, L.; Lan, Y.*; Gong, J.*; Yang, Z.* “Bioinspired Asymmetric Synthesis of Hispidanin A” Angew. Chem. Int. Ed. 2017, 56, 5844. (Hot paper)

4. Li, F.; Li, S.; Zhang, P.; Huang, Z.; Zhang, W.*; Gong, J.-X.*; Yang Z.* “A Chiral Pool Approach for Asymmetric Syntheses of (-)-Antrocin, (+)-Asperolide C and (-)-trans-Ozic acid.” Chem. Commun. 2016, 52, 12426. (Back cover)

3. Li, S.; Li, F.; Gong, J.*; Yang. Z.* “Palladium-Catalyzed Carbonylative Cyclization of Aryl Alkenes/Alkenols: A New Reaction Mode for the Synthesis of Electron-Rich Chromanes.” Org. Lett. 2015, 17, 1240.

2. Zhang, W.; Shao, W.; Li, F.; Gong, J.*; Yang. Z.* “Asymmetric Total Synthesis of (-)-Maoecrystal V.” Chem. Asian J. 2015, 10, 1874.

1. Han, J.; Li, F.; Li, C.-C.* “Collective Synthesis of Humulanolides Using a Metathesis Cascade Reaction.” J. Am. Chem. Soc. 2014, 136, 13610.