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成果及论文

1.Jianqing Gao* et al. Responsive assembly of sliver nanoclusters with biofilm locally amplified bactericidal effect to enhance treatments against multidrug-resistant bacterial infections, ACS Central Science, 2019, In press

2.Jianqing Gao* et al. Reactive oxygen species and near-infrared light dual-responsive indocyanine T green-loaded nanohybrids for overcoming tumour multidrug resistance, Eur J Pharmacol, 2019, 134:185-193

3.Jianqing Gao* et al. Enhancement of oral bioavailability of salmon calcitonin through chitosan-modified, dual drug-loaded nanoparticles, Int J Pharm, 2019 Feb 25;557:170-177

4.Jianqing Gao* et al.  Nanoscaled pearl powder accelerates wound repair and regeneration in vitro and in vivo, Drug Dev Ind Pharm, 2019 Jun;45(6):1009-1016

5.Jianqing Gao* et al. Co-delivery of metformin enhances the anti-multidrug resistant tumor effect of doxorubicin by improving hypoxic tumor microenvironment, Mol Pharm., 2019 May 16.doi: 10.1021/acs.molpharmaceut.9b00199.

6.Jianqing Gao* et al, Daishun Ling*Ferrimagnetic Nanochains-Based Mesenchymal Stem Cell Engineering for Highly Efficient Post-Stroke Recovery,Adv Func Mater, 20191 900603

7.Jian-Qing Gao* et al. Biomaterials for local drug delivery in central nervous system, Int J Pharm, 2019, 560:92-100

8.Jian-Qing Gao* et al. Dai-Shun Ling*,Promoting Angiogenesis in Oxidative Diabetic Wound Microenvironment Using a Nanozyme-Reinforced Self-Protecting Hydrogel,ACS Cent Sci, 2019 March 27; 5(3):477-485 (Front Cover)

9.Jian-Qing Gao* et al. Mesenchymal stem cell-based drug delivery strategy:from cells to biomimetic,J Control Rel, 2019:294:102-113

10. Jian-Qing Gao* et al. Neural Stem Cells Transfected with Reactive Oxygen Species-Responsive Polyplexes for Effective Treatment of Ischemic Stroke, Adv. Mater, 2019, Jan 11,e1807591

11. Jian-Qing Gao et al. Pharmaceutical science research training: an early practice course for first-year students, Med Educ, 2018, 52:1180-1209

12. Jian-Qing Gao* et al. Uniformly sized iron oxide nanoparticles for efficient gene delivery to T mesenchymal stem cells, Int J Pharm,2018,552:443-452 

13.Jian-Qing Gao* et al. Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advancesAsian J Pharm Sci, 2018, 13:16-32 

14.Jian-Qing Gao et al. Mesenchymal stem cells loaded with paclitaxel-poly(lactic-co-glycolic acid) nanoparticles for glioma-targeting therapy, Int J Nanomedicine,2018, 13:5231-5248

15.Jian-Qing Gao* et al. Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesisDrug Delivery, 2018, 25(1): 1779-1789

16.Jian-Qing Gao* et al. Enzyme-responsive charge-reversal polymer mediated effective gene therapy for intraperitoneal tumorsBiomacromolecules, 2018, 19: 2308-2319

17.Jian-Qing Gao* et al. Fabrication and Characterization of Peptide Modified Hyaluronic Acid Scaffolds Applied for the Growth of Bone Marrow Mesenchymal Stem Cells,中国现代应用药学2017123412):1647-53

18.Jian-Qing Gao* et al. Delivery of mitochondriotropic doxorubicin derivatives by a self-assembling hyaluronic acid nano-carriers to overcome drug resistance in breast cancer, Acta Pharmacologica Sinica, 2018,39:1-12

19.Jian-Qing Gao* et al. Targeting Tumor Hypoxia with HIF1α siRNA and Doxorubicin via Hypoxia Responsive Size-shrinkable Nanocarriers for Overcoming Tumor Drug ResistanceActa Biomaterialia, 2018, 71:351-362

20. Jian-Qing Gao* et al. A tumor targeted near-infrared light-controlled nanocomposite to combat with multidrug resistance of cancerJ Control Rel, 2018,288:34-44

21.Jian-Qing Gao* et al. Transplantation of BDNF Gene Recombinant Mesenchymal Stem Cells and Adhesive Peptide-modified Hydrogel Scaffold for Spinal Cord Repair, Curr Gene Ther2018,18(1):29-39

22.Jian-Qing Gao et al. A photosensitive liposome with NIR light triggered doxorubicin release as a combined photodynamic-chemo therapy system, J Control Rel, 2018,277:114-125

23. Jian-Qing Gao* et al. Mitochondrial Targeted Doxorubicin-Triphenylphosphonium Delivered by Hyaluronic Acid Modified and pH Responsive Nanocarriers to Breast Tumor: in Vitro and in Vivo Studies,Mol Pharm, 2018, 15:882-891

24.Jian-Qing Gao* et al.  Eur J Pharmacol 2018 Jan 31;823:72-78. 

