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成果及论文

2024



  1. Wenqiu Xu,

  2. Jiayi Liu,

  3. Yuzhu Zhang,

  4. Yilu Tang,

  5. Shihao Xu,

  6. Xiaojian Li,

  7. Xiaojian Li,

  8. Xiaojian Li,

  9. Xiaojian Li,

  10. Xiuqing Su,

  11. Binfa Liang#, Xiuqing Su#,

  12. Qiqi Shi#, YuZhu Zhang#,

  13. Yue Guan#, Yiwen Wang#, Chenghui Liao#, Huijie Ma*, Chenyang Li*.

  14. Yue Guan#, Yingying Han#Chenghui Liao#Huijie Ma*, Chenyang Li*.

  15. Qin Gong#, Yifan Song#

  16. Peng Yi#, Yaping Guo#

  17. Binfa Liang,

  18. Jiahua Lu, 

  19. Jin Zhang#, Xiaoling Cheng#, Gang Chen#, Xiya Chen, Xi Zhao, Weiji Chen, Hailing Wang, Dabo Pan, Jinhui Wang, Jian Huang, Zhendan He, Chenyang Li*, Xiaojun Yao*, Dahong Yao*. Design, Synthesis and Biological Evaluation of Novel PAK1/HDAC10 Dual Inhibitors with pyrido[2,3-d]pyrimidin-7(8H)-one scaffold for the Treatment of Triple Negative Breast Cancer. (Submitted)

  20. Guichan Huang#,  Hailing Wang#, Xi Zhao, Dahong Yao*, Chenyang Li*. Design, Synthesis and  Biological Evaluation of new SIRT3 Activators forthe Treatment of Triple-Negative Breast Cancer. (Submitted)

  21. Jianwei Wang#, Xiaojia Lv#, Ying Li, Haiqiang Wu, Meiwan Chen, Hua Yu, Jianwei Wu , Chenyang Li*, Wei Xiong*. A ROS-responsive hydrogel that targets inflamed mucosa to relieve ulcerative colitis by reversing intestinal mucosal barrier loss. (Submitted)

  22. Chenyang Li#, Shuai Wang#, Chenghui Liao, Ying Li, Yunfeng Zhou, Haiqiang Wu, Wei Xiong. An in situ sustained-release chitosan hydrogel to attenuate renalfibrosis by retaining klotho expression. Biomaterials Research, 2024. (中科院大类1区,JCR Q1,IF=8.1) 

  23. Yi Du#, Xiya Chen#, Weiji Chen, Gang Chen, Xiaoling Cheng, Hailing Wang, Chenyang Li*, Dahong Yao*. Design, Synthesis and Biological Evaluation of a Novel PAK1 degrader for the Treatment of Triple Negative Breast Cancer. Bioorganic & Medicinal Chemistry, 2024, 112: 117896. (中科院大类3区,JCR Q1,IF=3.3) 

  24. Yun-Shi Zhi#, Tie Chen#, Bin-Fa Liang, Qin Gong, Xiu-Qing Su, Shan Jiang, Da-Hong Yao, Zhen-Dan He, Chen-Yang Li*, Liang He*, Zheng-Yin Pan*. Endoplasmic Reticulum-Targeted Iridium(III) Photosensitizer Induces Pyroptosis for Augmented Tumor Immunotherap. Journal of Inorganic Biochemistry, 2024, 260, 112695. (中科院大类2区,JCR Q1,IF=3.8)  

  25. Dingjun Wei, Jiaxin Cai, Feixia Qin, Qingqing Zhou, Wei Xiong, Chenshu Xu, Chenyang Li*, Haiqiang Wu*. Structure-activity relationship of dual inhibitors containing maleimide and imidazole motifs against glutaminyl cyclase and glycogen synthase kinase-3β. Bioorganic & Medicinal Chemistry Letters, Available online 19 June 2024, 129851. (中科院大类3区,JCR Q2,IF=2.5)                                                                                                                                                                   2023
  26. Ruirui Yu, Xiaojian Li, Peng Yi, Ping Wen, Shuhong Wang, Chenghui Liao, Xun Song, Haiqiang Wu, Zhendan He* Chenyang Li*Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities. Molecules, 2023, 28(21), 7321. (中科院大类2区,JCR Q2,IF=4.6)

  27. 李晨阳*, 熊炜, 李颖, 郝悦, 陈铁王晓冬赵韵诗王子梅吴海强*. “创新创业”型教育模式在药学人才培养上的探究. 药学教育, 2023.(核心期刊,影响因子:1.14)