25.Jian-Qing Gao* et al. Metformin synergisitically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of g-glycoprotein in MCF7/ADR cells and xerograft models, Oncotarget2018;9(2):2158-2174.

26.Jian-Qing Gao* et al. Dai-Shun Ling*Ceria nanocrystals decorated mesoporous silica nanoparticle based ROS-Scavenging tissue adhesive for highly efficient regenerative wound healing,Biomaterials2018;151:66-77.

27.Jian-Qing Gao* et al. Application of 3D cultured multicellular spheroid tumor models in tumor-targeted drug delivery system research,J Control Release, 2018,270:246-259

28.Jian-Qing Gao et al. A Noncytotoxic Dendrimer of Innate and Potent Anticancer and Anti-metastatic ActivitiesNature Biomedical Engineering, 2017,1(9):745-757 

29. Jian-Qing Gao et al. Folate acid-Cyclodextrin/Docetaxel induces apoptosis in KB cells via the intrinsic mitochondrial pathway and displays antitumor activity in vivo.Eur J Pharm Sci.2017 Oct 31;111:540-548. 

30.Jian-Qing Gao* et al. Int J Nanomed, 2017,12:8557-72

31. Jian-Qing Gao* et al. MMP-2 sensitive HA end-conjugated poly(amidoamine) dendrimers via click reaction to enhance tumor penetration, ACS Appl Mater Interfaces. 2017 Dec 13;9(49):42459-42470. 

32.Jian-Qing Gao* et al. Peptide Modified Mesenchymal Stem Cells as Targeting Delivery System Transfected with MiR-133b for the Treatment of Cerebral Ischemia, Int J Pharm, 2017 Aug 18;531(1):90-100. 

33.Jian-Qing Gao et al. VEGF siRNA delivered by polycation liposomes encapsulated calcium phosphate nanoparticles (PLCP) for tumor angiogenesis inhibition in breast cancer, Int J Nanomed2017 Aug 21;12:6075-6088

34.Jian-Qing Gao* et al. A tumor-specific cascade amplification drug release nanoparticle for overcoming multidrug resistance in cancers, Adv Mater2017,29:1702342

35.Jian-Qing Gao et al.Supramolecular β-sheets Stabilized Protein Nanocarriers for Drug Delivery and Gene TransfectionACS Nano2017 May 23;11(5):4528-4541.

36.Jian-Qing Gao et al. Modifying the Surface of Silica Nanoparticles with Amino or Carboxyl Groups Decreases Their Cytotoxicity to Parenchymal Hepatocytes.Biol Pharm Bull. 2017;40(5):726-728.

37.Jian-Qing Gao* et al. Exosomes as novel bio-carriers for gene and drug deliver, Int J Pharm2017,521:167-175

38.Jian-Qing Gao* et al. Capsaicin loaded nanolipoidal carriers for topical application: Design, characterization and in vitro/in vivo evaluationInt J Nanomed,2017, 12:3881-3898

39.Jian-Qing Gao* et al. Efficient induction of antimicrobial activity with vancomycin nanoparticle-loaded poly(trimethylene carbonate) locolized drug delivery system, Int J Nanomed,  2017 Feb 10;12:1201-1214

40.Jian-Qing Gao* et al. Transdermal Gene Delivery by Functional Peptide Conjugated Cationic Gold Nanoparticle Reverses the Progression and Metastasis of Cutaneous MelanomaACS Appl Mater Interfaces.2017 Mar 22;9(11):9388-9401.

41.Jian-Qing Gao* et al. Evaluation of efficacy of aloin in treating acute trauma in vitro and in vivo, Biomedicine & Pharmacotherapy,2017 April, 88:1211–1219 

42.Jian-Qing Gao* et al.  Peptide-tethered Hydrogel Scaffold Promotes Recovery from Spinal Cord Transection via Synergism with Mesenchymal Stem Cells.ACS Appl Mater Interfaces.2017 Feb 1;9(4):3330-3342.

43. Jian-Qing Gao* et al. Sustained release of piroxicam from solid lipid nanoparticle as an effective anti-inflammatory therapeutics in vivo, Drug Development and Industrial Pharmacy,2017;43(1):55-66
44.Jian-Qing Gao et al. Cellular internalization, transcellular transport, and cellular effects of silver nanoparticles in polarized Caco-2 cells following apical or basolateral exposure, Biochemical and Biophysical Research Communications, 2017 Mar 11;484(3):543-549.

45.Jian-Qing Gao* et al. Design of Magnetic Gene Complexes as Effective and Serum Resistant Gene Delivery Systems for Mesenchymal Stem Cells, Int J Pharm, 2017 Jan 25;520(1-2):1-13

46.Jian-Qing Gao* et al. pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms, Drug Delivery, 2017 Nov;24(1):569-581.

47.Jian-Qing Gao* et al.Pluronic F68 (PF68)-conjugated polyamidoamine dendrimer conjugates for doxorubicin delivery forovercoming mltidrug resistance, and clarify thereversal mechanism, Nanomedicine (Lond),2016 Nov;11(22):2917-2934.

48.Jian-Qing Gao et al. Potential suppressive effects of two C60-fullerene derivatives on acquired immunity, Nanoscale Research Letters, 2016 Dec;11(1):449

49.Jian-Qing Gao et al. Local Delivery of Flavopiridol in PLGA Nanoparticles Regulates Inflammation and Repairs Spinal Cord InjuryTissue Engineering--Part A, 2016,12:S152-S152

50.Jian-Qing Gao* et al. Chitosan nanoparticles and their Tween 80 modified counterparts disrupt the developmental profile of zebrafish embryos,Int J Pharm, 2016,515:644-656

51.Jian-Qing Gao* et al. Fabrication and characterization of drug-loaded nano-hydroxyapatite/polyamide 66 scaffolds modified with carbon nanotubes and silk fibroin,Int J Nanomed, 2016:11 6181–6194

52.Jian-Qing Gao* et al. Coating with Spermine-Pullulan Polymer Enhances Adenoviral Transduction of Mesenchymal Stem Cells, Int J Nanomed, 2016:11 6763–6769

53. Jian-Qing Gao* et al. Combination of Photodynamic Therapy with Radiotherapy for Cancer Treatment,J Nanomaterials, 2016,Article ID 8507924, 7 pages

54. Jian-Qing Gao et al. Preparation and evaluation of folic acid receptor-targeted cyclodextrin complexes for anticancer drug delivery system,Nanomedicine:Nanotechnology Biology and Medicine,2016,12(2):541-541

55.Jian-Qing Gao* et al. Integration of antimicrobial peptides with gold nanoparticles as unique non-viral vectors for gene delivery to mesenchymal stem cells with antibacterial activityBiomaterials, 2016 Jun 27;103:137-149.

56.Jian-Qing Gao* et al. Pegylated or Non-pegylated Liposomal Doxorubicin in the Management of Advanced Breast Cancer: A Meta-analysis, Int J Clinical & Experimental Medicine2016;9(2):525-534

57.Jian-Qing Gao* et al. Chemosensitization of doxorubicin in multidrug-resistant cells by unimolecular micelles via increased cellular accumulation and apoptosis.J Pharm Pharmacol2016 Mar;68(3):333-41. 

58.Jian-Qing Gao* et al. Folate receptor-targeted liposomes loaded with diacid metabolite of norcantharidin enhanced the antitumor potency to H22 hepatocellular carcinoma: in vitro and in vivoInt J Nanomed, 2016,11:1395-1412
59.Jian-Qing Gao* et al. Toxicity Analysis of Various Pluronic F-68-Coated Carbon Nanotubes on Mesenchymal Stem Cells, Chemico-Biological Interactions, 2016 Mar 10;250:47-58. 

60.Jian-Qing Gao* et al. Preparation of sertraline-loaded nanoparticles and the pharmacokinetics studiesAfr J Pharm Phamcol, 2016,10(3):26-33

61.Jian-Qing Gao* et al. Adult Stem Cells Seeded on Electrospinning Silk Fibroin Nanofiberous Scaffold Enhance Wound Repair and Regeneration,Journal of Nanoscience and Nanotechnology, 2016,16(6):5498-5505

62.Jian-Qing Gao* et al. Evaluation of the pharmacokinetics of diacid metabolite of norcantharidin loaded in folic acid-targeted liposomes in mice by using liquid chromatography-tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2016,119:76-83

63.Jian-Qing Gao* et al. Nanomedicine:Nanotechnology Biology and Medicine, 2016 Feb;12(2):421-430.