  28. Ya-Ping Guo, Peng Yi, Qi-Qi Shi, Rui-Rui Yu, Jin-Hui Wang, Chen-yang Li*, Hai-Qiang Wu*. Cytotoxic Compounds from Belamcanda chinensis (L.) DC Induced Apoptosis in Triple-Negative Breast Cancer Cells. Molecules, 2023, 28(12), 4715. (中科院大类2区,JCR Q2,IF=4.927)

  29. Zhengyin Pan, Binfa Liang, Yunshi Zhi, Dahong Yao*Chenyang Li*, Hai-Qiang Wu* and Liang He*. Near-infrared AIE-active phosphorescent iridium(III) complex for mitochondria-targeted photodynamic therapy. Dalton Transactions, 2023. (中科院大类2区,JCR Q1,IF=4.569)

    2022

  30. Ying Li, Guoxing Deng, Xianlong HuChenyang Li, Xiaodong Wang, Qinchang Zhu, Kai Zheng, Wei Xiong, Haiqiang Wu. Recent advances in mesoporous silica nanoparticle-based targeted drug-delivery systems for cancer therapy. Nanomedicine, 2022, 17(18), 1253-1279. (中科院大类2区,JCR Q1,IF=6.096)

  31. Xiaopeng Hu, Ruirui Yu, Chenyang Li*. Experimental validation and virtual docking of anti-influenza effects of robinin based on network pharmacology. Experimental and Therapeutic Medicine. 2022. (中科院大类4区,JCR Q4,IF=2.751)

  32. Xiao-Peng Hu#, Ya-Ping Guo#, Tie Chen, Er-Jie Chen, Yi Du, Qian Zhang, Peng Yi, Rui-Rui Yu, Yun-Shi Zhi, Chen-Yang Li*Isolation, Structure Elucidation, and In-vitro Evaluation of New Trisubstituted Tetrahydrofuran Lignins from Rabdosia lophanthoides var. gerardiana as anti-inflammatory agents. Phytochemistry Letters. 2022, 52, 76-81. (中科院大类4区,JCR Q3,IF=1.873)

  33. Mengxun Zhang#, Yi Du#, Liping Huang, Qinchang Zhu, Chenyang Li*, Zhendan He*Electromediated Aldol Reaction in EtOH/H2O. Journal of The Electrochemical Society.  2022, 169(7), 075501. (中科院大类3区,JCR Q2,IF=4.386)

  34. Qian Zhang#, Mengxun Zhang#, Yingchao Wang, Tingting Zhen, Roujuan Wang, Shuhong Wang, Yi Du, Ruirui Yu, Peng Yi, Yifan Song, Yunshi Zhi, Xun Song, Yaping Guo, Zhendan He, Tie Chen, Chenyang Li*Natural compound 2-chloro-1,3-dimethoxy-5-methylbenzene, isolated from Hericium erinaceus, inhibits fungal growth by disrupting membranes and triggering apoptosis. Journal of Agricultural and Food Chemistry. 2022, 70(21), 6444–6454. (中科院大类1区,JCR Q1,IF=5.279)

    2021

  35. Xiaopeng Hu#, Tie Chen#, Shuquan Zhang, Qian Zhang, Chenyang Li*, Xiaodong Wang*Anti-tumor effect of Odoroside A and its derivative on human leukemia cells through the ROS/JNK pathway. Basic & Clinical Pharmacology & Toxicology. 2021, 130(1), 56-59(中科院大类3区,JCR Q2,IF=4.084)

  36. Huiling Hong, Yiu Ming Cheung, Xiaoyun Cao, Yalan Wu, Chenyang Li,  Xiao Yu Tian. REV-ERB alpha agonist SR9009 suppresses IL-1 beta production in macrophages through BMAL1-dependent inhibition of inflammasome. Biochemical Pharmacology. 2021, 192. (中科院大类2区,JCR Q1,IF=5.858)

  37. Mengxun Zhang, Jiaqing Zhong, Yongai Xiong, Xun Song, Chenyang Li*, Zhendan He*. Development of Broad-Spectrum Antiviral Agents-Inspiration from Immunomodulatory Natural Products. Viruses. 2021, 13(7), 1257. (中科院大类2区,JCR Q2,IF=5.048)

  38. Jonathan Shpigelman#, Fitzgerald S. Lao#, Shiyin Yao, Chenyang Li, Tetsuya Saito, Fumi Sato-Kaneko, John P. Nolan, Nikunj M. Shukla, Minya Pu, Karen Messer, Dennis A. Carson, Maripat Corr, Tomoko Hayashi*. Generation and application of a reporter cell line for the quantitative measurement of extracellular vesicle release. Frontiers in Pharmacology. 2021, 12, 668609. (中科院大类2区,JCR Q1,IF=5.81)