64.Jian-Qing Gao* et al. Polycation liposomes combined with calcium phosphate nanoparticles as a non-viral carrier for siRNA delivery,Journal of Drug Delivery Science and Technology, 30PA (2015) 575–588

65.Jian-Qing Gao* et al. Cell Membrane Capsules for Encapsulation of Chemotherapeutics and Cancer Cell Targeting In Vivo, ACS Applied Materials & Interfaces, 2015,7:18628-18637

66.Jian-Qing Gao* et al. Synergistic Effects of Co-administration of Suicide Gene Expressing Mesenchymal Stem Cells and Prodrug-encapsulated Liposome on Aggressive Lung Melanoma Metastases in Mice, J Control Rel.2015,209:260-71

67.Jian-Qing Gao* et al. Inhibition of G Protein-Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury.CNS Neurosci Ther.2015 Mar;21(3):271-9. 

68.Jian-Qing Gao et al. Human epidermal growth factor receptor-2 antibodies enhance the specificity and anticancer activity of light-sensitive doxorubicin-labeled liposomes.Biomaterials.2015 Jul;57:1-11

69.Jian-Qing Gao* et al. Design of cell niches for the regulation of stem cell fate in central nervous tissue regeneration,Materials Letters, 2015,148:96-98

70.Jian-Qing Gao* et al. ScreenFect A: an efficient and low toxic liposome for gene delivery to Mesenchymal stem cellsInt J Pharm, 2015,488,1-11

71.Jian-Qing Gao* et al. Brain Localization and Neurotoxicity Evaluation of Polysorbate 80-Modified Chitosan Nanoparticles in Rats, Plos One, 2015 Aug 6;10(8):e0134722.

72.Jian-Qing Gao* et al. Enhancement of mesenchymal stem cell angiogenic capacity by non-viral gene transfection for wound repair and regeneration in full-thickness skin wounds, J Biomed Nanotech, 2015,11(4):680-690

73.Jian-Qing Gao* et al. Microneedle-assisted Dendritic Cell-targeted Nanoparticles for Transcutaneous DNA Immunization,Polymer Chemistry, 2015,6(3):373-79

74.Jian-Qing Gao* et al. Silk fibroin/gelatin electrospun nanofibrous dressing functionalized with Astragaloside IV induces healing and anti-scar effects on burn wound, Int J Pharm, 2015 Feb 20;479(2):291-301.

75.Jian-Qing Gao* et al. Nanocarrier improves the bioavailability, stability and antitumor activity of camptothecin,Int J Pharm, 2014,477:536-545

76.Jian-Qing Gao* et al. Synthesis of mannosylated polyethylenimine and its potential application as cell-targeting non-viral vector for gene therapyPolymer,2014, 6, 2573-2587

77.Jian-Qing Gao* et al. Effect of PLGA Pore Sizes and 80 wt% PCP/PLGA Scaffolds on the Attachment and Proliferation of Costal Cartilage CellsInter J Tissue Regen, 2014;5,(2):46-52

78.Jian-Qing Gao et al. Doxorubicin encapsulated in micelles enhances radiosensitivity in doxorubicin-resistant tumor cells.Discov Med.2014 Oct;18(99):169-77.

79.Jian-Qing Gao* et al. Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells, Biochem Biophys Res Commun,2014,447(3):383-387

80. Jian-Qing Gao et al. Hybridization Scaffold: Tissue EngineeringEncyclopedia of Biomedical Polymers and Polymeric Biomaterials, in press

81.Jian-Qing Gao* et al. Recombinant stem cells as carriers for cancer gene therapy.Methods Mol Biol.2014;1141:103-8

82.Jian-Qing Gao et al. Angiopep-Conjugated Electro-Responsive Hydrogel Nanoparticles: Therapeutic Potential for Epilepsy.Angew Chem Int Ed Engl.2014 Nov 10;53(46):12436-40.