  39. Yongai Xiong, Muhammad Shahid Riaz Rajoka, MengXun Zhang, Ning Liang, Chenyang Li*, Zhendan He*. Virucidal activity of Moringa A from Moringa oleifera seeds against Influenza A Viruses by regulating TFEB. International Immunopharmacology. 2021, 95, 107561. (中科院大类3区,JCR Q1,IF=4.932)

  40. Mengxun Zhang#, Tie Chen, Shisong Fang, Weihua Wu, Xin Wang, Haiqiang Wu, Yongai Xiong, Jun Song, Chenyang Li*, Zhendan He*, Chi-Sing Lee*. Peroxide- and transition metal-free electrochemical synthesis of α,β-epoxy ketones. Organic & Biomolecular Chemistry. 2021, 19(11), 2481-2486. (中科院大类3区,JCR Q1,IF=3.876)

  41. Tongxin Song#, Pengli Wang#Chenyang Li#, Qianqian Liang, Yuanlin Cao, Pengzhi Dong, Hong Shi, Miaomiao Jiang*Salidroside simultaneously reduces de novo lipogenesis and cholesterol biosynthesis to attenuate atherosclerosis in apoE-deficient mice. Biomedicine & Pharmacotherapy. 2021, 134, 111137. (中科院大类2区,JCR Q1,IF=6.529)

  42. Chen-Yang Li#, Xiao-Jun Zhong#, Xiao-Peng Hu, Qin-Chang Zhu, Hai-Tao Xiao, Peng Zhai, Da-Hong Yao, Muhammad Shahid Riaz, Zhen-Dan He*, Xun Song*Modulation of antiviral cytokine production and lung protection against influenza virus by the glycosides from Ligustrum purpurascens. Asian Toxicology Research. 2021, 3 (1): 3.

    2020

  43. Qianqian Pang#, Weiyang Zhang#Chenyang Li#, Haibo Li, Yu Zhang, Lin Li, Caixia Zang, Xinsheng Yao, Dan Zhang*, Yang Yu*Antidementia effects, metabolic profiles and pharmacokinetics of GJ-4, a crocin-rich botanical candidate from Gardeniae fructus. Food & Function. 2020, 11(10), 8825-8836. (中科院大类1区,JCR Q1,IF=5.396)

  44. Dahong Yao#Chenyang Li#, Muhammad Shahid Riaz Rajoka, Zhendan He, Jian Huang, Jinhui Wang*, Jin Zhang*P21-Activated Kinase 1: Emerging biological functions and potential therapeutic targets in Cancer. Theranostics. 2020, 10(21), 9741-9766. (中科院大类1区,JCR Q1,IF=11.556)

  45. Dahong Yao#Chenyang Li#, Jin Jiang, Jian Huang, Jinhui Wang, Zhendan He*, Jin Zhang*. Design, synthesis and biological evaluation of novel HDAC inhibitors with improved pharmacokinetic profile in breast cancer. European Journal of Medicinal Chemistry. 2020, 205, 112648. (中科院大类2区,JCR Q1,IF=6.514)

  46. Xiaobin Li#Chenyang Li#, Yongqiang Zhu, Yongping Shi, Xuanming Zhang, Shanshan Zhang, Lizhen Wang, Houwen Lin, Hairong Hou, Chung-Der Hsiao, Liwen Han*, Kechun Liu*. Lipid Fingerprinting of Different Material Sources by UPLC-Q-Exactive Orbitrap/MS Approach and Their Zebrafish-Based Activities Comparison. Journal of Agricultural and Food Chemistry. 2020, 68(7), 2007-2015. (中科院大类1区,JCR Q1,IF=5.279)

    Prior to 2020

  47. Yuanlin Cao, Menghan Zhang, Yunfang Lu, Chenyang Li*, Jinshan Tang, Miaomiao Jiang*. Cardenolides from the leaves of Nerium oleander. Fitoterapia, 2018, 127, 293-300. (中科院大类3区,JCR Q3,IF=2.527)

  48. Xiaodong Wang#Chenyang Li#, Miaomiao Jiang, Dong Li, Ping Wen, Xun Song, Junda Chen, Lixuan Guo, Xiaopeng Hu, Guoqiang Li, Jian Zhang, Chunhua Wang*, Zhendan He*. Induction of apoptosis in human leukemia cells through an intrinsic pathway by cathachunine, a unique alkaloid isolated from Catharanthus roseus. Phytomedicine, 2016, 23(6), 641-653. (中科院大类2区,JCR Q1,IF=4.268)

  49. Jiangtao Zhou#Chenyang Li#, Chunhua Wang*, Yuefei Wang, Xiaodong Wang, Hongtao Wang, Yan Zhu, Miaomiao Jiang*, Xiumei Gao. Phenolic compounds from the roots of Rhodiola crenulata and their antioxidant and inducing IFN-γ production activities. Molecules, 2015, 20, 13725-13739. (中科院大类3区,JCR Q2,IF=3.267)