83. Jian-Qing Gao* et al. Hepatic-targeted gene delivery using cationic mannan vehicle, Mol Pharm, 2014 Oct 6;11(10):3322-9

84.Jian-Qing Gao* et al. TAT conjugated cationic noble metal nanoparticles for gene delivery to epidermal stem cells,Biomaterials, 2014 Jul;35(21):5605-18

85.Jian-Qing Gao* et al. A mannosylated cell-penetrating peptide-graft-polyethylenimine as a gene delivery vectorBiomaterials,2014,35(13):4236-4246

86.Jian-Qing Gao* et al. Repair of spinal cord injury by inhibition of astrocyte growth and inflammatory factor synthesis through local delivery of flavopiridol in PLGA nanoparticlesBiomaterials,2014 Aug;35(24):6585-94

87.Jian-Qing Gao* et al. Sequential release of salidroside and paeonol from a nanosphere-hydrogel system inhibits ultraviolet B-induced melanogenesis in guinea pig skin, Int J Nanomed, 2014 Apr 16;9:1897-1908

88.Jian-Qing Gao* et al. Novel macrophage mannose receptor–specific gene delivery vehicle for macrophage engineering,Acta Biomater2014,10(5):1847-1855

89.Jian-Qing Gao* et al. High Efficiency Intracellular Transport Cationic Peptide Stearate for Gene Delivery of Tumor Cells and Multipotent Stem Cells,J Biomed Nanotech, 2014,10(11):3231-3243

90.Jian-Qing Gao* et al. Antigen loaded chitosan nanoparticles enhanced migration of nanoparticle-stimulated langerhans cells to the draining lymph node and induced effective immunization,Nanomedicine:Nanotechnology Biology and Medicine, 2014,10:215-223

91.Jian-Qing Gao* et al. Gene recombinant bone marrow mesenchymal stem cellsas a tumor-targeted suicide gene deliveryvehicle for pulmonary metastasis therapy,Nanomedicine:Nanotechnology Biology and Medicine, 2014,10:257-267

92.Jian-Qing Gao* et al. Reversal of tumor growth by gene modification of mesenchymal stem cells using spermine-pullulan/DNA nanoparticles, J Biomed Nanotech, 2014 Feb, 10(2):299-308

93.Jian-Qing Gao* et al. Dual release of dexamethasone and TGF-β3 from polymeric microspheres for the stem cell matrix accumulation in a rat disc degeneration model.Acta Biomater2013 Dec;9(12):9423-33

94.Jian-Qing Gao* et al. Evaluation of pluronic nanosuspension loading a novel insoluble anticancer drug both in vitroand in vivoInt J Pharm,2013 Nov 1;456(1):243-50.

95.Jian-Qing Gao* et al. Role of scaffold properties in cell-based therapy for spinal cord regeneration, International Journal of Tissue Regeneration, 2013,4(3):65-70

96.Jian-Qing Gao* et al. A novel chitosan-based thermosensitive hydrogels containing doxorubicin liposomes for topical cancer therapy, J Biomater Sci Polym Ed.201341649-1659  

97.Jian-Qing Gao* et al. Mechanism of Enhanced Oral Absorption of Hydrophilic Drug Incorporated in Hydrophobic Nanoparticles,Int J Nanomed, 2013,8:2709-2717

98.Jian-Qing Gao* et al. Epidermal Stem Cells Manipulated by pDNA-VEGF165/CYD-PEI Nanoparticles Loaded Gelatin/beta-TCP Matrix as a Therapeutic Agent and Gene Delivery Vehicle for Wound Healing, Mol Pharm, 2013 Aug 5;10(8):3090-102

99.Jian-Qing Gao* et al. Inhibitory effects of salidroside and paeonol on tyrosinase activity and melanin synthesis in mouse B16F10 melanoma cells and ultraviolet B-induced pigmentation in guinea pig skin, Phytomedicine,2013,20(12):1082-1087     

100.Jian-Qing Gao* et al. Effective Gene Delivery to Mesenchymal Stem Cells Using a Synthesized Vector, Chitosan-linked-Polyethylenimine,Materials Express, 2013,3(2):151-158

101.Jian-Qing Gao* et al. Glioma targeting and blood-brain barrier penetration by dual-targeting doxorubincin liposomes,Biomaterials, 2013 Jul;34(22):5628-39

102.Jian-Qing Gao* et al. Transplantation of bone marrow and skin derived stem cells contribute to wound healing with different regenerative features,Cell Tissue Res,2013,352:573–583

103.Jian-Qing Gao* et al. Astragaloside IV-loaded nanoparticle-enriched hydrogel induces wound healing and anti-scar activity through topical delivery, Int J Pharm,2013,447(1-2):171-181

104.Jian-Qing Gao* et al. Co-transfection gene delivery of dendritic cells induced effective lymph node targeting and anti-tumor vaccinationPharm Res,2013 Jun;30(6):1502-12

105.Jian-Qing Gao* et al. Characteristics of sequential targeting of brain glioma for transferrin-modified cisplatin liposome, Int J Pharm, 2013,444(1-2):1-9