  50. 李晨阳#, 王晓冬, 郝悦, 贺震旦, 谢苗. 对我国现有药学课程改革与创新的思考.药学教育. 2015, (5), 9-13. (核心期刊,影响因子:1.14)

  51. Chenyang Li#, David Taiwai Lau#, Tina Tingxia Dong, Jian Zhang, Roy Chiyan Choi, Haiqiang Wu, Liyan Wang, Ruisha Hong, Shihe Li, Xun Song, Tian Yu, Weiwei Su, Karl Wahkeung Tsim*, Zhendan He*. Dual-Index Evaluation of Character Changes in Panax ginseng C. A. Mey Stored in Different Conditions. Journal of Agricultural and Food Chemistry, 2013, 61 (26): 6568-6573. (中科院大类1区,JCR Q1,IF=4.192)

  52. Xun Song#Chenyang Li#, Yong Zeng, Haiqiang Wu, Zhong Huang, Jian Zhang, Ruisha Hong, Xianxiong Chen, Liyan Wang, Xiaopeng Hu, Weiwei Su, Yan Li*, Zhendan He*. Immunomodulatory effects of crude phenylethanoid glycosides from Ligustrum purpurascens. Journal of Ethnopharmacology, 2012, 144 (3): 584-591. (中科院大类3区,JCR Q1,IF=3.690)

  53. Chenyang Li#, Hao Gao, Weihua Jiao, Long Zhang, Guangxiong Zhou, Xinsheng Yao*. Three new diterpenoids from Rabdosia lophanthoides var. gerandiana. Helvetica Chimica Acta, 2010, 93 (3): 450-456. (中科院大类4区,JCR Q3,IF=2.309)

专利

  1. 姚新生高昊赵峰李晨阳王国才焦伟华张龙贺飞戴毅姚志红周光雄叶文才复方消炎利胆制剂的质量控制方法中国公布号: CN101361793.

  2. 姚新生高昊赵峰焦伟华李晨阳贺飞戴毅姚志红周光雄叶文才苦木中的β-卡巴林类生物碱及其制备方法和用途中国公布号: CN101367802.

  3. 贺震旦廖程晖宋勋胡小鹏李晨阳紫茎女贞总苷诱导抗病毒细胞因子的应用专利号:ZL 2015 1 0083455.9. 授权日:2018年5月1日。

  4. 王春华李晨阳王晓冬王跃飞朱彦李东化合物、其提取方法、包含其的药物组合物及其用途专利号:ZL 2015 1 0108820.7. 授权日:2017年2月1日。

  5. 陈铁, 李璟端, 王绍祥, 李晨阳, 舒兴盛, 常港, 陈家杰. 一种新的胃癌肿瘤干细胞杀伤剂及其应用. 专利号:ZL 2018 1 0923567.4. 授权日:2020年11月27日。

  6. 熊炜, 王健伟, 李晨阳, 李颖. 一种可用于结肠炎症的制剂及其制备方法. 申请号:2023102254726。

  7. 李晨阳,韩颖颖,廖程晖,吴海强,郝悦. 一种射干流分的制备方法及其在制备抗单纯疱疹病毒 1 型药物上的应用. 申请号:202410068995.9。

  8. 李晨阳廖程晖吴海强郝悦陈铁张羽竹. 一种二萜类化合物及其制备方法和应用. 申请号:2024112907136


专著

  1. 李晨阳等编著,《中药学》[M],天津科技出版社,2020年10月。

  2. 李晨阳等编著,《药学技能综合实训》[M],中国海洋出版社,2020年10月。

  3. 贺震旦、赵韵诗、李晨阳等编著,《常用中药毒性成分分析与结构鉴定》[M],科学出版社,2020年10月。

获奖

  1. 冬青属药用植物与苦丁茶的药效物质及其在感冒灵中的应用. 2020年度高等学校科学研究优秀成果奖科技进步奖一等奖。

  2. 贺震旦, 吴序栎, 宋勋, 李晨阳, 胡小鹏. 深圳大学. 苦丁茶资源科学、物质基础及其功效机制研究. 2020年度深圳市科学技术奖,自然科学类二等奖(排名第四)。

  3. 深圳市优秀教师,2023、2024。

  4. 深圳大学腾讯益友奖“优秀班主任”,2016、2021。

  5. 深圳大学百篇优秀本科毕业论文指导教师,2017。

  6. 深圳大学学生创新发展基金基础实验项目一等奖(2015)和优秀奖(2015)。

  7. 深圳大学“优秀实习指导教师”,2021、2022

  8. 深圳大学2020-2021学年教学单项奖“优秀本科课程”奖,(生药学),2022。